Synthesis Of Triazole Derivatives Research Articles

Recent Developments Towards the Synthesis of Triazole Derivatives: A Review

Recent Developments Towards the Synthesis of Triazole Derivatives: A Review

Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review

The pharmacological activities of triazole derivatives have been studied extensively by researchers. Different derivatives of triazole have showed promise in treating various diseases. Most triazole derivatives have demonstrated anti-inflammatory, anti-cancer, anti-bacterial and anti-fungal activities. The ability of these compounds to modulate various biological processes has made them attractive for pharmaceutical development. Furthermore, the low cost and wide availability of triazoles have made them even more attractive for drug development. In addition to the pharmacological activities, triazole derivatives have also been reported to possess antioxidant properties. Studies have shown that 1,2,3-triazole can protect against oxidative damage and inhibit lipid peroxidation. Furthermore, 1,2,4-triazole has been found to act as an antioxidant and scavenge free radicals. The antioxidant properties of triazoles make them attractive for the development of new drugs. The synthesis of triazole derivatives has also been studied extensively. Various methods have been developed to synthesize triazole derivatives, including chemical and enzymatic methods. Chemical methods involve the formation of cyclic structures by the reaction of alkyl halides with azides. Enzymatic methods involve the use.

Fe3O4@C@prNHSO3H: A novel magnetically recoverable heterogeneous catalyst in green synthesis of diverse triazoles

AbstractThe core–shell magnetic nano‐catalyst of Fe3O4@C@PrNHSO3H was proposed, synthesized, and fully described by transmission electron microscopy, field‐emission scanning electron microscope, energy‐dispersive X‐ray, vibrating sample magnetometer, thermal gravimetric analysis, X‐ray diffraction, Fourier transform infrared, and X‐ray photoelectron spectroscopy analysis. Nontoxic texture, magnetic recovery capability, high thermal stability as well as low‐cost synthesis method were found as the unique features of the synthesized core–shell magnetic nano‐catalyst. Fe3O4@C@PrNHSO3H NPs were introduced as a modern magnetic heterogeneous catalyst in the solvent‐free synthesis of triazole derivatives through one‐pot, three‐component condensation of aldehyde, ammonium acetate, and nicotinic hydrazide. The pleasant yield of products, straightforward work‐up, mild reaction conditions, along with magnetically recoverable catalyst were enumerated as the most important advantages of the method. The Fe3O4@C@PrNHSO3H could be easily separated from the reaction mixture by an external magnet and reused six times with the desired catalytic activity.

Synthesis of Triazole Derivatives with Sterically Hindered Phenol Fragments

In recent decades, the chemistry of functionally substituted 1,2,4-triazoles and the fused heterocyclic systems based on them have received significant attention due to their structural and biologi...

Application of two magnetic nanoparticle-supported copper(I) catalysts for the synthesis of triazole derivatives

Catalytic performance of two magnetically recoverable copper(I) complexes is reported for the synthesis of 1,2,3-triazole derivatives. Boronic acids and alkyl halides, in the presence of either catalyst, react with terminal alkynes and NaN3, forming 1,2,3-triazole derivatives in good yields. Both catalysts are easily recoverable and show a high potential of reusability.

Click-Derived Triazolylidenes as Chelating Ligands: Achievement of a Neutral and Luminescent Iridium(III)-Triazolide Complex.

Versatility in the synthesis of triazole derivatives was exploited to obtain convenient mesoionic carbenes working as chelating or cyclometalating ligands for the preparation of cationic or neutral iridium(III) complexes. We present the synthesis and characterization of three new cationic cyclometalating iridium(III) complexes (1-3-BF4) and a neutral one (4), equipped with functionalized triazolylidene ligands. All the complexes are obtained in good yields, present irreversible or quasi-reversible oxidation and reduction processes, and display good photophysical stability. The complexes emit from 3MLCT or 3LC states, depending on the nature of the ancillary ligand. Compounds 1-3-BF4 display very low photoluminescence quantum yields (PLQY ≈ 1% in acetonitrile solution). Density functional theory calculations show that the luminescence of these three complexes is quenched by the presence of low-lying 3MC states, leading to a reversible detachment of the neutral ancillary ligands from the metal coordination sphere. On the contrary, this nonradiative deactivation pathway is not present in the case of the neutral complex 4, which in fact shows PLQYs above 10% and is the best emitter of the series. Moreover, complex 4 represents the first reported example of a photochemically and thermally stable neutral triazolide iridium(III) complex.

Copper (II) Ions Immobilized onto Aminoquinoline‐Functionalized Ferrite: A New Efficient and Recoverable Catalyst for “in Water” Synthesis of Triazole Derivatives

AbstractSince the design and development of new ideal catalysts pave the way to green chemistry, a concise, convenient and green protocol was developed for the one‐pot three‐component synthesis of 1,4‐disubstituted‐1,2,3‐triazoles in the presence of a magnetic heterogeneous copper catalyst at room temperature and micellar medium. An easily prepared copper(II) chloride immobilized on 8‐aminoquinoline functionalized magnetic Fe3O4@SiO2 (MNPs@8‐AQ.CuCl2) showed high catalytic performance for the micellar promoted 1,3‐dipolar cycloaddition of alkyl azides to terminal alkynes in water and ambient temperature condition. Various techniques, such as Fourier transform infrared (FT‐IR), X‐ray Diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Energy‐dispersive X‐ray spectroscopy (EDX), thermogravimetric analysis (TGA), Elemental analysis on carbon, hydrogen and nitrogen (CHN) and atomic absorption spectroscopy (AAS) were used to confirm the successful synthesis of the heterogeneous catalyst.

