Inhibition of the NLRP3 pathway as a strategy for SLE therapy.

To investigate whether systemic autoimmune rheumatic diseases (SARDs) were disproportionately reported as adverse events following COVID-19 vaccination compared with other vaccines, using data from the Vaccine Adverse Event Reporting System (VAERS). We conducted a retrospective disproportionality analysis of VAERS reports collected between December 2020 and December 2024. Reports were identified using a structured query based on MedDRA terms for specific SARDs, including polymyalgia rheumatica, giant cell arteritis, systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, myositis, and other vasculitides. For each disease, the proportional reporting ratio (PRR), reporting odds ratio (ROR), and Bayesian information component (IC) were calculated, comparing COVID-19 vaccines (BNT162b2, mRNA-1273, Ad26.COV2.S) with all other vaccines in VAERS. Analyses were further stratified by sex to explore consistency. Among approximately 680,000 valid adverse event reports, encompassing both COVID-19 and non-COVID-19 vaccines, no significant disproportionality signal was identified for any SARD. Polymyalgia rheumatica, giant cell arteritis, systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, and myositis showed no evidence of disproportionate reporting following COVID-19 vaccination. The category "other vasculitides" displayed a lower reporting frequency following COVID-19 vaccination compared with other vaccines. Stratified analyses yielded consistent findings across sex subgroups. In a large national pharmacovigilance dataset, COVID-19 vaccines were not associated with a disproportionate increase in reports of any SARD. These results support the favorable safety profile of COVID-19 vaccines with respect to autoimmune rheumatic events, while highlighting the value of ongoing post-marketing surveillance for rare immune-mediated reactions.

The role of clot waveform analysis and related parameters in the diagnosis and treatment of systemic lupus erythematosus.

Correlation between some Biomarker Levels and Disease Activity in Patients with Systemic Lupus Erythematosus

Fronto-cerebellar features associate with cognitive dysfunction in childhood-onset systemic lupus erythematosus.

Assessment of kinesiophobia in patients with rheumatoid arthritis and systemic lupus erythematosus and its association with disease activity, functional status, pain severity and depression

The oral-immune axis: neutrophil extracellular traps mediate the link between periodontitis and autoimmune diseases.

Exploring the Association Between Autoimmune and Inflammatory Diseases and Uveitis.

Therapeutic management of inflammatory heart diseases.

Genistein ameliorates lupus nephritis via enhancing ERβ-mediated inhibition of STAT3-driven inflammation.

Spontaneous intracranial hypotension (SIH) is a disorder caused by low cerebrospinal fluid (CSF) pressure due to a CSF leak located anywhere within the neuroaxis. Risk factors include trauma, degenerative disc disease, and especially connective tissue disorders. In most cases, SIH presents with orthostatic headache, worsening when upright and characteristic radiological features as diffuse pachymeningeal enhancement on MRI [4, 6]. There are a lot of publications concerning treatment of CSF leaks located in the lumbar and thoracic spine, but only scant information regarding treatment and its outcomes of CSF leaks in the upper cervical spine, e.g., C1-2. Three women presented with persistent headaches, worsening when standing, lasting weeks to months. Two reported cervical pain, one had double vision, and all experienced dizziness. Symptoms resolved in recumbency. All had connective tissue disorders: patient 1 had systemic lupus erythematosus (SLE) and Sjögren's syndrome, patient 2 had polymyositis, and patient 3 was under observation for SLE. The MRI showed typical SIH features, and the cervical spine MRI was unremarkable except for spinal longitudinal epidural collection (SLEC) in two patients. CT-myelography identified CSF leaks at C1-2 in all cases. Epidural blood patching (EBP) at C1-2 under CT guidance resolved symptoms, with only one patient experiencing a brief post-procedural headache. At 3 months' follow-up, all patients remained symptom-free. Repeated CT-myelography in one patient showed no residual CSF leak. SIH is a very rare and frequently misdiagnosed condition. Administration of EBP at the C1-2 level of the spine is troublesome; therefore, it should be performed under guidance of computed tomography. All three patients were discharged symptom free within 24-72 h.

Macrophage extracellular traps in autoimmunity: In vivo definition, pathogenic circuits, and therapeutic targeting.

Flare incidences of pre-existing rheumatologic diseases in patients with solid tumors receiving immune checkpoint inhibitors: A systematic review and meta-analysis.

