Synthesis Of Tricyclic Structure Research Articles

A radical cascade reaction triggered by thiyl radical; an approach toward synthesis of tricyclic structure of platensimycin

GRAPHICAL ABSTRACT

ChemInform Abstract: Combination of RCM and the Pauson—Khand Reaction: One‐Step Synthesis of Tricyclic Structures.

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Combination of RCM and the Pauson–Khand Reaction: One‐Step Synthesis of Tricyclic Structures

AbstractThe combination of ring‐closing metathesis (RCM) followed by an intramolecular Pauson–Khand reaction gives direct entry to tricyclic compounds. The RCM was carried out on a hexacarbonylcobalt‐complexed alkyne, this complex acting as a protecting group against enyne metathesis. The procedure was studied for dienynes containing heteroatoms and allows the building of [6,5,5] and [7,5,5] tricyclic systems. The feasibility of the process depends strongly on the nature of the substrate.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)