Diagnosis Of Systemic Diseases Research Articles

Advancing EEG prediction with deep learning and uncertainty estimation

Deep Learning (DL) has the potential to enhance patient outcomes in healthcare by implementing proficient systems for disease detection and diagnosis. However, the complexity and lack of interpretability impede their widespread adoption in critical high-stakes predictions in healthcare. Incorporating uncertainty estimations in DL systems can increase trustworthiness, providing valuable insights into the model’s confidence and improving the explanation of predictions. Additionally, introducing explainability measures, recognized and embraced by healthcare experts, can help address this challenge. In this study, we investigate DL models’ ability to predict sex directly from electroencephalography (EEG) data. While sex prediction have limited direct clinical application, its binary nature makes it a valuable benchmark for optimizing deep learning techniques in EEG data analysis. Furthermore, we explore the use of DL ensembles to improve performance over single models and as an approach to increase interpretability and performance through uncertainty estimation. Lastly, we use a data-driven approach to evaluate the relationship between frequency bands and sex prediction, offering insights into their relative importance. InceptionNetwork, a single DL model, achieved 90.7% accuracy and an AUC of 0.947, and the best-performing ensemble, combining variations of InceptionNetwork and EEGNet, achieved 91.1% accuracy in predicting sex from EEG data using five-fold cross-validation. Uncertainty estimation through deep ensembles led to increased prediction performance, and the models were able to classify sex in all frequency bands, indicating sex-specific features across all bands.

ADVANCED PREDICTIVE MODELING FOR THE BIOFIRE FILMARRAY SYSTEM IN INFECTIOUS DISEASE DIAGNOSTICS

The Bio Fire Film Array System has emerged as a powerful tool in clinical diagnostics, offering rapid and multiplexed detection of infectious pathogens. This study presents the development of a comprehensive mathematical model aimed at predicting the accuracy and sensitivity of the BioFire FilmArray System under diverse conditions. Key factors such as sample type, pathogen load, specimen characteristics, and environmental variables were systematically analyzed to elucidate their impact on the system's performance. The model incorporates a range of parameters including sample volume, specimen complexity, microbial diversity, and system-specific variables to generate probabilistic estimates of diagnostic outcomes. By leveraging large datasets encompassing diverse clinical scenarios and pathogen profiles, the model achieves robustness and generalizability, thereby facilitating its applicability across different healthcare settings and populations. Validation of the model against independent datasets demonstrates its efficacy in accurately predicting the performance of the BioFire FilmArray System across a spectrum of conditions. Overall, this mathematical model represents a significant advancement in optimizing the utility of the BioFire FilmArray System for infectious disease diagnosis. Its integration into clinical practice holds promise for improving patient care, guiding sample processing protocols, and informing decision-making processes in infectious disease management.

Multi-label dental disorder diagnosis based on MobileNetV2 and swin transformer using bagging ensemble classifier

Dental disorders are common worldwide, causing pain or infections and limiting mouth opening, so dental conditions impact productivity, work capability, and quality of life. Manual detection and classification of oral diseases is time-consuming and requires dentists’ evaluation and examination. The dental disease detection and classification system based on machine learning and deep learning will aid in early dental disease diagnosis. Hence, this paper proposes a new diagnosis system for dental diseases using X-ray imaging. The framework includes a robust pre-processing phase that uses image normalization and adaptive histogram equalization to improve image quality and reduce variation. A dual-stream approach is used for feature extraction, utilizing the advantages of Swin Transformer for capturing long-range dependencies and global context and MobileNetV2 for effective local feature extraction. A thorough representation of dental anomalies is produced by fusing the extracted features. To obtain reliable and broadly applicable classification results, a bagging ensemble classifier is utilized in the end. We evaluate our model on a benchmark dental radiography dataset. The experimental results and comparisons show the superiority of the proposed system with 95.7% for precision, 95.4% for sensitivity, 95.7% for specificity, 95.5% for Dice similarity coefficient, and 95.6% for accuracy. The results demonstrate the effectiveness of our hybrid model integrating MoileNetv2 and Swin Transformer architectures, outperforming state-of-the-art techniques in classifying dental diseases using dental panoramic X-ray imaging. This framework presents a promising method for robustly and accurately diagnosing dental diseases automatically, which may help dentists plan treatments and identify dental diseases early on.

