Synthesis Of Carbazole Derivatives Research Articles

Synthesis and antibacterial activities of novel 1-bromo-2-(6-bromo-1,2,3,4-tetrahydro-9H-carbazol-1-yl) ethanone and 1-bromo-2-(5-bromo-1,2,3-trihydrocyclopenta[b]indole-1-yl) ethanone.

Nitrogen containing hetero cyclic compounds constitute the interior structure of a number of biologically attracted compounds against bacteria and fungi. The synthesis of carbazole derivatives have been desire due to their importance in medicinal field. Enhanced approach of Fischer’s synthesis followed by bromoacetylation have been used to synthesis four different carbazole derivatives, namely 1-bromo-2-(6-bromo-1,2,3,4-tetrahydro-9H-carbazol-1-yl) ethanone, 1-bromo-2-(5-bromo-1,2,3-trihydrocyclopenta[b]indole-1-yl) ethanone. The synthesized compounds were identified and confirmed using spectral techniques Viz, FTIR, 1H NMR, 13C NMR, MASS Spectroscopy. Antibacterial evaluation of synthesized compounds found to have pronozed antibacterial activity.Nitrogen containing hetero cyclic compounds constitute the interior structure of a number of biologically attracted compounds against bacteria and fungi. The synthesis of carbazole derivatives have been desire due to their importance in medicinal field. Enhanced approach of Fischer’s synthesis followed by bromoacetylation have been used to synthesis four different carbazole derivatives, namely 1-bromo-2-(6-bromo-1,2,3,4-tetrahydro-9H-carbazol-1-yl) ethanone, 1-bromo-2-(5-bromo-1,2,3-trihydrocyclopenta[b]indole-1-yl) ethanone. The synthesized compounds were identified and confirmed using spectral techniques Viz, FTIR, 1H NMR, 13C NMR, MASS Spectroscopy. Antibacterial evaluation of synthesized compounds found to have pronozed antibacterial activity.

Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers

Novel topoisomerase II (Topo II) inhibitors have gained considerable interest for the development of anticancer agents. In this study, a series of carbazole derivatives containing chalcone analogs (CDCAs) were synthesized and investigated for their Topo II inhibition and cytotoxic activities. The results from Topo II mediated DNA relaxation assay showed that CDCAs could significantly inhibit the activity of Topo II, and the structure-activity relationship indicated the halogen substituent in phenyl ring play an important role in the activity. Further mechanism studies revealed that CDCAs function as non-intercalative Topo II catalytic inhibitors. Moreover, some CDCAs showed micromolar cytotoxic activities. The most potent compound 3h exhibited notable growth inhibition against four human cancer cell lines. Flow cytometric analysis revealed that compounds 3d and 3h arrested the HL-60 cells in sub G1 phase by induction of apoptosis. It was further confirmed by Annexin-V-FITC binding assay. Western blot analysis revealed that compound 3h induces apoptosis likely through the activation of caspase proteins.

Synthesis of Carbazole derivatives with Two-photon absorption via Solid-state method and Optical storage application

Synthesis of Carbazole derivatives with Two-photon absorption via Solid-state method and Optical storage application

Synthesis of carbazole derivatives with high quantum yield and high glass transition temperature

A series of fluorescent compounds derived from carbazole were synthesized via the Wittig–Horner reaction. The compounds had high glass transition temperatures ( T g), in the region of 172–232 °C, and high decomposition temperatures ( T d), ranging from 456 to 491 °C. The derivatives showed very high fluorescence efficiency in solution, with fluorescence quantum yields in the range of 0.88–1.00. The substituent effects on fluorescence emission differed between solution and solid state. In dichloromethane solutions, the substituents had only a minimal effect on the maximum emission wavelength of the compounds with the same bridge.

ChemInform Abstract: Transition Metal Complexes in Organic Synthesis. Part 31. A Novel Molybdenum‐Mediated Synthesis of Carbazole Derivatives: Application to the Total Synthesis of Mukonal and 1,1′‐Bis(2‐hydroxy‐3‐ methylcarbazole).

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: Synthesis of Carbazole Derivatives. Part 3. Synthesis of New Pyrrolidino(3,4‐c)carbazoles by Intramolecular Michael Addition.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis of carbazole derivatives — III. Synthesis of new pyrrolidino[3,4-c]carbazoles by intramolecular Michael addition

We have reported on the synthesis of carbazoles by inter- and intramolecular Michael addition. 1 Ellipticine derivatives are related to these compounds, and especially those with 9-methoxy- and 9-hydroxy substituents exhibit appreciable antitumor and antileukemic activity. 2 Therefore, we have prepared the tetrahydrocarbazoles 7a and 7b, starting from N-benzyl-2-formyl-5-methoxyindole ( 2a) and N-benzyl-2-formyl-7-methoxyindole ( 2b), respectively.

Photochemical synthesis of carbazole derivatives

Abstract The preparation of the dione 3 from ethyl-1,3-acetonedicarboxylate (11) is described. Its condensation with various aniline derivatives has been studied. The arylenaminoketone 5b was photocyclized and converted into the new carbazole 8.

Photochemical Synthesis of Carbazole Derivatives

Photochemical Synthesis of Carbazole Derivatives

ChemInform Abstract: Transition Metal‐Mediated Synthesis of Carbazole Derivatives

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: Synthesis of Carbazole Derivatives. Part 1. Reaction of 3‐(2‐ Nitroethenyl)‐indole‐2‐malonic Acid Esters with Michael‐Acceptors.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: Synthesis of Carbazole Derivatives. Part 2. C‐2‐Substituted Indoles as Intermediates of Pyrrolino(3,4‐c)carbazoles.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

The Stobbe Condensation with Indolyl‐3‐aldehyde. A synthesis of carbazole derivatives

AbstractThe condensation of indolyl‐3‐aldehyde with either dimethyl‐, or dimethyl methylsuccinate in the presence of potassium t‐butoxide gave predominatly the (E)‐half esters 1a and 1b, whose configuration is inferred by cyclisation with sodium acetate in acetic anhydride to the corresponding carbazole derivatives 2. Hydrolysis of the above half esters gives the corresponding acids 1c and 1d, which can be converted to the anhydrides 3.