Systematic Literature Research Research Articles

What is a fair price for a medicine? Establishing the main elements of a fair price based on the current policy debate

ObjectiveUnfair medicines prices have been discussed widely as an obstacle for patient access. This article aims to structure the discussion about fair pricing of medicines, analyses the elements for a fair price, and assesses its practical implications. MethodsA systematic literature research has been undertaken and complemented by gray literature. Definitions and elements of a fair price have been extracted from the sample, categorized via a thematic and a quantitative analysis, and mirrored against the traditional framework of ‘iustum pretium’ (fair price). ResultsThe most often attributes of a fair price mentioned were affordability (n = 30), followed by value and research and development (R&D) investment (n = 20). Other frequently mentioned attributes are profitability (n = 19), transparency of R&D costs (n = 18), cost-effectiveness (n = 17), and manufacturing (n = 14). Nearly all definitions present fair price as a balance between different objectives. ConclusionsMost publications stipulate that medicines are a common good and should be affordable. At the same time, most publications also propose a pricing approach based on covering costs for R&D and/or on value. Consequently, most of the attempts to clarify fair price result in a value-affordability dilemma, which does not necessarily warrant patient access. Many social health systems implement pricing regardless of the debate. This systematic review offers a set of attributes for fair price and helps refining the existing pricing and reimbursement regulations. Once complemented by empirical datapoints, it provides the basis for developing a framework for fair pricing.

The IMP research on business networks: a systematic literature review and research agenda

AbstractMore than 40 years of Industrial Marketing and Purchasing (IMP) research have revealed that in b2b markets, business exchange is carried out in continuous buyer–seller relationships. This involves direct and indirect interaction and dynamics resulting in significant related social and material investments and in extensive interdependencies that confer on the business landscape a market-as-network structure. Since the introduction of this ideas, research on business networks has been richly alimented by researchers of the IMP community. Yet, we do not have a clear overview of what this literature has covered in the last twenty years (in the period 2002–2022), in parallel with the many changes that have affected business landscape. With this study, we aim to examine what is the status of the last 20 years of IMP literature specifically dealing with the business networks level of analysis (45 articles) and to offer key directions for imminent research in this domain while analyzing and synthesizing extant literature.

Shaping ultrasound in midwifery: towards an evidence-based training framework for enhanced prenatal care.

Academic advancement of the midwifery profession highlights the need to establish standardized qualifications in obstetric ultrasound diagnosis, being a central part of prenatal care. Thus, introduction of an evidence-based training program is warranted. We aimed to reviewed curriculum designs used in midwifery ultrasound education. A systematic literature research was conducted. Embase, PubMed and Google Scholar database was reviewed for publications using the terms "[midwife], [midwives], [midwifery students], [obstetric ultrasound], [midwife sonographer] and [education], [teaching], [program], [course], [curriculum] and [learning]". Papers with full description of curriculum designs or educational programs on obstetrical ultrasound for midwives were included and scrutinized against pre-defined criteria according to the PICO (Population, Intervention, Comparator, Outcomes) scheme. 29 publications were included. Studies demonstrated a significant disparity according to course concepts being used. Differing parameters included: Duration, structure, learning approaches, course content, examination concepts and target groups (practising midwives vs. midwives in education). An evidence-based ultrasound educational program for midwives remains to be developed, including further educational guidelines. Clinical applications by midwives, as well as the distinctions from medical practise, particularly in terms of legal considerations, needs to be defined.

Reconceptualizing socio-tech entrepreneurship: A systematic literature review and research agenda

Socio-Tech Entrepreneurship is a growing observable phenomenon, often referred to as tech4good, and highly valued in society due to the major benefits it provides in meeting the United Nations' Sustainable Development Goals. However, academic research specifically dedicated to socio-tech entrepreneurial ventures is still incipient. To address this research gap, the paper develops a systematic literature review of 238 peer-reviewed studies on social, technology and socio-tech entrepreneurship published from 1988 to 31 December 2023. Through descriptive and content analysis methods, the paper develops the first framework conceptualizing Socio-Tech Entrepreneurship as an autonomous topic within the entrepreneurship research domain. Drawing on the literature, the conceptual framework shows that Socio-Tech Entrepreneurship is distinct from Social Entrepreneurship or Technology Entrepreneurship, which legitimates it as a conceptually relevant group of organizations/practices and as an autonomous research topic within the business sciences field. The paper's comprehensive assessment of the literature and the proposed conceptual framework also unveil topics that are specific to Technology or Social Entrepreneurship but have not been addressed yet for Socio-Tech Entrepreneurship, offering potential future research opportunities and contributing to a research agenda. Implications for theory and practice are discussed.

