Synthetic Hybrid Research Articles

Integration of plain woven carbon fiber yarn with 304 wire mesh reinforment on synthetic hybrid composite

This work focuses on a hybrid composite comprising a plain carbon fiber yarn weaved on a stainless steel wire mesh, bonded with epoxy resin (LY556) and hardener (HY951). The composite consists of a middle layer of wire mesh with carbon fiber yarns oriented at 90° and 45°, and incorporates carbon fiber mats into the top and bottom layers. The hand layup method was employed to stack these materials, and various mechanical tests were conducted to assess their properties. The composite with a 45° carbon fiber yarn plain-weaved on wire mesh had better mechanical performance than the 90° orientation. It had a maximum tensile stress of 83.63 MPa, which is 18.09 % higher than the 90° orientation. It also had 19.17 % higher flexural strength and 15.78 % higher toughness in impact tests. Additionally, field emission scanning electron microscope (FESEM) imaging and X-ray diffraction tests (XRD) were utilized to further analyze the composite’s structure and properties

An adaptive synthetic sampling and batch generation-oriented hybrid approach for addressing class imbalance problem in software defect prediction

An adaptive synthetic sampling and batch generation-oriented hybrid approach for addressing class imbalance problem in software defect prediction

Designing 1,2,3‐Triazole Derivatives for Targeted Inhibition of Proteolytic and Coagulant Activities in Bothrops Jararaca and Bothrops neuwiedi Snake Venoms

AbstractSnakebites inflict significant injuries on humans and animals, posing a severe global public health challenge due to high mortality and morbidity rates. This study presents results against the venoms of Bothrops jararaca and Bothrops neuwiedi using sixteen synthetic hybrid molecules containing thiophene and triazoles, designated as 6a–h and 7a–h. The compounds were assessed for their ability to inhibit proteolytic and plasma coagulant activities induced by the snake venoms, and their toxicity was analyzed. Most derivatives demonstrated nontoxicity through in silico analysis with the Osiris Property Explorer tool and in vitro cytotoxic hemocompatibility on red blood cells. Notably, only derivative 6e exhibited toxicity to erythrocytes, while 6b, 6d, 7c, and 7f displayed mutagenic, tumorigenic, or adverse effects on the reproductive system. Derivatives 6a, 6c–h, 7c–e, 7g, or 7h effectively inhibited the coagulating activity of B. jararaca venom, while 6a–b, 6d–e, 6h, or 7a–f inhibited coagulation induced by B. neuwiedi venom. All derivatives demonstrated inhibition of the proteolytic activity caused by B. jararaca venom, and derivatives 6a–d and 7e–f inhibited the activity of B. neuwiedi venom. Consequently, these derivatives exhibited varying degrees of efficacy in countering two crucial toxic effects of B. jararaca or B. neuwiedi venoms, suggesting their potential as antivenoms against both species.

In vitro Anticancer studies of new synthetic Hybrid Quinolines

In vitro Anticancer studies of new synthetic Hybrid Quinolines

Expanding the toolbox: Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens.

Interspecies interactions involving direct competition via bacteriocin production play a vital role in shaping ecological dynamics within microbial ecosystems. For instance, the ribosomally-produced siderophore bacteriocins, known as class IIb microcins, affect the colonization of host-associated pathogenic Enterobacteriaceae species. Notably, to date, only five of these antimicrobials have been identified, all derived from specific Escherichia coli and Klebsiella pneumoniae strains. We hypothesized that class IIb microcin production extends beyond these specific compounds and organisms. With a customized informatics-driven approach, screening bacterial genomes in public databases with BLAST and manual curation, we have discovered twelve previously unknown class IIb microcins in seven additional Enterobacteriaceae species, encompassing phytopathogens and environmental isolates. We introduce three novel clades of microcins (MccW, MccX, and MccZ), while also identifying eight new variants of the five known class IIb microcins. To validate their antimicrobial potential, we heterologously expressed these microcins in E. coli and demonstrated efficacy against a variety of bacterial isolates, including plant pathogens from the genera Brenneria, Gibbsiella, and Rahnella . Two newly discovered microcins exhibit activity against Gram-negative ESKAPE pathogens, i.e. Acinetobacter baumannii or Pseudomonas aeruginosa , providing the first evidence that class IIb microcins can target bacteria outside of the Enterobacteriaceae family. This study underscores that class IIb microcin genes are more prevalent in the microbial world than previously recognized and that synthetic hybrid microcins can be a viable tool to target clinically relevant drug-resistant pathogens. Our findings hold significant promise for the development of innovative engineered live biotherapeutic products tailored to combat these resilient bacteria.

