Safeguards System Research Articles

Synergistic Effects of Deterrence by Denial and Safeguards in the Biological Weapons Convention: Building on the History of International Nuclear Safeguards

ABSTRACT The notion of deterrence by denial has been introduced in relation to biosecurity. The goal of deterrence by denial in biosecurity extends beyond dissuading attacks. It also encompasses the protection of citizens in the event of an attack. In this vein, it may be considered as including the elements of deterrence and safeguards in terms of the protection of complying states from the hazards of violations and evasions. In presenting a historical overview of nuclear safeguards and shedding light on the limitations of the safeguard system of the International Atomic Energy Agency, this paper delineates the distinction between safeguards and verification for deterrence. Subsequently, it examines the case of the Biological Weapons Convention in which verification is considered a crucial factor for deterrence and investigates the potential for deterrence by denial to serve as an alternative to verification in effective safeguards. It argues that the adoption of deterrence by denial in biosecurity could exert synergistic effects by rectifying the shortcomings of the verification system within the Biological Weapons Convention and providing effective safeguards without the need for coercive measures.

Relations Developing in Arbitration Proceedings and the Subject of Civil Procedure Law

The paper examines the question of whether relations developing in arbitration proceedings are included in the subject of civil procedure law. The author describes the positions of researchers and the arguments justifying them. In the paper, the author derives a criterion for the unification of public relations under the subject of civil procedure law. As such a criterion the paper defines an objective social need or interest in the legal regulation of certain public relations in a unified system of procedural safeguards (in a civil procedural form), taking into account the nature of these relations and ensuring to the maximum extent the real protection of the rights and legally protected interests of persons. It is concluded that the legal regulation of public relations developing with the arbitral tribunal is designed to satisfy the need for a qualitatively different procedure for resolving civil cases as compared with the system of justice. These relations objectively are non-procedural in their nature and are not included in the subject matter of law of civil procedure. In confirmation, the fact is given that in arbitration proceedings there is a rejection regarding procedural guarantees that are fundamental for civil procedure law.

A chimeric antigen receptor-based cellular safeguard mechanism for selective in vivo depletion of engineered T cells.

Adoptive immunotherapy based on chimeric antigen receptor (CAR)-engineered T cells has exhibited impressive clinical efficacy in treating B-cell malignancies. However, the potency of CAR-T cells carriethe potential for significant on-target/off-tumor toxicities when target antigens are shared with healthy cells, necessitating the development of complementary safety measures. In this context, there is a need to selectively eliminate therapeutically administered CAR-T cells, especially to revert long-term CAR-T cell-related side effects. To address this, we have developed an effective cellular-based safety mechanism to specifically target and eliminate the transferred CAR-T cells. As proof-of-principle, we have designed a secondary CAR (anti-CAR CAR) capable of recognizing a short peptide sequence (Strep-tag II) incorporated into the hinge domain of an anti-CD19 CAR. In in vitro experiments, these anti-CAR CAR-T cells have demonstrated antigen-specific cytokine release and cytotoxicity when co-cultured with anti-CD19 CAR-T cells. Moreover, in both immunocompromised and immunocompetent mice, we observed the successful depletion of anti-CD19 CAR-T cells when administered concurrently with anti-CAR CAR-T cells. We have also demonstrated the efficacy of this safeguard mechanism in a clinically relevant animal model of B-cell aplasia induced by CD19 CAR treatment, where this side effect was reversed upon anti-CAR CAR-T cells infusion. Notably, efficient B-cell recovery occurred even in the absence of any pre-conditioning regimens prior anti-CAR CAR-T cells transfer, thus enhancing its practical applicability. In summary, we developed a robust cellular safeguard system for selective in vivo elimination of engineered T cells, offering a promising solution to address CAR-T cell-related on-target/off-tumor toxicities.

A robust yeast biocontainment system with two-layered regulation switch dependent on unnatural amino acid

Synthetic auxotrophy in which cell viability depends on the presence of an unnatural amino acid (unAA) provides a powerful strategy to restrict unwanted propagation of genetically modified organisms (GMOs) in open environments and potentially prevent industrial espionage. Here, we describe a generic approach for robust biocontainment of budding yeast dependent on unAA. By understanding escape mechanisms, we specifically optimize our strategies by introducing designed “immunity” to the generation of amber-suppressor tRNAs and developing the transcriptional- and translational-based biocontainment switch. We further develop a fitness-oriented screening method to easily obtain multiplex safeguard strains that exhibit robust growth and undetectable escape frequency (<~10−9) on solid media for 14 days. Finally, we show that employing our multiplex safeguard system could restrict the proliferation of strains of interest in a real fermentation scenario, highlighting the great potential of our yeast biocontainment strategy to protect the industrial proprietary strains.

