Synthesis Of Chlorins Research Articles

Synthesis of Chlorine- and Nitrogen-Containing Carbon Nanofibers for Water Purification from Chloroaromatic Compounds

Chlorine- and nitrogen-containing carbon nanofibers (CNFs) were obtained by combined catalytic pyrolysis of trichloroethylene (C2HCl3) and acetonitrile (CH3CN). Their efficiency in the adsorption of 1,2-dichlorobenzene (1,2-DCB) from water has been studied. The synthesis of CNFs was carried out over self-dispersing nickel catalyst at 600 °C. The produced CNFs possess a well-defined segmented structure, high specific surface area (~300 m2/g) and high porosity (0.5-0.7 cm3/g). The addition of CH3CN into the reaction mixture allows the introduction of nitrogen into the CNF structure and increases the volume of mesopores. As a result, the capacity of CNF towards adsorption of 1,2-DCB from its aqueous solution increased from 0.41 to 0.57 cm3/g. Regardless of the presence of N, the CNF samples exhibited a degree of 1,2-DCB adsorption from water-organic emulsion exceeding 90%. The adsorption process was shown to be well described by the Dubinin-Astakhov equation. The regeneration of the used CNF adsorbent through liquid-phase hydrodechlorination was also investigated. For this purpose, Pd nanoparticles (1.5 wt%) were deposited on the CNF surface to form the adsorbent with catalytic function. The presence of palladium was found to have a slight effect on the adsorption capacity of CNF. Further regeneration of the adsorbent-catalyst via hydrodechlorination of adsorbed 1,2-DCB was completed within 1 h with 100% conversion. The repeated use of regenerated adsorbent-catalysts for purification of solutions after the first cycle of adsorption ensures almost complete removal of 1,2-DCB.

Synthesis of chlorins and bacteriochlorins from cycloaddition reactions with porphyrins

Synthesis of chlorins and bacteriochlorins from cycloaddition reactions with porphyrins

Synthesis of Chlorin–(Arylamino)quinazoline Hybrids as Models for Multifunctional Drug Development

A series of multifunctional conjugates each consisting of a fluorescent chlorin photosensitizer and an (arylamino)quinazoline-based epidermal growth factor receptor/vascular endothelial growth factor receptor ligand, potentially useful in site-selective photodynamic antitumor therapy, were prepared and their photochemical properties were investigated.

Synthesis of Chlorins by Diels–Alder Cycloadditions of Pheophorbide a and Its Derivatives

The Diels–Alder reaction was exploited for the preparation of novel long-wavelength chlorin photodynamic therapy photosensitizers. The styryl group and furan carboxamide substituents were used as diene components in [4+2] cycloaddition functionalizations.

Synthesis of Chlorins with Chlorophyllous Chromophore Fused with Nitrogenous Heterocycle

Abstract Methyl 13-oxopyropheophorbide-a was prepared using one pot method from chlorophyll-a, and subsequently reacted with o-diaminobenzene to produce four chlorins fused with nitrogenous heterocycle derivatives. The hyperactive functional groups such as formyl and formymethyl groups were introduced at 3-position by oxidation with thallium nitrate or osmium tetroxide. Friedlander condensation of C-formymethyl group with o-aminobenzaldehyde was carried out smoothly to build quinolinic structure. The five-membered heterocyclic rings were established at 3-position via the 1,3-dipolar cycloaddition reaction of C-vinyl group with diazomethane and benzonitrile oxide. The structures of new chlorins with chlorophyllous basic skeleton were characterized by UV, IR, H NMR and elemental analysis.

The synthesis of chlorophyll-a skeleton homologs bearing linear six-carbon chain from methyl pheophorbide-a

The synthesis of chlorins bearing 6C-straight chain was accomplished from methyl pheophorbide-a. A series of chemical modifications were employed for the construction of active functional groups, such as bromine atom or aldehyde group, on the periphery of chlorins. These functionalized chlorins further reacted with the reagent containing straight carbon-chain by common chemical reactions to produce target compounds. The structures of all new chlorins were characterized by elemental analysis, IR, UV-Vis and 1H NMR spectra.

ChemInform Abstract: Synthesis of Chlorin and Bacteriochlorin Conjugates for Photodynamic and Boron Neutron Capture Therapy

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis of chlorin and bacteriochlorin conjugates for photodynamic and boron neutron capture therapy

The review summarizes the synthesis and study of properties of the bioconjugates of chlorophyll a and bacteriochlorophyll a with carbohydrates, carboranes and other moieties, focusing on the synthetic methods of obtaining conjugates and preliminary biological testing thereof. Boronated chlorins and bacteriochlorins can be used in both photodynamic and boron neutron capture therapy.

