Transformed System Research Articles

Characteristics of induced magnetic field on the time-dependent MHD nanofluid flow through parallel plates

Abstract The heat transfer characteristics of an unsteady magnetohydrodynamic flow through non-conducting infinite vertical parallel plates are presented in this investigation. The flow is subjected to an induced magnetic field, and the base fluid water contains carbon nanotubes (CNTs), in particular multi-wall carbon nanotubes, to present the behaviour of the nanofluid. The aim is to examine the effect of the applied magnetization and CNT concentration on the heat transport performance of the system. However, suitable transformation rules are adopted for the re-designing of the proposed design model into its non-dimensional form. This transformed system is then solved analytically following the standard transformations. The influence of key parameters, including the Hartmann number (Ha), the angle of inclination of the magnetic field, thermal buoyancy, heat source, and the concentration of CNTs in the nanofluid, on the flow phenomena is analysed. The consequences reveal that the occurrence of the inclined magnetic field affects the flow and heat transfer characteristics significantly. Additionally, the introduction of CNTs to the nanofluid enhances the heat transfer performance due to their unique thermal properties. The study demonstrates that enhanced Ha and CNT concentration augments the heat transfer rate.

TMOD-18. FUNCTIONAL DISSECTION OF RECURRENT COPY-NUMBER-ALTERATIONS INFORMS MECHANISMS OF LOW-GRADE-GLIOMA PROGRESSION

Abstract Low-grade gliomas (LGG) are slowly growing brain cancers that ultimately undergo a malignant progression to lethal secondary glioblastomas with a dismal prognosis. Despite intensive research, very little progress has been made in our understanding of this transformation. Hence, outside of known alternations in well-characterized driver genes CDKN2A, PTEN and PDGFRA, genetic drivers that underlie LGG transformation are largely unknown. Contrary to other types of cancer, LGGs exhibit very few driver mutations (30-40 mutations) as they progress. Interestingly, LGGs also exhibit a highly prevalent and heterogenous pattern of copy-number-alterations (CNAs) suggesting that they might be driven by changes in gene dosages that result from widespread chromosomal instability observed within these tumors. Through analysis of the human Mayo Clinic and TCGA LGG datasets (~1500 patients), we have identified eleven highly recurrent CNAs affecting LGG patients, many of which correlate with patient survival. We hypothesized that these CNAs contain driver genes that confer a growth advantage resulting in the highly recurrent CNA pattern and prognostic associations. To investigate the tumor suppressive potential of the ~1800 genes located in recurrently deleted regions and the oncogenic potential of the ~1200 genes located in recurrently amplified regions, our lab developed a novel in vivo ‘CRISPR-Knock Out and Activation Linked Assay’ (CRISPR-KOALA). Stereotaxic delivery of arm-level CNA lentiviral gRNA libraries targeting the mouse orthologs of genes in CNAs into the brain of our animal model (rs557mut;IDHmut;P53KO;AtrxKO;Cas9GFP: Yanchus et. al Science 2022) resulted in rapid formation of tumors compared to animals injected with control libraries. Deconvoluting the screen revealed enrichment of immune modulators such as Them6 as well as a modulator of NMDA receptors (Grina) implicating immune system and glutamate dysregulation in LGG malignant transformation. Taken together, our study provides insights into mechanisms underlying LGG progression which may serve to inform intervention strategies for this lethal disease.

Accountability management system of superior elementary school for digital transformation

The purpose of this research is to find out i) the quality of the accountability management system of superior schools, ii) elementary school digital transformation capabilities, and iii) the relationship between the quality of the accountability management system for superior schools and the digital transformation capabilities of elementary schools in Indonesia. The research approach used is quantitative. The research location is in public elementary schools in Malang City. The population of this research is all 195 public elementary schools. The research sample is 22 public elementary schools. The research subjects were school principals, class teachers, and subject teachers totaling 51 people. Data collection is done by using a questionnaire. Elementary schools with superior school accountability management systems have the ability to drive their digital transformation capabilities. Excellent school accountability management systems and school digital transformation capabilities guarantee equal access to education for all students. Implications for improving teaching and learning are also discussed in this paper. The variables studied can be used to determine the priority scale for planning, implementing and evaluating superior school accountability management systems in digital transformation, in increasing teacher competency.

