Synthesis Of 2-substituted Benzothiazoles Research Articles

Ultrasound-assisted efficient and green synthesis of 2-substituted benzothiazoles under solvent-free condition using recyclable sulfated tungstate

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the synthesis of 2-substituted benzothiazoles. The corresponding benzothiazoles were obtained using a condensation reaction of 2-aminothiophenol with various aldehydes under ultrasound irradiation at room temperature. Various functional groups on the 2-aminothiophenol as well as on the aldehydes were tolerated to provide 2-substituted benzothiazoles derivatives in excellent yields. The faster reaction rate, solvent-free or mild reaction conditions, wide functional group compatibility, excellent yields, easy work-up procedure, and excellent catalyst recyclability are the advantages of this protocol. These advantages make this process more practicable, cost-effective, and environmentally benign.

ZnO-NPs catalyzed condensation of 2-aminothiophenol and aryl/alkyl nitriles: Efficient green synthesis of 2-substituted benzothiazoles

The synthesis of 2-substituted benzothiazoles has been described using ZnO-nanoparticles as a catalyst. The condensation of 2-aminothiophenol and aryl/alkyl nitriles resulted in the formation of various 2-substituted benzothiazoles under solvent-free reaction conditions. The library of 2-substituted benzothiazoles has been synthesized in good to excellent yield. The reaction has shown a wide range of functional group compatibility for both varyingly substituted 2-aminothiophenols and nitriles. The protocol has many advantages such as faster reaction rate, mild reaction conditions, various functional group compatibility, excellent yield, solvent-free reaction conditions, easy recovery of materials, and excellent catalyst recyclability, among others. The various advantages of this protocol make it a more feasible, economical, and environmentally benign process.

Riboflavin as Photoredox Catalyst in the Cyclization of Thiobenzanilides: Synthesis of 2-Substituted Benzothiazoles.

Benzothiazoles are synthesized from thiobenzanilides using riboflavin as a photosensitizer and potassium peroxydisulfate as a sacrificial oxidizing agent under visible light irradiation. The methodology accepts a broad range of functional groups and affords the 2-substituted benzothiazoles by transition-metal-free organic photoredox catalysis under very mild conditions.

KF-Al2O3 as a Base Heterogeneous Catalyst for the Synthesis of 2-Substituted Benzoxazoles and Benzothiazoles under Mild Reaction Conditions at Room Temperature

A convenient synthesis of 2-substituted benzothiazoles and benzoxazoles from the reaction o-aminophenol or o-aminothiophenol with acyl chlorides or acid anhydrides has been accomplished. The various carboxylic acid derivatives were reacted with o-aminophenol or o-aminothiophenol in the presence of KF-Al2O3 as a base heterogeneous catalyst to form correspondence benzothiazoles and benzoxazoles in high yields, and the catalyst showed a good recyclability.

Progress in 2-Position Functionalized Synthesis of 2-Substitutedbenzothiazoles

2-取代苯并噻唑类衍生物在化工、医药、农业等领域具有广泛的应用价值.2-位官能团化是合成2-取代苯并噻唑化合物的一种便捷、有效的合成方法.综述了苯并噻唑2-位的烷基化、酰基化、芳基化、胺基化以及磷酸化等产物的合成方法并进行了归类和分析，同时对其发展进行了展望.

ChemInform Abstract: Acceptorless Dehydrogenative Synthesis of Benzothiazoles and Benzimidazoles from Alcohols or Aldehydes by Heterogeneous Pt Catalysts under Neutral Conditions.

Pt/Al2O3 and Pt/TiO2 were effective catalysts for the synthesis of 2-substituted benzothiazoles and benzimidazoles from 2-aminothiophenol and 1,2-phenylenediamine with alcohols or aldehydes under acceptor-free and additive-free conditions.

ChemInform Abstract: Room‐Temperature Ligand‐Free Pd/C‐Catalyzed C—S Bond Formation: Synthesis of 2‐Substituted Benzothiazoles.

ChemInformVolume 45, Issue 49 Heterocyclic Compounds ChemInform Abstract: Room-Temperature Ligand-Free Pd/C-Catalyzed C—S Bond Formation: Synthesis of 2-Substituted Benzothiazoles. Yannan Cheng, Yannan Cheng Key Lab. Org. Synth., Coll. Chem. Chem. Eng., Soochow Univ., Suzhou 215123, Peop. Rep. ChinaSearch for more papers by this authorQian Peng, Qian Peng Key Lab. Org. Synth., Coll. Chem. Chem. Eng., Soochow Univ., Suzhou 215123, Peop. Rep. ChinaSearch for more papers by this authorWeigang Fan, Weigang Fan Key Lab. Org. Synth., Coll. Chem. Chem. Eng., Soochow Univ., Suzhou 215123, Peop. Rep. ChinaSearch for more papers by this authorPixu Li, Pixu Li Key Lab. Org. Synth., Coll. Chem. Chem. Eng., Soochow Univ., Suzhou 215123, Peop. Rep. ChinaSearch for more papers by this author Yannan Cheng, Yannan Cheng Key Lab. Org. Synth., Coll. Chem. Chem. Eng., Soochow Univ., Suzhou 215123, Peop. Rep. ChinaSearch for more papers by this authorQian Peng, Qian Peng Key Lab. Org. Synth., Coll. Chem. Chem. Eng., Soochow Univ., Suzhou 215123, Peop. Rep. ChinaSearch for more papers by this authorWeigang Fan, Weigang Fan Key Lab. Org. Synth., Coll. Chem. Chem. Eng., Soochow Univ., Suzhou 215123, Peop. Rep. ChinaSearch for more papers by this authorPixu Li, Pixu Li Key Lab. Org. Synth., Coll. Chem. Chem. Eng., Soochow Univ., Suzhou 215123, Peop. Rep. ChinaSearch for more papers by this author First published: 20 November 2014 https://doi.org/10.1002/chin.201449132Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume45, Issue49December 9, 2014 RelatedInformation

