Transport System Research Articles

Development of a 3D printed perfusable in vitro blood-brain barrier model for use as a scalable screening tool.

Despite recent technological advances in drug discovery, the success rate for neurotherapeutics remains alarmingly low compared to treatments for other areas of the body. One of the biggest challenges for delivering therapeutics to the central nervous system (CNS) is the presence of the blood-brain barrier (BBB). In vitro blood-brain barrier models with high predictability are essential to aid in designing parameters for new therapeutics, assess their ability to cross the BBB, and investigate therapeutic strategies that can be employed to enhance transport. Here, we demonstrate the development of a 3D printable hydrogel blood-brain barrier model that mimics the cellular composition and structure of the blood-brain barrier with human brain endothelial cells lining the surface, pericytes in direct contact with the endothelial cells on the abluminal side of the endothelium, and astrocytes in the surrounding printed bulk matrix. We introduce a simple, static printed hemi-cylinder model to determine design parameters such as media selection, co-culture ratios, and cell incorporation timing in a resource-conservative and high-throughput manner. Presence of cellular adhesion junction, VE-Cadherin, efflux transporters, P-glycoprotein (P-gp) and Breast cancer resistance protein (BCRP), and receptor-mediated transporters, Transferrin receptor (TfR) and low-density lipoprotein receptor-related protein 1 (LRP1) were confirmed via immunostaining demonstrating the ability of this model for screening in therapeutic strategies that rely on these transport systems. Design parameters determined in the hemi-cylinder model were translated to a more complex, perfusable vessel model to demonstrate its utility for determining barrier function and assessing permeability to model therapeutic compounds. This 3D-printed blood-brain barrier model represents one of the first uses of projection stereolithography to fabricate a perfusable blood-brain barrier model, enabling the patterning of complex vessel geometries and precise arrangement of cell populations. This model demonstrates potential as a new platform to investigate the delivery of neurotherapeutic compounds and drug delivery strategies through the blood-brain barrier, providing a useful in vitro screening tool in central nervous system drug discovery and development.

Visualizing flow dynamics and restart of Carbopol gel solutions in tube and parallel-plates geometries with wall slip.

The present study examines the impact of slip in Carbopol solutions during the restart flow in pipelines utilizing in situ visualization techniques. Rheological tests were conducted using smooth and hatched parallel plate geometries to obtain the rheological characteristics of the solutions. The behavior of the solutions in the creep tests is compared with those in the experimental unit. Three flow regimes were identified through rheological and experimental setup tests: non-flow, slip, and yielded. The slip regime allowed the establishment of a slip static yield stress value, indicating significant deformation states, and a restart pressure decrease of about 61% when compared to the static yield stress. The flow dynamics under the wall slip effect is captured by velocity profiles, velocity contour maps and velocity gradient. Transient correlations of the scaling law type were determined, with wall slip in proportion to the velocity gradient and wall shear stress. Additionally, the concentration of viscoplastic material in the solution increased the scaling law index. This research seeks to provide valuable findings by quantifying the effects of apparent wall slip through in situ measurements. Such insights are crucial for designing and managing pipeline transport systems that handle yield stress fluids, applicable across various industries including cosmetics, food processing, and the production of waxy oils.

The role of transport systems in housing insecurity: a mobility-based analysis

With trends of urbanisation on the rise, providing adequate housing to individuals remains a complex issue to be addressed. Often, the slow output of relevant housing policies, coupled with quickly increasing housing costs, leaves individuals with the burden of finding housing that is affordable and in a safe location. In this paper, we unveil how transit service to employment hubs, not just housing policies, can prevent individuals from improving their housing conditions. We approach this question in three steps, applying the workflow to 20 cities in the United States of America. First, we propose a comprehensive framework to quantify housing insecurity and assign a housing demographic to each neighbourhood. Second, we use transit-pedestrian networks and public transit timetables (GTFS feeds) to estimate the time it takes to travel between two neighbourhoods using public transportation. Third, we apply geospatial autocorrelation to identify employment hotspots for each housing demographic. Finally, we use stochastic modelling to highlight how commuting to areas associated with better housing conditions results in transit commute times of over an hour in 15 cities. Ultimately, we consider the compounded burdens that come with housing insecurity, by having poor transit access to employment areas. In doing so, we highlight the importance of understanding how negative outcomes of housing insecurity coincide with various urban mechanisms, particularly emphasising the role that public transportation plays in locking vulnerable demographics into a cycle of poverty.