10.H. Round table: Transforming health systems in Europe to respond to the large-scale displacement from war in Ukraine

Abstract The Russian invasion of Ukraine in 2022 caused one of the largest population displacements in Europe since World War II. More than 6 million persons have sought international protection in other European countries, distributed in ways that take little account of the host countries’ population size, national income, or health system capacity. This workshop provides a platform to present and discuss findings of a health system impact assessment designed to anticipate the range of mid- to long-term impacts of this large-scale displacement on essential health system functions in refugee-receiving countries, identifying the challenges they face and opportunities to develop transformative policies and actions. This task is urgent given the risks of wider conflict in Europe. Objectives The workshop will 1) present the main findings from the health system impact assessment in seven refugee-receiving countries, 2) set out options for effective responses, considering policy and implementation perspectives, and 3) capitalise on the expertise of workshop participants to develop and refine policy options for structural reforms that not only help to sustain an effective response, but enhance the resilience of European health systems for the benefit of displaced populations and national residents alike. Format The workshop will comprise a panel with three speakers, followed by a roundtable discussion. Each panel member will make a short presentation (5 min) on different, but interrelated aspects of a transformative health system response to a protracted crisis scenario. These will highlight country and regional-level challenges arising during the Ukraine crisis, propose concrete policy options for transformation, and identify intersections between the health system response with other societal sectors and crises. The workshop objectives and rationales will be introduced by Kayvan Bozorgmehr, including a short pitch-presentation (3 min) highlighting the unequal distribution of displaced persons from Ukraine and the key-findings of the health system impact assessment. The panel will include follow-up presentations elaborating specific aspects in this context: 1. Healthcare models and needs for transformative response in a protracted crisis (Dr. Nino Berdzuli, WHO Special Envoy for Ukraine Emergency Response in refugee-receiving countries); 2. Supra-national health financing as transformative reform: pros and cons (Eilin Rast, Bielefeld University, Germany); 3. Regional Geopolitical Conflicts and Population Health in Caucasus, CIS and Ukraine (Prof. Akaki Zoidze, Ilia State University, Georgia). The subsequent roundtable discussion will be chaired by Martin McKee. It will focus on the proposed actions and considerations from a policy and implementation perspective, and workshop participants will be invited to contribute to a critical reflection regarding barriers and enablers, as well as required alliances and processes to translate the structural reforms into practice. Key messages • The ongoing conflict-related displacements from Ukraine have created a protracted crisis that will require structural transformations to enhance health system resilience. • Enhancing healthcare delivery, continuity of care, and effective health financing requires national and supra-national collaboration to sustain effective responses and prepare for future crises. Speakers/Panelists Nino Berdzuli Division of Country Health Programmes, WHO/Europe, Denmark Eilin Rast Bielefeld University, Bielefeld, Germany Akaki Zoidze Ilia State University, Tbilisi, Georgia

A system readiness approach to support the packaging and scaling of innovation bundles for farming systems transformation

