Synthesis Of Chiral Catalysts Research Articles

Organocatalytic Atroposelective Construction of Pentatomic Heterobiaryl Diamines through Arylation of 5-Aminoisoxazoles with Azonaphthalenes.

An efficient catalytic asymmetric Michael-type reaction of azonaphthalenes with 5-aminoisoxazoles has been developed. The reaction was based on the utilization of a chiral phosphoric acid as the catalyst, delivering a large panel of axially chiral heterobiaryl diamines in generally good yields with excellent enantioselectivities. The gram-scale reaction and postmodification of the chiral product demonstrated their potentials in the synthesis of chiral catalysts and ligands. This approach not only provides a useful method for the construction of pentatomic heterobiaryl scaffolds but also offers new members to the axially chiral diamine family with promising applications in synthetic and medicinal chemistry.

The Use of Cinchona Alkaloid Derivatives as Chiral Ligands and Organocatalysts in Asymmetric Catalysis

: Cinchona alkaloids are natural products extracted from cinchona plants, which contain quinine, quinidine, cinchonine, and cinchonidine. During the past 30 years, due to their attractive structural properties, these compounds have been used as chiral skeletons and organocatalysts in asymmetric organic synthesis. In this review, we summarize the applications of cinchona alkaloids derivatives in asymmetric catalysis recently developed by our group, including oxidation, reduction, and C-C bonds formation. These studies have solved some of the problems with the various asymmetric reactions discussed, while also enriching alkaloids chemistry, providing new ideas for the design and synthesis of chiral catalysts, and providing abundant experimental data for the chiral induction process.

Construction of thiocarbonyl (C = S) with inorganic sulfur

The strategy of combining inorganic sulfur sources with carbon sources has been successfully applied in the construction of thiocarbonyl (C = S), which avoids the utilization of traditional sulfuration reagents such as volatile carbon disulfide, highly toxic thiophosgene, malodorous Lawesson reagents et al. and provides a practical and environment-friendly process for the synthesis of thioamides, thiocarbamides, oxazolidinethiones and dithiocarbamates. These convenient methods are effective tools for drug late stage modification, the synthesis of chiral catalysts and material molecules et al.