This study focuses on the vulnerability evolution mechanism of regional economic-ecological systems and its adaptive leapfrogging path under the background of climate change. Based on the theory of complex adaptive systems and the framework of social-ecological system coupling, a regional economic-ecological system vulnerability assessment index system was constructed. Using the system dynamics model and scenario simulation method, the impact transmission mechanism of climate change on regional economic-ecological systems was analyzed, and the spatiotemporal evolution law of system vulnerability was revealed. The study found that climate change has aggravated the vulnerability of regional economic-ecological systems by changing resource endowments, disturbing industrial structure, and affecting ecological service functions. In response to this problem, this study proposed a leapfrogging path based on adaptive management: including building a climate-resilient industrial system, optimizing resource allocation efficiency, enhancing ecosystem service functions, and improving regional adaptive governance mechanisms. The research results have important theoretical value and practical significance for promoting regional sustainable development and ecological civilization construction.