INDIA AND THE CENTRAL ASIAN FACTOR OF EURASIA’S ENERGY AND TRANSPORT SECTOR RESTRUCTURING

The article analyzes the prerequisites and main directions of India’s possible actions to expand its influence in the Central Asian region. The author assesses the importance of transport and energy projects in Central Eurasia for India, as one of the key consumers of energy resources from Russia and Central Asian states. Another spotlight of this research is the strategy for expansion of Indian-Uzbek cooperation as the most promising support base for the implementation of India’s geopolitical and geo-economic interests in the region.The ongoing and deepening global geoeconomic and geopolitical transformations are creating a wide field of opportunities for restructuring of the continental energy and transport systems. In these conditions, the Indian leadership is required to take active steps in implementing its foreign policy so as not to remain on the sidelines of large-scale projects for the development of key areas of the continent, including the resource and transit potential of Russia and Central Asia.

The new layout and regulation of the ‘pulsating’ power conversion system of EU DEMO WCLL for an effective and safe control of pulse-dwell transitions and increase in plant efficiency

EUROFUSION DEMO is a Fusion Power Plant concept under assessment, based on Tokamak technology. Regarding the Balance of Plant definition, particular effort has been posed to the design of the Power Conversion System (PCS), thermally coupled to the Primary Heat Transport System. Several architectures of the PCS have been assessed, and the present work is focused on the PCS, based on the Rankine Cycle technology and equipped with a Small Energy Storage System (ESS) operated with Molten Salt. A new Energy Map has been released in 2021, revealing uncertainties on the thermal power deposited on the different in-Vacuum Vessel components (i.e. Breeding Blanket, Divertor, Limiters and Vacuum Vessel) and rejected to the coolant of related cooling circuits. This fact leads to several (12) possible operating scenarios. The following treatment will be analyzed the 2022 PCS Small ESS concept design review, performed by the industry with the main aim to align the new layout with the updated thermal inputs and its comparison with the preliminary design developed in 2018. Design novelties will be highlighted, especially those that dealt with improving the cycle control, robustness, safety of the operation and efficiency. The outcomes of the transient analysis will be shown and compared, to verify the mechanical and thermal stress during the DEMO period (pulse/dwell). Finally, a performance and efficiency analysis of the 2022 PCS layout is also presented and compared to 2018 configuration.

MODELLING DEVELOPMENT OF A RECEIVER-REACTOR OF TYPE R2Mx FOR THERMOCHEMICAL WATER SPLITTING

Abstract This work reports on the development of a transient heat transfer model for a prototype reactor of type R2Mx for thermochemical water splitting by temperature and pressure swing of ceria. Key aspects of the R2Mx concept, which are also incorporated in the prototype design, include a movable monolithic redox structure combined with a linear transport system, a reduction reactor as well as a dedicated oxidation reactor. With the model, the operation of the prototype is simulated for consecutive water splitting cycles, in which ceria is reduced in a continuously heated reactor, oxidized in a separate oxidation reactor and transported in between the reaction zones. A 2D axisymmetric numerical model of the prototype reactor was developed in ANSYS Mechanical. The model includes heat transfer calculations in combination with an approximated simulation of the transport of the redox material during cyclic operation. It incorporates the chemical reaction by means of a modified heat capacity for ceria and accounts for internal radiation heat transfer inside the porous redox material by applying effective heat transfer properties. A parametric analysis has been undertaken to evaluate different modes of operation of the oxidation reactor. Model results are used to size the power demand of the reduction reactor and vacuum pump, to define durations of the process steps as well as to assess operational parameters with respect to achieved temperatures. Findings suggest that suitable operation of the prototype reactor involves reduction durations ranging from 8 to 10 minutes and oxidations of 6 to 10 minutes.