Enhancement of Cruise Boat Resilience to Strong Convective Gusts with Global Model Cumulus Variable Prediction

Ship pilots and maritime safety administration have an urgent need for more accurate and earlier warnings for strong wind gusts. This study firstly investigated the “Oriental Star” cruise ship capsizing event in 2015, one of the deadliest shipwreck events in recent years, and explored all related hydro-meteorological components in a global mesoscale model. It was found that rather than the missing signal in raw surface-wind prediction, the cumulus precipitation variable (CP) increased dramatically during the accident occurrence, which significantly corresponds to a sub-grid strong wind gust. The effective lead time could be extended from 24 h (deterministic model) to 48 h (ensemble model). This finding was then verified in another two recent deadly cruise boat accidents. The introduction of the new variable aims to improve the current maritime safeguard system in predicting sub-grid strong wind gusts for small-sized cruise boats offshore and in inland rivers. Finally, an automatic response system was developed to provide economical convection prediction via INMARSAT email communication, aiming to explore operational severe convective gust early warning and appropriate numerical mesoscale model applications.

Fuel Supply Safeguard System

This project is an online application designed to streamline the pre-ordering of petrol, prioritizing speed and convenience. This platform incorporates advanced technology to display a map of available fuelling facilities, offering users a visual reference for nearby options. Additionally, the web application provides valuable information to aid travellers in their petrol orders. Every user request is meticulously recorded and maintained for future reference. This initiative marks a critical step toward enhancing the online experience for mobile users. Emergency Fuelling System simplifies the process of ordering petrol online, allowing customers to place orders, access additional services, and make payments from any location. Admins have the flexibility to add various petrol types, set availability, and even manage parking space reservations. The system also supports pricing adjustments based on booking duration and special promotions, offering a dynamic and user-friendly solution for both customers and administrators.

Why Didn’t Anyone Understand? Why Didn’t Anyone Ever Stand in the Way? Detecting Child Abuse in Out-of-Home care Setting: The Role of Safeguard and Protection Systems and Social Workers

Abstract The issue of institutional abuse (IA) in out-of-home care services is a difficult one, which we struggle to think about and which is slow to find attention and recognition: the victims are those children who, after experiencing maltreatment and abuse in the family, still suffer violence in the residential care services that should protect them. It represents the failure of the public system in protecting children, and it is often the result of institutions and professionals who allow, collude, cover, justify and minimise violence against children. Starting from a recent and paradigmatic Italian story and from the contribution of experience and thought of those who, as the first author, survived it, as well as from the analysis of the existing literature, this article examines the specific characteristics and dynamics of IA that motivate the extreme difficulty of its emergence. This article aims to improve professionals’ awareness concerning the phenomenon and their responsibilities in the prevention and early detection. For professionals and services to see institutional maltreatment implies questioning themselves, their own methodological tools and their own professional practices, as well as opening themselves to the concrete possibility of being able—at least—to make serious mistakes.

Brightness Based Password Safeguard System with Face Recognition in ATM

the importance of security in the authentication process as well as the increase in threat level posed by such malware has attracted many researchers to the field. Many attacks are successful in accessing social network accounts since the current password-based authentication paradigms are not efficient and robust enough as well as vulnerable to automated attacks. The traditional two-factor authentication mechanisms are not applicable to online social networks because physical token or biometric data cannot be easily used to log into users’ profiles. The simplest alternative is complementing the single factor (password-based) authentication process with additional identification elements, such as one-time PIN codes, generated by the user’s own device (e.g. the smart phone) or received via SMS. Proposed a brightness based authentication mechanism (i.e., Bright Pass) capable of enhancing the security of identity confirmation PIN codes without asking the user to memorize an additional secret value or to solve a complex cognitive task. This method introduces a new input value that is changed at every usage combining a something you know element (i.e., the PIN) with an interface element that cannot be captured by spyware, i.e., a bright or dark circle displayed on the phone screen to tell the user when to digit the correct PIN digit and when to digit a fake one. It prevents the malware from correctly inserting the PIN code, thereby disallowing the possibility to perform critical operations without the user’s agreement. Proposed work also focuses on implementing secure face recognition approach for user authentication. This approach will enhance the performance of ATM system

