Synthesis Of Substituted Quinolines Research Articles

Ruthenium complexes of redox non-innocent aryl-azo-oximes for catalytic α-alkylation of ketones and synthesis of 2-substituted quinolines

In this work we demonstrated the synthesis, characterisation and catalytic applications of Ru(ii)–azooximato complexes. This is the first report where arylazooximato complexes of a transition metal are used in catalytic C–C bond formation reactions.

Mn(OAc)3-Mediated One-Pot Condensation-Oxidative Annulation of 2-Alkynylanilines and 1,3-Ketoesters: Synthesis of 2-Substituted Quinolines.

A general protocol for oxidative annulation was developed for the preparation of 2-methyl-3,4-diacylquinolines directly from 2-alkynylanilines and 1,3-ketoesters. The reactions were mediated by Mn(OAc)3 in acetic acid at room temperature, which led to the desired quinoline products in one-pot in low to good overall yields on a wide range of substrates. The current method was convenient to conduct and proceeded under mild conditions in short reaction times.

Synthesis of 2-substituted quinolines from alcohols

A facile and economic method for the construction of 2-substituted quinolines by AgOTf-catalyzed 2-aminobenzyl alcohol and alkyne/ketone or 2-aminophenethyl alcohol and aldehyde has been developed. The electronic properties of the substituents on the alkyne, ketone, and aldehyde were investigated. It was found that molecules with both electron-donating and -withdrawing substituents were perfectly suitable substrates for this transformation, and the expected products were obtained in moderate to excellent yields. Moreover, the use of inexpensive starting materials and environmentally benign oxidants makes this atom efficient method particularly attractive.

Dowex-50W Promoted Friedländer Synthesis of Substituted Quinolines under Solvent-Free Conditions

Dowex-50W Promoted Friedländer Synthesis of Substituted Quinolines under Solvent-Free Conditions