Long-Term Performance of Natural Stone Cobbles for Paving Raised Junctions: Findings from over a Decade of Use

Raised junctions (RJs) are chosen more and more frequently by town planners and road designers in traffic calming (TC) projects. This choice is supported by analyses of the existing transport systems in question. Where a few raised junctions have been designed for the project, use of different paving options may be worth consideration. This article describes a situation where a few RJs were placed on a short street section, all of which were provided with a cobblestone or cobblestone pavement (SBP). In order to verify the commercial viability of this option, we examined the traffic conditions, assessed the severity of condition of the pavements under analysis, and estimated the vehicle accelerations (ACs) and decelerations (DEs) in two chosen study areas, further referred to as the first and second study area. Two noise surveys were also carried out for the purposes of this research: the first one after a few years of operation and the second one after another ten years. Considering the problems of sustainable road construction, many environmental factors were taken into account in the studies. Based on the experimental results, we could assess the effectiveness of using RJs as the only TC measure in 30 km/h zones and check whether the severity of pavement condition depended on the AC and DE values and if SBP can be recommended to mitigate environmental impacts of street traffic. Finally, two pavement structures are proposed to choose from, depending on the local transport system conditions and streetscape characteristics. In addition, the authors recommend the use of solar-power elements at RJs to enhance their visibility and increase the traffic slowing effect.

Transcriptome analysis of the degradation process of organic nitrogen by two heterotrophic nitrifying and aerobic denitrifying bacteria.

The heterotrophic nitrification aerobic denitrification bacteria (HNDS) can perform nitrification and denitrification at the same time. Two HNDS strains, Achromobacter sp. HNDS-1 and Enterobacter sp. HNDS-6 which exhibited an amazing ability to solution nitrogen (N) removal have been successfully isolated from paddy soil in our lab. When peptone or ammonium sulfate as sole N source, no significant difference in gene expression related to nitrification and denitrification of the strains was found according to the transcriptome analysis. The expression of phosphomethylpyrimidine synthase (thiC), ABC transporter substrate-binding protein, branched-chain amino acid ABC transporter substrate-binding protein, and RNA polymerase (rpoE) in HNDS-1 were significantly upregulated when used peptone as N source, while the expression of exopolysaccharide production protein (yjbE), RNA polymerase (rpoC), glutamate synthase (gltD) and ABC-type branched-chain amino acid transport systems in HNDS-6 were significantly upregulated. This indicated that these two strains are capable of using organic N and converting it into NH4+-N, then utilizing NH4+-N to synthesize amino acids and proteins for their own growth, and strain HNDS-6 can also remove NH4+-N through nitrification and denitrification.

Transforming E-Commerce Logistics: Sustainable Practices through Autonomous Maritime and Last-Mile Transportation Solutions

The logistics landscape in e-commerce is undergoing a profound transformation toward sustainability and autonomy. This paper explores the implementation of autonomous maritime and last-mile transportation solutions to optimize the entire logistics chain from factory to customer. Building on the lessons learned from the maritime industry’s digital transformation, the study identifies key features and proposes a forward-looking autonomous maritime and last-mile transportation system. Emphasizing the role of geospatial technologies, the proposed system employs GIS-based electronic route optimization for efficient goods delivery, integrating onboard and ashore GIS-based sensors for enhanced location precision. A case study was built to analyze the implementation of autonomous means of transport along the route of a product from factory to customer. The integration of autonomous systems shows substantial improvements in logistics performance. Synchromodal logistics and smart steaming techniques can be utilized to optimize transportation routes, resulting in reduced fuel consumption and emissions. The findings reveal that autonomous maritime and last-mile transport systems can significantly enhance the efficiency, flexibility and sustainability of e-commerce logistics. The study emphasizes the need for advanced technological integration and provides a comprehensive framework for future research and practical applications in the logistics industry.

