Systemic Poisoning Research Articles

Heavy Metal Analysis Using Inductively Couple Plasma – Optical Emission Spectrometry (ICP-OES) on Hair of Breast Cancer Patients

Heavy metals can be found in everyday environments and can enter the human body through food, water, and air. Heavy metals are categorized into three groups by the World Health Organization (WHO): essential elements such as Copper (Cu), Chromium (Cr), Cobalt (Co), Iron (Fe), and Zinc (Zn); potentially essential elements like Manganese (Mn) and Nickel (Ni); and potentially toxic elements such as Cadmium (Cd) and Lead. (Pb). The heavy metal is a systemic poison that causes organ dysfunction in humans. The aim of this research is to analyze the levels of heavy metal elements Copper (Cu), Iron (Fe), and Zinc (Zn) in the hair of breast cancer patients. The method used to measure heavy metal content is Inductively Coupled Plasma – Optical Emission Spectrometry. (ICP-OES). The levels of heavy metal elements Cu, Fe, and Zn in five hair samples from breast cancer patients differ from the standards GBW07601 and IAEA-086. The levels of Cu and Fe in breast cancer patients are lower than the standard, while the level of Zn is higher than the standard.

Bodies-territories and intersectionalities: contributions to public health surveillance.

Multiple bodies and territories experience impacts, conflicts, and socioenvironmental injustices in different ways. The consequences of the neoextractivist accumulation patterns weigh differently on women, especially non-white women. This text brings narratives of a wide range of women who live in different territories and experience different impacts from major undertakings. Through their narratives, we seek to understand how they constitute their territorial bodies; how they are impacted; and how they resist colonialist domination, defend life, and restore health. These impacts affect women's means and ways of life, and restrict their ways of being, power, and knowledge in these territories, rendering them vulnerable, subject to the precariousness of life, immersed in systemic intoxication, reaching situations classified as genocide. Faced with such threats, they manage collective resistance; trigger what makes them active subjectivity; and decolonize themselves as beings, knowledge, and power. In this way they defend life and restore their health and that of their environments. These experiences indicate ways to strengthen public health surveillance perspectives and networks.

Acute Systemic Toxicity Caused by Topical Application of EMLA Cream on a Leg Ulcer: Case Report and Review of Literature.

Systemic toxicity of eutectic mixture of local anesthetics (EMLA) cream is rare and is most commonly observed in children, for example, upon extensive application, and rarely occurs in adults with certain dispositions. We report the case of a 71-year-old man who developed methemoglobinemia and systemic intoxication upon topical application of EMLA cream for leg ulcer and stasis dermatitis prior to surgical debridement. Approximately 45 min after application, the patient was found to be in a somnolent state, was unable to articulate, and showed peripheral cyanosis. The blood concentration of methemoglobin (MetHb) was 15.1%, and therefore, a diagnosis of systemic toxicity of EMLA due to methemoglobinemia was established. After removal of the cream, oxygen was applied, and further observation revealed that the patient's condition rapidly improved without any residue. In the following, we also discuss literature related to systemic EMLA intoxication. EMLA cream may cause severe systemic toxicity even in adults under certain conditions, for example, when applied on damaged skin or in extensive amounts.

EFECTIVENESS OF GREEN BETEL LEAF EXTRACT (PIPER BETLE L.) AND LIQUID SMOKE AGAINST PLUTELLA XYLOSTELLA IN CHICORY PLANTS

Chicory is one of the horticultural crops that is widely cultivated in Indonesia. Plutella xylostella are the main pests of the chicory plant. The attack damaged P. xylostella by 58-100%. The intensive use of chemical pesticides in pest control can use damage the environment and humans. Utilization of green betel leaves extract and liquid smoke in an alternative control of P.xylostella. This study aims to determine the ability of green betel leaf extract and liquid smoke to P. xylostella on the laboratory scale. The study was conducted with 7 treatments, namely, control = 0%, green betel leaf concentrations of J1 = 10%, J2 = 15%, J3 = 15%, and liquid smoke concentrations of J4 = 10%, J5 = 15%, and J6 = 20%, and repeated 4 times. The results showed that the application of green betel leaf extract and liquid smoke at a concentration of 20% caused mortality of P. xylostella of 87.5% and 100%. This is because green betel leaves contain tannins and alkaloid compounds that inhibit cell and nerve metabolism in the larvae P. xylostella which occurs continuously and causes death. Liquid smoke contains phenolic compounds that cause respiratory problems in the larvae of P. xylostella and if swallowed can cause systemic poisoning. Green leaf extract with a concentration of 3.26% and liquid smoke with a concentration of 0.34% effectively killed 50% of the larvae P. xylostella.