Implementation of Restorative Justice in Criminal Cases in Indonesia

Restorative justice has received attention in settlement of criminal cases in Indonesia. The settlement of cases in restorative justice has not been regulated in the Criminal Code and the Criminal Procedure Code. This concept is only regulated through regulations set by law enforcement agencies in the criminal justice system. The question of this research is how to implement restorative justice in solving cases in Indonesia? What is the model of restorative justice in the regulations and applied to customary law communities in Indonesia? This research is a doctrinal or normative legal research method. Restorative justice has been implemented in indigenous peoples in various parts of Indonesia, such as the Balinese indigenous peoples, the Bajawa indigenous peoples, Flores East Nusa Tenggara, the Lampung indigenous peoples and the Karo Batak indigenous peoples. The model of restorative justice that the Indonesian people have practiced is known as the Safeguard System. A model designed to handle case resolution through a restorative approach. Communities have various restoration programs as the primary means of dealing with various problems. The concept of restorative justice, applied in investigation, prosecution and court, adheres to a dual-track system model. This model is an alternative companion to the criminal justice system. The conflicting parties will be given the freedom to choose how to settle criminal cases. If the efforts through the restorative approach are successful, the settlement through the criminal justice system will be abolished.

Efficient Dynamic Phishing Safeguard System Using Neural Boost Phishing Protection

The instances of privacy and security have reached the point where they cannot be ignored. There has been a rise in data breaches and fraud, particularly in banks, healthcare, and government sectors. In today’s world, many organizations offer their security specialists bug report programs that help them find flaws in their applications. The breach of data on its own does not necessarily constitute a threat or attack. Cyber-attacks allow cyberpunks to gain access to machines and networks and steal financial data and esoteric information as a result of a data breach. In this context, this paper proposes an innovative approach to help users to avoid online subterfuge by implementing a Dynamic Phishing Safeguard System (DPSS) using neural boost phishing protection algorithm that focuses on phishing, fraud, and optimizes the problem of data breaches. Dynamic phishing safeguard utilizes 30 different features to predict whether or not a website is a phishing website. In addition, the neural boost phishing protection algorithm uses an Anti-Phishing Neural Algorithm (APNA) and an Anti-Phishing Boosting Algorithm (APBA) to generate output that is mapped to various other components, such as IP finder, geolocation, and location mapper, in order to pinpoint the location of vulnerable sites that the user can view, which makes the system more secure. The system also offers a website blocker, and a tracker auditor to give the user the authority to control the system. Based on the results, the anti-phishing neural algorithm achieved an accuracy level of 97.10%, while the anti-phishing boosting algorithm yielded 97.82%. According to the evaluation results, dynamic phishing safeguard systems tend to perform better than other models in terms of uniform resource locator detection and security.

ABACC to the future

At the end of the Cold War, two South American rivals built a system of nuclear safeguards that culminated in the 1991 founding of a bilateral organization, ABACC. Can that nonproliferation regime be exported?

COVID-19 and the Mental Capacity Act in care homes: Perspectives from capacity professionals.

This study explores the experiences of professionals who worked with care home residents with impaired mental capacity in England and Wales during the COVID‐19 pandemic. It explores (i) how competing risks were balanced and (ii) how the Mental Capacity Act (MCA) functioned in care homes under pandemic conditions, with particular focus on its associated Deprivations of Liberty Safeguards (DoLS) and Independent Mental Capacity Advocacy (IMCA) systems. Between March and May 2021, we held an online survey and five focus groups aimed at professionals who worked in or with care homes during the pandemic. The study explored issues pertaining to residents with impaired mental capacity, alongside several other topics on which we report elsewhere. For this paper, we filtered data to only include responses from ‘capacity professionals’. The resulting sample comprised 120 (out of 266) survey participants and 18 (out of 22) focus group participants. We performed manifest content analysis on the filtered data and found that (1) participants reported a ‘massive discrepancy’ between the ways different care homes balanced the risk of COVID‐19 infection with the risks associated with severe restrictions. (2) Some suggested this was due to vague guidance, as well as care home type and size. Participants told us the pandemic (3) obstructed smooth operation of statutory safeguards designed to protect residents’ human rights and (4) resulted in confusion about the remit of the MCA during a public health crisis. Our findings raise concerns about the impact of pandemic‐related measures upon care home residents with impaired mental capacity. We urge further exploration and analysis of (a) the variability and inconsistency of restrictions applied at care homes, (b) the strain placed on key safeguards associated with the MCA, (c) uncertainty about the remit of the MCA during a public health crisis and (d) the human rights implications hereof.

