Future OncologyVol. 7, No. 5 EditorialIntegrated cancer systems biology: current progress and future promiseJohn F McDonaldJohn F McDonaldDepartment of Biology, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA. Search for more papers by this authorEmail the corresponding author at mcgene@gatech.eduPublished Online:13 May 2011https://doi.org/10.2217/fon.11.33AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: biological complexitycancercellular networksystems biologyBibliography1 Futreal PA, Coin L, Marshall M et al.: A census of human cancer genes. Nat. Rev. Cancer4,177–183 (2004).Crossref, Medline, CAS, Google Scholar2 Faivre S, Djelloul S, Raymond E: New paradigms in anticancer therapy: targeting multiple signalling pathways with kinase inhibitors. Semin. Oncol.33,407–420 (2006).Crossref, Medline, CAS, Google Scholar3 Brenner H: Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis. Lancet360,1131–1135 (2002).Crossref, Medline, Google Scholar4 Khalil IG, Hill C: Systems biology for cancer. Curr. Opin. Oncol.17(1),44–48 (2005).Crossref, Medline, CAS, Google Scholar5 Kirschner MW: The meaning of systems biology. Cell121,503–504 (2005).Crossref, Medline, CAS, Google Scholar6 Meyerson M, Gabriel S, Getz G: Advances in understanding cancer genomes through second-generation sequencing. Nat. Rev. Gen.11,685–696 (2010).Crossref, Medline, CAS, Google Scholar7 Morozova O, Hirst M, Marra MA: Applications of new sequencing technologies for transcriptome analysis. Ann. Rev. Gen. Hum. Gen.10,135–151 (2009).Crossref, Medline, CAS, Google Scholar8 Yang L, Guo S, Li Y, Zhou S, Tao S: Protein microarrays for systems biology. Acta Biochem. Biophys. Sin.43,161–171 (2011).Crossref, Medline, CAS, Google Scholar9 Spratlin JL, Serkova NJ, Eckhardt SG: Clinical applications of metabolomics in oncology: a review. Clin. Cancer Res.15(2),431–440 (2009).Crossref, Medline, CAS, Google Scholar10 Kalderon D: Signaling pathways in cancer. In: Principles of Molecular Oncology. Bronchud MH, Foote M, Giaccone G et al. (Eds). Humana Press, Totowa, NJ, USA 153–188 (2008).Google Scholar11 Sen R, Baltimore D: Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism. Cell47,921–928 (1986).Crossref, Medline, CAS, Google Scholar12 Karin, M: NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer. Cold Spring Harbor Laboratory Press, NY, USA (2010).Google Scholar13 Zhang J, Li J, Deng H-W: Identifying gene interaction enrichment for gene expression data. PLoS One4(11),E8064 (2009).Crossref, Medline, Google Scholar14 Jones S, Zhang X, Parsons DW et al.: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science321(5897),1801–1806 (2008).Crossref, Medline, CAS, Google Scholar15 Wilbert ML, Yeo GW: Genome-wide approaches in the study of microRNA biology. Wiley Interdiscip. Rev. Syst. Biol. Med.128 (2011).Google Scholar16 Zhou M, Guan W, Walker LD et al.: Rapid mass spectrometric metabolic profiling of blood sera detects ovarian cancer with high accuracy. Cancer Epidem. Biomark. Prev.19,2262–2271 (2010).Crossref, Medline, CAS, Google Scholar17 Bach FR, Lanckriet GRG, Jordan MI: Multiple kernel learning, conic duality, and the SMO algorithm. ICML ‘04 Proceedings of the Twenty-first International Conference on Machine Learning.69,6 (2004).Crossref, Google ScholarFiguresReferencesRelatedDetailsCited ByNMI promotes hepatocellular carcinoma progression via BDKRB2 and MAPK/ERK pathway6 January 2017 | Oncotarget, Vol. 8, No. 7Transcriptome and proteome of human hepatocellular carcinoma reveal shared metastatic pathways with significant genes18 March 2015 | PROTEOMICS, Vol. 15, No. 11Yeast Systems Biology Vol. 7, No. 5 eToC Sign up Follow us on social media for the latest updates Metrics Downloaded 385 times History Published online 13 May 2011 Published in print May 2011 Information© Future Medicine LtdKeywordsbiological complexitycancercellular networksystems biologyFinancial & competing interests disclosureThe author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.PDF download