Synergistic Relationship Research Articles

Nonlinear and synergistic effects of demographic characteristics on urban polycentric structure using SHAP

Polycentric urban development is promoted by urban planners and policy makers for its perceived benefits of alleviating urban issues. Theoretically, a polycentric urban structure is formed when different demographic groups present a collection of diverse and unique housing location preferences. Yet, only limited empirical studies have fully captured the complex effects of demographic characteristics on urban polycentric structures. Our study utilizes detailed demographic data and employs interpretable machine learning models to elucidate the nonlinear and synergistic relationship between demographic characteristics and the urban polycentric structure in the context of a city of 10 million population in China. When characterizing urban centers, the three most important demographic groups are young females, senior married couples, and middle-aged single individuals with basic education. Each urban center presents distinctive demographic compositions; for instance, middle-aged married individuals exerting a stronger influence in certain contexts, whereas in senior resident groups, married individuals have a more pronounced impact. Spatial heterogeneity is observed in the demographic profiles of urban centers; for instance, primary central cores are predominantly young, single females, whereas peripheral and secondary centers have stronger presence of highly educated residents.

Techno-enviro-economic assessment of hydropower-driven decarbonization pathways for Nepalese cement industry

This study presents a comparative techno-enviro-economic assessment of decarbonization measures for the Nepalese cement sector, focusing on post-combustion carbon capture (PCC), use of alternative fuels and oxy-combustion techniques. A typical Nepalese clinker plant is first modelled in Aspen Plus using industrial data, the results of which is then utilized to simulate various decarbonization pathways. Performance of the measures is evaluated based on four performance indicators. The combination of oxy-combustion with hydrogen as fuel (25% thermal substitution rate) is identified as a favorable pathway compared to PCC only and combination of refuse derived fuel and PCC pathways. However, this pathway is sensitive to hydrogen byproduct price. The levelized cost of clinker (LCOC), CO2 abatement cost (CAC), specific electricity consumption for avoided CO2 and carbon intensity for this pathway are 145 USD/tclinker, 98 USD/tCO2, 1.88 MWh/tCO2 and 100 kgCO2/tclinker respectively. The LCOC value for the reference clinker plant without decarbonization is 75 USD/tclinker. The electricity consumption increased by 2153.80%, and the emissions rate decreased by 88%, compared to the reference clinker plant. Capacity utilization rates above 80% are favorable for decarbonization. Sensitivity analysis showed that a 30% decrease in the hydroelectricity cost would lower the LCOC and CAC from base values by 21.160% and 42.379% respectively. Similarly, increasing the tariff rebate to 30% would lower the LCOC and CAC for this case by 12.447% and 24.928% respectively. The results highlight a synergistic relationship between cement industry decarbonization and hydroelectricity utilization, both key targets of Nepal for net zero pathway.

Ion selective rapid transport enabled by functionalized CeO2/LiX zeolite modified separator in high performance lithium sulfur batteries

With regard to the issues in the application of lithium sulfur batteries (LSBs), for instance, the low-rate performance due to the difficulty in Li+/S2-n diffusion, and the poor cycling stability caused by lithium dendrites and polysulfide shuttle. This work reports a unique strategy for protecting lithium anode, that is, using the “size sieving” and “Donnan effect” of CeO2/LiX modified separator to simultaneously regulate the transfer behavior of Li+/S2-n based on the differences in size and charge. The CeO2, which is carefully constructed with oxygen defects, together with the negatively charged properties of zeolite framework, exhibits a synergistic relationship in controlling the flux and diffusion rate of Li+ and suppressing the polysulfide shuttling, which is confirmed by the experimental and theoretical investigations. As a result, the symmetric cell assembled with CeO2/LiX modified separator achieves stable cycling for 5000 h at 5 mA cm−2 and 5 mA h cm−2, and a deep Li stripping/plating for more than 2000 h at 10 mA h cm−2. The corresponding full battery shows a competitive areal capacity of 4.7 mA h cm−2 under a high sulfur loading of 4.0 mg cm−2. This strategy offers a low-cost solution to achieve the practical application of LSBs.