Key factors influencing the effectiveness of hospital quality management tools: using the quality control circle as an example–a cross-sectional study

ObjectiveTo identify the key factors influencing the effectiveness of hospital quality management tools and analyse the mechanisms needed for long-term scientific hospital management.MethodsIn this cross-sectional study, a large number of...

Контрольная деятельность МАГАТЭ

The article explores the verification activity by the International Atomic Energy Agency (IAEA). This activity involves three key aspects: the legal framework, goals, and measures and verification procedures to achieve these goals. The author analyzes legal and technical aspects of the IAEA verification activity, including the notions of diversion of nuclear material and a state’s noncompliance with its commitments related to corresponding safeguards agreements. The analysis is based on the systematic approach that takes into account the evolution of the safeguards system. The author proposes an original approach to reduce the risks of politicization of decisions on noncompliance of states with safeguards agreements by specifying the main notions related to the system of safeguards.

The Customer as a Subject of Protection on the Financial Market in European Union

The crisis begun in 2007 exposed the weakness of the existing regulations, revealing challenges for legislators all over the world. Financial stability started to be understood as an essential value for the proper operation of the financial market. It has become important to address the question as to how to protect financial markets from more crises, or at least alleviate their effects. The idea of supervision of a financial market has undergone thorough transformation. Particular emphasis has been placed on protecting buyers of financial services. Adequate customer protection has been recognized as a sign of trust in the market and its stability and has gained systemic importance and relevance for the European financial system. There is a growing tendency to enlarge the group of subjects eligible for special protection. it is becoming an increasingly common idea that not only consumers but all non-professional customers should be protected. The idea is becoming widespread that the weaker party to a legal transaction can be not only a consumer [natural person] but also a non-professional market entity. Such a solution is certainly appropriate. Narrowing down the ‘consumer’ to a natural person may seem artificial and out of line with market realities, not to mention the serious consequences of bad financial decisions taken by non- professional financial market participants. Another important challenge facing the modern financial market is to establish a system of institutional safeguards to ensure security for all market entities and to enforce fair play rules. However, even the best provisions of substantive law, though necessary, may prove to fall short. Therefore, there is a pressing need for strong and competent both state and international institutions duly equipped with auditing and supervisory powers to deal with the present situation. They should also have the possibility of enforcing substantive laws in a way that allows for flexible responses to any emerging threat to the protected values. The shift towards a regulatory and supervisory method of protection sets a more serious tone for the supervision model adopted for the financial market. In it, the market is responsible not only for ensuring that the supervised entities operate correctly, but also for the quality of services that they provide.

RNA-binding protein dysfunction in neurodegeneration.

Protein homeostasis (proteostasis) is a prerequisite for cellular viability and plasticity. In particular, post-mitotic cells such as neurons rely on a tightly regulated safeguard system that allows for regulated protein expression. Previous investigations have identified RNA-binding proteins (RBPs) as crucial regulators of protein expression in nerve cells. However, during neurodegeneration, their ability to control the proteome is progressively disrupted. In this review, we examine the malfunction of key RBPs such as TAR DNA-binding protein 43 (TDP-43), Fused in Sarcoma (FUS), Staufen, Pumilio and fragile-X mental retardation protein (FMRP). Therefore, we focus on two key aspects of RBP dysfunctions in neurodegeneration: protein aggregation and dysregulation of their target RNAs. Moreover, we discuss how the chaperone system responds to changes in the RBP-controlled transcriptome. Based on recent findings, we propose a two-hit model in which both, harmful RBP deposits and target mRNA mistranslation contribute to neurodegeneration observed in RBPathologies.

Polarization, diversity, and democratic robustness

In the Madisonian Constitution, fragmented and overlapping institutions of authority are supposed to manage democracy’s innate rivalry, channeling competition to serve the public interest. This system of safeguards makes democracy more robust: capable of withstanding and, if need be, adapting to challenges posed by a changing problem environment. In this essay, I suggest why affective polarization poses a special threat to democratic robustness. While most scholars hypothesize that polarization’s dangers are that it leads to bimodality and extremism, I highlight a third hypothesized effect: Polarization reduces interest and information diversity in the political system. To be effective, democracy’s safeguards rely upon interest diversity, but Madison took that diversity for granted. Unique among democracy’s safeguards, federalism builds in a repository for diversity; its structure enables differences between national- and state-expressed interests, even within the same party. This diversity can be democracy hindering, as the United States’ history with racially discriminatory politics painfully makes clear, but it can also serve as a reservoir of interest and information dispersion that could protect democracy by restoring the possibility that cross-cutting cleavages emerge.