Role of urinary biomarkers in the diagnosis of lupus cystitis in systemic lupus erythematosus patients: Relation to disease activity and lower urinary tract manifestations

Double-negative T cells (DNTs) are significantly elevated in autoimmune diseases and are thought to play an important role in inflammation. The purpose of this study was to explore their role in childhood-onset systemic lupus erythematosus (cSLE). DNTs, as well as T and B cell subsets in peripheral blood, were detected by flow cytometry in 78 patients, including 34 cSLE. Clinical and laboratory data of cSLE patients were collected to analyze the correlation between DNTs and these indices, including demographics: proportion of female patients and mean age (± SD); Organ involvement: presence of lupus nephritis, neuropsychiatric manifestations, and pulmonary involvement; Hematologic parameters: leukopenia, anemia, and thrombocytopenia (WBC, Hb, and PLT counts); Autoantibody profiles: ANA, anti-dsDNA, and anti-Sm antibodies. The changes in DNT levels after glucocorticoid treatment were observed, and the effects of different doses of glucocorticoids on DNTs were analyzed. DNT levels were significantly increased in the peripheral blood of cSLE patients. DNTs were correlated with SLE disease activity, organ involvement, the production of autoantibodies, naive B cells, and plasmablasts. DNT levels increased after low-dose glucocorticoid treatment (9.12 ± 1.43 vs 14.24 ± 1.36, p < 0.01) but gradually decreased with increasing glucocorticoid doses (14.24 ± 1.36 vs 13.45 ± 1.51 vs 7.45 ± 1.01 vs 4.72 ± 1.20, p < 0.05). DNT levels significantly decreased from the fourth day of glucocorticoid pulse therapy. DNT levels were positively correlated with disease activity in cSLE patients, and the effect of glucocorticoid dose on DNT levels varied. Key Points • DNT cells are significantly elevated in cSLE patients and correlate with disease activity, organ involvement, and autoantibody profiles. Low-dose glucocorticoids transiently increase circulating DNT levels, while higher doses progressively reduce DNT frequencies. DNT levels positively correlate with B-cell subsets, suggesting a potential role in autoantibody production in pediatric SLE. • Dynamic changes in DNTs may be influenced by glucocorticoid treatment.

The efficacy of rituximab plus telitacicept in neuropsychiatric systemic lupus erythematosus: A retrospective study.

Association of Anti-KU Antibodies with Clinical Manifestations of Systemic Lupus Erythematosus

A severe case of rhabdomyolysis, acute kidney injury, cardiogenic shock, and chronic complications caused by an excessively large dose of Tripterygium glycoside.

The potential role of neutrophil, eosinophil, and platelet to lymphocyte ratios in the assessment of disease activity in systemic lupus erythematosus patients

Compelling evidence documents an association between autoimmune diseases and several types of cardiovascular diseases. Knowledge on whether autoimmune diseases may increase the risk of subarachnoid hemorrhage (SAH), a rare but severe type of cerebrovascular event, is very limited. The aim of this study was to determine the association between autoimmune diseases and SAH. We conducted a nationwide cohort study including individuals who were parents of all live births recorded in the Swedish Medical Birth Register during 1973-2014 and who were alive, resided in Sweden, and had no history of SAH at study baseline. We obtained data on autoimmune diseases, SAH, and covariates through linkage to several population-based registers and followed participants from January 1, 2001, until SAH diagnosis, death, emigration, or December 31, 2023. We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for SAH in relation to autoimmune diseases. Among the 3,824,528 study participants (mean age at baseline 38.1 (±13.2) years, 55.2% female), 608,043 (15.9%) had a record of any autoimmune disease before or during the study period; 10,311 (0.3%) were diagnosed with SAH over the follow-up period of 83.5 million person-years. Overall, any autoimmune disease was associated with an increased risk of SAH (HR = 1.18; 95% CI 1.11-1.25). Several categories, as well as some specific autoimmune diseases, that is, type 1 diabetes (HR = 1.36; 95% CI 1.15-1.61), rheumatoid arthritis (HR = 1.29; 95% CI 1.10-1.50), systemic lupus erythematosus (HR = 1.49; 95% CI 1.01-2.21), psoriasis vulgaris (HR = 1.18; 95% CI 1.04-1.33), multiple sclerosis (HR = 1.35; 95% CI 1.02-1.78), primary biliary cirrhosis (HR = 2.66; 95% CI 1.57-4.49), and IgA nephropathy (HR = 1.42; 95% CI 1.08-1.87), were associated with an increased risk of SAH. This study suggested that a broad range of autoimmune diseases may be involved in the etiology of SAH. If confirmed by future research, the results may inform the development of targeted SAH prevention strategies for individuals with autoimmune diseases; however, reliance on register-based diagnoses and the lack of detailed lifestyle information such as smoking may have led to misclassification and residual confounding.