Synthesis Of Geiparvarin Research Articles

A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: application to the formal synthesis of (±)-ascofuranone and geiparvarin.

A unified approach to both 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone rings systems centered on a [3+2] nitrile oxide cycloaddition strategy as a tool for the crucial carbon-carbon bond forming step has been successfully applied to the formal synthesis of )(±)-ascofuranone and to a new synthesis of geiparvarin from common intermediates.

ChemInform Abstract: Isoxazole‐Mediated Synthesis of Geiparvarin and Dihydrogeiparvarin.

ChemInform Abstract: Isoxazole‐Mediated Synthesis of Geiparvarin and Dihydrogeiparvarin.

A simple synthesis of geiparvarin

A simple, efficient (nine steps, 22% overall yield) synthesis of geiparvarin is described.

Synthesis of geiparvarin: a novel antitumor agent possessing a 3(2H)-furanone ring

The first synthesis of geiparvarin as well as assignment of configuration of the previously undefined trisubstituted olefinic bond has been achieved.