Synthesis Of Bioactive Glass Research Articles

Using the Extraction–Pyrolysis Method in Synthesis of Bioactive Glass

Using the Extraction–Pyrolysis Method in Synthesis of Bioactive Glass

Engineering the surface functionality of 45S5 bioactive glass-based scaffolds by the heterogeneous nucleation and growth of silver particles

An emerging topic in the field of biomaterials is the incorporation of silver ions, metallic silver or silver oxides into bioactive glasses to impart novel functionalities. In this work, a new approach of surface functionalization of 45S5 bioactive glass (BG) is introduced. In contrast to more common methods, which are based on the inclusion of silver during the sol–gel synthesis of BG, our method allows the surface functionalization of BG powders and BG scaffolds after their preparation. Hereby, we demonstrate the transferability of a previously reported approach on the wet chemical synthesis of cup-like and dendritic silver patches first from colloidal silica particles to BG particles and further to macroscopic highly porous BG scaffolds which were prepared by the sacrificial foam replica technique. The time-dependent silver releases of BG scaffolds with different silver loadings into simulated body fluid (SBF) were measured. Further studies were addressed to investigate the bioactivity of BG scaffolds before and after the silver coating procedure. It was found the silver deposition on 3D BG scaffolds did not affect the formation of crystalline hydroxyapatite during immersion into simulated body fluid.

Rice husk derived bioactive glass-ceramic as a functional bioceramic: Synthesis, characterization and biological testing

Bioactive glasses represent a class of attractive materials in bone reconstruction. This study describes the detailed preparation and characterization of a silicate-based bioactive glass-ceramic (R-SBgC). Synthesis of bioactive glasses using the sol–gel method has advantages compared to the melting method. However, expensive raw materials are required and pose a major issue. To overcome this, R-SBgC was synthesized via the sol–gel method using Rice Husk (RH) as a natural silica precursor. The RH was heat treated and used as an alternative to tetraethyl orthosilicate (TEOS), which is a common synthetic silica precursor. X-ray diffraction (XRD), X-ray Fluorescence (XRF) and Scanning Electron Microscopy (SEM) were used to characterize the rice husk ash (RHA). The findings reveal that the extracted silica has a high purity (~99%). The synthesized R-SBgC powder was characterized using SEM, Energy Dispersive X-ray Analysis (EDX), XRD, XRF and Fourier-Transform Infrared Spectroscopy (FTIR) to complete the morphological and elemental analysis. Moreover, in vitro bioactivity via an immersion assessment was conducted for up to 14 days. The HA layer formation, which is an indicator of the bioactivity on the surface of the R-SBgC, was confirmed using SEM, EDX and further by FTIR. Biocompatibility of the R-SBgC was evaluated in vitro. After 3 days of human bone marrow stromal cell (hBMSC) seeding, SEM analysis revealed cell attachment on the surface of the R-SBgC. Alamar blue and XTT cytotoxic assays demonstrated cell proliferation abilities and the non-cytotoxic effect of the R-SBgC. Altogether, the results demonstrate that prepared rice husk-derived bioactive glass ceramic may be a promising carrier for tissue engineering applications.

Synthesis of Bioactive Glass by Microwave Energy Irradiation and Its In-Vitro Biocompatibility

Bioactive glasses were synthesized in an inexpensive hydrothermal chemical route by the use of microwave energy irradiation. Compositional changes were carried out to synthesis bioactive glass with different Si content. Densification behavior was investigated by microwave sintering process from 700°C to 1000°C temperature. The powders were characterized for their physical and morphological characteristics like degree of crystallinity, crystallization temperature etc. Optimization of the heat treatment of the obtained amorphous powder was carried out. Biocompatibility test of the synthesized materials was carried out by in-vitro investigation by apatite formation behavior investigation by inserting the bioactive glass in simulated body fluid. Mechanical properties like density, compressive strength, hardness etc. were investigated for the dense bioactive glasses depending on the Si content. Apatite formation extent was investigated in SBF in 1 to 3 days.