CONTEXTA newly established ‘systemic approach to technology packaging’ for improved scaling has emerged in the literature. This approach suggests that core transformative innovations can be scaled more effectively through scaling readiness, which helps identify complementary innovations that support and facilitate the scalability of the core innovation. Since these packaging approaches start with single core innovations, we propose that they can benefit from the broader literature on sustainable agricultural systems transformation and readiness. OBJECTIVEThe objective of this paper is to advocate for a more comprehensive packaging of innovations for sustainable agricultural system transformations by better understanding gaps in the agricultural system – and its capacity for change. This approach provides a stronger rationale for the selection of relevant innovations to be packaged together. We introduce the concept of agricultural ‘system readiness’ as a possible framework for guiding such bundles. METHODSThe paper begins with a comprehensive literature review that identifies the current gaps in tools and methods to guide system transformation. It also focuses on the specific literature on innovation packaging for scaling, and builds on the gaps of existing approaches as a rationale for introducing the concept of system readiness (mostly used in infrastructure engineering), and adapting it to agricultural science. We also use illustrative hypothetical examples from mixed crop-livestock systems in the drylands to show how two approaches – ‘packaging for scaling’ and ‘packaging for transformation’ – can lead to different innovation packages. RESULTS AND CONCLUSIONSThe concept of system readiness is introduced, defined and advocated. We show that it can help identify performance gaps in agricultural systems and guide better planning for system strengthening and integration. We conclude with possible complementarities between the two approaches of scaling and system readiness. SIGNIFICANCEThe agricultural system readiness approach, as outlined in this paper, would be particularly beneficial for agricultural research-for-development, as well as other agricultural investment programs that seek to identify strategies for fostering sustainable transition in farming systems. Such programs would typically entail complexity-aware theories of change that focus on stimulating sustainable transformation pathways related to key target areas, such as agroecology, sustainable intensification, and system integration (e.g., crop-livestock integration and integrated pest management). The system readiness approach can support such programs through the identification, prioritization, targeting, and empowerment of the most significant (and transformative) system components by identifying respective innovations to be packaged.

Принципы, содержание и эволюция учебной программы подготовки кинорежиссеров «Гранит кинонауки» (1933) Сергея Эйзенштейна

The research aims to present Sergei Eisenstein’s groundbreaking curriculum for film directors, “Granite of Film Science” (1933), as a pioneering educational product and as a reflection of his aesthetic philosophy. The authors analyze the principles and content of the curriculum, as well as its subsequent evolution into “A Program for Teaching the Theory and Practice of Directing” (1936). Eisenstein, a pioneer in film directing education, developed the first curriculum for film directors, whose principles were later incorporated into his foundational works “Method” and “Montage”. He proposed a unique teaching method, namely, the directing practicum, based on collaborative work and group discussions to identify contradictions and construct artistic images. The novelty of this research lies in identifying the fundamental principles and foundations of the development of Russian and global directing education, demonstrating that any educational program is a flexible, transformable system built upon a shared pursuit of truth between teacher and student. The article also examines the evolution of the curriculum. Following its publication, “Granite of Film Science” faced both criticism and self-critique, leading to the creation of its revised version, “A Program for Teaching the Theory and Practice of Directing” in 1936. The study reveals that Eisenstein defined the principles of film pedagogy and the guiding principles of directing education at the Higher State Institute of Cinematography (VGIK) in his “Granite of Film Science” curriculum. This program formed the basis for a series of lectures delivered by Eisenstein at VGIK between 1933 and 1936.

Secure Blockchain Assisted Attribute-Based Keyword Search for Collaborative E-Healthcare

In the age of technological advancement, collaborative E-healthcare emerges as a transformative system eliminating traditional location and accessibility barriers in healthcare services. Here, Searchable Encryption (SE) plays a key role in enabling healthcare providers to outsource encrypted medical data and search services to third parties like cloud servers, thereby reducing storage and management expenses. This intermediary approach poses challenges of single-point failure, privacy breaches, and potentially untrustworthy results. State-of-the-art public key-based SE methods use a cloud-assisted architecture that doesn’t support reliable and practical searches with fine-grained permissions. Also, such systems require additional support to address potential privacy leakages and ensure data availability at the storage server. To address these concerns, we propose a B lockchain-assisted E fficient and S ecure K eyword S earch (BESKS) scheme to enforce fine-grained keyword search privilege control while achieving practical search complexity. Our scheme employs a ciphertext policy attribute-based keyword search mechanism where keywords are encrypted using expressive access policies to build an inverted index structure. The encrypted indexes are stored on the blockchain while encrypted medical documents are stored on InterPlanetary File System (IPFS) nodes to enhance availability and ensure the reliability and scalability of our approach. Our scheme utilizes blockchain-based smart contract for efficient, secure search operations and ensures financial fairness in fine-grained searches. Search tokens are generated based on user attributes and query keywords to facilitate private searches on-chain. To enhance the search process, our secure index enables exact match for a query keyword in constant time to ensure expensive authorization operations are performed only once. Theoretical analysis suggests that our BESKS is more efficient and secure than state-of-the-art schemes. Prototype implementation results on the Ethereum blockchain network further validate its feasibility for real-world applications, demonstrating the scheme's practical applicability in collaborative E-Healthcare systems.

