Synthesis Of Novel Peptidomimetics Research Articles

Design and synthesis of novel peptidomimetics for cancer immunotherapy

Design and synthesis of novel peptidomimetics for cancer immunotherapy

ChemInform Abstract: β3R3‐Peptides: Design and Synthesis of Novel Peptidomimetics and Their Self‐Assembling Properties at the Air‐Waste Interface.

ChemInformVolume 44, Issue 41 Natural Products ChemInform Abstract: β3R3-Peptides: Design and Synthesis of Novel Peptidomimetics and Their Self-Assembling Properties at the Air-Waste Interface. Simone Mosca, Simone Mosca MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this authorClaudia Dannehl, Claudia Dannehl MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this authorUwe Moeginger, Uwe Moeginger MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this authorGerald Brezesinski, Gerald Brezesinski MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this authorLaura Hartmann, Laura Hartmann MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this author Simone Mosca, Simone Mosca MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this authorClaudia Dannehl, Claudia Dannehl MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this authorUwe Moeginger, Uwe Moeginger MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this authorGerald Brezesinski, Gerald Brezesinski MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this authorLaura Hartmann, Laura Hartmann MPI Kolloide Grenzflaechen, D-14424 Potsdam, GermanySearch for more papers by this author First published: 19 September 2013 https://doi.org/10.1002/chin.201341202AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume44, Issue41October 8, 2013 RelatedInformation

β3R3-Peptides: design and synthesis of novel peptidomimetics and their self-assembling properties at the air–water interface

In this study we present the design and synthesis of a novel class of peptidomimetics, the β(3R3)-peptides. Via alternating directions of the amide bonds along β-peptide sequences, β(3R3)-peptides can potentially extend the structural space available to β-peptidic foldamers. Detailed analysis at the air-water interface shows strand conformations and the formation of sheet assemblies with different degrees of crystallinity. Furthermore β(3R3)-peptides exhibit a high proteolytic stability thus making them an interesting new class of peptidomimetics for biomedical applications.

ChemInform Abstract: Synthesis of Novel Peptidomimetics as Inhibitors of Protozoan Cysteine Proteases Falcipain‐2 and Rhodesain.

AbstractNovel peptidomimetics of type (I) are supplied with a protected aspartyl aldehyde moiety to increase lipophilicity.

Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain

This paper describes the synthesis of novel peptidomimetics bearing a protected aspartyl aldeyde warhead leading to the thioacylals 2a, b and the acylals 3a, b. Compounds 2a and 3a proved to possess an increased antiplasmodial activity with respect to the parent molecule 1. Furthermore thioacylal 2a can be considered as a promising trypanocidal agent.

Selective protecting group manipulations on the 1-deoxynojirimycin scaffold

Iminosugars are inhibitors of glycoprocessing and are of interest as scaffolds for medicinal chemistry, as their successful application as peptide mimetics has shown. The synthesis of novel peptidomimetics based on 1-deoxynojirimycin (DNJ) requires practical strategies that allow introduction of amino acid side chains or pharmacophore groups at each of its hydroxyl groups or to the nitrogen atom. This paper describes one approach towards achieving selective protection and deprotection at the hydroxyl and amino groups of DNJ and a novel synthesis of DNJ from l-sorbose is included.

Synthesis of Novel Peptidomimetics, Cyclic Hexamers of Unnatural Amino Acids, 2,5-Disubstituted 3-Aminobenzoic Acids

Synthesis of Novel Peptidomimetics, Cyclic Hexamers of Unnatural Amino Acids, 2,5-Disubstituted 3-Aminobenzoic Acids