Synthesis Of Praziquantel Research Articles

A palladium-catalyzed intramolecular Heck/Hydrogenation approach towards the synthesis of praziquantel

Starting from 3-methoxy N-acylpyrazinium salts, a new approach towards the synthesis of the antischistosomal drug praziquantel (PZQ) has been developed. Utilization of a palladium-catalyzed intramolecular Heck reaction to form dehydro-PZQ followed by a Hydrogenation step, in a stepwise or one-pot manner, allowed for the gram scale synthesis of PZQ in 4 or 5 steps and in good overall yields. This methodology proved to be well suited for generating the pyrazino[1,2-a] isoindole and pyrazino[1,2-a] benzazepine analogues of PZQ.

A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug

A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug

A Practical and Efficient Preparation of Key Intermediates in the Synthesis of Praziquantel

A Practical and Efficient Preparation of Key Intermediates in the Synthesis of Praziquantel

Solid phase synthesis of praziquantel

The first solid phase synthesis of the important anthelmintic praziquantel is described. The synthesis is rapid and efficient. The method may be extended to the synthesis of libraries of urgently needed replacements for this drug.

Síntese do anti-helmíntico praziquantel,a partir da glicina

This paper deals mainly with the synthesis of praziquantel, a powerful anti-helminthic used against schistosomiasis, an endemic disease which infest millions of people around the world.

Synthesis of Praziquantel via N-Acyliminium Ion Cyclization of Amido Acetals through Several Synthetic Routes

Synthesis of Praziquantel via N-Acyliminium Ion Cyclization of Amido Acetals through Several Synthetic Routes