Connected Food: First Steps for an Ambitious National Food Strategy

Background: The global food system faces growing pressure from population growth, climate change, wealth inequity, geo-political instability, and damage to the ecosystems on which our food supply depends. Fragmentation of the priorities and needs of food system stakeholders—citizens, food producers, food industries, governments—compounds the problem, with competing or misaligned interests increasing the risk of failure to adequately meet the needs of those that form, and are served, by the food system. Growing consensus on the need for transformative system level change to address the problems facing the food system is yet to be significantly reflected in strategic action. Methods: The national food strategy of the UK is offered as an exemplar to discuss the need to promote more coherent and ambitious visions of transformative change that acknowledge the complexity of the food system as a whole. We draw upon cross-sectoral experience to distil the needs, priorities, and key food system tensions that must be acknowledged to promote transformative systems change that equitably delivers healthy sustainable diets, contributes to a resilient global food system, and protects the environment. Results: Greater coherence, ambition, and consideration of the food system as a whole are needed if a UK national food strategy is to contribute to significant transformative change. Conclusions: To promote this, we advocate for (1) a food system digital twin to model and test potential food system interventions or legislation; (2) a citizens’ forum to inform and co-develop a cohesive national food strategy; and (3) increased cohesion and integration of food system governance within government to drive a coherent, ambitious national food strategy.

Pathways for Strengthening Lived Experience Leadership for Transformative Systems Change: Reflections on Research and Collective Change Strategies.

The Activating Lived Experience Leadership (ALEL) project was a South Australian participatory action research project that aimed to improve the ways lived experience is recognised, valued and integrated across mental health and social sector systems. ALEL was completed during 2019-2021, where it engaged 182 participants in generating community action and research knowledge. Our paper discusses the project's processes of building a collective partnership among lived experience leaders and other leaders from within the sector, so that the actions and strategies identified through research could be implemented by systems-level impact. We describe the collaborative process and key learnings that resulted in eight key action areas for transformative systems change in South Australia. The project invited a diverse range of self-identified lived experience and other leaders to be involved in a PAR process featuring formal qualitative research (focus groups, surveys and interviews) as well as community development activities (leaders' summit meetings, consultations, training and community of practice meetings). These processes were used to help us describe the purpose, achievements and potential of lived experience leadership. Project priorities and systems-level analysis was also undertaken with lived experience sector leaders and project advisors across two leaders' summit meetings, integrating research outcomes with sector planning to define high-level actions and a vision for transformational change. Participatory action research as informed by systems change and collective impact strategies assisted the project to generate detailed findings about the experiences and complexities of lived experience leadership, and collective responses of how systems could better support, be accountable to and leverage lived experience perspectives, experience and peer-work approaches. Systems change to define, value and embed lived experience leadership benefits from collective efforts in both formal research and sector development activities. These can be used to generate foundational understandings and guidance for working together in genuine ways for transforming mental health and social sector systems, experience and outcomes. Members of lived experience communities codesigned the project, and contributed to project governance and the development of all findings and project reports.

A Framework of Foreseen and Unforeseen Harms in Transformative Service Systems

Transformative service systems (TSSs) are designed to uplift human well-being. Yet, paradoxically, by necessity and in design, TSSs can also generate unintended harms for system actors. Our conceptual paper builds on recent service literature, as well as that on unintended consequences from a range of fields, to advance an integrative framework of harms in TSSs. Through the enabling theory of the doctrine of double effect, our framework organizes harms in the transformative service context, identifying that unintended harms can be both foreseen and unforeseen. Additionally, we find that the mechanism underlying these harms is system emergence. Emergence arises from the relative complexity of the service system and the relative dynamism of the issue the TSS aims to address. Our framework demonstrates that greater service system complexity increases the likelihood of foreseen harms, while greater relative dynamism increases the likelihood of unforeseen harms arising. Furthermore, we show how these two factors combine to promulgate the emergence of harms. We find that in instances where harm arises, greater service system adaption is required to mitigate such harms. However, some TSS harms are an inevitable and unfortunate secondary outcome of doing good, and these harms necessitate acknowledgment and acceptance by service designers.