Chiral Bioelectrocatalytic Oxidations Driven By Electrocatalytic Oxygen Reduction and Horseradish Peroxidase or Cytochrome P450

Biocatalysis, the use of enzymes for synthesis, has emerged as a powerful tool for synthesis of chiral molecules in pharmaceutical and fine chemical industries. Natural enzymes offer inherent stereoselectivity, making them attractive catalysts for this purpose. Peroxidases and cytochrome P450s enzymes utilize an iron-heme cofactor to perform a diverse array of chemical transformations including CH2 hydroxylation, epoxidations, and sulfur-oxidations. Here, we report chiral biocatalytic oxidations in microemulsion media driven by horseradish peroxidase (HRP) coupled with a synthetic Cu2+-polymer electrocatalyst to convert O2 to H2O2. This tandem system uses crosslinked layer-by-layer (LBL) films of polyelectrolytes with Cu2+- poly(2-hydroxy-3-dipicolylamino) propyl methacrylate (Py-PGMADPA) to drive O2 reduction. Peroxide in turn activates HRP crosslinked in LbL films on magnetic beads (MB) to biocatalytically oxidize styrene, ethylbenzene, and methyl phenylacetate to chiral products. R-stereoisomers of these reactants were selectively formed with a high enantiomeric excess of > 80%. Conductive microemulsion reaction media are used to provide solubility to the non-polar reactants and water to hydrate the enzymes to function. The enzyme films show high thermal stability and high chiral selectivity up to 90 °C. A second synthetic goal was to compare chiral products of reactions catalyzed by cyt P450’s natural catalytic pathway mimicked by electrocatalysis versus via electrochemical generation of H2O2. We immobilized baculosome-P450s in LBL films with polystyrene sulfonate for the natural catalytic pathway, and for peroxide activation crosslinked P450 LbL on magnetic beads. These synthetic hybrid approaches open new doors to designing biocatalytic syntheses using an electrochemical driving force. Keywords: Biocatalysis, organic syntheses, cytochrome P450, horseradish peroxidase, regioselective and stereoselective oxidation

Synthesis of new synthetic hybrid glasses using metallic nano-particles and rare-earth: Effect of plasmonic diluents

Borophosphate-based glass materials have the potential to revolutionize optical technology because of their outstanding optical properties, long-lasting nature, and cost-effectiveness. The present research addresses the intricate functions of rare earth and metallic nanoparticles (NPs) in borophosphate glass, which have significant potential for optical photonic and medical applications by incorporating Dy3+ ions and Cu NPs. We developed novel hybrid glasses through the melt-quenching technique, which includes the creation of functional groups and the establishment of bonds between P2O5 and B2O3, as confirmed by FTIR and Raman spectroscopy. UV–visible absorption spectra were used to identify the presence of Cu⁺ and Cu (Saeed et al., 2021) [2]⁺ ions and Cu nanoparticles, with the absorption peaks indicating their respective states. Furthermore, the underlying mechanisms of energy transfer in a glass matrix that is co-doped with dysprosium ions (Dy3+) have been studied. The experimental findings of this research not only provide valuable information about the physical properties of borophosphate glass but also emphasize the collaborative relationship between the rare-earth ion and copper nano-powders. The Tauc plot analysis demonstrated a correlation between the concentration of Cu and Dy dopants and a decrease in the energy band gap of the glass. This suggests that these dopants influence the electronic structure of the glass. This study opens up possibilities for creating innovative photonic materials with customized optical attributes.

Hybrid Cas12a Variants with Relaxed PAM Requirements Expand Genome Editing Compatibility.

Cas12a is a widely used programmable nuclease for genome editing across a variety of organisms, but its application is limited by its PAM recognition restriction. To alleviate these PAM constraints, protein engineering efforts have been applied to expand the PAM recognition range. In this study, we designed and constructed 990 synthetic hybrid Cas12a chimeras through domain shuffling and screened an efficient hybrid Cas12a (ehCas12a) that could recognize a broad range PAM of 5'-TYYN-3' (Y is T or C and N is A, T, C, or G). Furthermore, we constructed an ehCas12a variant, ehCas12a RRVR (T167R/N572R/K578V/N582R), with expanded PAM preference to 5'-TNYN, TWRV-3' (W is A or T, R is A or G, and V is A, C, or G), which can efficiently recognize -2* A/G PAMs that are barely recognized by Cas12a-type proteins and their mutants. Finally, we demonstrated that the DNase-inactivated ehCas12a RRVR base editor (dehCas12a RRVR-BE) was capable of targeting noncanonical PAMs in vivo and disease-related loci for potential therapeutic applications. Overall, our findings highlight the modular design and reconfiguration of Cas proteins for enhanced functionality.