The microbiome in recurrent pregnancy loss – A scoping review

Recurrent pregnancy loss (RPL) is a troubling condition that affects couples worldwide. Despite extensive research efforts, many RPL cases remain unexplained, highlighting the need for novel approaches to unravel its underlying mechanisms. Recent advances in microbiome research have shed light on the potential role of the microbiome in reproductive health and outcomes. Based on a systematic literature research, this review aims to comprehensively explore the current understanding of the microbiome's involvement in RPL, focusing on the vaginal, endometrial, and gut microbiomes. Evidence from the available studies is examined to explain the relationship between the microbiome and RPL. Furthermore, we discuss the diagnostic potential of the microbiome, therapeutic interventions, and future directions in microbiome research for RPL. Understanding the complex interactions between the microbiome and reproductive health holds promise for developing targeted interventions to help patients today diagnosed as unexplained.

A Deep Dive into Robot Vision - An Integrative Systematic Literature Review Methodologies and Research Endeavor Practices

Novel technological swarm and industry 4.0 mold the recent Robot vision research into innovative discovery. To enhance technological paradigm Deep Learning offers remarkable pace to move towards diversified advancement. This research considers the most topical, recent, related and state-of-the-art research reviews that revolve around Robot vision, and shapes the research into Systematic Literature Survey SLR. The SLR considers a combination of more than 100 reviews and empirical studies to perform a critical categorical study and shapes findings against research questions. The research study contribution spans over multiple categories of Robot vision and is tinted along with technical limitations and future research endeavors. Previously multiple research studies have been observed to leverage Robotic vision techniques. Yet, there is none like SLR summarizing recent vision techniques for all targeted Robotic fields. This research SLR could be a precious milestone in Robot vision for each glimpse of Robotics.

Technology acceptance model in halal industries: a systematic literature review and research agenda

Purpose The continued relevance of technologies in halal industries requires managers to understand the factors contributing to such technologies’ acceptance. The technology acceptance model (TAM) is dominant in the literature that predicts user acceptance and behaviour towards technology. Despite the model’s significance, there has yet to be a systematic review of studies featuring halal sectors that use TAM. The purpose of this study is to systematically review the existing literature on TAM in halal industries to understand the research trends as well as TAM modifications and research opportunities in halal industries. Design/methodology/approach Guided by the preferred reporting items for systematic review and meta-analysis protocol, a framework-based review using the theories, contexts, characteristics and methods (TCCM) framework was conducted. The Scopus and Web of Science databases were used to retrieve English journal articles that investigated TAM in the context of halal markets. In total, 44 eligible articles were reviewed in terms of the developments and extensions of TAM in their studies across the halal industries. Findings The first study related to the use of TAM in the context of halal industries was published in 2014. The most prominent halal industry in the review, which used TAM, was Islamic finance. Indonesia was the leading economy in halal studies using TAM. Perceived usefulness was found to be a more significant factor than perceived ease of use for technology acceptance in TAM studies on halal industries. The significance of religiosity on TAM was inconsistent. Most research was done using quantitative surveys with consumers as the target sample. Research limitations/implications The studies in this review are based on the Scopus and Web of Science databases, which may be perceived as a study limitation. This study also only considered English journal articles and research in which the focus was on the use of TAM in halal industries rather than general industries with Muslim consumers. Practical implications Halal industries will continue to rely on technology for the provision of goods and services. With the rise of emerging technological innovations, this review will provide managers with an appreciation of technology acceptance across different contexts. Researchers can use the results of this review to guide future studies and contribute toward the development of this research area. Originality/value This review contributes to the Islamic marketing literature by being the first to comprehensively review the TAM model in the context of halal industries using the TCCM framework-based review approach. A research agenda is proposed to advance research on technology acceptance and TAM in halal industries.

