The article is devoted to the life and work of the outstanding Soviet scientist, pioneer of informatics and cybernetics, initiator of the development of a nationwide automated management information system, Academician of the Academy of Sciences of the USSR Viktor Mikhailovich Glushkov (1923–1982). The author tells about the main stages of his biography, focusing on the scientific achievements: the solution of the fifth generalized Hilbert problem, the creation of the USSR’s largest Institute of Cybernetics of the Academy of Sciences of the Ukrainian SSR, the development of the theory of digital automata, the first personal computers for engineering calculations, the most powerful supercomputers in the USSR with a new macro-pipeline architecture, contribution to cybernetics and computer science, programming theory and systems of algorithmic algebras, to the creation of artificial intelligence systems. Attention is paid to the role of V.M. Glushkov as an ideologist and one of the creators of the industry of management information systems in the USSR, scientific director of large industrial management information systems. Particular attention is paid to the National Automated System for the Collection and Processing of Information proposed by him for accounting, planning and management of the national economy.