MUF Calculation of Indonesian 10-MWt RDE Experimental HTGR Using Combined Uncertainty Approach

A safeguards assessment for the 10-MWt RDE Experimental HTGR needs to be established in order to fulfill the requirements needed to construct it. Methods and instruments used for the RDE’s nuclear material accounting and safeguards system are reviewed in this paper. Material unaccounted for (MUF) is calculated using the uncertainty of each method and instrument. The effectiveness of the safeguards system is examined by comparing the resulting MUF with the number of SQ ( = significant quantity, i.e. the approximate amount of nuclear material for which the possibility of manufacturing of a nuclear explosive device cannot be excluded). The total uncertainty from each KMP showed a number less than 10%. The number of MUF in each KMP according to total uncertainty showed a number below 1 kg of U-235 in one inventory period (~12 months). According to the number of MUF counted, it is impossible to reach 1 SQ if the diversion done is only by taking the advantage of MUF in the measurement. The result of total uncertainty and MUF calculation showed that the safeguards system and the material measurement designed for RDE is amendable. The sets of instruments and measurements designed will give a comprehensive data of each nuclear material in the RDE. The low number of MUF in comparison with the SQ showed that the RDE has a high proliferation resistance.

Raspberry Pi House Safeguard System with Alarm and Email Alert

This paper is helpful in providing not only safeguard to the house but also alerts the owner through email. This system quickly alerts the presence of an unknown person using Raspberry Pi. This system deploys a Pi camera which takes the picture of the unknown person and includes the image in the email. This system has various areas such as our House s, offices or anywhere, wherever safeguard is necessary, picture captured by using the webcam will send to user email by using SMTP protocol, Email notifications can be sent out to your customers using either Gmail SMTP server or your own SMTP server

Exploring patient perspectives on telemedicine monitoring within the operating room

BackgroundClinical decision support systems and telemedicine for remote monitoring can together support clinicians' intraoperative decision-making and management of surgical patients' care. However, there has been limited investigation on patient perspectives about advanced health information technology use in intraoperative settings, especially an electronic OR (eOR) for remote monitoring and management of surgical patients. PurposeOur study objectives were: (1) to identify participant-rated items contributing to patient attitudes, beliefs, and level of comfort with eOR monitoring; and (2) to highlight barriers and facilitators to eOR use. MethodsWe surveyed 324 individuals representing surgical patients across the United States using Amazon Mechanical Turk, an online platform supporting internet-based work. The structured survey questions examined the level of agreement and comfort with eOR for remote patient monitoring. We calculated descriptive statistics for demographic variables and performed a Wilcoxon matched-pairs signed-rank test to assess whether participants were more comfortable with familiar clinicians from local hospitals or health systems monitoring their health and safety status during surgery than clinicians from hospitals or health systems in other regions or countries. We also analyzed open-ended survey responses using a thematic approach informed by an eight-dimensional socio-technical model. ResultsParticipants’ average age was 34.07 (SD = 10.11). Most were white (80.9%), male (57.1%), and had a high school degree or more (88.3%). Participants reported a higher level of comfort with clinicians they knew monitoring their health and safety than clinicians they did not know, even within the same healthcare system (z = -4.012, p < .001). They reported significantly higher comfort levels with clinicians within the same hospital or health system in the United States than those in a different country (z = -10.230, p < .001). Facilitators and barriers to eOR remote monitoring were prevalent across four socio-technical dimensions: 1) organizational policies, procedures, environment, and culture; 2) people; 3) workflow and communication; and 4) hardware and software. Facilitators to eOR use included perceptions of improved patient safety through a safeguard system and perceptions of streamlined care. Barriers included fears of incorrect eOR patient assessments, decision-making conflicts between care teams, and technological malfunctions. ConclusionsParticipants expressed significant support for intraoperative telemedicine use and greater comfort with local telemedicine systems instead of long-distance telemedicine systems. Reservations centered on organizational policies, procedures, environment, culture; people; workflow and communication; and hardware and software. To improve the buy-in and acceptability of remote monitoring by an eOR team, we offer a few evidence-based guidelines applicable to telemedicine use within the context of OR workflow. Guidelines include backup plans for technical challenges, rigid care, and privacy standards, and patient education to increase understanding of telemedicine’s potential to improve patient care.