Discovery of the synergy between sulindac and NO expands the application of NSAIDs in cardiac complications

Cardiac inflammation, a pathological cornerstone in cardiac dysfunction, triggers diastolic impairment, leading to profound myocardial hypoxia. This hypoxic state serves as a potent stimulus for the amplification of inflammatory mediator release, ultimately limiting the therapeutic potential of monotherapies. To address this challenge, compounds that integrate non-steroidal anti-inflammatory drugs (NSAIDs) with nitric oxide (NO) donors was synthesized. The in vitro screening unveiled the remarkable anti-hypoxic inflammatory injury activity of a sulindac derivative, despite its suboptimal COX-2 inhibition when comparing with other NSAIDs derivatives. This revelation propelled us to delve deeper into the intricate synergistic relationship between sulindac and NO. Employing two-way ANOVA and high-throughput screening technique, we incontrovertibly confirmed their synergism. Further, the underlying mechanism was unmasked through the detection of signal molecule release levels and western blot analysis. In a definitive step, we evaluated the therapeutic effects of sulindac and its derivatives in vivo, leveraging a rat model that recapitulates cardiac inflammation coupled with hypoxia. Our findings herald a promising drug candidate and establish a foundation for the expanded utilization of NSAIDs in the intricate landscape of cardiovascular diseases.

AI-powered financial crime prevention with cybersecurity, IT, and data science in modern banking

Financial crime in modern banking has evolved significantly with the digital transformation of financial services, presenting unprecedented challenges to traditional prevention methods. This comprehensive review examines the integration of artificial intelligence (AI), cybersecurity frameworks, and data science methodologies in combating financial crime within the banking sector. We analyze the current state of AI-powered solutions, including machine learning models, real-time detection systems, and advanced analytics frameworks that have transformed financial crime prevention. The review synthesizes findings from recent studies and industry implementations, highlighting the synergistic relationship between AI technologies and cybersecurity measures in creating robust defense mechanisms. Our analysis reveals that while AI-powered solutions demonstrate superior detection rates and reduced false positives compared to traditional methods, significant challenges remain in areas of data privacy, regulatory compliance, and system integration. The paper concludes by identifying critical research gaps and proposing future directions for enhancing the effectiveness of AI-based financial crime prevention systems. This review provides valuable insights for researchers, banking professionals, and policymakers working at the intersection of AI, cybersecurity, and financial crime prevention.

THE role of Artificial Intelligence in industry 5.0: Enhancing human-machine collaboration

The emergence of Industry 5.0 marks a transformative shift in the manufacturing landscape, emphasizing a synergistic relationship between humans and machines. This paper explores the pivotal role of Artificial Intelligence (AI) in enhancing human-machine collaboration within this paradigm. By leveraging AI technologies, industries can foster a more personalized, efficient, and innovative work environment. AI systems facilitate seamless communication and decision-making processes, thereby augmenting human capabilities rather than replacing them. This collaboration allows for the optimization of workflows, reduction of operational risks, and enhancement of product quality through advanced predictive analytics and real-time data processing. Furthermore, the integration of AI in Industry 5.0 supports sustainability initiatives by minimizing waste and energy consumption, aligning with the global push for greener manufacturing practices. Case studies demonstrate the successful implementation of AI-driven solutions across various sectors, showcasing improvements in productivity and employee satisfaction. As Industry 5.0 continues to evolve, the interplay between AI and human labour will redefine traditional roles, empowering workers with augmented intelligence tools. The findings indicate that embracing AI not only enhances operational efficiency but also contributes to a more resilient and adaptive workforce. Ultimately, this paper posits that the future of industry lies in the harmonious collaboration between human intellect and artificial intelligence, which together will drive innovation, productivity, and sustainable practices in the manufacturing sector.

Alvar Aalto and his three Italian collaborators: cultural cross-pollination and architectural legacy

This article delves into the synergistic relationship between Alvar Aalto and his three Italian collaborators: Leonardo Mosso, Federico Marconi, and Vezio Nava. By examining their contributions, experiences, and professional trajectories, the paper sheds light on the significance of the Italian influence on the Finnish architect and challenges misconceptions surrounding the organisation of his architectural studio. Interviews with the three Italian architects provide insights into their early interest in Aalto's work, the trajectories that brought them to Finland, and their roles within the atelier. The article also explores the process behind Aalto's architectural projects, emphasising his approach to nurturing creativity and his collaborative and empowering nature. Additionally, it investigates the lasting impact of Aalto on the three Italian architects, their subsequent careers, and their efforts to promote and preserve Aalto's architectural legacy in Italy. Finally, the study highlights the enduring significance of the relationship between Aalto and his Italian colleagues for contemporary architects and designers.

