Pineapple is a sub-tropical fruit grown in India, Bangladesh, Malaysia, Sri Lanka, Maldives and many more. It has a juicy taste and flavour and has been used from the historical ages and used for different purposes like cardiovascular effects, antianginal, wound healing, anticancer, osteoarthritis, antidiarrheal, and anti-aging properties. There are different important phytoconstituents available in different parts of pineapple like root, peel, core, and leaves like flavonoids, terpenoids, glycosides, carbohydrates, amino acids, and many more. Most important is Bromelain which is a very good enzyme having proteolytic activity, burn wound healing activity, and good digestive properties. Due to enormous uses in versatile pharmacological profiles, there are numerous formulations that have also been discovered. These formulations are overcoming the side effects of synthetic drugs and playing a crucial role in herbal drug technology. Bromelain is a complex enzyme and different amino acids are present in it. Many researchers are trying to isolate and are trying to establish unknown pharmacological activity. The pineapple is a magic fruit and many more are yet to be discovered.