Emerging technologies and principle-based project management: a systematic literature review and research agenda

Emerging technologies and principle-based project management: a systematic literature review and research agenda

Sustainable Finance and ESG Importance: A Systematic Literature Review and Research Agenda

Over the last decade, sustainable finance has appeared to be capturing a high level of interest as a crucial pillar of sustainable development. The process of taking environmental, social, and governance (ESG) considerations into account when making investment decisions in the financial sector is expected to play a key role in this framework, and although it has attracted the attention of many scholars and academics, a lack of understanding of the nature of the phenomenon remains. Therefore, on the basis of a systematic literature review of 80 studies, we examine, in detail, the subject areas and emphasize the main points in the existing literature. The findings reveal that there are four main thematic areas attracting research interest, as follows: (1) A shift in value creation; (2) green bonds; (3) ESG ratings and performance; and (4) sustainable finance, banking, and financial risks. Finally, this study outlines future research avenues in the field.

Efficacy and safety of pharmacological treatment of psoriatic arthritis: a systematic literature research informing the 2023 update of the EULAR recommendations for the management of psoriatic arthritis

ObjectivesTo obtain an overview of recent evidence on efficacy and safety of pharmacological treatments in psoriatic arthritis (PsA).MethodsThis systematic literature research (SLR) investigated the efficacy and safety of conventional synthetic...

Co-creation and innovation in higher education institutions: a systematic literature review and research agenda

PurposeThis systematic literature review aims to identify the main areas of study related to co-creation and innovation in Higher Education Institutions (HEIs), as well as the main external and internal stakeholders with whom co-creation is made.Design/methodology/approachThe empirical approach is based on 258 articles selected from the Web of Science (WoS), Clarivate Analytics and Scopus, Elsevier databases, with analysis of titles, abstracts and keywords following a research protocol. VOS viewer and CitNetExplorer software were used, with the twin aim of identifying publications with a higher number of citations and designing maps of reference word co-occurrence.FindingsThe analysis led to three clusters being identified: Cluster 1. Management and transfer of knowledge from HEIs to companies; Cluster 2. Co-creation and innovation in HEIs through cooperation between universities and companies; and Cluster 3. Universities’ third mission and their role in developing entrepreneurship education. The results of the literature clusters analysis led to proposing a conceptual model of analysis.Research limitations/implicationsDespite only employing two databases and the content analysis criteria, the three found clusters are linked, recognising the interplay between co-creation and innovation in HEIs, knowledge transfer to enterprises and the influence on HEIs' third goal.Practical implicationsThis systematic literature review highlights and gives a picture of the state-of-the-art in co-creation and innovation in HEIs, as well as presenting a model of co-creation and innovation in HEIs that can contribute to reinforcing the University-Industry-Community ties.Social implicationsThis study can lead to a better knowledge of the issue of co-creation and innovation at HEIs, as well as a deeper analysis of the sorts of relationships between HEIs and their stakeholders, as well as its impact on surrounding areas and influence.Originality/valueThe research highlights the interaction between HEIs and their stakeholders on a basis of value co-creation and innovation, providing mutual benefits for all involved, as well as greater development and recognition of HEIs and their surrounding regions’ image andreputation. A future research agenda is also presented on the topic of co-creation and innovation in HEIs.

Classification of Congenital Leptin Deficiency.

Bi-allelic pathogenic leptin gene variants cause severe early onset obesity usually associated with low or undetectable circulating leptin levels. Recently, variants have been described resulting in secreted mutant forms of the hormone leptin with either biologically inactive or antagonistic properties. We conducted a systematic literature research supplemented by unpublished data from patients at our center as well as new in vitro analyses to provide a systematic classification of congenital leptin deficiency based on the molecular and functional characteristics of the underlying leptin variants and investigated the correlation of disease subtype with severity of the clinical phenotype. A total of 28 distinct homozygous leptin variants were identified in 148 patients. The identified variants can be divided into three different subtypes of congenital leptin deficiency: classical hormone deficiency (21 variants in 128 patients), biologically inactive hormone (3 variants in 12 patients) and antagonistic hormone (3 variants in 7 patients). Only 1 variant (n=1 patient) remained unclassified. Patients with biological inactive leptin have a higher percentage of 95th BMI percentile (%BMIp95) compared to patients with classical hormone deficiency. While patients with both classical hormone deficiency and biological inactive hormone can be treated with the same starting dose of metreleptin, patients with antagonistic hormone need a variant-tailored treatment approach to overcome the antagonistic properties of the variant leptin. Categorization of leptin variants based on molecular and functional characteristics helps to determine the most adequate approach to treatment of patients with congenital leptin deficiency.