Integrated assessment of farm-level mitigation measures for gaseous emissions

ContextSome gaseous emissions continue to pose a serious threat to human health and the environment locally, regionally and globally. This has resulted in several studies advocating for the implementation of mitigation measures to reduce the emissions of harmful gases. ObjectiveWhile the vast majority of studies focus on a single type of gas, much less attention has been paid to the complementary or conflicting effects of mitigation measures across multiple harmful gaseous emissions dimensions. MethodsTo address this research gap, this study uses Irish farm-level data to assess the holistic costs and benefits of a suite of mitigation measures that have the potential to abate greenhouse gases, ammonia or both. A cost-benefit analysis framework is employed to assess the impact of the mitigation measures across five different farm system types. Results and conclusionsResults indicate that the relative effectiveness of the mitigation measure varies depending on the gaseous emission dimension being examined. SignificanceAnalyses that fail to account for such synergistic and antagonistic relationship impacts may lead to flawed policy decisions.

Community-Based Nursing and Public Health: A Synergistic Approach to Health Promotion

Community-based nursing and public health are pivotal in addressing the complex health needs of populations, particularly in underserved and vulnerable communities. This article examines the synergistic relationship between these fields and their collective impact on health promotion. Employing a mixed-methods approach, the study combines qualitative insights from community-based nurses with quantitative analysis of health outcomes in three diverse communities. Results indicate that collaboration between community-based nursing and public health improves health literacy, enhances access to care, and reduces preventable health disparities. Key challenges, such as resource constraints and workforce shortages, are discussed alongside opportunities for leveraging technology and policy support to strengthen these partnerships. The findings underscore the transformative potential of integrating nursing expertise with public health strategies to achieve sustainable health outcomes.

Communication Capacities and Mutual Connection System of Teachers in Public Elementary Schools

This study examined the communication capabilities and mutual connection system of public elementary school teachers in the Davao Central District, Division of Davao City. A universal sampling method was employed using a non-experimental quantitative research design with a correlational approach. The respondents were 132 public elementary school teachers. Statistical tools utilized included the mean, Pearson Product-Moment Correlation Coefficient (Pearson r), and regression analysis. The findings revealed that the communication capabilities of public elementary school teachers—measured in terms of connections, compelling communication, stability, manners, listening, and charm—were often demonstrated. Similarly, the mutual connection system, assessed through revision, goal achievement, unification, and potential, was also frequently evident. A significant relationship was found between the teachers' communication capabilities and their mutual connection system. Furthermore, specific domains of communication capabilities significantly influenced the mutual connection system. These results underscore the synergistic relationship between communication capabilities and a mutual connection system, where effective communication enhances mutual connections, and a well-structured connection system fosters continuous and efficient communication. Conversely, weaknesses in these areas could result in communication breakdowns, misunderstandings, or diminished group cohesion. The study highlights the importance of fostering both robust communication skills and a supportive connection system among public elementary school teachers to promote collaboration and effectiveness in the educational setting. This study was limited to public elementary school teachers in the Davao Central District, which may affect the generalizability of the findings to other contexts. Future research could explore other educational levels or regions and consider mixed methods to provide deeper insights and validate the results.

Research on the Relationship between the Lotus Cave Art Village and Population Mobility

Rural revitalization has emerged as a key strategic initiative in the new era, with population mobility playing a crucial role in shaping rural development. This study focuses on the art-driven revitalization of Lotus Cave Village, where the interplay between art and the countryside has created a synergistic relationship: art enriches the countryside, and the countryside, in turn, revitalizes art. The research aims to explore the dynamics of population mobility within this context, examining the characteristics and motivations that drive such movement. Through an analysis of the village’s artistic transformation, the study uncovers how population mobility influences and supports rural art initiatives. The findings highlight the role of population mobility in facilitating rural art, and the paper concludes by proposing strategies for the protection and sustainable development of Lotus Cave Art Village, with a focus on leveraging population mobility to enhance cultural preservation and rural vitality.