A Comprehensive Case of Emphysematous Gastritis in A Young Patient-Case Report

Gastric emphysema is caused by traumatic mucosal injury. A rare condition called emphysematous gastritis is characterized by intramural gas in the stomach and symptoms of systemic poisoning. It has a mortality rate of between 45% and 60%, thus early diagnosis and rapid treatment, such as fluid resuscitation, nil by mouth, broad-spectrum antibiotics, and bowel rest, are essential to halting the spread of this lethal condition. Surgery is only recommended in cases of stomach perforation. Rare and severe, emphysematous gastritis is characterized by indications of systemic poisoning and air in the stomach wall. It is often brought on by a mucosal defect that allows gas-forming organisms to infect the area, or by hematogenous dissemination from a distant centre. Emphysematous gastritis has a fulminant course, and a 60% death rate, thus early diagnosis and treatment are essential. Here we describe a case of a 17-year-old guy who complained of stomach pain; a CT scan revealed emphysematous gastritis, which is compatible with the diagnosis. Antibiotics were administered to him, and he recovered quickly. It is associated with good prognosis. Keywords: Emphysematous Gastritis; NSAIDS; Ulcer; Gastric Emphysema; Pathophysiology; Ischemic Injury

REMOVAL OF RETAINED BULLETS FROM THE HIP JOINT IN CIVILIAN GUNSHOT INJURIES

Removal of bullets retained within joints is indicated to prevent mechanical blockade, 3rd body wear and resultant arthritis, plus lead arthropathy and systemic lead poisoning. The literature is sparse on this subject, with mostly sporadic case reports utilizing hip arthroscopy. We report on the largest series of removal of bullets from the hip joints using open surgical.We reviewed prospectively collected data of patients who presented to a single institution with civilian gunshot injuries that breached the hip joint between 01 January 2009 and 31 December 2022.We included all cases where the bullet was retained within the hip joint area. Exclusion criteria: cases where the hip joint was not breached, bullets were not retained around the hip area or cases with isolated acetabulum involvement.One hundred and eighteen (118) patients were identified. One patient was excluded as the bullet embedded in the femur neck was sustained 10 years earlier. Of the remaining 117 patients, 70 had retained bullets around the hip joint. In 44 patients we undertook bullet removal using the followingsurgical hip dislocation (n = 18), hip arthrotomy (n = 18), removal at site of fracture fixation/replacement (n = 2), posterior wall osteotomy (n = 1), direct removal without capsulotomy (tractotomy) (n = 5).In 26 patients we did not remove bullets for the following reasons: final location was extra-capsular embedded in the soft tissues (n=17), clinical decision to not remove (n=4), patients’ clinical condition did not allow for further surgery (n= 4) and patient refusal (n=1). No patients underwent hip arthroscopy.With adequate pre-operative imaging and surgical planning, safe surgical removal of retained bullets in the hip joint can be achieved without the use of hip arthroscopy; using the traditional open surgical approaches of arthrotomy, tractotomy and surgical hip dislocation.

Aeromonas hydrophila infection in acute myeloid leukemia: A case report

Rationale: Aeromonas hydrophila, a bacterium commonly found in a variety of soils, aquatic habitats, and other natural environments, is known for causing infections and hemorrhagic diseases in both aquatic and terrestrial animals. Patients with leukemia, when infected by Aeromonas hydrophila following chemotherapy, face an increased risk of developing necrotizing fasciitis. Patient concerns: A 48-year-old male with a history of acute myeloid leukemia presented with swelling and pain in his right hand after being stabbed by a grass carp two days ago. The injury occurred on the fifth day after his last chemotherapy session when he was accidentally punctured in the right thumb and ring finger by a carp while fishing. Two days following the injury, the skin isurrounding the wound turned black immediately, while the rest of his hand was reddened, swollen, and bleeding. Diagnosis: Aeromonas hydrophila infection in the soft tissue of the right hand. Interventions: Intravenous antibiotics and local debridement. Outcomes: The patient experienced an alleviation of systemic poisoning symptoms, effective control of the local wound infection. Lessons: It is important for physicians to appreciate the potential for highly unusual and life-threatening infections in patients with acute myeloid leukemia. Early diagnosis and prompt treatment can prevent the development of necrotizing fasciitis and save patients' lives.