Consumer embarrassment: A systematic literature review and research agenda

AbstractEmbarrassment plays a crucial role in shaping the consumer landscape by influencing perceptions, choices, and experiences. In a marketplace, customers get embarrassed when personally implicated in transgressions, and also vicariously, while observing the predicament of others. Vicarious embarrassment, though ubiquitous and detrimental for firms, has received limited attention in marketing scholarship. This article offers a comprehensive review of consumers' personal and vicarious embarrassment by incorporating content and bibliometric analysis methodologies. The bibliometric study comprises a review of 203 articles published from 1900 to 2022. Techniques of citation analysis and co‐citation analysis reveal the prominent authors, journals, and articles and trace the intellectual structures of thoughts contributing to the domain. Additionally, social network analysis delineates the centrality features of the leading studies in the consumer embarrassment domain. Further, the article provides a comprehensive content analysis of 109 studies relevant to the purchase and consumption contexts. A review of the extant findings on major theoretical perspectives, triggers, coping strategies, moderators, and desirable and adverse outcomes of personal and vicarious embarrassment is presented. The article offers actionable future research directions for theoretical advancement of the phenomenon of consumer embarrassment. This research will assist firms and marketers in understanding and mitigating the aversive outcomes of embarrassment.

Decentralized Autonomous Organizations: A Systematic Literature Review and Research Agenda

The coordination and organization of economic activity has always been one of the greatest challenges of humanity. For a long time, centralized models have been the dominant approach, but the emergence of technologies such as the internet, open-source software, peer-to-peer and ubiquitous computing, smart contracts and blockchain is leading to a shift toward decentralization. This trend is now culminating with a new phase of innovation called Decentralized Autonomous Organization (“DAO”). DAOs offer the potential to empower communities, promote decentralization and reliable coordination, and increase transparency and meritocracy in corporate governance using the institutional technology that is blockchain. In this paper, we present a systematic literature review of 195 academic publications on the DAO phenomenon using the PRISMA methodology. We aim to answer the following research questions: What are the characteristics of DAOs? What topics related to DAOs were researched by whom? Why do DAOs show great potential? When do DAOs face limitations? Where can solutions be found for the identified limitation? We also propose a research agenda and suggest future research directions.

Mechanical Circulatory Support Strategies in Takotsubo Syndrome with Cardiogenic Shock: A Systematic Review.

Takotsubo syndrome is, by definition, a reversible form of acute heart failure. If cardiac output is severely reduced, Takotsubo syndrome can cause cardiogenic shock, and mechanical circulatory support can serve as a bridge to recovery. To date, there are no recommendations on when to use mechanical circulatory support and on which device is particularly effective in this context. Our aim was to determine the best treatment strategy. A systematic literature research and analysis of individual patient data was performed in MEDLINE/PubMed according to PRISMA guidelines. Our research considered original works published until 31 July 2023. A total of 93 publications that met the inclusion criteria were identified, providing individual data from 124 patients. Of these, 62 (50%) were treated with veno-arterial extracorporeal life support (va-ECLS), and 44 (35.5%) received a microaxial left ventricular assist device (Impella). Eighteen patients received an Impella CP and twenty-one an Impella 2.5. An intra-aortic balloon pump (IABP) without other devices was used in only 13 patients (10.5%), while other devices (BiVAD or Tandem Heart) were used in 5 patients (4%). The median initial left ventricular ejection fraction was 20%, with no difference between the four device groups except for the IABP group, which was less affected by cardiac output failure (p = 0.015). The overall survival was 86.3%. Compared to the other groups, the time to cardiac recovery was shorter with Impella (p < 0.001). Though the Impella treatment is new, our analysis may show a significant benefit of Impella compared to other MCS strategies for cardiogenic shock in Takotsubo syndrome.