Pd/C-Catalyzed Synthesis of 2-Substituted Benzothiazoles

Pd/C-Catalyzed Synthesis of 2-Substituted Benzothiazoles

Room-temperature ligand-free Pd/C-catalyzed C-S bond formation: synthesis of 2-substituted benzothiazoles.

The synthesis of 2-substituted benzothiazoles has been achieved via cyclization of o-iodothiobenzanilide derivatives using Pd/C as the catalyst at room temperature. The protocol is ligand-free, additive-free, and high-yielding and involves very mild conditions.

Recent advances in the synthesis of 2-substituted benzothiazoles: a review

Recent advances in various synthetic protocols of 2-substituted benzothiazole derivatives.

Synthesis of 2-Substituted Benzothiazoles from 1-Iodo-2-nitrobenzenes by a Copper-Catalyzed One-Pot Three-Component Reaction

A novel method was developed for synthesizing 2-substituted 1,3-benzothiazoles through a copper-catalyzed, one-pot, three-component reaction of a 1-iodo-2-nitrobenzene with sodium sulfide and an aldehyde.

Visible-light-driven synthesis of 2-substituted benzothiazoles using CdS nanosphere as heterogenous recyclable catalyst

This Letter reports simple, green, and efficient synthesis of mesoporous CdS nanosphere (CdSNS) and its application as heterogeneous catalyst for the synthesis of 2-substituted benzothiazole. We report, for the first time, the synthesis of 2-substituted benzothiazoles from various aryl and alkyl aldehydes under visible light irradiation at room temperature. CdSNS catalyst generated in water demonstrates excellent catalytic activity for both the alkyl and aryl aldehydes, with good recyclability. The reaction yield is high for the electron-donating and electron withdrawing substituents as well as heterocyclic aldehydes with good turn over number (TON) and turnover frequency (TOF).

Synthesis of 2-Substituted Benzothiazoles with CuO Nanoparticles

Synthesis of 2-Substituted Benzothiazoles with CuO Nanoparticles

Iodine-Mediated Intramolecular Oxidative Cyclization of 2-(Styrylthio)anilines: Synthesis of 2-Substituted Benzothiazoles

A novel metal-free iodine-mediated intramolecular oxidative cyclization protocol is presented, which allows for the preparation of various 2-substituted benzothiazoles.

ChemInform Abstract: Synthesis of 2-Substituted Benzothiazoles from 2-Fluorophenyl Isothiocyanate.

ChemInform Abstract: Synthesis of 2-Substituted Benzothiazoles from 2-Fluorophenyl Isothiocyanate.

Perchloric Acid–Doped Polyaniline as an Efficient and Reusable Catalyst for the Synthesis of 2-Substituted Benzothiazoles

2-Substituted benzothiazoles have been efficiently synthesized in good yields by the condensation reaction of o-aminothiophenol with aldehydes in the presence of a catalytic amount of perchloric acid–doped polyaniline (HClO4/PANI). The low cost, simple recovery, and efficient reusability are remarkable characteristics of this catalyst.

Synthesis of 2-Substituted Benzothiazoles Containing Amino Acid, Imino or Heteroaryl Moieties with Anticipated Fungicidal Activity

2-Aminothiophenol reacted with cyanoacetic acid derivatives to form 2-substituted benzothiazoles, which were used for further cyclization to yield quinoline, pyrazole or dihydropyridine derivatives.

Synthesis of 2-Substituted Benzothiazoles from 2-Fluorophenylisothiocyanate

Abstract Treatment of 2-fluorophenylisothiocyanate with a Grignard reagent, followed by base-induced cyclization of the resulting thioamide, provides a convenient method of synthesizing 2-substituted benzothiazoles. Best results are obtained upon isolation and purification of the intermediate thioamide, but a direct one-pot isothiocyanate-to-benzothiazole transformation has also been achieved.

Cyclization ofo-(Methylthio)-anilides with Phosphonitrile Dichloride; Synthesis of 2-Substituted Benzothiazoles

Cyclization of<i>o</i>-(Methylthio)-anilides with Phosphonitrile Dichloride; Synthesis of 2-Substituted Benzothiazoles