Comprehensive assessment of the relationship between indicators of systemic intoxication and intra-abdominal pressure at the patients operated for peritonitis

Comprehensive assessment of the relationship between indicators of systemic intoxication and intra-abdominal pressure at the patients operated for peritonitis

Fat overload syndrome after treatment of systemic poisoning by local anesthetics: A case report.

El uso de las emulsiones lipídicas como antídotos para la intoxicación sistémica por anestésicos locales (ISAL) ha aumentado en las últimas décadas. El síndrome de sobrecarga grasa (FOS) es una de sus complicaciones. Presentamos el caso de una gestante que para cesárea recibió bolo de lidocaína 2% a través de catéter epidural normofuncionante. Ante la sospecha de una ISAL por alteraciones neurológicas, recibió una carga de Intralipid®. En el postoperatorio debutó con ictericia, hipertermia, taquicardia y acidosis láctica. Una vez descartadas otras complicaciones, se sospechó FOS por la presencia de plasma lechoso. Se decidió tratamiento con fluidoterapia intensiva y antitérmicos. Si bien el FOS es una complicación rara, debe sospecharse ante pacientes que hayan recibido altas dosis de emulsiones lipídicas. No existen estudios sobre este síndrome en población obstétrica y hay opiniones encontradas respecto a su tratamiento, aunque el eje central es la fluidoterapia para disminuir la viscosidad plasmática.

H01 Chloracne: historical perspectives on an occupational disease, often the result of notorious environmental poisoning

Abstract First described by the Heidelberg dermatologist Siegfried Bettman in 1897 as an occupational disease in chemical workers cleaning out towers filled with hydrochloric acid, chloracne—not a true acne, despite showing comedones, cysts and pustules, but the manifestation of systemic poisoning by halogenated aromatic compounds—has been the subject of several controversial environmental disasters for over a century (www.biusante.parisdescartes.fr/sfhd/wp-ontent/uploads/2021/05/chloracne.pdf). These disasters include the 1949 Monsanto plant explosion at Nitro, West Virginia, with 226 affected; the 1976 Seveso disaster, which released tetrachlorodibenzo-p-dioxin (TCDD) over a civilian population of around 100 000 (193 definite cases); and mass poisoning by cooking oils contaminated with polychlorinated biphenyls in Kyushu, Japan, in 1968 (> 2000 affected) and Taiwan in 1979 (> 2000 poisoned). Cases have even occurred in England. An explosion at the Coalite and Chemical Products Company works at Bolsover in 1968 released dioxin, leading to 79 cases of chloracne (https://api.parliament.uk/historic-hansard/lords/1980/mar/14/dioxin-escape-at-bolsover-april-1968). An outbreak in 1992 affected 17 workers in North Derbyshire at a plant manufacturing the herbicide dichloroaniline. Another incident occurred in 1997, when seven pharmaceutical chemists who manufactured triazoloquinoxalines, not previously known to be chloracnegenic but 100 times more powerful than dioxins, were affected. Perhaps the most notorious chloracne poisoning, with TCDD, was that of the Ukrainian president Viktor Yushchenko in 2004. Unless exposure is overwhelming, as it was in Seveso, chloracne takes a few weeks to manifest, and systemic changes can be found in the blood count and liver functions tests. Resolution typically takes about 3 years, although skin changes can be permanent. Dermatologists should be vigilant for new cases, especially at the time of industrial accidents, as the chloracnegenic potential of new chemicals is not always apparent.

Evaluation of phenol degradation rate using advanced oxidation/reduction process (AO/RP) in the presence of sulfite and zinc oxide under UV

Phenol and its derivatives is known as one of the most common pollutants in industrial wastewater. Drinking water containing Phenolic compounds can cause systemic poisoning, serious gastrointestinal damage, skin burns, muscle tremors, and death. Since phenol is not removed by conventional wastewater treatment methods, hybrid methods are needed. Therefore, in the present study, two processes of oxidation and reduction (AO/RPs) were combined in a photoreactor as a new method, so that oxidizer and reducer agents simultaneously degrade and mineralize phenol. Degradation efficiency of the UV-only, UV/ZnO, UV/SO3 and UV/SO3/ZnO processes were obtained as 27%, 59.24%, 77.93% and 98.8% respectively, at 30 min reaction time, 5 mg/L phenol concentration and pH 11. According to the results obtained, 0.3 g/L ZnO dose and 1.5 mg/L SO3 were the optimal values in phenol degradation. GC-MS analysis showed that within 30 min, phenol was converted to simpler linear hydrocarbons, however more time was required for complete mineralization. In general, the removal efficiency of AO/RP was twice as high as the AOP or ARP alone. According to the results obtained from the toxicity unit (TU<1), it can be concluded that the toxicity of the effluent from AO/RP was low and has a low environmental risk.