Synthesis of chlorins with a distal vinyl group

A series of chlorins containing a vinyl group on the periphery of the chlorin ring that was attached by linkers of various length, potential monomers for synthesis of polymers containing chlorin via copolymerization, was synthesized from methylpheophorbide a.

Chemistry of Oximes of meso‐Porphyrin Metal Complexes. Synthesis of Chlorine with Fused 1,2‐Oxazocine Ring.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Chemistry of Oximes of meso -Porphyrin Metal Complexes. Synthesis of Chlorine with Fused 1,2-Oxazocine Ring

Chemistry of Oximes of meso -Porphyrin Metal Complexes. Synthesis of Chlorine with Fused 1,2-Oxazocine Ring

Synthesis of chlorin e 6 amide derivatives

The reactions of methylpheophorbide a with primary and secondary amines have been investigated as a means for the synthesis of sensitizers used in the photodynamic therapy of tumors

A New Synthesis of Chlorins

A New Synthesis of Chlorins

A New Synthesis of Chlorins.

AbstractFor Abstract see ChemInform Abstract in Full Text.

A New Synthesis of Chlorins

A new synthesis of chlorins has been developed, based upon the acid-catalyzed condensation of dialdehydes AB with dipyrromethanes CD.

ChemInform Abstract: The Synthesis of Chlorins, Bacteriochlorins, Isobacteriochlorins, and Higher Reduced Porphyrins

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Novel chlorins with a δ-lactone ring

The synthesis of chlorins possessing an additional δ-lactone ring via reduction of the anhydride ring in purpurins with sodium borohydride has been performed.

Conversion process of chlorine containing polysilanes into silicon carbide: Part I Synthesis and crosslinking of poly(chloromethyl)silanes–carbosilanes and their transformation into inorganic amorphous silicon carbide

Synthesis of chlorine containing polysilanes by catalytic redistribution is described and the obtained polymers are characterized by infrared (IR)-, magic angle spinning nuclear magnetic resonance (MAS-NMR)-spectroscopy and elemental analysis. The pyrolysis of such polysilanes was investigated by thermoanalysis, IR-, MAS NMR- and electron spin resonance (ESR)-spectroscopy. The conversion process from polysilane into polycarbosilane is described in terms of the results of the performed investigations and a model of the process is developed. Differences between this conversion process and those for chlorine free polysilanes or polycarbosilanes previously described by other authors are discussed.

Synthese von Chlorinen aus dem roten Blutfarbstoff Hämin

Synthesis of Chlorins from the Red Blood Pigment HemeHydroxyalkylporphyrins rac‐8h, k and rac‐9h, k prepared from the readily accessible red blood pigment heme can be transformed into the geminally dialkylated chlorins rac‐10–13 upon reaction with N,N‐dimethylacetamide dimethyl acetal. The chlorins are promising candidates for application in Photodynamic Tumor Therapy (PDT). The reported synthetic method should be useful for the synthesis of natural hydroporphyrins containing geminally dialkylated structural parts.

REGIOSELECTIVE PHOTOREDUCTION OF ZINC(II) PORPHYRINS TO GIVE CHLORINS

The ascorbic acid/organic base photoreduction of zinc(II) porphyrins was investigated. It was established that certain substituents can direct the photoreduction to the site of the macrocycle to which they are attached. For example, zinc(II) vinylporphyrins (8, 12, 16, 20) are photoreduced with cis stereochemistry on the ring bearing the vinyl group to give the corresponding chlorins. Zinc(II) acetylporphyrins (22, 24) were likewise reduced to chlorins such that cis-hydrogenation took place on the ring bearing the acetyl group. Zinc(II) formylporphyrins 33 also appear to reduce at the ring bearing the formyl group. When the zinc(II) acrylic porphyrin 28 was photoreduced, reduction did take place at the ring bearing the acrylic side chain, but migration of the acrylate double bond was very rapid, and the product isolated was the corresponding porphyrin propionate 30. Reduction of a zinc(II) porphyrin 35 bearing both a vinyl group and a nuclear carboxylic ester took place at the ring bearing the carboxylic ester. The reaction provides a general method for regioselective synthesis of chlorins from zinc(II) porphyrins without any evidence of formation of over-reduction products characteristic of many other procedures for formation of chlorins from porphyrin precursors.