Purpose: The H1N1 2009 influenza were found in the United States and Mexico in April 2009. It spread almost all countries of the world. The World Health Organization announced that the status of the influenza was a pandemic in June 2009. H1N1 influenza spread rapidly in Takamatsu city Japan also. The H1N1 influenza has been epidemic form yet. We analyzed number of influenza patients during 2009/2010 and 2017/2018 in Takamatsu city and on a university campus in Japan. Methods & Materials: We analyzed number of patients infected with influenza in Takamatsu city and on a university campus in Japan from August 2009 to February 2010 and from September 2017 to June 2018. We used SPSS 24.0 for Windows (IBM Inc., Chicago, IL, USA) for multiple regression analysis. Results: According to multiple regression analysis results, temperature and humidity were significantly correlated with number of daily patients in Takamatsu city 2017/2018 (p < 0.001, R = 0.763, AIC = 162.374). It was suggested that temperature, humidity, a holiday the next day after the lecture and a holiday 2 days after the lecture were significantly correlated with number of daily patients on a university campus 2009/2010 (p < 0.001, R = 0.348, AIC = 441.986). Conclusion: We made influenza models in Takamatsu city and on a university campus by multiple regression analysis. The following models were obtained. In Takamatsu city 2017/2018; y = -2.2x1 + 2.1x2 + 18.1; (x1: temperature, p < 0.001, OR -3.3 – -1.2; x2: humidity, p = 0.017, OR 0.4 – 4.0). On a university campus 2009/2010; y = -0.07x1 + 0.06x2 + 2.2x3 + 2.3x4 + 0.02; (x1: temperature, p = 0.029, OR -0.14 – -0.007; x2: humidity, p = 0.004, OR 0.02 – 0.11; x3: a holiday the next day after the lecture, p = 0.011, OR 0.5 – 3.8; x4: a holiday 2 days after the lecture, p = 0.011, OR 0.5 – 4.0).