SoftLungX: leveraging transfer learning with convolutional neural networks for accurate respiratory disease classification in chest X-ray images

Medical imaging is an indispensable and very important step in the diagnosis and treatment of illnesses. However, due to large amounts of resources necessary for training the model, training from scratch may not invariably emerge as the optimal recourse. Transfer learning has emerged as a viable solution, where pretrained weights from ImageNet are initially utilized and fine-tuninned afterwards. This paper presents a novel approach employing transfer learning to classify both respiratory diseases and radiological findings from chest X-rays. The dataset comprises 191 660 X-ray images gathered from public databases and 752 chest X-ray images obtained from a retrospective study at the University Clinical Center of Kragujevac, forming the foundation of Big data analysis. It includes various conditions such as atelectasis, cardiomegaly, infiltration, pleural thickening, non-viral pneumonia, pneumothorax, COVID-19 viral pneumonia, tuberculosis, etc. as well as masses and nodules indicative of tumors and images of healthy subjects. Although there are existing solutions with some diseases, this is the first paper that inlcludes differentiation between healthy and diseased cases, as well as in case of present disease, as much as 18 different classes are inlcuded in the analysis, which has not been done so far. The proposed methodology included transfer learning with DenseNet121 as the backbone and CheXNeXt weights as initialisation scheme, upon which additional layers were added for fine tuning. The results demonstrate the model’s capacity to distinguish between healthy and diseased, with an average area under curve (AUC) of 0.99. The AUC ranges from 0.86 for nodules to 0.99 for pneumonia and 0.99 for COVID-19. Our method outperforms the state-of-the-art in accuracy across all 18 classes, with the exception of classes consolidation, mass, and nodule. These findings are promising for a tested clinical site, though further validation in clinical environment accros multiple sites may be necessary before using the model as a standalone decision system, rather than a decision support system for disease diagnosis based on chest X-rays.

Mango leaf disease diagnosis using Total Variation Filter Based Variational Mode Decomposition

Mango leaf diseases significantly threaten mango cultivation, impacting both yield and quality. Accurate and early diagnosis is essential for effectively managing and controlling these diseases. This study introduces a novel approach for diagnosing mango leaf diseases, leveraging Total Variation Filter-based Variational Mode Decomposition. The proposed method enhances the extraction of disease-specific features from leaf images by decomposing them into intrinsic mode functions while simultaneously reducing noise and preserving important edge information. Experimental results demonstrate that the proposed method effectively isolates relevant patterns associated with various mango leaf diseases, improving diagnostic accuracy compared to traditional methods. Deep learning models, DenseNet121 and VGG-19, are used for feature extraction from sub-band images, and extracted features are concatenated and fed to Random Forest for classification. Utilizing tenfold cross-validation, our model demonstrated enhanced classification accuracy (98.85 %), specificity (99.37 %), and sensitivity (98.0 %) in detecting diseases from Mango leaf images. Feature maps and Gradient-weighted Class Activation Mapping analysis was conducted to visualize and scrutinize the essential regions crucial for accurate predictions. Statistical analysis indicates that our proposed architecture outperforms pre-trained models and existing mango leaf disease detection methods. This diagnostic approach can be a rapid disease detection tool for imaging specialists utilizing leaf images. The robustness and efficiency of the presented work in handling complex and noisy image data make it a promising tool for automated agricultural disease diagnosis systems, facilitating timely and precise interventions in mango orchards.

Penerapan Metode Cased Based Reasoning dalam Mendiagnosa Penyakit TB Paru Berbasis Web

Collaboration of computer science disciplines with other disciplines has been widely carried out, for example, medical science. Expert systems for disease diagnosis are one of the many computer programs used by doctors to assist them in their work and provide good results. Researchers in the field of artificial intelligence are working to improve existing systems to cover their shortcomings. Expert systems are used in many applications for disease diagnosis. Expert systems have been used in various industries and have had a significant impact. An innovative method for diagnosing diseases is the application of case-based reasoning systems, compared to expert systems. The solution to diagnosing and treating diseases can be found in the expert system for diagnosing pulmonary tuberculosis. Because this web-based system is based on a web application, all pulmonary tuberculosis patients can access it. A rule-based system that applies the CBR method can identify various types of diseases through the use of weighting techniques and offer treatment recommendations.