Z-YOLOv8s-based approach for road object recognition in complex traffic scenarios

Object detection in road scenarios is crucial for intelligent transport systems and autonomous driving, but complex traffic conditions pose significant challenges. This paper introduces Z-You Only Look Once version 8 small (Z-YOLOv8s), designed to improve both accuracy and real-time efficiency under real-world uncertainties. By incorporating Revisiting Perspective Vision Transformer (RepViT) and C2f into the YOLOv8s framework, and integrating the Large Selective Kernel Network (LSKNet), the model enhances spatial feature extraction. Additionally, the YOLOv8s backbone is optimized with Space-to-Depth Convolution (SPD-Conv) for better small object detection. The Softpool-Spatial Pyramid Pooling Fast (SoftPool-SPPF) module ensures precise characteristic information preservation. Z-YOLOv8s improves mean average precision (mAP)@0.5 on the Berkeley Deep Drive 100 K (BDD100K) and Karlsruhe Institute of Technology and Toyota Technological Institute (KITTI) datasets by 7.3 % and 3.8 %, respectively. It also achieves accuracy increases of 5.7 % and 6.5 % in Average Precision (AP)-Small, and a real-time detection speed of 78.41 frames per second (FPS) on the BDD100K. Z-YOLOv8s balances detection precision and processing speed more effectively than other detectors, as demonstrated by experimental results and comparisons.

Формування умов ефективного функціонування транспортної системи автотранспортного підприємства

Road transport enterprises must constantly pay attention to increasing the efficiency of the production of quality transport services, in accordance with the requirements and expectations of consumers. During the production and provision of transport services, the flow of production processes in the transport system, problems often arise in the external and internal environment of the enterprise, which require a mandatory solution. The most common problems include the following: non-compliance of technical means with the requirements and expectations of service consumers in terms of the quality of passenger service, ensuring the necessary conditions for cargo transportation; significant negative impact of the transport process on the natural environment; not fully ensuring the safety of passenger transportation and ensuring the safety of traffic on the roads; imperfection of the system, methods, mechanism of planning and monitoring of transportation processes; imperfection of regulatory and legal regulation and control of the technical condition of vehicles in the organization of transportation; the level of driver training is not always sufficient. When conducting research on the organization of transport processes and ensuring traffic safety on roads, the enterprise must use a methodical approach to evaluate the process of production of transport services, the functioning of the enterprise's production process, which must include three main stages: development of indicators and mechanisms for evaluating the flow of processes; assessment of the efficiency of the transportation process; analysis of assessment results and development of measures to improve service production processes. The main tasks of improving the processes of service production are the formation of the transport system of the enterprise, which includes: transport flows, personnel and technical support of transport, road environment in the transport zone. The transport system and all its constituent parts must be provided with means of monitoring and mechanisms of influence and improvement of the processes of production of transport services. The process of improving the functioning of the enterprise's transport system should be conducted in three important directions: monitoring the transport process, studying and analysing the service market and taking into account the requirements and expectations of consumers, using calculation methods to determine negative impacts on the process and developing measures and mechanisms to prevent them.

