The configuration spaces of software systems are often too large to test exhaustively. Combinatorial interaction testing approaches, such as covering arrays, systematically sample the configuration space and test only the selected configurations. In an attempt to reduce the cost of testing, standard t-way covering arrays aim to cover all t-way combinations of option settings in a minimum number of configurations. By doing so, they simply assume that every configuration costs the same. When the cost varies from one configuration to another, however, minimizing the number of configurations is not necessarily the same as minimizing the cost. To overcome this issue, we have recently introduced cost-aware covering arrays. In a nutshell, a t-way cost-aware covering array is a standard t-way covering array that “minimizes” a given cost function modeling the actual cost of testing. In this work we develop a simulated annealing-based approach to compute cost-aware covering arrays, which takes as input a configuration space model enhanced with a cost function and computes a cost-aware covering array by using two alternating neighboring state generation strategies together with a fitness function expressed as a weighted sum of two objectives: covering all required t-way option setting combinations and minimizing the cost function. To the best of our knowledge, the proposed approach is the first approach that computes cost-aware covering arrays for general, non-additive linear cost functions with multiplicative interaction effects. We evaluate the approach both by conducting controlled experiments, in which we systematically vary the input models to study the sensitivity of the approach to various factors and by conducting experiments using real cost functions for real software systems. We also compare cost-aware covering arrays to standard covering arrays constructed by well-known algorithms and study how fast the construction costs are compensated by the cost reductions provided. Our empirical results suggest that the proposed approach is more effective and efficient than the existing approaches.