A Novel Targeted Microtubules Transformable Nanopeptide System Yields Strong Anti-Prostate Cancer Effects by Suppressing Nuclear Translocation of Androgen Receptors.

The extended use of androgen deprivation therapy (ADT) may often lead to the progression from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC) in prostate cancer. To address this, it is essential to inhibit the nuclear translocation of the androgen receptor (AR) as part of an effective disease-modifying strategy. Microtubules play a central role in facilitating AR nuclear translocation, highlighting their importance as a therapeutic target. In this regard, a designated as the targeted microtubules transformable nanopeptide system (MTN) is developed. This system is designed to disrupt microtubule structure and function through dual-targeting of prostate-specific membrane antigen (PSMA) and β-tubulin. Initially, MTN targets prostate cells via PSMA and then specifically binds to β-tubulin within microtubules, leading to the formation of nanofibers. These nanofibers subsequently induce the polymerization of microtubules, thereby disrupting AR transport. Notably, MTN exhibits efficient and prolonged suppression of prostate cancer across the spectrum from CSPC to CRPC, with a highly favorable safety profile in normal cells. These findings highlight the potential of MTN as a novel and promising approach for comprehensive prostate cancer therapy throughout its entire progression.

BIM- and blockchain-enabled Automatic Procurement System (BBAPS) removing relationship bias

In the subcontractor (Sub) procurement process, the General Contractor (GC) can seek potential Subs from a limited pool based on their past relationships. This challenges new subcontractors who are qualified for the project but lack prior relationships with the GC. Furthermore, it creates a relationship bias that impedes the creation of a constructive business environment where potential Subs are encouraged to enhance their quality and compete fairly to secure procurement contracts. To address these challenges, this paper proposes a proof-of-concept of a transformational procurement system that integrates blockchain-enabled smart contracts and Building Information Modeling (BIM)-based project management. The proposed system can facilitate the data-driven automatic matching of GC with Subs, thus extending the pool of Subs and eliminating relationship bias in the procurement proceedings to enhance the effectiveness and fairness of the procurement. It contributes to the body of knowledge by enabling a digitalized and automated subcontractor procurement leveraging blockchain.

Research on the Influence of Firm Digital Intelligence Transformation and Management Innovation on Performance and Sustainable Development: Empirical Evidence from China

From the perspective of firm capability, this study explores the impact of digital intelligence transformation and management innovation on the performance and sustainable development of Chinese firms. On the basis of constructing an evaluation index system of firm digital intelligence transformation and management innovation, a comprehensive evaluation model of firm digital intelligence transformation and management innovation is constructed via the analytic network process (ANP) and fuzzy comprehensive evaluation method. Taking Chinese film and television firms as an example, this study selects 160 data samples from 85 firms and constructs a structural equation model to empirically analyze the impact of digital intelligence transformation and management innovation on the performance of firms. The study results show that, in the context of digitalization and intelligence, firm digital intelligence capability and dynamic capability have a significant positive effect on firm performance. Firm digital intelligence transformation and management innovation directly impact performance and can play a role through firm digital intelligence capability and dynamic capability as intermediaries, and the chain intermediary effect of digital intelligence capability and dynamic capability is significant. The research results show that firm digital intelligence and dynamic capabilities provide a functional path for firm digital intelligence transformation and management innovation to improve performance. Moreover, the innovative application of digital intelligence technology has an important impact on the sustainable development of firms. Digital transformation and management innovation can help firms enhance their ability to manage environmental uncertainties, improve firm performance and foster the achievement of sustainable development goals.

