Systematic Translation Research Articles

Translation, extension, and evaluation of usability, usefulness, and safety of a fall prevention and management program for people living with spinal cord injury and multiple sclerosis who use wheelchairs or scooters full time.

Falls are prevalent among people living with Multiple Sclerosis (PwMS) and Spinal Cord Injury (PwSCI) who use wheelchairs or scooters (WC/S) full time, however, there is a scarcity of evidence-based fall prevention and management programs. To describe the systematic translation of an in-person fall prevention and management program (Individualized Reduction Of FaLLs - iROLL) for PwMS to an online platform, extending its scope to include PwSCI, and to evaluate the preliminary useability, usefulness, and safety of the intervention. iROLL was systematically translated to an online platform (iROLL-O). PwMS and PwSCI who use a WC/S full time, experienced at least one fall within the past 36 months, and could transfer independently or with minimal to moderate assistance, enrolled in iROLL-O. Usability, usefulness, and safety were evaluated through 1:1 semi-structured interviews, gathering feedback on: perceived impact of the intervention on falls and functional mobility, program experiences, adverse events, and recommendations for improvement. Five participants successfully completed the iROLL-O program. No safety concerns were raised by participants. Themes emerging from the semi-structured interviews included: (1) barriers and facilitators to program access, (2) motivation for participation, (3) program outcomes, and (4) program content and structure. Participants reported reduced concerns about falling, enhanced functional mobility skills, and highlighted the supportive nature of synchronous group meetings for learning. No adverse events occurred during the implementation of iROLL-O and participants found the program to be useable and useful. Further testing is needed to examine efficacy among a large and diverse population.

Identifikasi Tujuan Tata Kelola Teknologi Informasi PLT FST UIN Jakarta Menggunakan Framework COBIT 2019

Information technology (IT) has an important role in increasing efficiency and providing benefits to decision making in various sectors. IT governance is important for organizational sustainability and performance. This research focuses on the Integrated Laboratory Center (PLT) FST UIN Jakarta which still depends on external parties for IT governance, creating potential risks and uncertainty in its operations. Therefore, this research aims to analyze the implementation of COBIT 2019 as a guide in identifying IT governance objectives that suit the needs of PLT FST UIN Jakarta. The research method used in this research involves the COBIT 2019 theoretical approach, with a focus on the goal cascade concept. This approach enables a systematic translation process of stakeholders' needs for IT systems into more specific goals and appropriate strategic steps. The results show eight COBIT 2019 domains that are relevant to IT governance objectives in PLT, which include APO02 (Managed strategy), APO08 (Managed relationships), APO10 (Managed vendors), APO11 (Managed quality), BAI04 (Managed availability and capacity), DSS01 (Managed operations), DSS03 (Managed problems(, and MEA02 (Managed system of internal control) The recommendations resulting from this research are designed to improve the performance and maturity of IT processes at PLT FST UIN Jakarta in accordance with the IT governance objectives that have been identified. This is expected to provide a stronger foundation for managing and optimizing the use of IT to support operations and achieve organizational goals more effectively.

Translating Healthcare Simulationist Code of Ethics into Urdu: bridging gaps in Pakistani healthcare simulation

This paper detailed the translation process of the Healthcare Simulationist Code of Ethics from English to Urdu, Pakistan’s national language, addressing the need for healthcare simulation in the country’s native language. Pakistan, a lower–middle-income country, faces challenges accessing healthcare education in Urdu. The systematic translation by bilingual simulation and social sciences experts considered linguistic and cultural nuances by combining translation by committee and back-translation of selected text. Bilingual experts in linguistic research and healthcare practice verified this translation from healthcare, healthcare simulation and linguistics perspectives. This research contributes to the theoretical understanding of ethical values in healthcare simulation, positively influencing healthcare professionals and educators in Pakistan. The translation sought to enhance access to responsible healthcare training initiatives, specifically targeting remote regions and underserved rural communities. This includes health workers, who serve as the primary conduits for health-related initiatives in these areas.

