Synthesis Of Organic Carbamates Research Articles

Cover Feature: N‐Aryl and N‐Alkyl Carbamates from 1 Atmosphere of CO2 (Chem. Eur. J. 72/2021)

We have successfully isolated the zinc carbamate complex (phen)Zn(OAc)(OC(=O)NHPh) (1, phen=1,10-phenanthroline), which is an intermediate in the Zn(OAc)2/phen-catalyzed synthesis of organic carbamates from CO2, amines, and Si(OMe)4. By analyzing the reaction mechanism based on the reactivity of 1 and DFT calculations, we improved the catalytic system and synthesized various organic carbamates—including polyurethane raw materials—by using CO2 at 1 atm. More information can be found in the Full Paper by J.-C. Choi et al. (DOI: 10.1002/chem.202103587).

Polystyrene supported Zinc complex as an efficient catalyst for cyclic carbonate formation via CO2 fixation under atmospheric pressure and organic carbamates production

Chemical fixation of CO2 and synthesis of organic carbamates through phosgene –free eco-friendly pathway using a heterogeneous and sustainable catalyst is always a demanding field in synthesis chemistry. Herein, we presented the design and synthesis of a polymer support sustainable heterogeneous [PS-Zn(II)L] catalyst from modified chloromethylated polystyrene. The heterogeneous catalyst has been characterized by IR, PXRD, AAS, TG-DTA, SEM and EDX studies. The catalyst showed its efficient catalytic activity towards the formation of organic cyclic carbonate from epoxides via CO2 fixation at room temperature under 1 atm CO2 pressure in solvent free condition and production of organic carbamates from corresponding amines. The synthesis of carbamates in presence of this catalyst is a phosgene-free protocol where green reagent Dimethyl carbonate (DMC) is used as a carboxylating agent as well as the solvent. The catalyst is highly efficient and reusable even after five cycles.

Chloroformate Free, Scalable Approach for the Synthesis of Organic Carbamates and Their Alkylation

The synthesis of carbamates of 2-aminopyridine is described, avoiding the employment of hazardous chloroformate reagents.

Carbon Dioxide: Versatile, Cheap and Safe Alternative in the Syntheses of Organic Carbamates

Organic carbamates represent an important class of compounds showing various interesting properties. They find wide utility in various areas as pharmaceuticals, agrochemicals (pesticides, herbicides, insecticides, fungicides etc.), intermediates in organic synthesis, protection of amino group in synthetic organic chemistry, as linkers in combinatorial chemistry etc. Classical synthesis of carbamates involves use of harmful reagents such as phosgene, its derivatives and carbon monoxide. Recently, carbon dioxide has frequently been employed as a green reagent in its various conditions and forms for the synthesis of organic carbamates employing diversity of starting materials, reagents and catalytic systems. In the present review, we would like to highlight the recent developments on the synthesis of organic carbamates using various conditions and forms of carbon dioxide. Keywords: Amines, Carbon dioxide, Carbamation, Organic carbamates, tetra-ethyl ammonium bromide-superoxide/CO2, ethynyl alcohols, ruthenium, propargyl amines 41, regioselective, isopropenylacetylene 45

ChemInform Abstract: Polyethylene Glycol Enhanced Chemoselective Synthesis of Organic Carbamates from Amines, CO2, and Alkyl Halides.

Abstract An efficient and environmentally benign method for the synthesis of organic carbamates was developed. Amines, CO2, and alkyl halides underwent a three-component reaction with the aid of K2CO3 and polyethylene glycol (PEG, MW = 400), affording the organic carbamates under ambient conditions. PEG could presumably act as a solvent and phase-transfer catalyst (PTC). Notably, the presence of PEG could also depress the alkylation of both the amine and the carbamate, thus resulting in enhanced selectivity toward the target carbamate. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.

ChemInform Abstract: Perspectives on the Synthesis of Organic Carbamates

AbstractReview: ca. 350 refs.

Carbon dioxide as carbon source: Activation via electrogenerated O 2[rad]− in ionic liquids

The activation of carbon dioxide has been obtained in O 2/CO 2 saturated ionic liquids, via electrochemically generated O 2 −, at a less negative potential than the one of the direct cathodic reduction of CO 2. This electrochemical activation has been applied to the C–N bond formation from amines and carbon dioxide in the synthesis of organic carbamates. A competitive reaction between electrogenerated superoxide ion and imidazolium cations yielding 2-imidazolones has been pointed out. This procedure allows to avoid the utilization of volatile and toxic organic solvents, supporting electrolytes and catalysts.

ChemInform Abstract: Synthesis of Organic Carbamates Without Using Phosgene — Carbonylation of Amines with Carbonic Acid Diesters

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis of Organic Carbamates without Using Phosgene: Carbonylation of Amines with Carbonic Acid Diesters

Synthesis of Organic Carbamates without Using Phosgene: Carbonylation of Amines with Carbonic Acid Diesters

Mild and Convenient Synthesis of Organic Carbamates from Amines and Carbon Dioxide using Tetraethylammonium Superoxide

A safe and simple method of preparing organic carbamates has been achieved from amines and carbon dioxide using tetraethylammonium superoxide generated in situ.

Versatile Use of Carbon Dioxide in Synthesis of Organic Carbamates

Versatile Use of Carbon Dioxide in Synthesis of Organic Carbamates