Методологічний підхід до розв’язання проблеми надійності функціонування автомобільних транспортних систем

An analysis of methods and techniques for solving the problem of increasing and ensuring the appropriate level of reliability of technical systems was carried out, which made it possible, based on the use of analogies, to find out the directions for ensuring the reliability of automobile transport systems. The essence of the concept of the reliability of the functioning of automobile transport systems for the transportation of goods and passengers from a methodological point of view is clarified. The insufficiency of regulatory and legal documentation for the development of methods and techniques for assessing the reliability of transport systems is substantiated. The synthesis of the concepts of "management" and "reliability" of the functioning of transport systems in comparison with similar concepts of technical systems is considered. The expert method and methodology of expert assessment of the reasons for failures of the production subsystem of the motor vehicle enterprise and its services are considered. It was found that factor analysis in combination with expert assessment makes it possible to assess the significance of the reasons for failure of transport systems and their frequency. In accordance with the classification of failures of technical systems, an analysis of their belonging to automobile transport systems was carried out. The classification of failures of technical systems according to different sets of features is analyzed. It was established that the classification of failures of automobile transport systems is based on the use of analogy with the classification of failures of technical systems, as well as on the results of the analysis of the factors of the causes of failures that occur in the production system of the carrier's enterprise. It was revealed that the selection of significant factors affecting the failure of automobile transport systems is based on the method of expert evaluations, their ranking by importance was carried out, and their relative frequencies were calculated. The results of the factor analysis of the reasons for the failure of the production subsystem of the motor vehicle enterprise are given. It is assumed that by analogy with technical automobile transport systems, they are also subject to decomposition by stages of the life cycle. Therefore, a sudden failure of automobile transport systems is characterized by a sudden change in the values of one or more initial parameters agreed with the customer, and a gradual one occurs as a result of a slow, gradual deterioration of the functioning characteristics of the subsystem or the system as a whole or a participant in the transportation of goods and passengers.

Дослідження процесу перевезення пасажирів з моделюванням роботи зупинок громадського транспорту

Public transport is characterized by its accessibility and sharing and is intended for a wide range of people, regardless of social status or income. The main function is to provide the ability to move people from one place to another within the city. Bus stops are a strategic place to ensure territorial accessibility from central to peripheral neighborhoods. They maintain order and organization in the operation of public transport. It is the study of the network of public transport routes and stops that is crucial for improving the quality of service, increasing the efficiency of transport systems and ensuring convenience for users. However, in each case, it is necessary to use an individual approach to organizational and planning decisions. The article describes the peculiarities of the functioning of public transport in the city of Dubno, Rivne region, in the context of research on infrastructure, route network, passenger flow, location and modeling of stops, taking into account the future development of new neighborhoods. It was found that the route network in Dubno includes 22 public transport routes with 64 stops. On average, 19544 passengers use public transport and get off at bus stops every day - 54% of all city residents. The rapid development of the city requires the arrangement of new public transport stops with changing routes, the operation of which in the overall transportation system was investigated by simulation modeling. The results obtained will make it possible to develop schedules and routes for public transport and to perform technical and economic calculations for the modern arrangement of stops. The research reported in this article was conducted at the National University of Water and Environmental Engineering with the support of the Department of Economics and Property of the Dubno City Council.

Identification of a multi-modal mechanism for Se(VI) reduction and Se(0) allotropic transition by Stenotrophomonas bentonitica.

Microorganisms can play a key role in selenium (Se) bioremediation and the fabrication of Se-based nanomaterials by reducing toxic forms (Se(VI) and Se(IV)) into Se(0). In recent years, omics have become a useful tool in understanding the metabolic pathways involved in the reduction process. This paper aims to elucidate the specific molecular mechanisms involved in Se(VI) reduction by the bacterium Stenotrophomonas bentonitica. Both cytoplasmic and membrane fractions were able to reduce Se(VI) to Se(0) nanoparticles (NPs) with different morphologies (nanospheres and nanorods) and allotropes (amorphous, monoclinic, and trigonal). Proteomic analyses indicated an adaptive response against Se(VI) through the alteration of several metabolic pathways including those related to energy acquisition, synthesis of proteins and nucleic acids, and transport systems. Whilst the thioredoxin system and the Painter reactions were identified to play a crucial role in Se reduction, flagellin may also be involved in the allotropic transformation of Se. These findings suggest a multi-modal reduction mechanism is involved, providing new insights for developing novel strategies in bioremediation and nanoparticle synthesis for the recovery of critical materials within the concept of circular economy.

