Purpose: Systematic pavement management plays a vital role in the better Road Asset Management system. The lifespan of pavement can be preserved and prolonged by adequate maintenance measures in proper time. By early detection and repair of defects at initial stages with predictive maintenance reduces the rapid deterioration of the pavement. Moreover, inaccuracy in pavement deterioration prediction leads to an improper maintenance with wastage of time, cost and labor strength. To overcome all of these obstacles, this paper attempts an approach on optimal pavement maintenance strategy by means of fuzzy rule-based system. Materials and Methods: In this research, four pavement indicators of PCI, IRI, PSR and PSI have been taken into account as antecedents and five different types of pavement maintenance as consequents. In this research, ASTM D-6433, Road Lab Pro software, AASHTO guidelines and Fuzzy Logic (Mamdani) model have been used to evaluate the current pavement condition and optimal pavement maintenance strategies. Findings: According to research area, 130 total pavement sample units were undertaken to study for the mean pavement condition of PCI value 54.93 (poor), IRI 7.01 (fair), PSR 3.33 (fair) and PSI 3.35 (fair). Due to 13 years-old life span of traffic volume, temperature and other external factors, this expressway is suffering from potholes, bleeding, longitudinal and transverse cracking, weathering, joint reflection cracking for Asphalt Concrete (AC) overlay and linear cracking, joint seal failure, scaling, faulting, depression, lane/shoulder drop off for existing concrete pavement. According to the fuzzy logic model results, 42 numbers of fuzzy If-Then maintenance rules were verified as the most relevant pavement maintenance and rehabilitation strategies for Yangon-Mandalay Expressway. Implications to Theory, Practice and Policy: This research provide implications to the study and contributions to theory, practice and policy. This research paper insights into effective infrastructure maintenance and investment, emphasizing the role of advanced computational techniques in transportation economics. The key advantage of this research paper is to be effective, supportive, easy and accessible decision-making tool for transportation and pavement engineers, expressway planners and highways department authorities especially from developing countries.