Synthesis Of Β-phosphonomalonates Research Articles

Synthesis of β-phosphonomalonates using a recyclable choline hydroxide catalyst

Choline hydroxide (ChOH) is an effective ionic liquid (IL) that enables the straightforward construction of β-phosphonomalonates in basic medium. A variety of compounds, including aromatic/heterocyclic and aliphatic aldehydes (1a–p) were reacted with dicyanomethane (2) and diethyl phosphonate (3) to produce the targeted products in good yields (4a–p). The constructed compounds as well as the IL were characterized using spectral 1H, 13C, and 31P NMR.

Mesoporous titania–ceria mixed oxide (MTCMO): a highly efficient and reusable heterogeneous nanocatalyst for one-pot synthesis of β-phosphonomalonates via a cascade Knoevenagel–phospha-Michael addition reaction

Mesoporous titania–ceria mixed oxide (MTCMO) was synthesised in a sol–gel method using cerium chloride and titanium isopropoxide (TTIP) as CeO2 as well as TiO2 precursors and sodium dodecyl sulphate (SDS) as a structure-directing agent and its application was evaluated in the synthesis of aromatic β-phosphonomalonate derivatives via cascade Knoevenagel–phospha-Michael addition reaction. The catalyst characterised by various techniques like FT-IR spectroscopy, XRD, SEM, EDS, TEM and N2 adsorption-desorption. Partial substitution of Ti4+ cations with Ce4+ improved the BET surface area because TiO2 crystallites were suppressed to be grown. Furthermore, as a consequence of charge imbalance in the obtained Ti-O-Ce solid solution, some oxygen vacancies have generated that act as Lewis base sites while cations (Ti and Ce) around the oxygen vacancies act as Lewis acid sites. Reusability up to eight consecutive runs without significant decrease in reactivity, Mild reaction conditions, environmentally benign and compatibility with various functional groups are some of the advantages of this work.

LiBr-catalyzed one-pot three-component domino strategy toward the construction of β-phosphonomalonates scaffolds in aqueous conditions

LiBr-mediated domino Knoevenagel-phospha-Michael strategy has been established for the synthesis of β-phosphonomalonates under aqueous conditions. It is noteworthy that the developed protocol is effective with a wide range of aldehydes to deliver a diverse range of β-phosphonomalonates in good to excellent yields. The mild reaction conditions, easier procedure, use of aqueous media, inexpensive and water tolerant property of LiBr are important advantages of this protocol.

Synthesis of β-Phosphonomalonates with Pyridine-Grafted Graphene Oxide

Synthesis of β-Phosphonomalonates with Pyridine-Grafted Graphene Oxide