Effect of Snakebite on Osteomyelitis and Cardiac Shock in Pediatric and Adult Patients

Snakebite is a defense mechanism of snakes and can be a medical emergency. Snake venom contains a mixture of protein components that affect the functional activity of the target physiology. The structure of the poison in snake venom has different variations for different snake species. As for snakebite, it can be life-threatening if it has neurotoxic, cytotoxic, or hemotoxic toxic effects. The purpose of this study is to determine the relationship between snakebite incidence to osteomyelitis and cardiogenic shock. The results of this study can be used as a source of information and an objective correlation reference regarding the relationship between snakebite and osteomyelitis and cardiogenic shock. This research is a Systematic Review using the Preferred Reporting Items for Systematic Reviews and Meta-analyses method or commonly called PRISMA, this method is carried out systematically by following the correct research stages or protocols. Antivenom neutralizes toxins in fixed quantities. Both children and adults are given the same amount of antivenom because snakes inject the same amount of poison into both adults and children. Antivenom can be effective as long as the poison is still active in the patient's body causing symptoms of systemic intoxication. It can last for several days or even weeks after the bite. After a series of processes have been passed, based on the results of research in the Scopus-indexed journal on the systematic "The Relationship of Snakebite with Osteomyelitis and Cardiac shock in Pediatric and Adult Patients" a conclusion can be drawn, namely that the majority of journals discuss heart disorders and infections, necrosis of muscles and bones related to poisonous snake bites.

Multidimensional Profiling of Human Body Hairs Using Qualitative and Semi-Quantitative Approaches with SR-XRF, ATR-FTIR, DSC, and SEM-EDX

This study aimed to assess the potential of a multidimensional approach to differentiate body hairs based on their physico-chemical properties and whether body hairs can replace the use of scalp hair in studies linked to forensic and systemic intoxication. This is the first case report controlling for confounding variables to explore the utility of multidimensional profiling of body hair using synchrotron synchrotron microbeam X-ray fluorescence (SR-XRF) for longitudinal and hair morphological region mapping) and benchtop methods, including attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) (complemented with chemometrics analysis), energy dispersive X-ray analysis (EDX) (complemented with heatmap analysis), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analysis (complemented by descriptive statistics) to profile different body hairs in terms of their elemental, biochemical, thermal, and cuticle properties. This multidimensional approach provided supportive information to emphasize the intricate and rather complex interplay between the organization and levels of elements and biomolecules within the crystalline and amorphous matrix of different body hairs responsible for the differences in physico-chemical properties between body hairs that are predominantly affected by the growth rate, follicle or apocrine gland activity, and external factors such as cosmetic use and exposure to environmental xenobiotics. The data from this study may have important implications for forensic science, toxicology and systemic intoxication, or other studies involving hair as a research matrix.

Matrine can be absorbed and transmitted bidirectionally to defend againstaphids (Hemiptera: Aphididae) on wheat and pepper.

Although matrine is widely used, its absorption and transport mechanisms in crops remain unexplored. In this study, three methods including foliar application, hydroponics and seed immersion were used to investigate whether matrine molecules could enter into plants through different channels, and to further resolve its transport characteristics. The systemic activity of matrine also was evaluated. Matrine was quickly absorbed and transported downwards after the leaves of wheat or peppers were treated, and also accumulated and transmitted upwards by roots. It was not only absorbed by seeds, but also appeared continuously in young roots and leaves in both plants for nearly 20 days. There were some differences in the uptake and conduction of matrine between pepper and wheat: matrine concentrated in pepper upper leaves with less delivered downwards to roots than in wheat, and also transduction of matrine in pepper lower leaves upwards to upper leaves was less than in wheat. Matrine had systemic activity, with LC50 of 361.99 and 904.24 μg·mL-1 against Rhopalosiphum padib on wheat and Myzus persicae (Sulzer) on pepper plants at 48 h, separately. Matrine can be absorbed by the roots, seeds and leaves of plants, and transmitted bidirectionally to any organs, presenting satisfactory systemic poisoning activity against aphids. It is of great significance to develop new formulation products of matrine and promote its commercialized value. © 2023 Society of Chemical Industry.

