Synthesis Of 8-hydroxyquinoline Research Articles

8-Hydroxyquinoline Glycoconjugates Containing Sulfur at the Sugar Anomeric Position-Synthesis and Preliminary Evaluation of Their Cytotoxicity.

One of the main factors limiting the effectiveness of many drugs is the difficulty of their delivery to their target site in the cell and achieving the desired therapeutic dose. Moreover, the accumulation of the drug in healthy tissue can lead to serious side effects. The way to improve the selectivity of a drug to the cancer cells seems to be its conjugation with a sugar molecule, which should facilitate its selective transport through GLUT transporters (glucose transporters), whose overexpression is seen in some types of cancer. This was the idea behind the synthesis of 8-hydroxyquinoline (8-HQ) derivative glycoconjugates, for which 1-thiosugar derivatives were used as sugar moiety donors. It was expected that the introduction of a sulfur atom instead of an oxygen atom into the anomeric position of the sugar would increase the stability of the obtained glycoconjugates against untimely hydrolytic cleavage. The anticancer activity of new compounds was determined based on the results of the MTT cytotoxicity tests. Because of the assumption that the activity of this type of compounds was based on metal ion chelation, the effect of the addition of copper ions on cell proliferation was tested for some of them. It turned out that cancer cells treated with glycoconjugates in the presence of Cu2+ had a much slower growth rate compared to cells treated with free glycoconjugates in the absence of copper. The highest cytotoxic activity of the compounds was observed against the MCF-7 cell line.

Corrosion Analysis of Mild Steel in Sulphuric Acid Using 8-Hydroxy Quinoline and Pyridine N-Oxide as Inhibitors

Inhibition of corrosion of mild steel material in sulphuric acid medium has been tried with many synthetic and green inhibitors. Each inhibitor has its own merits and limitations. The present study aims at the synthesis of 8-Hydroxy Quinoline (8HQ) and Pyridine N-Oxide (PyNO) and the study of their inhibition behaviour on the corrosion of mild steel in 2 N sulphuric acid. The inhibition behaviour of the synthesised compounds was studied by subjecting to weight loss measurements, polarisation studies and electrochemical impedance spectra (EIS) for the assessment of their performance. The studies were made with 2 N sulphuric acid as the corroding medium, but with the inhibitor concentration in the range of 50 -350 ppm. The results revealed that the inhibitors studied perform better in the medium and function by the mechanism of adsorption onto the metal surface.

Synthesis of 8-Hydroxyquinolines by the Cyclization ofm-Hydroxyphenethyl KetoneO-2,4-Dinitrophenyloximes

8-Hydroxyquinolines are synthesized from O-2,4-dinitrophenyloximes of m-hydroxyphenethyl ketones by the treatment with sodium hydride, and then with 2,3-dichloro-4,5-dicyano-p-benzoquinone (DDQ).

ChemInform Abstract: Investigation of the Single‐Stage Synthesis of 8‐Hydroxyquinoline.

ChemInform Abstract: Investigation of the Single‐Stage Synthesis of 8‐Hydroxyquinoline.

Synthesis of 8-hydroxyquinoline from quinoline and its purification

Synthesis of 8-hydroxyquinoline from quinoline and its purification

On the Synthesis of 8-Hydroxyquinoline

Abstract 1) 8-Sulfoquinoline has been obtained with a yield of 80.3% by sulfonating quinoline with 50% oleum at 140°C for 2 hrs. 2) 8-Hydroxyquinoline has been synthesized by fusing 1 mole of 8-sulfoquinoline with 9 moles of NaOH at 300-315°C for 10 to 15 minutes, decomposing the with dilute sulfuric acid, neutralizing with sodium hydroxide and soda to a pH 7.2, and by distilling with steam for 1.5 hrs. The remaining 8-hydroxyquinoline in the residue and in the filtrate was collected in the form of its copper salt. The highest yield of 8-hydroxyquinoline including its copper salt was 84.14%. 3) Copper 8-hydroxyquinolinate has been obtained with a yield of nearly 100% by heating 8-hydroxyquinoline with 0.86 times its weight of crystalline copper sulfate together with a large quantity of water at 80° to 100°C.