Explainable AI for Transparent and Trustworthy Tuberculosis Diagnosis: From Mere Pixels to Actionable Insights

Building transparent and trustworthy AI-powered systems for disease diagnosis has become more paramount than ever due to a lack of understanding of black box models. A lack of transparency and explainability in AI-driven models can propagate biases and erode patients' and medical practitioners' trust. To answer this challenge, Explainable AI (XAI) is drastically emerging as a practical solution and approach to tackling ethical concerns in the health sector. The overarching purpose of this paper is to highlight the advancement in XAI for tuberculosis diagnosis (TB) and identify the benefits and challenges associated with improved trust in AI-powered TB diagnosis. We explore the potential of XAI in improving TB diagnosis. We attempt to provide a complete plan to promote XAI. We examine the significant problems associated with using XAI in TB diagnosis. We argue that XAI is critical for reliable TB diagnosis by improving the interpretability of AI decision-making processes and recognising possible biases and mistakes. We evaluate techniques and methods for XAI in TB diagnosis and examine the ethical and societal ramifications. By leveraging explainable AI, we can create a more reliable and trustworthy TB diagnostic framework, ultimately improving patient outcomes and global health. Finally, we provide thorough recommendations for developing and implementing XAI in TB diagnosis using X-ray imaging

RFMiD: Retinal Image Analysis for multi-Disease Detection challenge

In the last decades, many publicly available large fundus image datasets have been collected for diabetic retinopathy, glaucoma, and age-related macular degeneration, and a few other frequent pathologies. These publicly available datasets were used to develop a computer-aided disease diagnosis system by training deep learning models to detect these frequent pathologies. One challenge limiting the adoption of a such system by the ophthalmologist is, computer-aided disease diagnosis system ignores sight-threatening rare pathologies such as central retinal artery occlusion or anterior ischemic optic neuropathy and others that ophthalmologists currently detect. Aiming to advance the state-of-the-art in automatic ocular disease classification of frequent diseases along with the rare pathologies, a grand challenge on “Retinal Image Analysis for multi-Disease Detection” was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI - 2021). This paper, reports the challenge organization, dataset, top-performing participants solutions, evaluation measures, and results based on a new “Retinal Fundus Multi-disease Image Dataset” (RFMiD). There were two principal sub-challenges: disease screening (i.e. presence versus absence of pathology — a binary classification problem) and disease/pathology classification (a 28-class multi-label classification problem). It received a positive response from the scientific community with 74 submissions by individuals/teams that effectively entered in this challenge. The top-performing methodologies utilized a blend of data-preprocessing, data augmentation, pre-trained model, and model ensembling. This multi-disease (frequent and rare pathologies) detection will enable the development of generalizable models for screening the retina, unlike the previous efforts that focused on the detection of specific diseases.

A review of deep learning methods for gastrointestinal diseases classification applied in computer-aided diagnosis system.

Recent advancements in deep learning have significantly improved the intelligent classification of gastrointestinal (GI) diseases, particularly in aiding clinical diagnosis. This paper seeks to review a computer-aided diagnosis (CAD) system for GI diseases, aligning with the actual clinical diagnostic process. It offers a comprehensive survey of deep learning (DL) techniques tailored for classifying GI diseases, addressing challenges inherent in complex scenes, clinical constraints, and technical obstacles encountered in GI imaging. Firstly, the esophagus, stomach, small intestine, and large intestine were located to determine the organs where the lesions were located. Secondly, location detection and classification of a single disease are performed on the premise that the organ's location corresponding to the image is known. Finally, comprehensive classification for multiple diseases is carried out. The results of single and multi-classification are compared to achieve more accurate classification outcomes, and a more effective computer-aided diagnosis system for gastrointestinal diseases was further constructed.