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine.

3D bioprinting is recognized as the ultimate additive biomanufacturing technology in tissue engineering and regeneration, augmented with intelligent bioinks and bioprinters to construct tissues or organs, thereby eliminating the stipulation for artificial organs. For 3D bioprinting of soft tissues, such as kidneys, hearts, and other human body parts, formulations of bioink with enhanced bioinspired rheological and mechanical properties were essential. Nanomaterials-based hybrid bioinks have the potential to overcome the above-mentioned problem and require much attention among researchers. Natural and synthetic nanomaterials such as carbon nanotubes, graphene oxides, titanium oxides, nanosilicates, nanoclay, nanocellulose, etc. and their blended have been used in various 3D bioprinters as bioinks and benefitted enhanced bioprintability, biocompatibility, and biodegradability. A limited number of articles were published, and the above-mentioned requirement pushed us to write this review. We reviewed, explored, and discussed the nanomaterials and nanocomposite-based hybrid bioinks for the 3D bioprinting technology, 3D bioprinters properties, natural, synthetic, and nanomaterial-based hybrid bioinks, including applications with challenges, limitations, ethical considerations, potential solution for future perspective, and technological advancement of efficient and cost-effective 3D bioprinting methods in tissue regeneration and healthcare.

Investigation of the energy absorption behavior and damage mechanisms of aramid/carbon/jute fiber hybrid epoxy composites

AbstractToday, various fiber reinforcements are used in automotive, aerospace and defense industries. Many of these fibers are synthetic structures, which can cause problems such as environmental pollution and high manufacturing costs. Researchers have turned to the use of more environmental‐friendly and cost‐effective natural materials to minimize these problems. In this study energy absorption properties of the fiber laminate‐hybrid epoxy composites were investigated with dynamic loadings. Fiber type and hybridization effects were investigated under drop weight impact tests with 10, 20, 30 and 50 Joule impact energies. Besides, mechanical characteristics were examined via quasi‐static bending tests. In this context, double and triple fiber reinforced natural/synthetic and synthetic/synthetic hybrid composites were manufactured as sandwich type. Furthermore, it is also aimed an evaluation of using natural fibers in ballistic activities with this study. Fiber materials consist of woven type carbon, aramid and jute fibers. Hybrid composites were manufactured with the aim of providing mechanical optimization between the fibers and enabling the fiber layers to absorb more impact energy. In addition, performance evaluation was made by comparing natural/synthetic reinforced hybrid composites with full synthetic hybrid composites. The results show that significant improvements were achieved in bending and impact resistance of the composites by using jute fibers to the inner layers.Highlights Drop weight impact tests were carried out to determine the energy absorption behavior of the hybrid composites. Fiber type is effective in the mechanical behavior of the composite materials. Natural hybrid composites show well enough mechanical properties as well as low cost.

Confronting Tuberculosis: A Synthetic Quinoline-Isonicotinic Acid Hydrazide Hybrid Compound as a Potent Lead Molecule Against Mycobacterium tuberculosis.

The current tuberculosis (TB) treatment is challenged by a complex first-line treatment for drug-sensitive (DS) TB. Additionally, the prevalence of multidrug (MDR)- and extensively drug (XDR)-resistant TB necessitates the search for new drug prototypes. We synthesized and screened 30 hybrid compounds containing aminopyridine and 2-chloro-3-formyl quinoline to arrive at a compound with potent antimycobacterial activity, UH-NIP-16. Subsequently, antimycobacterial activity against DS and MDR Mycobacterium tuberculosis (M.tb) strains were performed. It demonstrated an MIC50 value of 1.86 ± 0.21 μM for laboratory pathogenic M.tb strain H37Rv and 3.045 ± 0.813 μM for a clinical M.tb strain CDC1551. UH-NIP-16 also decreased the MIC50 values of streptomycin, isoniazid, ethambutol, and bedaquiline to about 45, 55, 68, and 76%, respectively, when used in combination, potentiating their activities. The molecule was active against a clinical MDR M.tb strain. Cytotoxicity on PBMCs from healthy donors and on human cell lines was found to be negligible. Further, blind docking of UH-NIP-16 using Auto Dock Vina and MGL tools onto diverse M.tb proteins showed high binding affinities with multiple M.tb proteins, the top five targets being metabolically critical proteins CelA1, DevS, MmaA4, lysine acetyltransferase, and immunity factor for tuberculosis necrotizing toxin. These bindings were confirmed by fluorescence spectroscopy using a representative protein, MmaA4. Envisaging that a pathogen will have a lower probability of developing resistance to a hybrid molecule with multiple targets, we propose that UH-NIP-16 can be further developed as a lead molecule with the bacteriostatic potential against M.tb, both alone and in combination with first-line drugs.

