Synthesis Of Thiosemicarbazones Research Articles

GREEN SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME THIOSEMICARBAZONE AND SEMICARBAZONE DERIVATIVES

The interaction of substituted pyridine carboxaldehyde with thiosemicarbazide and semicarbazide via a greener approach resulted in the synthesis of thiosemicarbazone and semicarbazone derivatives; respectively. The resultant compounds were synthesized in aqueous media and were characterized by FTIR and 1H-NMR spectral studies. The antimicrobial evaluation of the final compounds has proven that they are active against the strains (S. aureus, P. aeruginosa, A. niger, and C. glabrata) incorporating the microdilution method.

Synthesis of Thiosemicarbazones and Their Organoiodine Cocrystals: Cooperative Effects of Halogen and Hydrogen Bonding

Synthesis of Thiosemicarbazones and Their Organoiodine Cocrystals: Cooperative Effects of Halogen and Hydrogen Bonding

One pot synthesis and spectral characterization of 5-Substitutedfuran-2-carbaldehyde N4-cyclohexyl thiosemicarbazones and their Ni(II) complexes

In this work, the synthesis of thiosemicarbazones (I-V) was carried out using one pot method, multicomponent and catalyst-free reaction of cyclohexyl isothiocyanate, hydrazine monohydrate and 5-substituted-2-furancarbaldehydes in good yields. The chemical structures of 5-substituted-2-furancarbaldehyde thiosemicarbazones were eludicated using UV‐Vis, IR, 1H NMR, 13C NMR, mass spectra, and elemental analysis. Also, the reaction of NiCl2.6H2O with thiosemicarbazones in 1:2 molar ratio by refluxing gave the nickel (II) complexes (Ia-Va) as binuclear and their structures characterized by UV-Vis, IR, and elemental analysis.

Microwave and Ultrasound‐Assisted Synthesis of Thiosemicarbazones and Their Corresponding (4,5‐Substituted‐thiazol‐2‐yl)hydrazines

Hantzsch cyclization of thiosemicarbazone intermediates is a very popular approach to the synthesis of substituted thiazoles. We developed a convenient microwave and ultrasound‐assisted method both for the synthesis of 1‐(alkyliden/cycloalkyliden/aryliden)thiosemicarbazone intermediates and their cyclization into (4,5‐substituted‐thiazol‐2‐yl)hydrazines. The search for optimal reaction conditions included the use of different catalysts (Lewis acids and resins) and solvents at discrete temperatures, pressures, and irradiation powers. Comparing yields, reaction times, and efforts proved that microwave and ultrasound‐assisted techniques outmatch conventional heating and have a remarkable influence on the synthesis.

Synthesis of Thiosemicarbazones as Substrates for Xanthine Oxidase Enzyme Activity

Synthesis of Thiosemicarbazones as Substrates for Xanthine Oxidase Enzyme Activity

Heterocyclizations of pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations

Pregnenolone (1) was used as a template to develop new anticancer compounds. Ring D modification of 1 through its reaction with 4-phenyl-3-thiosemicarbazide gave the thiosemicarbazone derivative 3. The latter compound underwent heterocyclization reactions to give the thiazolyl hydrazonoandrostane and pyrazolyl semicarbazidoandrostane derivatives 5a–d, and 9a–d, respectively. On the other hand compound 1 reacted with either malononitrile or ethyl cyanoacetate to give the Knoevenagel condensated products 11a and 11b, respectively. Compounds 11a,b afforded the thiophenyl pregnane derivatives 12a and 12b, respectively, their reactivity toward some chemical reagents was studied. The cytotoxicity of the newly synthesized heterocyclic steroids against three human tumor cell lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were studied. Some of tested compounds were found to exhibit much higher inhibitory effects toward the three tumor cell lines than the reference drug, doxorubicin.

An Expedient Method for the Synthesis of Thiosemicarbazones under Microwave Irradiation in Solvent‐Free Medium.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity

Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.