#920 A knowledge management system enabling telemedicine for hemodialysis: an ongoing project

Abstract Background and Aims Knowledge management (KM) systems, when applied to telemedicine, leads to multiple benefits regarding the organizational model and the dissemination of knowledge among the stakeholders. There are some studies on the application of telemedicine in Chronic Kidney Disease (CKD) and TeleDialysis (TD). TD allows the provision of personalized care through technology (dialysis services at home, in hospitals, in satellite centers). ASL Lecce represents the Regional Health System of the Puglia Region managing the health needs of the population of the province of Lecce. Currently, 800 patients are treated in dialysis facilities within the hospital, in satellite centres or at home (home haemodialysis, HHD). A hub&spoke model of dialysis care provided through a distributed network has been created. In this complex scenario, KM is particularly relevant since it allows the creation, modelling, sharing and systematic translation of health knowledge. We did not find any research on the application of Knowledge Management systems in TD. The aim of our study is to fill the gap regarding the application of a KM system to TD in the context of ASL Lecce. Method In September 2023, a TD platform applied to 24 patients already receiving Home Hemodialysis (HHD) was implemented in the Department of Nephrology at the V. Fazzi Hospital, ASL Lecce, to combine the patients’ home, satellite units and the central institution into a single common workplace. The integrated TD platform is intended as a set of infrastructural components, software and hardware functional to the continuous monitoring of dialysis treatments (Fig. 1). Results A KM system was created acquiring information from the dialytic network (schedules, clinical data, diagnoses, medical indications, observations of health personnel, accuracy of the performance, degree of satisfaction of the patient and health professionals). All the collected material was organized in a systemic way so that it could be used for the decision-making processes of the specialists and medical staff of the Nephrology Department, also valid for junior doctors and trainees. Fig. 2 shows how the KM system, applied in the near future also to the TD process, may facilitate the processes of capturing, storing and transforming knowledge into wisdom (Fig. 2). Objectives of the research: The implementation of the KM system in the TD service is focused on sharing knowledge as data-driven and people-centric: 1. Data-Driven: In the next months, the existing datasheets and clinical records will be integrated with a huge amount of data on the patient side, collected remotely via the TD platform. The ability of KM to influence performance is studied in Fig. 3. 2. People-Centered: Collaboration and communication are essential for discovering, exploring, and disseminating knowledge. Especially as part of TD, the hub&spoke organization helps to build a team that share common concerns, increase knowledge, and improve quality of care. Conclusion As for dialytic services, the TD platform integrates into the organizational model of hub&spoke. The KM system has a pivotal role in effectively update the process of care, both in the care practices and for the support of the decision-making processes. Going forward with the TD program, we aim to show that KM improves healthcare services and case management in terms of performance and value creation.

Validating the Teacher Version of Pediatric Symptom Checklist–17 in Chinese Elementary Schools

Before adopting a scale for a new culture, researchers should conduct systematic translation procedures and evaluations to ensure its psychometric quality. The Pediatric Symptom Checklist–17 (PSC-17) is a brief and valid scale developed by American researchers to evaluate children’s emotional, attentional, and behavioral problems. This study aimed to adapt the PSC-17 to a Chinese version for use in elementary school settings. In this process, 74 teachers rated 666 students using the PSC-17. These students were also assessed using the Strengths and Difficulties Questionnaire (SDQ) and additional questions (e.g., teachers’ referral status and demographic information). The scale was successfully translated into simplified Chinese using a standard procedure. Factor analysis supported a general factor model for the PSC-17. Furthermore, decent criterion validity and internal consistency were verified. Finally, a cut-off score of 17 was established, slightly higher than the original cut-off score of 15. We concluded that the PSC-17 is a high-quality screening tool in Chinese elementary schools. The findings are particularly relevant to researchers investigating children’s emotional, attentional, and behavioral development within the Chinese cultural context.

Integrated characterization of hepatobiliary tumor organoids provides a potential landscape of pharmacogenomic interactions

Despite considerable efforts to identify human liver cancer genomic alterations that might unveil druggable targets, the systematic translation of multiomics data remains challenging. Here, we report success in long-term culture of 64 patient-derived hepatobiliary tumor organoids (PDHOs) from a Chinese population. A divergent response to 265 metabolism- and epigenetics-related chemicals and 36 anti-cancer drugs is observed. Integration of the whole genome, transcriptome, chromatin accessibility profiles, and drug sensitivity results of 64 clinically relevant drugs defines over 32,000 genome-drug interactions. RUNX1 promoter mutation is associated with an increase in chromatin accessibility and a concomitant gene expression increase, promoting a cluster of drugs preferentially sensitive in hepatobiliary tumors. These results not only provide an annotated PDHO biobank of human liver cancer but also suggest a systematic approach for obtaining a comprehensive understanding of the gene-regulatory network of liver cancer, advancing the applications of potential personalized medicine.