APLIKASI EKSTRAK Dioscorea hispidia PADA HAMA Pomacea speciosa DI PERTANAMAN PADI SAWAH

The golden snail is a pest originating from the American continent and entering Asia as a food ingredient. Initially, these animals were used as ornamental animals and joined the rice fields through waterways. Even the golden snail is one of the main pests that attack rice plants. Utilization of gadung tuber is an alternative to controlling golden snails considering the abundant presence of gadung tuber and its toxic cyanide content. This study aims to determine the ability of gadung tuber extract to control golden snail pests, the concentration of gadung tuber extract is the best in controlling golden snail pests. The research method was arranged in a randomized block design, with 4 repetitions and 5 treatments at the yam tuber extract level, namely, G0 (0 g/5 l), G1 (3 g/5 l), G2 (6 g/5 l), G3 ( 9 g/5 l) and G4 (12 g/5 l). The application of gadung tuber extract was carried out 2 times, namely on rice plants aged 7 hst and 18 hst which were given by spraying on each research plot in the morning at 07.00-Wita. The results of the study showed that gadung tuber extract had activity as a contact, stomach, and systemic poison with the best dose being 3 grams/5 liters

THE INFLUENCE OF ENTEROSORPTION ON SYSTEM “TUMOR AND HOST” AND TOXIC MANIFESTATIONS OF SOME CHEMOTHERAPEUTIC AGENTS

Summary. Development of malignant neoplasms is a serious pathological condition accompained by a significant body intoxication. Complex application of surgery, radiation and chemotherapy greatly improves the results of treatment of the patients with cancer, however, their toxic effects are enhanced that manifested as suppression of hematopoesis, immunosupression, nephrotoxicity, hepatotoxicity, cardiotoxicity. Enterosorption using highly active carbon sorbents is one of the perspective methods of overcoming endotoxicosis caused by systemic intoxication. The results of the study obtained on laboratory animals, namely on mice with Leweis lung carcinoma, rats with Geren’s carcinoma treated with cisplatin, rats treated with melphalan, doxorubicin, as well as irradiated rats, showed excellent efficiency of carbon enterosorbents in reducing the toxic manifestations of radiation and chemotherapy. The enterosorbents showed a myeloprotective action, lead to significant improvement of some haematological and biochemical parameters of blood and reduced manifestations of oxidative stress and the level of endogenous intoxication.

Pseudotumor as adverse local tissue reaction due to implant corrosion

Introduction. The term adverse local tissue reactions (ALTRs) is used to describe pathologic tissue conditions appearing after total joint replacement, and it includes osteolysis, bone necrosis, muscle necrosis, cystic lesions, excessive fluid collections, soft tissue masses, pseudotumors, metal sensitivity, metallosis, and chronic inflammatory lesions. ALTRs are rarely described in the literature after the breakage of the ceramic components of the hip prosthesis. Case report. We present a case of a patient with massive fluid collections filled with metallic and tissue detritus, along with signs of systemic cobalt (Co) and chromium (Cr) intoxication. Symptoms developed after revision of the acetabular component with the application of a metal-on-polyethylene coupling. Previously, several revisions were made due to breakage of the ceramic components of the endoprosthesis and instability of the hip. After removal of pseudotumor masses and revision of all components of the endoprosthesis with implantation of a coupling between the ceramic head and the polyethylene insert, there was a significant drop in the serum values of Co and Cr. Conclusion. Trunnion damage should be assessed during revision procedures, and if present, both prosthetic components should be replaced to prevent disastrous effects of metallic corrosion, ALTRs, and systemic metallic ions intoxication. Measurement of serum levels of Co and Cr in patients after joint replacement could identify patients at risk for the development of ALTRs and metallosis.