Удосконалення методу оцінки програмного забезпечення контролю параметрів транспортних засобів

The purpose of the conducted research is to improve the method of evaluating the performance of the vehicle parameter control software. It is stated that a new technique for road transport in the field of monitoring its working condition is the creation of information systems for organizational and functional support of rolling stock operation processes with the help of information integration, namely the stages of the life cycle of rolling stock and systems for its technical control and diagnostics. It is shown that nowadays in road transport the basis of life cycle information support can be CALS or IPV/CALS/PLM - technologies (continuous support of the life cycle of vehicles), which are sometimes called product information support systems and are a part of intelligent transport systems. The analysis and clarification of the structure of the intelligent vehicle monitoring system was carried out on the example of the assessment of its environmental safety and its engine parameters. In the work, it is also planned to obtain experimental data from vehicle, the results of processing of which will allow to prove the existence of a real possibility of using the diagnostic complex on a modern automatic transmission system. It should be noted that the system for monitoring environmental safety indicators of vehicle, which is proposed by the authors, also contains in its composition the subsystem of intelligent processing of primary information, which can be used precisely in the role of "intelligent monitoring system". The data obtained and analyzed in the work indicate the need to also improve the efficiency of the neutralization of harmful substances in the engine warm-up mode, which can be implemented by reducing the engine warm-up time and more effective control of the injection/ignition process in transient modes, as well as by introducing an improvement algorithm of the control subsystem composition of the mixture precisely with feedback. The main diagnostic parameters of the vehicle engine during the start-up and warm-up processes, which affect the composition of harmful substances in the exhaust gases, were obtained experimentally. The proposed scheme for monitoring pollution of the roadside environment by traffic flows in the city.

Identifying and hierarchizing factors that affect the choice of transport routes in land ferry transport chains

Motives: The choice of a transport route has long been the subject of research because it is regarded as one of the most crucial decisions in transport organizations. However, there is a lack of studies addressing this issue in the context of land-ferry supply chains, where two transport modes have to be integrated. Therefore, analyses of multimodal transport should involve a holistic approach to account not only for seaborne transport, but also for the land leg before and after the ferry trip. This knowledge gap should be urgently addressed due to the importance of land-ferry supply chains in the transport system. Aim: The aim of this study was to identify and hierarchize factors that determine the choice of a multimodal transport route combining ferry and road transport. Results: The factors that determine the choice of ferry routes were identified and hierarchized according to their importance as primary, supplementary, and additional routes. The study demonstrated that the cost and time of transport are the main determinants in the decision-making process, with time being marginally more important than cost.

Using open-source tools to project bulk and critical material demand and assess implications for low-carbon energy and transport systems: Introducing Mat-dp model tools

Material demand is growing rapidly, increasing pressure on natural resources and greenhouse gas emissions. Accurate material demand projections require reliable estimates of material intensities- material amount required to produce a unit of output. However, there is a lack of comprehensive, up-to-date, and open-source material intensities. Studies that have estimated material demand usually focus on technology or location subsets, without reusable calculations and visualisations. To address these gaps, two open-source tools are introduced as part of the Material Demand Projections (Mat-dp) model: Mat-dp database, a comprehensive and open-source database of material intensities of energy and transport technologies; and Mat-dp pipeline, a tool to standardise, calculate and visualise results for given scenarios. The paper showcases the application of the tools and demonstrates material demand and supply considerations in planned and ongoing low-carbon transitions. The tools are, as far as the authors are aware, novel in their technology coverage and usable scenario sources.