Implementation of the "Healthy Moms, Healthy Kids" Program in Head Start: An Application of the RE-AIM QuEST Framework Centering Equity.

Marginalized mothers are disproportionately impacted by depression and face barriers in accessing mental health treatment. Recent efforts have focused on building capacity to address maternal depression in Head Start; however, it is unclear if mental health inequities can be addressed by two-generation programs in Head Start settings. Therefore, this study examined the implementation outcomes and processes of a two-generation program called "Healthy Moms, Healthy Kids" (HMHK) that provided an evidence-based depression treatment to ethnic minority Head Start mothers. Quantitative and qualitative data were collected and merged in a convergent mixed method design in accordance with the RE-AIM Qualitative Evaluation for Systematic Translation (RE-AIM QuEST) framework. Qualitative data included interviews with 52 key stakeholders, including intervention participants and staff members, and 176 sets of meeting minutes from the implementation period. Quantitative data included intervention study data and administrative data. It was difficult for HMHK to reach the target population, with only 16.8% of eligible mothers choosing to participate. However, mothers who participated experienced reductions in depressive symptoms and parenting stress and shared a variety of positive impacts in interviews. The program was also more successful in enrolling Latinx mothers who were Spanish-speaking or bilingual rather than English-speaking and Black/African American mothers, limiting its reach. Providing IPT therapy groups was effective in reducing maternal depressive symptoms and stress for those who enrolled, but additional work should focus on reducing barriers to participation, considering other delivery models to meet participants' needs, and identifying culturally relevant ways to meet the needs of Black mothers.

Research on Untranslatability of Tang Poetry from the Perspective of Theory of Three Beauties Taking Xu Yuanchong's Translation of 300 Tang Poems as an Example

On the platform of international cultural exchange, the traditional Chinese culture, with its rich content, shines brightly in the world. Tang poetry is an important part of traditional Chinese culture and is also loved by many foreign readers. Therefore, exploring effective translation strategies is one of the important tasks to promote the dissemination of Tang poetry. Untranslatability exists in the translation of Tang poetry, which is one of the key problems troubling translators. In the existing research, there is still a gap in how to solve the untranslatability of Tang poetry, and there is a lack of effective and systematic translation strategies. The theory of Three Beauties is an important translation theory put forward by Xu Yuanchong, a leading scholar in Chinese translation circles. The theory of Three beauties requires that the translation should conform to three standards: beauty of sound, beauty of form, and beauty of meaning. This paper chooses the case analysis method and analyzes some cases of Xu Yuanchong's English Translation of 300 Tang Poems based on the theory of three beauties to explore how to deal with the untranslatability of Tang poems in line with the standard of three beauties. This paper divides the case into two parts: language and culture. Author comes up with translation strategies to deal with these two types of untranslatability. This paper focuses on the compensatory strategies of Tang Poems found by the author when reading Xu Yuanchong's English Translation of 300 Tang Poems. This strategy is an innovation of the previous compensation methods, and it also shows the translator's overall understanding of the text for readers to read. According to the research findings, the author concludes that the most important thing for translators is to understand the connotation of Tang poetry and use translation strategies according to the specific situation.

COVIDanno, COVID-19 annotation in human.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 19 (COVID-19), has caused a global health crisis. Despite ongoing efforts to treat patients, there is no universal prevention or cure available. One of the feasible approaches will be identifying the key genes from SARS-CoV-2-infected cells. SARS-CoV-2-infected in vitro model, allows easy control of the experimental conditions, obtaining reproducible results, and monitoring of infection progression. Currently, accumulating RNA-seq data from SARS-CoV-2 in vitro models urgently needs systematic translation and interpretation. To fill this gap, we built COVIDanno, COVID-19 annotation in humans, available at http://biomedbdc.wchscu.cn/COVIDanno/. The aim of this resource is to provide a reference resource of intensive functional annotations of differentially expressed genes (DEGs) among different time points of COVID-19 infection in human in vitro models. To do this, we performed differential expression analysis for 136 individual datasets across 13 tissue types. In total, we identified 4,935 DEGs. We performed multiple bioinformatics/computational biology studies for these DEGs. Furthermore, we developed a novel tool to help users predict the status of SARS-CoV-2 infection for a given sample. COVIDanno will be a valuable resource for identifying SARS-CoV-2-related genes and understanding their potential functional roles in different time points and multiple tissue types.