Trka milosrđa - kada čovekoljublje pomera granice

Diphtheria is an infection of the respiratory tract or skin with systemic intoxication caused by aerobic gram-positive bacteria, Corynebacterium diphtheriae. Epidemiology of infection and clinical manifestations of the disease vary in different parts of the world. In the past, this disease was among the leading causes of child mortality and occurred in massive outbreaks. Developed at the end of the 19th century, diphtheria antitoxin (DAT) played a key role in the history of public health and vaccinology prior to the diphtheria-tetanus toxoid and combined vaccines against diphtheria, tetanus and pertussis with the acellular pertussis component (DTaP). One of the more significant events from the past that showcase the importance of DAT was the dire need for its use during the diphtheria outbreak in the town of Nome, Alaska. It was January, 1925, when Doctor Curtis Welch declared a diphtheria outbreak and sent a radio telegram to all major cities in Alaska, as well as to the US Public Health Service in Washington, D.C., begging for help. Despite the quarantine, the disease spread, and the only available serum supplies were discovered at a hospital in the small town of Anchorage, hundreds of kilometres away from Nome. The serum was delivered from Anchorage by train to the Nenana village, where the nearest railway station was located, and from there teams of sledding dogs were organised to take the serum to Nome in a relay dash. They needed to cross 1085 kilometers as fast as possible, in dire weather conditions. The teams took over from each other, pushing the limits of their endurance. The musher, the dog sled driver, had to be prepared for these conditions. All the dogs on the team had significant roles, but the lead dog was the key, and he had to be resourceful, strong and well trained. It took five and a half days (127 and a half hours), 20 people and more than 150 dogs for the so-called "Great race of mercy". A coordinated emergency delivery of this serum, thanks to the sled relay accomplished by Alaskan malamutes and Siberian huskies and their mushers in extreme weather conditions in order to save lives, left a great legacy in the history of vaccinology and public health. The most difficult parts of the relay were led by Siberian huskies, Balto and Togo and their mushers, Gunnar Kaasen and Leonhard Seppala, but it should be noted that most of the mushers were native Alaskans, Athabascans. This race, where the dogs pulled the sleds carrying the precious serum represents a dynamic illustration of the contribution of a non-human species to mass immunization in the history of vaccinology. Many dogs died during this relay, while their mushers suffered severe frostbite due to extremely low temperatures. Every single individual on our planet (both human and animal) plays a part, the significance of which should not be forgotten, in the historical chain of survival and not giving up the goal of improving the life of every living creature, while at the same time trying not to harm another living being. This unique example of cooperation between human and animal species emphasizes the importance of a human-animal relationship in the one health approach initiative.

Mortality and Recovery of Kidney Function in Kidney Replacement TherapyRequiring AKI: Data from All Affected In-Hospital Subjects

Acute kidney injury (AKI) affects increasing numbers of hospitalized patients in Central Europe and in the US. Kidney replacement therapy (KRT) becomes mandatory if other strategies fail to prevent patients from systemic intoxication, resistant hyperhydration, or refractory hyperkalemia. The majority of data related to survival rates of AKI subjects that require KRT have been acquired under intensive care conditions. In the current letter to the editor we provide outcome data of all patients with in-hospital diagnosed AKI that received KRT at least once. We retrospectively assessed subjects receiving one or more individual sessions of KRT due to AKI of various etiology. Subjects were partly treated in the ICU or under non-ICU conditions. The in-hospital mortality was 35.4% complete recovery of kidney function occurred in 48.8%. In summary, the mortality of all inhospital AKI subjects is comparable to the mortality of AKI patients in the ICU. In addition, more than 50% do not recovery completely. Therefore, subjects with hospital-acquired AKI and an incident or prolonged need for KRT require the highest attention of nephrologists in general, no matter whether they received intensive care treatment or not.

Comparative treatment with hyperbaric oxygen therapy in a model of systemic loxoscelism in rats.

Spiders of the Loxosceles genus, known as violin spiders, produce venom with dermonecrotic and systemic effects, as it is a species widely distributed in the world, its study represents a high medical relevance. Systemic loxoscelism, which occurs in 1 in 5 cases and is the most frequent in children, can be fatal, so the study of effective therapy is of great relevance. In the present study, we compared different therapeutic options to mitigate the systemic effects of Loxosceles boneti venom in a model in which prepubertal rats were used. A model of systemic intoxication by L. boneti venom was provoked in male Wistar rats. Study groups were formed: healthy control, with venom and untreated control, treatment with N-acetylcysteine, and/or hyperbaric oxygenation therapy. Subsequently, pathological analysis of the kidney and lung was performed. The oxidant-antioxidant response was evaluated, and molecular analysis of the COX-1 and COX-2 enzymes was performed. Regenerative changes were observed at the cellular level in both treatments, being more noticeable in the hyperbaric oxygen therapy (HBO) group. The anti-oxidant response was outstanding in the same group. Both treatments offer considerable benefits, however; further studies are needed to provide adequate therapeutics.