Effect of Oral Probiotic Supplementation on Gut Inflammation and Related Variables in Individuals with Obesity: A Systematic Review

Obesity has become a worldwide concern because of its rapidly increasing prevalence, which affects not only individuals but also society. Recently, the gut microbiota has been reported as a new path to obesity treatment. Probiotics have become the most recognized method to improve the gut microbiota and treat dysbiosis. This study was conducted to review the effect of oral probiotics on body mass index and gut inflammation in individuals with obesity. Systematic literature research was conducted in PubMed, Scopus, and ScienceDirect databases up to June 23, 2023, to identify eligible articles. The “Advanced Search” option and “All fields” were selected for the following search terms: “obese” AND “probiotic” AND “gut inflammation”. The research from the databases resulted in 136 literature sources, from which only 3 literature sources were included in this review. From the included literature, it was found that the supplementation of oral probiotics in adults, adolescents, and children had no significant effect on the BMI level. The gut inflammation biomarkers also showed a lack of significant change after probiotic consumption compared to the placebo group. Further studies are needed to review the effectiveness of the strain used in the probiotic, the difference in the exact dosage, the duration of intervention, and the side effects of oral probiotic consumption for overweight and obesity.

The impact of environmental policy on renewable energy innovation: A systematic literature review and research directions

AbstractRenewable energy innovations are imperative to tackle the climate change crisis. However, there is a gap in the literature regarding the effectiveness of environmental policies in promoting renewable energy innovations. To bridge this gap, we have adopted a systematic literature review process covering the period from 2005 to 2023. We identified and analysed 29 articles in our final sample. Further, we employ two levels of analysis (individual‐policy and policy‐mix levels) for analysing the extant research. Our findings show that fiscal incentives and emissions trading policies such as the European Union (EU) Emissions Trading System (ETS) consistently promote renewable energy innovations. In contrast, the effectiveness of feed‐in tariffs and quotas in supporting renewable energy innovations varies, reflecting diverse impacts across distinct regions and renewable energy technologies. Our analysis also suggests that combinations of various policy types can enhance innovation more effectively than individual policies. We contribute to the extant literature by developing a classificatory analysis of the effect of environmental policies on renewable energy innovations. Our review also provides research directions for future scholarship.

The Virtual Teaching in Statistics Course in Higher Education: A Bibliometric Analysis and Systematic Literature Research

The research presents a bibliometric review aimed at understanding the most effective educational practices for teaching statistics in a virtual setting. It identifies the primary scopes, achievements, and challenges associated with this recent approach. To achieve this, the study explores articles published in journals indexed in databases like Scopus and Web of Science between 2017 and 2023. These articles offer recommendations based on evidence-backed pedagogical practices. Out of the scrutinized articles, 50 studies aligning with inclusion criteria were analyzed. These studies were subjected to a bibliometric approach and systematic literature research supported by the R bibliometrix software. This software was utilized to identify various research trends. Based on the study results, the analysis grouped teaching methods that exhibit greater efficacy in the virtual learning of the statistics.

Digital Technologies for Food Loss and Waste Prevention and Reduction in Agri-Food Supply Chains: A Systematic Literature Review and Research Agenda

Digital Technologies for Food Loss and Waste Prevention and Reduction in Agri-Food Supply Chains: A Systematic Literature Review and Research Agenda

Tren dan hasil penggunaan model pembelajaran pendidikan jasmani (systematic literatur review)

The purpose of systematic literature research is to review scientific literature regarding research trends and results of using physical education learning models. This research uses the Harzing's Publish or Perish application by establishing a Google Scholar database with a time span of the last 10 years, used to select articles that contain information about the use of physical education learning models. The journal search used the systematic literature review method. The prism flow diagram was used to identify articles through the filtering and data extraction process. Of the 487 articles downloaded, the remaining 88 final articles went through the inclusion and exclusion screening process using criteria and were analyzed. The results of the review article are in accordance with the systematic review analysis of the literature. The trend review is the cooperative learning learning model, proven by the analysis of the number of articles per year. The results of using the physical education learning model in primary and secondary schools provide a positive influence on students. The use of innovative and relevant physical education learning models can increase student participation, learning outcomes, health and physical condition, motivation, and student involvement in the learning process.