Implementation of medication for opioid use disorder treatment in Indian health clinics in California: A qualitative evaluation

IntroductionAmerican Indians and Alaska Native (AIAN) populations are disproportionately affected by opioid misuse. Medication for opioid use disorder (MOUD) is essential to decrease overdose events and overdose deaths. AIAN communities can benefit from MOUD programs that are housed within primary care clinics to improve treatment accessibility. This study aimed to gather information on the needs, barriers, and successes related to implementing MOUD programs in Indian health clinics (IHCs) offering primary care. MethodsThe study used the Reach, Effectiveness, Adoption, Implementation, and Maintenance Qualitative Evaluation for Systematic Translation (RE-AIM QuEST) evaluation framework to structure key informant interviews with clinic staff who received technical assistance for MOUD program implementation. The study incorporated RE-AIM dimensions into a semi-structured interview guide. We developed the coding approach for analyzing interview data using Braun and Clarke's (2006) reflexive thematic analysis in qualitative research. ResultsEleven clinics participated in the study. The research team conducted twenty-nine interviews with clinic staff. We found that inadequate education about MOUD, scant resources, and limited availability of AIAN providers adversely impacted reach. Challenges with integrating medical and behavioral care, patient-level barriers (e.g., rural conditions, geographical dispersion), and limited workforce capacity impacted MOUD effectiveness. Stigma at the clinic level was detrimental to MOUD adoption. Implementation was challenging due to a limited number of waivered providers, and the need for technical assistance and MOUD policies and procedures. Staff turnover and restricted physical infrastructure negatively influenced MOUD maintenance. ConclusionsClinical infrastructure should be strengthened. The integration of culture into clinic services must be embraced by staff to support MOUD adoption. Increased representation from AIAN clinical staff is needed to appropriately represent the population being served. Stigma at various levels must be addressed, and the multiple barriers that AIAN communities face must be considered in understanding MOUD program implementation and outcomes.

Cross-cultural adaptation and validation of the Recognizing And Addressing Limited Pharmaceutical Literacy (RALPH) interview guide in community pharmacies.

The RALPH (Recognizing and Addressing Limited PHarmaceutical Literacy) interview guide makes it possible to identify patients with limited pharmaceutical knowledge and to assess their skills in the functional, communicative, and critical health literacy domains. (s): To perform a cross-cultural validation of the RALPH interview guide in Spanish population; to conduct a descriptive analysis based on patients' responses. A cross-sectional study of patients' pharmaceutical literacy skills was conducted in three stages: systematic translation, administration of the interview and analysis of psychometric properties. The target population included adult patients (≥18 years) who attend one of the participating community pharmacies in Barcelona (Spain). Content validity was evaluated by an expert committee. Viability was assessed in the pilot test, and reliability was assessed using internal consistency and intertemporal stability. Construct validity was assessed by factor analysis. A total of 103 patients were interviewed at 20 pharmacies. Cronbach's alpha values based on standardized items ranged between 0.720 and 0.764. For the longitudinal component, the ICC test-retest reliability was 0.924. The factor analysis was verified by KMO (0.619) and Bartlett's test of sphericity (P-value <0.05). The definitive RALPH guide translated into Spanish maintains the same structure as the original. Some expressions were simplified, and the questions on the comprehension of warnings or specific instructions for use, contradictory information and shared decision-making were reformulated. Pharmaceutical literacy skills were seen to be most limited with regard to the critical domain. The responses of the Spanish patients were in agreement with the original results of the RALPH interview guide. The RALPH interview guide in Spanish complies with the requirements viability, validity, and reliability. This tool may be able to identify the low pharmaceutical literacy skills of patients coming to community pharmacies in Spain, and its use may also be extended to other Spanish-speaking countries.

Connecting Black families in Houston, Texas, to hereditary cancer genetic counseling, genetic testing, and cascade testing by using a simple cancer genetic risk assessment and telegenetics.

