Synthesis Of Pyrrolidine Derivatives Research Articles

Progress in the Stereoselective Synthesis Methods of Pyrrolidine-Containing Drugs and Their Precursors.

The presented review systematizes and summarizes the data on the synthesis of pyrrolidine derivatives, which are precursors for obtaining drugs. Based on the analysis of published data, the most promising directions in the synthesis of biologically active compounds containing a pyrrolidine ring are identified. Stereoselective synthesis methods are classified based on the source of the pyrrolidine ring. The first group includes methods that use a pyrrolidine ring as the starting compound. The second group combines stereoselective methods of cyclization of acyclic starting compounds, which lead to optically pure pyrrolidine derivatives.

Progress in Synthesis of Pyrrolidine Derivatives by Hofmann-Löffler-Freytag Type Reactions

Progress in Synthesis of Pyrrolidine Derivatives by Hofmann-Löffler-Freytag Type Reactions

Nitrogen-containing acetals and ketals in the synthesis of pyrrolidine derivatives

This review offers analysis and generalization of data regarding the synthesis of substituted pyrrolidines by using nitrogen-containing acetals and ketals as starting compounds published from year 2000 to 2016. Particular attention has been focused on the synthesis of pyrrolidines that are substituted at position 2. Biological activity data for several pyrrolidine derivatives are reported.

ChemInform Abstract: Synthesis of Pyrrolidine Derivatives by a Platinum/Broensted Acid Relay Catalytic Cascade Reaction.

AbstractVarious N‐Boc protected alkynamine substrates are treated with appropriate simple alkenes or alkynes and silane analogues (XIV) and (XVI).

ChemInform Abstract: Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides

AbstractReview: 29 refs.

Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides

Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides

Efficient gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation of unactivated alkenes with α-ketones

The gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation reaction offers a simple and efficient method for the synthesis of pyrrolidine derivatives in moderate to excellent product yields and with moderate to good diastereoselectivities. The reaction conditions and the substrate scope of this reaction are examined, and a possible mechanism involving AgClO4 catalyzed intermolecular N-Michael addition and the subsequent gold(I)-catalyzed hydroalkylation is proposed.

ChemInform Abstract: New Synthesis of Pyrrolidine Derivatives via the Chromacyclobutanes Generated from Enynes and Fischer Carbene Complexes.

Pyrrolidine derivatives have been synthesized via chromacyclobutanes formed from the Fischer carbene complex 2b and the aza-enyne 5a; a mechanism is suggested on the basis of the products that are formed.

ChemInform Abstract: Microwave‐Assisted Synthesis of Pyrrolidine Derivatives.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Microwave-assisted synthesis of pyrrolidine derivatives

Microwave-assisted bismesylate amination is an efficient method of synthesizing pyrrolidine ring derivatives and provides a good to excellent product yield.

New Efficient RCM-Mediated Synthesis of Pyrrolidine Derivatives

Fast and effective ring-closing olefin metathesis (RCM) of diallyamine derivatives of coumarin, quinolone, pyridine, and substituted benzene, using first-generation RCM ruthenium-based catalyst, leads to corresponding pyrrolidine derivatives in 70–95% yields under very mild conditions.

Metal‐Complex Catalysis During the Reduction of Functional Groups by Sodium Borohydride in the Synthesis of Pyrrolidine Derivatives.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Metal-complex catalysis during the reduction of functional groups by sodium borohydride in the synthesis of pyrrolidine derivatives

A selective method was developed for the reduction of functional groups with sodium borohydride using complexes of CoCl2 and CuCl2 with triethylbenzylammonium chloride and cobalt and copper mesotetra[4-(2-hydroxyethyl)pyridyl]porphyrinates as catalysts.

Development of New Synthetic Methods of Heterocycles Using Chloramine‐T as a Nitrogen Source

AbstractFor Abstract see ChemInform Abstract in Full Text.

クロラミンＴを窒素源とする新しいヘテロ環合成法の開発

We have exploited the novel strategies for construction of N-heterocycles using Chloramine-T as an N 1 unit. Copper (I) chloride or iodine was found to be a good catalyst for aziridination of various alkenes with Chloramine-T. The combination of Chloramine-T and silver nitrate directly led to not only aziridines from alkenes including α, β-unsaturated carbonyl compounds but also bicyclic pyrrolidines from 1, 6-dienes. The synthesis of pyrrolidine derivatives was achieved efficiently and stereoselectively from alkenyl iodides and Chloramine-T, in which the iodo group of the substrates has multiple functions to perform the cyclization. Furthermore, organic-solvent-free aziridination of alkenes was developed by utilizing Chloramine-T-I2 system under phase-transfer catalyst conditions or under the reaction media of silica and water.

Synthesis of Pyrrolidine Derivatives by the Palladium-Catalyzed Cyclization ofN-(2-Cyclohexenyl)bromoacetamide Derivatives

N-(2-Cyclohexenyl)bromoacetamide derivatives underwent intramolecular cyclization to give pyrrolidine derivatives in the presence of a base and a catalytic amount of palladium catalyst.

New synthesis of pyrrolidine derivatives via the chromacyclobutanes generated from enynes and Fischer carbene complexes

Pyrrolidine derivatives have been synthesized via chromacyclobutanes formed from the Fischer carbene complex 2b and the aza-enyne 5a; a mechanism is suggested on the basis of the products that are formed.

ChemInform Abstract: High‐Enantioselective Synthesis of Pyrrolidine Derivatives as Chiral Building Blocks.

AbstractStarting with the Z‐benzyloxypentenol (I) or its E‐isomer (IX), the diastereomeric epoxides (II) and (X) are prepared.

ChemInform Abstract: Synthesis of Pyrrolidine Derivatives by Improved Aminoselenation via Addition of Boron Trifluoride Complex of Dihomoallylcuprate to Aldimines Containing α‐Hydrogen.

AbstractThe unsaturated amines (III) derived from the imines (I) are cyclized and selenenylated to give the phenylselenenylmethylpyrrolidines (V) which are reduced, forming the methylpyrrolidines (VI).

ChemInform Abstract: Synthesis of Pyrrolidine Derivatives with Pharmacological Activity. Part 12. Synthesis and Anticholinergic Activity of 1,1‐Dialkyl‐3‐diphenylmethylene‐2,4‐dimethylpyrrolidinium Halides.

AbstractThe pyrrolidinium compounds (VIII), (X), (XIII), and (XIV) are prepared via the pyrrolidine (IV), as outlined in the reaction scheme.