Evolutionary Dynamics of Chromatin Structure and Duplicate Gene Expression in Diploid and Allopolyploid Cotton.

Polyploidy is a prominent mechanism of plant speciation and adaptation, yet the mechanistic understandings of duplicated gene regulation remain elusive. Chromatin structure dynamics are suggested to govern gene regulatory control. Here, we characterized genome-wide nucleosome organization and chromatin accessibility in allotetraploid cotton, Gossypium hirsutum (AADD, 2n = 4X = 52), relative to its two diploid parents (AA or DD genome) and their synthetic diploid hybrid (AD), using DNS-seq. The larger A-genome exhibited wider average nucleosome spacing in diploids, and this intergenomic difference diminished in the allopolyploid but not hybrid. Allopolyploidization also exhibited increased accessibility at promoters genome-wide and synchronized cis-regulatory motifs between subgenomes. A prominent cis-acting control was inferred for chromatin dynamics and demonstrated by transposable element removal from promoters. Linking accessibility to gene expression patterns, we found distinct regulatory effects for hybridization and later allopolyploid stages, including nuanced establishment of homoeolog expression bias and expression level dominance. Histone gene expression and nucleosome organization are coordinated through chromatin accessibility. Our study demonstrates the capability to track high-resolution chromatin structure dynamics and reveals their role in the evolution of cis-regulatory landscapes and duplicate gene expression in polyploids, illuminating regulatory ties to subgenomic asymmetry and dominance.

A synthetic resveratrol-curcumin hybrid derivative exhibits chemopreventive effects on colon pre-neoplastic lesions by targeting Wnt/β-catenin signaling, anti-inflammatory and antioxidant pathways.

The present study aimed to evaluate the chemopreventive effects of the hybrid against pre-neoplastic lesions induced in the colon of rodents. The doses were determined based on the reduction in DNA damage induced by doxorubicin [15 mg/kg body weight (b.w.)] in peripheral blood of Swiss mice. Doses of 8, 16, 32, and 64 mg/kg b.w. were antimutagenic. For the evaluation of pre-neoplastic lesions in the colon, Wistar rats were treated with PQM-162 at doses of 0.5, 1, and 2 mg/kg b.w. for 6 weeks using three approaches: simultaneous treatment, pre-treatment, and post-treatment. Pre-neoplastic lesions were induced with 1,2 dimethylhydrazine (160 mg/kg b.w.). PQM-162 reduced the formation of aberrant crypt foci in the simultaneous treatment and post-treatment. TNF-α and COX-2 mRNA levels decreased, while Nrf2 mRNA levels increased. PQM-162 also reduced the expression of COX-2, PCNA, and β-catenin protein markers and increased Nrf2 expression. Our findings suggest a chemopreventive potential of PQM-162 in colorectal carcinogenesis, which acts on anti-inflammatory, antioxidant, and cell proliferation pathways.

Error Propagation and Control in 2D and 3D Hybrid Seismic Wave Simulations for Box Tomography

