Opioids are widely utilized by the public as both legal and illegal substances. Opiates, particularly heroin, are among the most widely used illicit narcotics and still account for the majority of seizures globally, despite the development of Novel Psychoactive Substances (NPS), particularly new fentanyl derivatives. The article gives a general review of opiates' pharmacology, analgesic action, and classification. It discussed how they might be abused by the general public and in the event of tampering. Because of the hazards of accidents linked to opiate use and dependence, opiates are furthermore closely monitored in workplace drug testing programs around the world. Also it covered analytical techniques for opiate detection in biological fluids. In the modern era, substance abuse has emerged as a global epidemic. Opium and its derivatives are second only to cannabis in terms of global consumption among illegal narcotics.