A clinical expert system for Noma disease diagnosis

A clinical expert system for Noma disease diagnosis

EAR DISEASE CLASIFICATION USING DEEP LEARNING WITH XCEPTION AND MOBILENET-V2 ARCHITECTURE

Hearing loss is a significant global health problem, with a high prevalence in Indonesia. Limited access to ENT specialists, especially in remote areas, causes delays in diagnosis and treatment of ear diseases. This research aims to develop an early diagnosis system for ear diseases using deep learning. The proposed method applies Xception and MobileNet-V2 Convolutional Neural Network (CNN) architecture with hyperparameter optimization using Bayesian Optimizer. The dataset consists of 1,101 images covering 20 types of ear diseases, collected using an endoscope ear cleaning kit at Mataram University Hospital. The dataset was divided into 60% training data, 20% validation data, and 20% test data. Xception recorded the best performance with accuracy, precision, recall, and f1-score of 0.911, 0.166, 0.166, and 0.151, respectively. The best model performance was obtained on MobileNet-V2 with the application of Bayesian Optimizer, resulting in the best hyperparameters at Unit Dense 174, Dropout Rate 0.2, and LXceptionearning Rate 0.003. This scenario resulted in an increase in accuracy, precision, recall, and f1-score compared to the scenario without hyperparameter search of 0.004, 0.010, 0.018, and 0.012, respectively. This research demonstrates the potential of deep learning in improving early diagnosis of ear diseases.

A multi-modal Parkinson’s disease diagnosis system from EEG signals and online handwritten tasks using grey wolf optimization based deep learning model

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the gradual deterioration of motor function, affecting speech, writing, muscle control, and mobility. The existing studies have not utilized both the electroencephalography (EEG) signals and online handwritten tasks together to diagnose PD. The studies have also not explored the EEG signals collected from specific brain regions like the substansia niagra (SN) and ventral tegmental area (VTA), crucial for dopamine production linked to PD. This article proposes a multi-modal PD diagnosis system from EEG signals (collected from SN and VTA regions of the brain), collected during performing online handwritten tasks, using grey wolf optimization (GWO) algorithm. Mel-frequency cepstral coefficients (MFCC) features have been generated from the EEG signals and optimized by the GWO algorithm. The classification (diagnosis) experiments on the optimal number of feature values, obtained from GWO algorithm, have been carried out using bidirectional long short-term memory (BLSTM) variant of recurrent neural network (RNN). The classification experiments have also been conducted using support vector machine (SVM), bagged random forest (BRF), and long short-term memory (LSTM) variant of RNN classifier to have a performance comparison with the proposed method. The effectiveness of the introduced PD diagnosis system has been analyzed on a self-generated dataset named EEG signal based on online handwriting (ESOH). A maximum classification accuracy of 99.30% has been achieved from the proposed PD diagnosis system. The experimental outcomes illustrate that the introduced PD diagnosis system outperforms the state-of-the-art PD diagnosis systems relying on the EEG signals for diagnosing the PD.

Development of a Web-based Tomato Plant Disease Detection and Diagnosis System using Transfer Learning Techniques

A significant obstacle to agricultural productivity that jeopardizes the availability of food is crop diseases and farmer livelihoods by reducing crop yields. Traditional visual assessment methods for disease diagnosis are effective but complex, often requiring expert observers. Recent advancements in deep learning indicate the potential for increasing accuracy and automating disease identification. Developing accessible diagnostic tools, such as web applications leveraging CNNs, can provide farmers with efficient and accurate disease identification, especially in regions with limited access to advanced diagnostic technologies. The main goal is to develop a productive system that can recognize tomato plant diseases. The model was trained on a collection of images of healthy and damaged tomato leaves from PlantVillage using transfer learning techniques. The images from the dataset were cleansed by resizing them from 256 × 256 to 224 × 224 to match the dimensions used in pre-trained models using min-max normalization. An evaluation of VGG16, VGG19, and DenseNet121 models based on performance accuracy and loss value for 7 categories of tomatoes guided the selection of the most effective model for practical application. VGG16 achieved 84.54% accuracy, VGG19 achieved 84.62%, and DenseNet121 achieved 98.28%, making DenseNet121 the chosen model due to its highest performance accuracy. The web application development based on the DenseNet121 architecture was integrated using the Django web framework, which is built on Python. This enables real-time disease diagnosis for uploaded images of tomato leaves. The proposed system allows early detection and diagnosis of tomato plant diseases, helping to mitigate crop losses. This supports sustainable farming practices and increases agricultural productivity.