Greening the dragon: how Malaysian SMEs can achieve SDGs through engaged employees

This research explores the synergistic relationship between sustainable development goals (SDGs) and employee well-being in Malaysian small and medium enterprises (SMEs). We delve into the impact of perceived organizational support (POS), thriving organizational culture, strong organizational commitment, and high-level job satisfaction on achieving ambitious goals like SDG 12: Responsible Consumption and Production and SDG 8: Decent Work and Economic Growth. By unleashing the potential of their workforce, Malaysian SMEs can chart a course towards a greener future, fostering sustainable practices and empowering employees to thrive in the process. This research showed that POS for talent was favorably correlated with organizational culture, based on a survey of 599 employees in Malaysia. Furthermore, there were strong links between organizational culture and job satisfaction, as well as between organizational culture and organizational commitment.

The Driving Factors of the Tradeoff-Synergistic Relationship Among Forest Ecosystem Service Values in the Yangtze River Delta, China

The forest ecosystem is one of the planet’s critical ecosystems. Identifying the tradeoff-synergistic relationships among forest ecosystem service values and exploring their driving factors in the Yangtze River Delta are crucial for promoting the optimal overall benefits of regional ecosystem service values and realizing a mutually beneficial scenario that harmonizes regional socio-economic development with ecological and environmental conservation. The forest ecosystem service value in the Yangtze River Delta was evaluated through the improved equivalent factor method. Furthermore, an examination of the tradeoff-synergistic relationship among these ecosystem service values, along with their driving factors, was performed utilizing both the Pearson correlation coefficient method and the Geodetector model. The findings reveal that from 2000 to 2020, the forest ecosystem service values presented a general growth trend in the Yangtze River Delta, with higher values noted in the southern areas and lower values found in the northern regions. The average annual forest ecosystem service value was 279 billion RMB. The tradeoff-synergistic relationship among forest ecosystem service values mainly showed a synergistic relationship, while a significant tradeoff relationship was observed between the values of support and cultural services. The factors influencing the tradeoff-synergistic relationship among forest ecosystem service values included precipitation, normalized difference vegetation index, and temperature. Consequently, local governments should enhance forest coverage, particularly by expanding the regions of evergreen broadleaf, deciduous broadleaf, and coniferous forests. They should also proactively seek ways to realize the value of forest ecosystem services.

ESG rating and default risk: Evidence from China

Based on the data of Chinese A-share listed companies from 2009 to 2022, this study constructs a bivariate panel vector autoregression (PVAR) model to examine the dynamic equilibrium relationship between default risk and environmental, social, and governance (ESG) performance and its individual dimensions. Results indicate that ESG performance and corporate stability exhibit growth inertia and self-reinforcing mechanisms, with overall ESG performance significantly mitigating default risk. Although no bidirectional causality was found between environmental and governance performance and default risk, corporate stability positively impacts both over time. The findings indicate a synergistic relationship between social performance and default risk, in which strong social performance helps mitigate default risk. Financial stability encourages companies to engage in social responsibility initiatives. Heterogeneity analysis demonstrates that the mitigating effects of ESG performance on default risk are more pronounced for non-state-owned enterprises (non-SOEs) and small- and medium-sized enterprises (SMEs). Social responsibility and corporate governance are more significant in enhancing financial stability in manufacturing firms. These findings provide valuable insights for investors and policymakers in mitigating default risks while promoting the development of green finance.

A Comprehensive Exploration of the Synergistic Relationship between DMSO and Peroxide in Organic Synthesis.

In the realm of organic synthesis, reagents can serve not only as solvents but also as synthons. Dimethyl sulfoxide (DMSO) is recognized for its efficiency in this dual capacity, enabling diverse chemical transformations. DMSO can generate various synthons, including methyl, methylene, methine, oxygen, and methyl sulfoxide, broadening the accessible compound repertoire. Activation of DMSO as a reagent relies heavily on synergies with secondary agents like peroxide, persulfate, or iodine. Recent years have witnessed a surge in innovative synthetic techniques harnessing the synergistic interplay of DMSO and peroxide, leading to environmentally friendly and cost-effective reactions with mild conditions. This review highlights the synergistic effects of DMSO and peroxides (up to 2023), detailing their activation mechanisms and the generation of various synthons, along with numerous reported derivatives. Although this topic has received considerable attention in recent years, there are numerous discrepancies and a plethora of possibilities yet to be explored. We anticipate that this review will significantly support researchers in advancing their innovations to a greater extent in the future.