Transformational Impact Rating System: a method to assess the impact potential of hospitals in low-resource settings

Background: Historically, many Christian mission hospitals were established by home churches from developed countries in their colonies. With countries gaining independence and missionary medical staff leaving these hospitals, the majority have closed. These hospitals provide critical assistance to communities that need their services the most, yet they often lack the financial and human resources needed to realize their full potential for community impact. Existing charity rating organizations rate few charities and lack transparency for donors, and limited resources exist to help volunteers find organizations that would benefit from their services the most. We propose a transparent Transformational Impact Rating System (TIRS) that can be used by funding agencies and volunteer directing agencies to assess the potential for transformational impact of any hospital anywhere in the world. Methods: Research to inform the rating system was conducted via a comprehensive review of existing charity rating organizations, in-depth interviews, and surveys. The rating system was developed by identifying, down-selecting, categorizing, and allocating weights to variables of importance. The rating system was then implemented via a custom-built website. Results: To receive a score, data is collected from the hospital and surveys of donors, volunteers, staff, patients, and the local community. Hospitals receive an overall score and scores in each of five categories: regional impact potential, financial health, operational performance, external relations, and volunteer experience. Conclusion: TIRS provides a proof-of-concept platform through which all hospitals in low-resource settings can make their impact potential visible to donors and volunteers. If TIRS (or modified similar tools) are used by those interested in helping mission hospitals, they will be more likely to adopt best practices, and invisible hospitals that are struggling in remote areas will be more likely to receive much-needed resources. The Christian community has a mandate to serve the poor and marginalized, resulting in a large number of Christian schools, colleges, and hospitals established across the globe. These establishments face increasing threats to their existence, and tools like TIRS can help direct declining funds and manpower to hospitals that have the highest potential for transformational impact.

Addressing disparities in rural and remote access for rheumatology practice through a transformative tele-healthcare delivery system: Experience of a large cohort of patients in eastern India.

Background We present the experience of telerheumatology consultation services carried out in an eastern state of India. Methods We did this prospective, observational study of patients with rheumatological disorders and followed through telemedicine between December 2015 and May 2019. Results During the study period, we provided teleconsultation to 3583 patients with the help of 11 201 telemedicine visits. Patients resided at a median distance of 248 (13 to 510) km from the telemedicine hub. The cumulative savings of the patients as a result of this service were ₹2.4 crore (24 million). The median travel time saved was 7 hours (30 minutes to 12 hours) per patient per visit and a median of ₹6700 was saved per visit per patient. Conclusion Sustained efforts over a long period can lead to the delivery of essential rheumatology services via telemedicine to an under-priviledged population, reduce the financial burden of the poor, and help women to access healthcare services in remote parts of low- and middle-income countries (LMICs).

Monitoring, evaluation, and learning: the key to building effective partnerships with government to improve maternal and child health in the Rakai and Kyotera Districts of Uganda.

This article emphasizes the significance of the Monitoring, Evaluation, and Learning (MEL) system within Babies and Mothers Alive (BAMA) Foundation in building effective sustainable interventions at scale. The foundation aims to enhance the availability of high-quality reproductive, maternal, and newborn care services within the government health sector. The distinguishing characteristic of the MEL system is its integration of organizational learning as a strategic approach to inform the development of dynamic program designs. To do this, it has been necessary to identify crucial requirements through open data exchange with all pertinent stakeholders. This paper demonstrates that our approach to evidence-based learning in a diverse population of locally-based actors and stakeholders, gives voice to the community-based health practitioners and patients that is necessary for transformative maternal health delivery systems. The act of sharing data has presented several possibilities for enhancing current initiatives and extending the reach and scale of our partnership model. We trace the development of the core components of learning and decision making, and reflect on the transition of the program to scale using the LADDERS paradigm. The application of our model of practice has been associated with the increased financially viability and the potential for the sustainable scaling of the program intervention.

Intravascular Casting Radiopaque Hydrogel Systems for Transarterial Chemo/Cascade Catalytic/Embolization Therapy of Hepatocellular Carcinoma.