Development of an Expert System for Diagnosing Musculoskeletal Disease

Musculoskeletal diseases (MSDs), encompasses various conditions affecting muscles, bones, tendons, ligaments, and joints, resulting to pain, inflammation, and limited mobility, significantly impacting individuals' quality of life. Diagnosing these diseases poses a challenge for healthcare professionals due to symptom similarities with other conditions. To address this, the development of expert systems tailored for musculoskeletal diagnosis has emerged as a promising approach to enhance clinical decision-making and improve patient outcomes. This study aims at developing and evaluating an expert system for musculoskeletal disease diagnosis, by leveraging a knowledge base containing information on common musculoskeletal diseases and symptoms. The system utilized a combination of rule-based and machine learning techniques to provide diagnostic recommendations to physicians. Comparative analysis with experienced physicians, using a dataset of patients with known musculoskeletal diseases, revealed the expert system’s diagnostic accuracy of 92%, recall of 98%, Precision of 91%, F1-Score of 94% and a quicker diagnosis compared to physicians. Additionally, the system demonstrated ease of use and user-friendliness. This project focuses on predictive algorithms, leveraging expert systems dating back to the 1970s, emulating human expert decision-making, particularly in disease diagnosis. The development of an expert system for musculoskeletal disease diagnosis symbolizes the convergence of medical expertise, computer science, and artificial intelligence. By integrating machine learning, natural language processing, and decision support systems, these expert systems have the potential to revolutionize musculoskeletal healthcare delivery. In conclusion, our results show that expert systems hold promise in transforming clinical practice and improving patient outcomes in musculoskeletal healthcare through interdisciplinary collaboration and continuous innovation.

Salivary Short-chain Fatty Acids (SCFAs) Are Viable Predictors of Early Changes in Systemic Health.

Short-chain fatty acids (SCFAs) are the metabolites identified in both the oral cavity and the gut. They play an important role in the triggering, development and progression of systemic diseases. SCFAs can alter the gut microbial components, intestinal epithelium and host immune system, and are also associated with cancer incidence. Salivary SCFAs, produced by the oral microbiome, are correlated with some oral diseases. The occurrence of systemic diseases associated with gut SCFAs is more clearly defined than oral SCFAs. Salivary SCFAs can enter the bloodstream directly via inflamed gingiva to cause continuous low-grade systemic inflammation. Hence, salivary SCFAs could be an indicator for the early diagnosis of systemic diseases. Furthermore, they provide a basis for understanding the oral-systemic axis driven through salivary SCFAs in the pathogenesis of several diseases.

Advances in Oral Exfoliative Cytology: From Cancer Diagnosis to Systemic Disease Detection.

Oral exfoliative cytology has emerged as a valuable tool in the early detection of oral cancer and other systemic diseases. This review comprehensively examines the current applications and recent advancements in oral exfoliative cytology techniques. We analyzed published literature from the past decade, focusing on methodological improvements, diagnostic accuracy, and emerging applications. Key findings include: (1) Enhanced cell collection and preparation methods have significantly improved sample quality and diagnostic reliability. (2) Integration of molecular markers and DNA analysis with traditional cytomorphological assessment has increased diagnostic sensitivity and specificity for oral cancer detection. (3) Novel applications in systemic disease detection, including diabetes and iron overload disorders, demonstrate the expanding utility of this technique. (4) Computer-assisted analysis and deep learning algorithms show promise in improving diagnostic accuracy and efficiency. Despite these advancements, challenges remain in standardization and widespread clinical implementation. This review provides a critical evaluation of oral exfoliative cytology's current status and future potential in oral and systemic disease diagnosis.