트리아졸 계열의 에너지 가소제 합성 연구

세계적으로 사용 중인 대부분의 추진물질들은 연소 시 메탄가스, 이산화탄소 등의 환경유해 물질을 다량 발생시킨다. 본 연구에서는 이러한 문제를 개선하기 위해 에너지 가소제로 사용 가능한 고질소 화합물인 트리아졸 계열의 4,5-bis(azidomethyl)-methyl-1,2,3-triazole(DAMTR)의 합성공정을 확립하였다. 또한, 분광분석(NMR, IR)을 통해 DAMTR의 구조를 분석하였고, 유리전이온도, 녹는점, 분해온도, 밀도, 점도, 충격감도, 점도, 휘발성 등의 물리적 특성을 측정하였다. 그리고 Gaussian 09와 EXPLO5를 이용하여 생성열과 폭발 특성(폭압, 폭속) 등을 계산하였다. Most of propellants that is used widely in the world release toxic gases such as methane gas and carbon dioxide during combustion which are noxious to the environment. This study established a synthetic process of a high nitrogen containing derivative of triazole, 4,5-bis(azidomethyl)-methyl-1,2,3-triazole (DAMTR), which can be applied as energetic plasticizer to environmental concerns. Also, the compound was characterized by NMR, IR spectroscopy, and physical properties such as glass transition temperature, melting point, decomposition temperature, density, impact sensitivity, viscosity and volatility were measured. In addition, the heats of formation (<TEX>${\Delta}H_f$</TEX>) and detonation properties (pressure and velocity) of DAMTR were calculated using Gaussian 09 and EXPLO5 programs.

Immobilization of copper ions onto α‐amidotriazole‐functionalized magnetic nanoparticles and their application in the synthesis of triazole derivatives in water

A new heterogeneous copper catalyst was synthesized by immobilization of copper ions onto magnetic nanoparticles with a new ligand based on triazole. The catalyst was characterized using scanning and transmission electron microscopies, atomic absorption and Fourier transform infrared spectroscopies, and thermogravimetric, elemental and energy‐dispersive X‐ray analyses. The results confirmed that a good level of organic groups was immobilized on the magnetic nanoparticles. Huisgen cycloaddition reaction was chosen as a model reaction for the investigation of catalyst activity under green conditions. Phenylacetylene and benzyl bromide derivatives were used for the synthesis of triazoles. The reaction proceeded with good to excellent yields for various alkynes and alkyl halides. To investigate catalyst activity for inactive alkynes, aliphatic alkynes were used in the model reaction. The corresponding triazoles were obtained in good to excellent yields and a high regioselectivity for products was obtained. The catalyst was easily separated using an external magnetic field and subsequently reused in ten reaction cycles without any loss of catalytic activity. Copyright © 2016 John Wiley &amp; Sons, Ltd.

Synthesis of 2RS,4RS-1-[2-Phenyl-4-[2-(2-trifluromethoxy-phenoxy)-ethyl]-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole Derivatives as Potent Inhibitors of Brassinosteroid Biosynthesis

Brassinosteroids are important phytohormones that affect many aspects of plant growth and development. In order to manipulate brassinosteroid levels in plant tissues by using specific biosynthesis inhibitors, we have carried out a systemic search for specific inhibitors of brassinosteroid biosynthesis. Synthesis of triazole derivatives based on the ketoconazole scaffold revealed a series of novel brassinosteroid biosynthesis inhibitors (the YCZ series). To explore the structure-activity relationships of this synthetic series, we now report the synthesis of new triazole derivatives with different aromatic structures at position 2 of 1,3-dioxolane skeleton. We found that the variation of aromatic substituent significantly affect the inhibitory potency. Structure-activity relationships studies indicated that 4-chlorophenyl analogue is the most potent inhibitor of BR biosynthesis with an IC50 value approximately 0.12 ± 0.04 µM, while a bulky biphenyl group exhibited a great negative effect on promoting the inhibitory potency with an IC50 larger than 10 µM.

ChemInform Abstract: 1‐(4‐Nitrophenyl)‐4‐phenyl‐1H‐1,2,3‐triazole vs. 5(6)‐Nitrobenzofuroxan Formation and Their Antifungal Activity.

AbstractThe synthesis of triazole derivatives (III) via Cu‐catalyzed “click” reaction of corresponding nitrophenylazides (I) with phenylacetylene is attempted.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF THIAZOLE DERIVATIVES CONTAINING TRIAZOLE MOIETY USING LiBr AS A CATALYST

Synthesis of triazole derivatives from 2-mercaptobenzothiazole has been achieved in four steps under microwave irradiation. LiBr potentially replace solvents and corrosive acids in this reaction scheme. The products of triazole derivatives have shown antimicrobial activity.