TPS10638 Background: Hereditary breast and colorectal cancers accounts for 5-10% of all cases, but less than half of all eligible patients undergo NCCN guideline-concordant screening. This proportion is even lower among Black patients, who have a higher breast cancer and colorectal incidence and mortality. Recruitment through community organizations has been shown to identify patients who are eligible for genetic testing but have not been offered it by their doctor. Our one-page cancer genetic risk assessment (CGRA) and telegenetics were previously shown to improve adherence to genetic testing guidelines for hereditary breast and ovarian cancer. Our objective is to identify adults eligible for hereditary breast and colorectal cancer syndromes genetic testing using trusted community organizations that serve the Black community as entry points, reach them with our tailored program, and measure impact. Methods: In this prospective single-arm trial, adults of &gt; 18 years old who self-identify as Black or African American are recruited during events put together by community organizations in Houston, Texas. The CGRA was modified to encompass hereditary breast and colorectal cancer syndromes based on NCCN guidelines. To improve convenience, eligible participants can be consented and fill out the CGRA in-person or via QR code link using a smart phone. Study team members attend community events and are also available via phone to help with informed consent, CGRA, etc. Those at high risk for hereditary breast and colorectal cancer syndromes are provided with educational materials and can be sent the saliva-based kit or complete it on-site. When results of genetic testing include a pathogenic mutation (PV) or variant of uncertain significance, individuals receive telegenetic counseling and risk reduction resources, including about cascade genetic testing. Others are notified of negative results. The program includes education for interested community organization members about importance of genetic testing. The program is projected to reach 1,000 participants with 300 completing genetic testing and identification of 11 PV. The study is overseen by a Community Advisory Board. Impact will be evaluated via a multiple methods design using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Qualitative Evaluation for Systematic Translation (QuEST) framework six months after program start. Quantitative data will be analyzed using descriptive statistics and standard tests of association. Data collected via semi-structured interviews with participants and program implementers will be audio-recorded, transcribed, double-coded, and analyzed via thematic analysis. Enrollment started December of 2022. 15 participants patients enrolled during two community events. Clinical trial information: NCT05694559 .

Implementation of the Good Life with osteoArthritis in Denmark (GLA:D®) program via telehealth in Australia: A mixed-methods program evaluation

We aimed to evaluate the implementation of the Good Life with osteoArthritis in Denmark (GLA:D®) program via telehealth in Australia using Reach, Effectiveness, Adoption, Implementation, and Maintenance Qualitative Evaluation for Systematic Translation framework. Using a convergent mixed-methods design, semi-structured one-on-one interviews with physiotherapist adopters and nonadopters of GLA:D® via telehealth were analyzed thematically alongside the examination of registry data (1 March 2020-10 February 2022) from patients with hip or knee osteoarthritis completing GLA:D® via telehealth (telehealth-only) or combined with in-person care (hybrid). Effectiveness was determined as changes from baseline to 3-month follow-up (mean differences, 95% confidence intervals, effect size) for Knee injury and Osteoarthritis Outcome Score (KOOS-12)/Hip disability and Osteoarthritis Outcome Score-12 (HOOS-12), and chair stand test. Group- and individual-level changes were compared to published minimally clinically important change scores. Twenty-three interviews (12 adopters, 11 nonadopters) found key barriers/facilitators to reach and adoption, high perceived effectiveness, and strategies to support sustainability. Of 2612 registered patients, 85 (3%) and 115 (4%) completed GLA:D® via telehealth-only or hybrid model, respectively. Most effectiveness outcomes were associated with moderate-large improvements. Group-level changes exceeded minimally clinically important change values for KOOS/HOOS-quality of life and chair stand test. Nearly two out of three patients reached a minimally clinically important change for KOOS/HOOS-quality of life. With telehealth-only and hybrid delivery, 99% (n = 82) and 85% (n = 97) were satisfied/very satisfied. Physiotherapist adoption was limited (n = 128, 6%). GLA:D® delivered via telehealth is effective, had high patient satisfaction, and was perceived positively by physiotherapist adopters. Addressing low reach and adoption requires further implementation strategies to facilitate greater telehealth opportunities for patients and physiotherapists.

Implementing the learning health system paradigm within academic health centers.

