Synthesis Of Oxygen-Containing Heterocycles Research Articles

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies.

Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and -expansion reactions. These applications have driven numerous studies on the synthesis of oxygen-containing heterocycles and considerable effort has been devoted toward the development of methods for the construction of saturated oxygen heterocycles. This paper provides an overview of the biological roles and synthetic strategies of saturated cyclic ethers, covering some of the most studied and newly discovered related natural products in recent years. This paper also reports several promising and newly developed synthetic methods, emphasizing 3–7 membered rings.

Effective Hydroalkoxylation/Cyclization of Alkynyl Alcohol Catalyzed by In(OTf)<sub>3</sub>

An effective hydroalkoxylation/cyclization of alkynyl alcohol catalyzed by In (OTf)3 was reported, which could be used to the synthesis of oxygen-containing heterocycles.

New β-Hydroxy Acylsilane-Derived Building Blocks and Their Use in the Synthesis of Oxygen-Containing Heterocycles

Starting from easily accessible β-hydroxy acylsilanes, several 1C-, 2C- and 3C-extension reactions have been developed to efficiently afford five new functionalized building blocks, which have been used for the preparation of several five- and six-membered lactones.

Phosphine-Mediated Synthesis of Oxygen-Containing Heterocycles

Phosphine-Mediated Synthesis of Oxygen-Containing Heterocycles

Synthesis of Oxygen-containing Heterocycles Using Palladium(II) Catalysts

Alkenes, dienes, and alkynes bearing hydroxy groups, when treated with palladium(II) catalysts, afford a variety of oxygen-containing heterocycles via cyclizations involving intramolecular oxypalladation as a key step. Trapping the oxypalladation intermediates with CO also creates useful entries to oxygen-containing heterocycles. Synthetic aspects of these cyclizations as well as the catalyses of palladium(II) are surveyed in this article

Pyridine carboxaldehyde-based synthesis of oxygen-containing heterocycles

Heterocycles containing one or two atoms of oxygen are synthesized by the condensation of pyridine carboxaldehydes with ethylene glycol, 1,3-propanediol, and 3-methyl-3-buten-1-ol. When the unsaturated alcohol is used, linear acetals are formed along with the cyclic products.

Recent Advances in the Synthesis of Oxygen-Containing Heterocycles.

Recent Advances in the Synthesis of Oxygen-Containing Heterocycles.