ABSTRACT To enhance the local resolution of global waveform tomography models, particularly in areas of interest within the Earth’s deep structures, a higher resolution localized tomography approach (referred to as “box tomography”) is crucial for a more detailed understanding of the Earth’s internal structure and geodynamics. Because the small-scale features targeted by box tomography are finer than those in global reference models, distinct spatial meshes are necessary for global and local (hybrid) forward simulations. Within the spectral element method (SEM) framework, we employ the intrinsic Lagrangian spatial interpolation to compute and store hybrid inputs (displacement/potential) in the global numerical simulation. These hybrid inputs are subsequently imposed into the localized domain during the iterative box tomography. However, inaccurate spatial Lagrange interpolation can lead to imprecise hybrid inputs, and this error can propagate from the global simulation to the hybrid simulation. It is essential to quantitatively analyze this error propagation and control it to ensure the credibility of box tomography. We introduce a unique spatial window function into the conventional “direct discrete differentiation” hybrid method. When the local mesh and structure align with those in the global simulation, the synthetic hybrid waveforms match the global ones, serving as a reference for quantitatively assessing error propagation stemming from changes in the local spatial mesh during hybrid simulation. Significantly, the relative waveform error arising due to spatial Lagrange interpolation is around 5% when employing the traditional SEM with five Gauss–Lobatto–Legendre points per minimum wavelength in the 3D global simulation through SPECFEM3D_GLOBE. Ultimately, we achieve hybrid waveforms with an accuracy of about 1.5% by increasing the spectral elements by about 1.5 times in the standard global simulation.

Effect of filler surface treatment on the physico-mechanical properties of filler/styrene-butadiene rubber nanocomposites

In the present work, the effects of various filler types and content on the characteristics and properties of styrene-butadiene rubber (SBR) were studied. This study prepared SBR filled with different fillers: kaolin, metakaolinite, synthetic zeolite Na-A, alumina (Al2O3) nanoparticles, and hybrid filler (synthetic zeolite Na-A/Al2O3). The silane coupling agent 3-aminopropyltriethoxysilane (APTES) was employed to treat the surface with fillers. Scanning electron microscope (SEM) and X-ray diffraction (XRD) were used to determine the surface morphology. The results demonstrated that fillers improved the physicomechanical properties. Tensile strength and elongation at break (%) in composites containing synthetic zeolite Na-A increased by up to 158.6% at 3 phr and 100% at 2 phr, respectively. The results showed that the surface properties displayed by SEM analysis indicated a good distribution of filler particles. Also, the rubber compound’s resistance to organic solvents such as toluene was improved, as evidenced by swelling properties; the swelling ratio decreased by 17.5% while the crosslink density increased by 42.6% at 5 phr Al2O3/synthetic zeolite Na-A. The constants of the various hyperelastic models that explain the behavior of the composite materials under study were determined, and their predictions of the experimentally obtained stress-strain curves were compared. The study’s experimental findings will be helpful for several industrial uses, including an extender in water-based paints, rubber fillers, ceramic materials, paper fillers, and coating pigments.

Applications of Scaffolds in Tissue Engineering: Current Utilization and Future Prospective.

Current regenerative medicine tactics focus on regenerating tissue structures pathologically modified by cell transplantation in combination with supporting scaffolds and biomolecules. Natural and synthetic polymers, bioresorbable inorganic and hybrid materials, and tissue decellularized were deemed biomaterials scaffolding because of their improved structural, mechanical, and biological abilities.Various biomaterials, existing treatment methodologies and emerging technologies in the field of Three-dimensional (3D) and hydrogel processing, and the unique fabric concerns for tissue engineering. A scaffold that acts as a transient matrix for cell proliferation and extracellular matrix deposition, with subsequent expansion, is needed to restore or regenerate the tissue. Diverse technologies are combined to produce porous tissue regenerative and tailored release of bioactive substances in applications of tissue engineering. Tissue engineering scaffolds are crucial ingredients. This paper discusses an overview of the various scaffold kinds and their material features and applications. Tabulation of the manufacturing technologies for fabric engineering and equipment, encompassing the latest fundamental and standard procedures.

SAMP-VGG16: Force-field assisted image-based deep neural network prediction model for short antimicrobial peptides.

During the last three decades, antimicrobial peptides (AMPs) have emerged as a promising therapeutic alternative to antibiotics. The approaches for designing AMPs span from experimental trial-and-error methods to synthetic hybrid peptide libraries. To overcome the exceedingly expensive and time-consuming process of designing effective AMPs, many computational and machine-learning tools for AMP prediction have been recently developed. In general, to encode the peptide sequences, featurization relies on approaches based on (a) amino acid (AA) composition, (b) physicochemical properties, (c) sequence similarity, and (d) structural properties. In this work, we present an image-based deep neural network model to predict AMPs, where we are using feature encoding based on Drude polarizable force-field atom types, which can capture the peptide properties more efficiently compared to conventional feature vectors. The proposed prediction model identifies short AMPs (≤30 AA) with promising accuracy and efficiency and can be used as a next-generation screening method for predicting new AMPs. The source code is publicly available at the Figshare server sAMP-VGG16.

