Synthesis Of Maleimide Derivatives Research Articles

Stereoselective Synthesis of Tetrasubstituted Olefins via Visible-Light-Promoted Iodine-Mediated Homo-Coupling of Diazo.

A visible-light-promoted iodine-mediated homo-coupling of diazo was first described. A series of tetrasubstituted olefins were synthesized in high yields and with low to high Z-selectivities from phenyldiazoacetates. For 3-diazooxindoles, isoindigo derivatives were provided in moderate to high yields and with excellent E-selectivities. Experimental results showed that the reaction proceeded through a diiodo intermediate. The synthetic usefulness of this reaction was illustrated by the synthesis of maleimide derivatives and dispiro epoxy.

Copper-Catalyzed Diazo Cross-/Homo-Coupling toward Tetrasubstituted Olefins and Applications on the Synthesis of Maleimide Derivatives.

A challenging selective intermolecular cross-coupling and homocoupling of aryl-aryl or aryl-alkyl diazo compounds has been accomplished via a copper system, which afforded tetrasubstituted olefins in moderate to high yields with good to excellent Z-selectivity. This novel methodology enables rapid synthesis of tetrasubstituted olefins, which would find broad application in accessing maleimide libraries of nature products and bioactive small molecules.

One-step Barton decarboxylation by micellar catalysis – application to the synthesis of maleimide derivatives

Maleimides being studied or used in various applications, for the first time, a facile entry to Barton decarboxylation in aqueous media is described to obtain in one step substituted N-phenylmaleimide synthons.

Fluorescence and structure of proteins as measured by incorporation of fluorophore. II. Synthesis of maleimide derivatives as fluorescence-labeled protein-sulfhydryl reagents.

A novel approach to studies of structure and function of proteins utilizing fluorescencelabeled specific reagent is proposed. N-[p-(2-Benzoxazolyl) phenyl] maleimide (IIIa) and N-[p-(2-benzthiazolyl) phenyl] maleimide (IIIb) were synthesized as sulfhydryl reagents of this type and the addition reaction with cysteine ester was investigated. Cyclization of maleamic acids with PPA is demonstrated to be a good method for synthesis of N-substituted maleimides.