The learning health system (LHS) concept represents a bold innovation that combines organizational learning, strategic analysis of patient data, stakeholder engagement and the systematic translation of research into practice - all in service of improving the quality of health care delivered across the organization. This innovation has been diffused and widely adopted by healthcare organizations over the past 15 years, but academic health centers (AHCs) have been slower on the uptake. The irony is that AHCs have the resources (e.g., trained researchers, sophisticated clinical data systems, informatics infrastructure) that are necessary to do the highest-quality and most impactful LHS work. Based on a review of publications describing how AHCs have implemented LHS work, as well as the authors' direct experience promoting the adoption of the LHS paradigm at Atrium Health Wake Forest Baptist (AHWFB), we:identify a set of factors that have inhibited broader adoption of the LHS paradigm among AHCs; distinguish between the forms of LHS work that are consistent and inconsistent with the mission of AHCs; and offer recommendations for broader adoption and fuller implementation of the LHS paradigm. The LHS paradigm represents an expansion of the scientific paradigm which serves as the foundation of research enterprise within AHCs. Both paradigms value rigorous studies of new treatments and practices, including pragmatic clinical trials. The LHS paradigm also places a high value on quality improvement studies, organizational learning, and the translation of research findings into improved patient care and operations within the local health system. The two paradigms differ on the origin of the research question, i.e., a pressing patient-care issue facing the health system versus the investigator's own research interests. Academic researchers have been disincentivized from pursuing at least some forms of LHS research. However, a growing number of AHCs are finding ways to integrate the LHS paradigm into their research enterprise, either by providing research faculty with institutional funding to cover their effort on studies that address the health system's priority issues, or by establishing an institute dedicated to LHS research. The LHS paradigm is a disruptive intervention for AHCs, one that was initially resisted but is increasingly being embraced. AHCs are developing strategies for conducting LHS research, typically in parallel to the more traditional biomedical science that is core to academic medicine. Full implementation of the LHS paradigm will require further alignment between LHS and science, including a shift in the criteria for promotion and tenure to support those researchers who choose to focus on the pressing issues facing the health system.

Rational In Silico Design of Molecularly Imprinted Polymers: Current Challenges and Future Potential.

The rational design of molecularly imprinted polymers has evolved along with state-of-the-art experimental imprinting strategies taking advantage of sophisticated computational tools. In silico methods enable the screening and simulation of innovative polymerization components and conditions superseding conventional formulations. The combined use of quantum mechanics, molecular mechanics, and molecular dynamics strategies allows for macromolecular modelling to study the systematic translation from the pre- to the post-polymerization stage. However, predictive design and high-performance computing to advance MIP development are neither fully explored nor practiced comprehensively on a routine basis to date. In this review, we focus on different steps along the molecular imprinting process and discuss appropriate computational methods that may assist in optimizing the associated experimental strategies. We discuss the potential, challenges, and limitations of computational approaches including ML/AI and present perspectives that may guide next-generation rational MIP design for accelerating the discovery of innovative molecularly templated materials.

A Study of Historical Urban Landscape Layering in Luoyang Based on Historical Map Translation

China has undergone a tremendous urbanization process over the past four decades, resulting in a considerable conflict between the desire to construct contemporary urban areas and the desire to safeguard old urban structures. In addition to destroying the physical space of ancient urban sites, urban development has fragmented the natural landscape and severed its structural relationship with the historical urban landscape. In this study, we selected Luoyang as the research object and digitally translated and laminated the laminar process of Luoyang’s historical urban landscape based on historical maps and related historical documents. It is intended to establish a digital historical urban landscape information database comprising data from different periods of the city through the systematic translation of historic maps and through combining the following different landscape carriers: urban spatial patterns, roads and streets, landscape units, and landmark buildings. While reading the historical maps of the city, the spatial analysis tool, ArcGIS, was used to identify the trajectory of the spatial evolution of Luoyang’s spatial structure throughout its history. In this paper, we suggest the establishment of a Luoyang urban historical axis system to integrate the city’s fragmented historical urban landscape, thereby strengthening the social perception of such historical urban landscapes and preserving their memory.

General Self-Efficacy Scale (GSE) in Simple Language: Internal Consistency, Standard Values and Correlations with Demographic Variables in a Representative German Sample

Approximately 6,2 million people with limited literacy live in Germany. They are unable to communicate in written language beyond single sentences and thus experience limited social participation in many everyday areas. In addition, they are also excluded from participation in survey-based social science research. In order to enable persons with limited literacy to participate in written surveys, existing questionnaires need to be converted to easy language and their psychometric quality needs to be reexamined. We went through this process for the Self-Efficacy Expectancy (SWE) questionnaire and tested the new scale in easy language (SWE-LS) on a representative sample of the German population aged 14 years and older (N=2,531). The SWE-LS scale showed good internal consistency (Cronbach's-Alpha=0,84) and adequate item difficulty and discriminatory power. We found correlations consistent with expectations for the demographic variables surveyed. Thus, men and persons with higher education and higher income showed significantly higher self-efficacy expectations. The effect was also evident for East Germans versus West Germans, married persons living together versus separated, unmarried, or persons living as singles. Compared to the original SWE scale, the SWE-LS scale in easy language has no methodological disadvantages. The additional effort of linguistic adaptation and renewed psychometric testing is thus directly offset by enabling participation in survey-based research by over 12% of the adult population. A systematic translation of particularly frequently used questionnaires or those that do not concern fundamental research but research areas in which demographic variables themselves are part of the research object would be desirable.