This paper introduces catheter-directed intravascular casting hydrogels for transarterial chemo/starvation/chemodynamic embolization (TACSCE) therapy of hepatocellular carcinoma (HCC). Comprising Mn ion-crosslinked hyaluronic acid-dopamine (HD) with glucose oxidase (for glucose decomposition to H2O2 in starvation therapy), doxorubicin (for chemotherapy), and iopamidol (for X-ray imaging), these hydrogels are fabricated for transarterial embolization therapy guided by X-ray fluoroscopy. Mn4+ (from MnO2) demonstrates strong coordination with the catechol group of HD, providing hypoxia relief through O2 generation and cellular glutathione (GSH) consumption, compared to the OH radical generation potential of Mn2+. The gelation time-controlled, catheter-injectable, and rheologically tuned multitherapeutic/embolic gel system effectively reaches distal arterioles, ensuring complete intravascular casting with fewer complications related to organic solvents. Glucose deprivation, cascade reactive oxygen species (ROS) generation, GSH depletion, and sustained release profiles of multiple drug cargos from the hydrogel system are also achieved. The combined chemo/starvation/chemodynamic efficacies of these designed hydrogel systems are confirmed in HCC cell cultures and HCC-bearing animal models. The developed radiopaque/injectable/embolic/sol-to-gel transformable systems for TACSCE therapy may offer enhanced therapeutic efficacies compared to typical transarterial embolization and transarterial chemoembolization procedures for HCC.

Specificity of modeling the actuator for the deployment of transformable large-scale space structures

Abstract The creation of large-scale structures will be necessary for the development of information and transport space systems. Transformable systems form a distinct category of such space structures, designed based on automatic configuration changes. The transport and deployed operating states of transformable space systems can vary in dimensions by tens of times, with force actuators carrying out the deployment process. The optimal force actuator suitable for use in transformable space structures is an actuator comprising of active elements made of a titanium nickelide material with a shape memory effect, which has the ability to generate significant force, reliability, compactness, light weight and low power consumption. In the pursuit of developing large-scale transformable space systems, tremendous importance is placed on conducting full-scale experiments, which require costly equipment to be simulated in ground conditions. Therefore, an alternative option to verify the functionality of the large-scale transformable space system in development is through conducting a mathematical experiment utilizing the identifiable parameters of the developed computational models. Experimental and theoretical analyses of the active elements of the force actuator made of titanium nickelide material (1.5 mm diameter wire) have confirmed the fundamental possibility of creating a force actuator for opening large-scale transformable space structures.

Injecting Sustainability into Epoxy-Based Composite Materials by Using Bio-Binder from Hydrothermal Liquefaction Processing of Microalgae.

We report a transformative epoxy system with a microalgae-derived bio-binder from hydrothermal liquefaction processing (HTL). The obtained bio-binder not only served as a curing agent for conventional epoxy resin (e.g., EPON 862), but also acted as a modifying agent to enhance the thermal and mechanical properties of the conventional epoxy resin. This game-changing epoxy/bio-binder system outperformed the conventional epoxy/hardener system in thermal stability and mechanical properties. Compared to the commercial EPON 862/EPIKURE W epoxy product, our epoxy/bio-binder system (35 wt.% bio-binder addition with respect to the epoxy) increased the temperature of 60% weight loss from 394 °C to 428 °C and the temperature of maximum decomposition rate from 382 °C to 413 °C, while the tensile, flexural, and impact performance of the cured epoxy improved in all cases by up to 64%. Our research could significantly impact the USD 38.2 billion global market of the epoxy-related industry by not only providing better thermal and mechanical performance of epoxy-based composite materials, but also simultaneously reducing the carbon footprint from the epoxy industry and relieving waste epoxy pollution.

Eliminating Health Care Access and Quality Inequities in Sickle Cell Disease: Policy Lessons from the End Sepsis Initiative

Abstract: Sickle cell disease is a prime example of the devastating impact of healthcare inequities. The End Sepsis Initiative developed after a tragic death due to sepsis, provides a powerful model for the sickle cell community. This model recognizes the importance of evidence-based protocols and policy recommendations/mandates to drive transformative systems change. We propose that the sickle cell community mirror this approach. We propose that hospital systems, healthcare organizations, and insurers implement evidence-based protocols, including personalized pain plans, stigma reduction through staff training, vaccinations, preventative screening, disease-modifying therapies, pediatric to adult transition, and connecting unaffiliated SCD patients to a medical home. We recommend state-level interventions, such as using SCD navigator in electronic health records for quality reporting, supporting community health workers' use, and ensuring rural hospitals have access to SCD specialists.