Synthesis Of Mesoporous Bioactive Glass Research Articles

Facile synthesis of mesoporous bioactive glasses with controlled shapes

In this work, a facile method was developed for fabrication of mesoporous bioactive glasses (BGs) with controlled shapes using cetyltrimethylammonium bromide (CTAB) as templating agent for sol–gel process. The morphologies, specific surface areas and pore sizes of the BGs were characterized by FE-SEM, TEM, and the BET and BJH methods, respectively. Rod-like BGs with mesoporous structures and high specific surface areas were prepared using CTAB as the templating agent. The shaping of the samples depicted a dynamic process from sphere to short rod then to long rod as the CTAB concentration was increased. This study presents an effective approach for controlling the spherical and rod-like structures of BGs.

Application of orthogonal experimental design in synthesis of mesoporous bioactive glass

An orthogonal experimental design method combining with quantitive analysis of small-angle X-ray scattering (SAXS) pattern was applied to optimize the synthesis of bioactive glasses with highly ordered mesoporous structure (MBGs). The quantitive analysis of SAXS pattern allows a quantified evaluation of the ordering of the mesoporous structure, which makes it possible to tailoring the mesoporous structure of the MBGs with complex component by a traditional orthogonal experimental design method. The number of trials for preparing MBGs can be greatly reduced and the primary factors affecting the formation of mesoporous structure and the properties of MBGs can be easily found out by this orthogonal experimental design method. MBGs containing SiO2, CaO, Fe2O3 were prepared as an example to present the way to obtain optimized ordered mesoporous structure. It confirmed that Fe2O3 was the primary factor influencing the mesoporous structure of the MBGs. The ordering of the mesopores increased in the first and then decreased with the increase of F127 content.

Bio-templated synthesis of mesoporous bioactive glass with a hierarchical pore structure

The bimodal porous structured mesporous bioactive glass (MBG) materials consisting of macropores were prepared using the natural Mediterranean sea sponge as macropored hard templates and P123 as mesopore soft templates, respectively. The macroporous structures of the natural Mediterranean sea sponge as macropored were replicated with the walls containing highly ordered MBG as well. Dexamethasone (DEX) was employed as a model drug and the release profiles showed that the dual porous materials had a sustained drug delivery capability. In addition, the materials had higher ability to induce hydroxycarbonate apatite (HAp) formation. Therefore, such highly ordered dual pore MBG materials might be used as a bioactive drug release system for preparation of bone implant materials.