The interactive effect of the application of accreditation standards (JCIs) and the practice of administrative control in improving the quality of health services: a study on Yemeni hospitals

BackgroundThis study aimed to examine the interactive effect of applying JCI accreditation standards and administrative control in improving the quality of health services in Yemeni hospitals. By examining the synergistic relationship between these two components, this study sought to shed light on how hospitals can improve their performance and achieve sustainable advancements in healthcare quality.MethodsThis study utilized a quantitative research design and collected data from Yemeni hospitals. The sample size was determined via the Krejcie and Morgan table, which provides a recommended sample size on the basis of the population. A total of 310 healthcare professionals were selected through a random sampling technique. Hypotheses were formulated to examine the impact of JCI accreditation standards and administrative control on healthcare quality. Statistical analyses were also conducted to test these hypotheses and determine the interaction effect between the two variables.ResultsThe results confirmed that applying JCI accreditation standards has a statistically significant positive effect on improving the quality of health services in hospitals. Additionally, the practice of administrative control had a statistically significant effect on healthcare quality. Furthermore, there was an interactive effect between the application of JCI accreditation standards and administrative control, indicating that their combined implementation led to even greater improvements in healthcare quality.ConclusionThe significance of this study lies in its potential to inform healthcare policymakers, administrators, and practitioners about the importance of integrating accreditation standards with robust administrative control measures. The findings emphasize the need for hospitals to prioritize both the implementation of accreditation standards and the establishment of effective administrative control systems to ensure the delivery of high-quality healthcare services. This study contributes to the literature by highlighting the interactive impact of these factors and providing insights into their synergistic relationship.

Global Versus Local? A Study on the Synergistic Relationship of Ecosystem Service Trade-Offs from Multiple Perspectives Based on Ecological Restoration Zoning of National Land Space—A Case Study of Liaoning Province

Clarifying the trade-offs and synergies of ecosystem services in Liaoning’s ecological restoration zones is crucial for strengthening the positioning of ecological restoration zones and optimizing ecosystem services. This study is based on “Liaoning Provincial Land Spatial Planning (2021–2035)” and divides the area into ecological restoration zones. We utilized the InVEST model, ArcGIS Pro, and Geoda in this study to quantify five ecosystem services (Soil Conservation, Carbon Storage, Habitat Quality, Water Yield, and Food Production) and constructed an evaluation framework to assess the trade-offs and synergies of ecosystem services at both global and local levels. The conclusions are as follows: (1) The global relationships among ecosystem services in different ecological restoration zones are ranked as: strong trade-offs (35.51%) > weak trade-offs (33.17%) > low synergies (29.09%) > high synergies (2.24%); (2) The area exhibiting synergistic relationships between pairs of local ecosystem services in ecological restoration zones is larger than the area exhibiting trade-offs; (3) The strongest synergy is observed between water yield and soil conservation, while the most significant trade-off occurs between food production and soil conservation. These relationships exhibit similar spatial characteristics in the WSFR, SWCR, and WCR zones; (4) The proportion of areas showing trade-offs and synergies differs between global and local scales.

Exploring the Relationship of Paediatric Nutritional Status with Diarrhoeal Disease in Children Below Two Years of Age.

Background and objective: Paediatric malnutrition has a synergistic relationship with diarrhoea. In children under two years of age, diarrhoea occurs in more than half of malnutrition cases and is associated with increased duration of illness, increased length of hospital stays, increased morbidity, and mortality. A well-established relationship exists between diarrhoeal and various standalone forms of malnutrition, but their association with coexisting forms of malnutrition (CFM) has not yet been investigated. Thus, this study assessed the association of CFM with diarrhoea among Pakistani children using datasets retrieved from Demographic Health & Survey and UNICEF. Study design: A pooled analysis of datasets of Pakistan Demographic & Health Surveys (PDHS) and Multiple Indicator Cluster Surveys (MICS) from the year 2010 to 2018 was conducted. Methods: Data of 70,723 children aged below two years were analysed after excluding those with incomplete anthropometry and outliers. Findings: Of the total study population, this study reported the presence of either diarrhoea or malnutrition or both in over half of Pakistani children aged between 0 and 23.9 months. Both standalone forms of undernutrition and coexisting forms of undernutrition were significantly associated with increased odds of diarrhoea by 1.07 (1.02 to 1.12) and 1.21 (1.16 to 1.27) times. The practice of breastfeeding, secondary/higher level of maternal education, and improvement in socioeconomic status reduced the risk of diarrhoea, while the children aged between 6 and 23.9 months residing in urban areas showed a high risk of diarrhoea. Conclusions: The presence of any type of undernutrition, i.e., standalone and/or coexisting forms were associated with increased risk of diarrhoeal diseases in children. An improvement in socioeconomic status, adherence to the continuation of breastfeeding, and maternal education are keys to reducing the burden of diarrhoea among children.