Development and Validation of the German Version of the Community of Inquiry Survey

The Community of Inquiry (CoI) Framework describes success factors for collaborative online-based learning. The CoI Survey is a validated instrument to measure these factors from the perspective of course participants. Until now, no validated translation of this Survey to German was available. The aim of this work was to translate the original English Survey to German and to validate the translated Survey instrument. After a systematic translation process, we validated the German translation in two higher education settings in two countries (entire data set of n=433 Surveys). By conducting item analysis, reliability analysis, exploratory factor analysis, and confirmatory factor analysis, we were able to confirm the reliability and validity of the German CoI Survey. Only one item (CP6) shows cross-loadings on two factors, a finding that was already discussed for the original CoI Survey. To conclude, the validated German version of the CoI Survey is now available.

Understanding factors affecting implementation success and sustainability of a comprehensive prevention program for cardiovascular disease in primary health care: a qualitative process evaluation study combining RE-AIM and CFIR.

Our aim was to evaluate the implementation process of a comprehensive cardiovascular disease prevention program in general practice, to enhance understanding of influencing factors to implementation success and sustainability, and to learn how to overcome barriers. Cardiovascular disease and its risk factors are the world's leading cause of mortality, yet can be prevented by addressing unhealthy lifestyle behavior. Nevertheless, the transition toward a prevention-oriented primary health care remains limited. A better understanding of factors facilitating or hindering implementation success and sustainability of prevention programs, and how barriers may be addressed, is needed. This work is part of Horizon 2020 project 'SPICES', which aims to implement validated preventive interventions in vulnerable populations. We conducted a qualitative process evaluation with participatory action research approach of implementation in five general practices. Data were collected through 38 semi-structured individual and small group interviews with seven physicians, 11 nurses, one manager and one nursing assistant, conducted before, during, and after the implementation period. We applied adaptive framework analysis guided by RE-AIM Qualitative Evaluation for Systematic Translation (RE-AIM QuEST) and Consolidated Framework for Implementation Research (CFIR). Multiple facilitators and barriers affected reach of vulnerable target populations: adoption by primary health care providers, implementation and fidelity and intention to maintain the program into routine practice. In addition, our study revealed concrete actions, linked to implementation strategies, that can be undertaken to address identified barriers. Prioritization of prevention in general practice vision, ownership, and shared responsibility of all team members, compatibility with existing work processes and systems, expanding nurse's roles and upskilling competence profiles, supportive financial and regulatory frameworks, and a strong community - health care link are crucial to increase implementation success and long-term maintenance of prevention programs. COVID-19 was a major barrier to the implementation. RE-AIM QuEST, CFIR, and participatory strategies are useful to guide implementation of prevention programs in primary health care.

Пахомианские тексты русского Добротолюбия

The article examines the issue of collecting and translating ascetic literature into Slavic and Russian languages in the 18–19 centuries using the example of the Pakhomian corpus of texts. Comparative analysis of the composition of the Greek Philokalia and the Russian Philokalia – the latter is considered not just as an ascetic five-volume book prepared for publication by st. Feofan the Recluse, but as a systematic translation activity that united several generations, and thanks to which there was a flourishing of monasticism and the resumption of eldrship in Russia. The reasons for the differences in the composition of Greek and Russian Philokalia are also considered, in particular, the interest not only in Hesychast literature, but also in monastic statutes, primarily in the tradition of Egyptian cenobitic monasticism, which was initiated by st. Pachomium. Based on the correspondence of the participants, the circumstances of the work on the texts of the Pachomian circle are traced: Pachomius the Great, his predecessor Orsicius and John Cassian the Roman. The collected material and analysis of individual translation principles of this period allows us to speak about the wide interest in Russia in the history of monasticism, about the good knowledge of European patristic publications when choosing texts for translation, about the high level of Latin language proficiency and the exceptional importance of the results achieved, which will never lose their significance, as they serve as evidence of the time of flowering on Russian soil translation activities.