Improving Community Wellbeing through transport policy: a literature review and theoretical framework, based on the Capability Approach

ABSTRACT Transport policies affect the quality of life and social wellbeing of citizens and communities; incorporating such impacts in policy and decision making, however, remains a challenge. This paper aims to: (1) present a systematic literature review that links transport policy to Community Wellbeing using the Capability Approach by Sen and Nussbaum, and (2) using that basis, establish a theoretical framework to systematically address Community Wellbeing impacts of municipal transport policies. This can improve qualitative assessments of policy interventions on multiple dimensions, such as safety, health, the (built) environment and accessibility, and inequalities within those dimensions. Using existing literature on the Capability Approach, Community Wellbeing dimensions can indeed successfully be integrated in transport policies. Additional tools and theories, such as the Theory of Change, are needed to structure relations between the sociotechnical transport system and the policy process. For analyses and assessment of policy interventions, additions from the affordances theory, potential accessibility, activity spaces, and sufficientarianism are needed to finalise the framework. Further development and testing of the framework is recommended. The most prominent research gaps are processes to set thresholds for sufficient accessibility, as well as potential limits to mobility behaviours through collective capabilities.

Breast Cancer Resistance Protein: Structure, Localization, Functions, Significance for Rational Pharmacotherapy

INTRODUCTION: Currently, investigation of efflux transport systems of an organism is an important scientific and practical task permitting to more deeply investigate the pharmacokinetics of medical drugs and to optimize pharmacotherapy of a number of diseases. The super family of ABC transporters plays a significant role in transport of biobiotics, the processes of absorption, distribution and excretion of medical drugs from an organism, in realization of undesired drug-drug interactions and development of pharmacoresistance. An important representative of this super family is breast cancer resistance protein (BCRP). AIM: Systematization of the data on BCRP structure, localization, functions, substrates and modulators of its activity. This literature review presents modern data on the molecular and spatial structure of BCRP, its localization in the cell, in organs and tissues. The data from studies of the functions of BCRP in an organism, of its role in the development of undesired drug-drug interactions at different stages of pharmacokinetics are summarized. An up-to-date list of medicinal drugs that are substrates and inhibitors of BCRP is given. Modern approaches to testing medical drugs for belonging to BCRP substrates or modulators of its activity are disclosed. CONCLUSION: The significance of BCRP consists in the existence of a wide range of drugs that are its substrates or modulators of its activity. Upon that, of increasing significance is the investigation both of new and long-known medicinal substances for their belonging to substrates, inducers or inhibitors of breast cancer resistance protein, in order to increase the effectiveness of pharmacotherapy and reduce the risk of undesired drug interactions. Search for non-drug substrates and modulators of BCRP activity permits to obtain new markers for conducting effective studies of safe pharmacokinetics both in vitro and in vivo.

Improving Community Wellbeing through transport policy: a literature review and theoretical framework, based on the Capability Approach

ABSTRACT Transport policies affect the quality of life and social wellbeing of citizens and communities; incorporating such impacts in policy and decision making, however, remains a challenge. This paper aims to: (1) present a systematic literature review that links transport policy to Community Wellbeing using the Capability Approach by Sen and Nussbaum, and (2) using that basis, establish a theoretical framework to systematically address Community Wellbeing impacts of municipal transport policies. This can improve qualitative assessments of policy interventions on multiple dimensions, such as safety, health, the (built) environment and accessibility, and inequalities within those dimensions. Using existing literature on the Capability Approach, Community Wellbeing dimensions can indeed successfully be integrated in transport policies. Additional tools and theories, such as the Theory of Change, are needed to structure relations between the sociotechnical transport system and the policy process. For analyses and assessment of policy interventions, additions from the affordances theory, potential accessibility, activity spaces, and sufficientarianism are needed to finalise the framework. Further development and testing of the framework is recommended. The most prominent research gaps are processes to set thresholds for sufficient accessibility, as well as potential limits to mobility behaviours through collective capabilities.