Nailfold capillaroscopy for diagnosis of onychodystrophies: A prospective cross-sectional study

Nail diseases are often associated with significant physical and psychosocial burden, but diagnosis is challenging due to non-specific clinical and histological findings. Nail fold capillaroscopy has been studied for diagnosis of systemic diseases, but studies on nail diseases are lacking. Our objectives were to characterize and compare capillary changes in a set of nail conditions vs. controls, between nail groups, and based on demographic/clinical criteria. This was a prospective cross-sectional study of patients with nail psoriasis, onychomycosis, idiopathic onycholysis, brittle nail syndrome, nail lichen planus, retronychia, other nail conditions, and no nail findings (controls) undergoing capillaroscopy imaging/analysis. Nail psoriasis vs. control patients demonstrated decreased capillary length/density and increased abnormal capillaries, with higher frequency in older, male patients. Onychomycosis was associated with increased meandering capillaries compared to controls, nail psoriasis, and nail lichen planus. Retronychia is associated with increased disorganized polymorphic capillaries compared to controls and onychomycosis. Limitations include small sample size for certain nail conditions and small numbers of nail psoriasis patient with psoriatic arthritis. Our findings highlight nailfold capillaroscopy as a potentially quick, cost-effective, and non-invasive imaging modality, as an adjunct for diagnosis and treatment initiation for patients with onychodystrophies.

Sound Classification for Non-Destructive Diagnosis of Basal Stem Rot Disease based on Stem Density in Oil Palm Trunks

Oil palm trees play a crucial role in the economies of Southeast Asian countries, providing palm oil that is essential for various products and consumption. However, the Basal Stem Rot (BSR) disease caused by the white-rot fungus Ganoderma spp. poses a significant challenge, leading to wilting and death of the trees. This study proposes a practical and accessible approach for the routine detection of Basal Stem Rot (BSR) disease in oil palm trees caused by Ganoderma spp. A prototype system for initial disease diagnosis is developed by utilizing the local wisdom technique of tapping and assessing knocking sounds based on stem density in oil palm trunks. Three algorithms, Convolutional Neural Network (CNN), Support Vector Machine Classifier (SVC), and Multi-Layer Perceptron (MLP) models are compared for accuracy in two sound recognition experiments. The first experiment involves a three-class classification model (healthy, boundary, and infected areas), while the second excludes the boundary area. Results demonstrate that the CNN model outperforms SVC and MLP, achieving the highest accuracy of 90.73% in the two-class scenario and 84.97% in the three-class scenario, along with superior precision, recall, and F1 score. The CNN model proves to be the most effective in accurately classifying the data in both scenarios compared to the other models. This prototype system offers promising implications for the early detection and proactive management of Ganoderma spp. disease, contributing to the preservation and sustainability of oil palm plantations in Southeast Asia.

A Hybrid Approach for Thyroid Disease and Classification Using Attribute Associations Rule Mining

In recent years, thyroid diseases have become increasingly prevalent worldwide. In India, for instance, one in eight women is affected by hypothyroidism, hyperthyroidism, or thyroid cancer. Research indicates that approximately 20% of Indians are diagnosed with endemic goiter. Several factors influence thyroid function, including stress, infection, trauma, toxins, low-calorie diet, and certain medications. Preventing such diseases is crucial as treatments often involve long-term medication or surgical intervention. Thyroid disease diagnosis is pivotal in medicine, where precise classification is essential for prompt treatment. This paper proposes a novel approach to thyroid disease classification by integrating Particle Swarm Optimization (PSO) and Ant Colony Optimization (ACO) with Association Rule Mining (ARM). The hybridization of PSO and ACO enhances exploration and exploitation capabilities, thereby improving the efficiency of association rule mining for feature selection. The proposed method aims to identify significant association rules among thyroid disease attributes, thereby facilitating accurate classification. Experimental evaluations conducted on benchmark thyroid disease datasets demonstrate the effectiveness of the proposed approach in terms of classification accuracy and computational efficiency. The results indicate that the hybrid PSO and ACO-based association rule mining approach surpasses traditional methods, underscoring its potential to enhance thyroid disease diagnosis systems.

Decision Support Systems for Disease Detection and Diagnosis

The last few years have been characterized by a large amount of research activity in the field of healthcare for both the improvement of diagnostic treatments and the development of simple, efficient, and multi-tasking applications [...]