Influence of solid solution time on microstructure and precipitation strengthening of novel maraging steels

Effective subsequent heat treatment is crucial for achieving the desired microstructure and excellent mechanical properties in laser-deposited high-performance maraging steel. In this paper, we systematically investigate the synergistic relationship and tuning mechanism of different solution treatment times on the microstructure-property synergy of new maraging steels fabricated using laser direct energy deposition (LDED). To determine the optimal heat treatment process, solution treatment was conducted at 840 °C for varying durations, followed by aging at 530 °C for 2 h to induce precipitation strengthening. The results indicate that after 2 h of solution treatment, the alloy exhibits optimal ductility with an elongation of 7.90 % ± 0.15 %, attributed to the refinement of the martensitic matrix and precipitated phases, along with the formation of a small amount of residual austenite. When the solution treatment time is extended to 4 h, the alloy achieves its highest tensile strength, reaching 1958 ± 24 MPa. However, the elongation decreases to 7.31 % ± 0.12 % due to the coarsening of the martensite and secondary phase particles. After 6 h of solution treatment, significant coarsening and aggregation of the martensite and Fe2Mo intermetallic compounds markedly reduce the hardness, strength, and toughness of the alloy. By adjusting the solution treatment time, the size, morphology, and distribution of the martensitic matrix, Fe2Mo, and nanoscale precipitated phases play a critical role in the strengthening and fracture processes. Therefore, optimizing the precipitation behavior of the martensitic matrix and Fe2Mo intermetallic compounds through rational solution heat treatment is key to enhancing the mechanical properties of laser-deposited new maraging steels.

EXTH-72. INTEGRATED MULTIOMIC ANALYSIS OF ISOGENIC EGFRVIII MODELS OF GBM REVEALS EXPLOITABLE THERAPEUTIC VULNERABILITIES

Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor with an abysmal 15-month median survival. Therefore, novel therapeutic interventions are urgently needed. EGFR is a receptor tyrosine kinase that is mutated in over 50% of GBM and is a logical target for precision oncology approaches. While aberrant EGFR signaling has been successfully targeted in other cancers, early attempts to target EGFR in GBM clinical trials have not been successful. Since these early trials, several studies have revealed that GBM EGFR biology is unique and cannot be generalized from other EGFR-driven neoplasms. To better understand EGFR biology in a GBM-specific context, we have characterized the GBM transcriptome with RNAseq, the epigenome with CUT&RUN, and the kinase proteome with Multiplexed inhibitor beads with Mass Spectrometry (MIB-MS), collectively referred to as ‘multiomics’, after modeling EGFR resistance. An isogenic mouse astrocyte (mAc) model of GBM was genetically engineered to overexpress EGFRvIII (CEv3), the most common EGFR mutation in GBM. Expression of EGFRvIII induces a unique multiomic profile that mediates many hallmark cancer phenotypes including proliferation and stemness. Chronic EGFR resistance was modeled both in vitro and in vivo through continuous exposure to erlotinib or gefitinib, EGFR tyrosine kinase inhibitors (TKI). Additionally, acute EGFR resistance was modeled using a single exposure to EGFR TKI afatinib or neratinib in vitro over a 48-hour time course. Preliminary multiomic characterization of these data has revealed several targets that can be further investigated for therapeutic exploitation. Further investigation into these targets using orthotopic allografts with CEv3 cells shows that combinatorial therapy with neratinib and abemacilib, a CDK inhibitor, significantly (p < 0.001, n= 20 mice per group) extends survival (56 days) compared to neratinib alone (31.5 days). Future integrated multiomic analysis aims to elucidate the synergistic relationship between neratinib and abemacilib.