In situ bio-mineralized Mn nanoadjuvant enhances anti-influenza immunity of recombinant virus-like particle vaccines

Virus like particles (VLPs) have been well recognized as one of the most important vaccine platforms due to their structural similarity to natural viruses to induce effective humoral and cellular immune responses. Nevertheless, lack of viral nucleic acids in VLPs usually leads the vaccine candidates less efficient in provoking innate immune against viral infection. Here, we constructed a biomimetic dual antigen hybrid influenza nanovaccines THM-HA@Mn with robust immunogenicity via in situ synthesizing a stimulator of interferon genes (STING) agonist Mn3O4 inside the cavity of a recombinant Hepatitis B core antigen VLP (HBc VLP) having fused SpyTag and influenza M2e antigen peptides (Tag-HBc-M2e, THM for short), followed by conjugating a recombinant hemagglutinin (rHA) antigen on the surface of the nanoparticles through SpyTag/SpyCatcher ligating. Such inside Mn3O4 immunostimulator-outside rHA antigen design, together with the chimeric M2e antigen on the HBc skeleton, enabled the synthesized hybrid nanovaccines THM-HA@Mn to well imitate the spatial distribution of M2e/HA antigens and immunostimulant in natural influenza virus. In vitro cellular experiments indicated that compared with the THM-HA antigen without Mn3O4 and a mixture vaccine consisting of THM-HA+MnOx, the THM-HA@Mn hybrid nanovaccines showed the highest efficacies in dendritic cells uptake and in promoting BMDC maturation, as well as inducing expression of TNF-α and type I interferon IFN-β. The THM-HA@Mn also displayed the most sustained antigen release at the injection site, the highest efficacies in promoting the DC maturation in lymph nodes and germinal center B cells activation in the spleen of the immunized mice. The co-delivery of immunostimulant and antigens enabled the THM-HA@Mn nanovaccines to induce the highest systemic antigen-specific antibody responses and cellular immunogenicity in mice. Together with the excellent colloid dispersion stability, low cytotoxicity, as well as good biosafety, the synthetic hybrid nanovaccines presented in this study offers a promising strategy to design VLP-based vaccine with robust natural and adaptive immunogenicity against emerging viral pathogens.

Mechanical properties for composites with dammar resin reinforced with crushed corn cob

The study focused on the potential use of agricultural waste (corn cob) in the manufacturing of composite materials. In the first stage, composite materials were manufactured and tested using synthetic matrices (epoxy and acrylic) and hybrid matrices based on dammar resin (50% dammar, 60% dammar, and 70% dammar). Since it was observed that the samples had low mechanical properties under tensile and bending loads, the study was expanded to the production of sandwich-type composites with silk fabric facings. It was found that, by utilizing silk fiber, both tensile and bending strength increased from a few hundred percent up to a few thousand percent, compared to the samples that are only reinforced with crushed corn cob.

Mechanical and frictional properties of coconut husk powder reinforced polymer immersed in a simulated acidic medium for oil/gas applications

Polymeric materials are constantly exposed to aggressive environments, negatively impacting their mechanical and chemical properties. In salt, acid, or alkaline solutions, polymer materials degrade due to surface flaws, microcracks, or other irregularities. For the first time, this study considers the behaviour of coconut powder/coir-reinforced synthetic LDPE hybrid composite immersed in an aggressive (acidic) medium for 15, 30 and 45 days. The structural, mechanical, and frictional behaviour of the developed coir/coconut husk powder/LDPE hybrid composites were measured after ageing in hydrochloric acid (HCl) as potential materials for oil and gas applications. From the XRD patterns, the prominent reflections in the control samples increased with the acid ageing days, while less prominent reflections characterized the hybrid composites. The hardness of the reinforced samples immersed for 30 and 45 days (30B and 45A) showed the highest values of 0.28 Hv, while the control samples immersed for 15 days had the least hardness. The reinforced samples immersed for 15 and 30 days (15B and 30B) showed the lowest and highest fracture toughness, respectively. The control samples were observed to absorb little water after immersion for 144 h. The result showed that although the reinforced hybrid composites showed better mechanical properties, with an increase in the days of immersion in an aggressive medium, the properties became compromised compared to the un-reinforced samples. Hence, the applications of the produced reinforced polymers in the oil and gas industries may be limited.