Syndrome In Middle-aged Women Research Articles

한국 중년여성의 대사증후군에 영향을 미치는 요인

This study aimed to investigate the prevalence of metabolic syndrome and the impact of health-related variables and women's health-related variables on metabolic syndrome in middle-aged women of normal weight. The objective was to provide foundational data for the development of preventive education and intervention programs for metabolic syndrome among this population in the future. The study included 1,357 middle-aged women who participated in the 7th Korea National Health and Nutrition Examination Survey (2016, 2017, 2018) and were categorized as normal weight (BMI 18.5-22.9). Data analysis was conducted using SPSS WIN 27.0, and for all analyses, variance estimation strata, clusters, and integrated weights were calculated to perform complex sample analysis. Among the subjects, the prevalence of metabolic syndrome was 5.3%. In the multiple logistic regression analysis, age, menopausal status, and menopausal age were not significant factors. However, compared to those who reported their subjective health status as “good,” individuals reporting “reasonable” health had a significantly increased risk of metabolic syndrome. Additionally, individuals who did not engage in regular physical activity had a significantly increased risk of metabolic syndrome compared to those who did. The factor that most influences metabolic syndrome in middle-aged women of normal weight is subjective health status. Subjective health status can serve as an indicator for identifying high-risk groups for diseases or prioritizing interventions in the health management of middle-aged women in the future.

Abstract #1183320: Cushing's Disease due to Recurrent Cystic Macroadenoma

Crooke's tumor is a rare histological type of ACTH-producing adenomas. The most frequent clinical presentation is as Cushing's syndrome in middle-aged women and on other occasions as silent corticotropic adenomas. We present the case of a patient with recurrent Cushing's disease due to cystic Crooke's tumor.

Polycystic ovary syndrome in middle-aged women: associated diseases

<h3></h3> Синдром поликистозных яичников (СПЯ) — одно из наиболее часто встречающихся заболеваний в эндокринологической гинекологии, этиология которого остается до конца не раскрытой. Клинические симптомы СПЯ включают олиго- или аменорею, гирсутизм, акне, бесплодие, которые, как правило, определяют основное направление лечения. Тем не менее нельзя упускать из виду влияние СПЯ на будущий риск развития сердечно-сосудистых заболеваний (ССЗ) и возможности их профилактики у женщин среднего возраста. Патогенез СПЯ обычно включает инсулинорезистентность, которая приводит к ряду кардиометаболических нарушений (дислипидемия, артериальная гипертония, нарушение толерантности к глюкозе, сахарный диабет 2-го типа и метаболический синдром), тем самым подвергая женщин повышенному риску развития ССЗ. СПЯ ассоциируется также с депрессией, онкологическими заболеваниями органов репродуктивной системы у женщин среднего возраста.

The Effect of Eight Weeks of Iyengar Yoga With an Emphasis on Spine and Shoulder Exercises on the Upper Cross Syndrome in Middle-aged Women

Introduction: Upper Crossed Syndrome (UCS) is a combination of forward head, rounded shoulder, and hyperkyphosis deformities. Yoga is a non-competitive physical exercise with the potential to correct postural imbalances in the human body. Iyengar yoga is a form of Hatha yoga.&#x0D; Materials and Methods: The purpose of present study was to evaluate the effect of Iyengar yoga with an emphasis on spine and shoulder exercises on the UCS in middle-aged women. In this quasi-experimental applied research, 15 subjects were purposefully recruited out of middle- aged women affected with UCS. The participants performed Iyengar yoga exercises with an emphasis on the spine and shoulder. The photogrammetry method was used to measure UCS.&#x0D; Results: At the end of 8 weeks exercises, there was a significant increase in the cervical (P&lt;0.001) and shoulder angles (P&lt;0.005), and a significant decrease in thoracic flexion angle (P&lt;0.001).&#x0D; Conclusion: All relevant coaches and therapists are recommended considering Iyengar yoga as an alternative for training programs in middle-aged women affected by UCS.

필라테스 프로그램이 중년여성의 인슐린저항성 및 대사증후군에 미치는 영향

The purpose of this study is to explore the effects of the Pilates program on insulin resistance and metabolic syndrome in middle-aged women. A total of 20 middle-aged women in their 40s were divided into athletic groups (10 people) and control groups (10 people), and pilates programs were conducted for 50 minutes for 50 minutes three times a week for 12 weeks. Measurement was carried out twice before and after. Analysis of all data used SPSS (Ver. 23.0), yielding mean values (M), standard deviations (SD), using paired t-test for intragroup differences and independent t-test for intergroup comparisons. As a result, the insulin-resistant HOMA-IR showed significant differences in the exercise group, no significant changes in the control group, and a significant difference in the post-measurement between groups. Among the mid- and post-metabolic groups, WHR, TG, and Glucose showed significant differences in the exercise group, no significant changes in the control group, and no significant differences between the groups. HDL-C showed high kinetic groups by significant differences in the posterior measurement between groups. Taken together, the 12-week Pilates program has a positive effect on insulin resistance and metabolic syndrome in middle-aged women, requiring the development of various programs for middle-aged women.

What Types of Exercise Are More Effective in Reducing Obesity and Blood Pressure for Middle-Aged Women? A Systematic Review With Meta-Analysis.

A systematic review was performed to identify the types of physical activities effective as interventions in preventing metabolic syndrome in middle-aged women. Electronic databases (MEDLINE, EMBASE, the Cochrane Library, and CINAHL) served as the data sources. Cochrane's Risk of Bias 2 was applied to assess the risk of bias of the randomized controlled trials. Meta-analyses were performed on selected studies using Review Manager 5.3. Thirty-one trials enrolling 2,202 participants were included. Compared to controls, the effects of physical activity were indicated by pooled mean differences, which were -0.57 kg for body weight, -0.43 kg/m2 for body mass index, -1.63 cm for waist circumference, -4.89 mmHg for systolic blood pressure (BP), and -2.71 mmHg for diastolic BP. The effects were greater on the measurements of waist circumference and BP than on body weight and BMI. The types of physical activities were further analyzed according to sub-groups. Only aerobic exercise did not affect body weight and resistance exercise did not significantly change any results. Contrarily, combined exercises significantly reduced measurements of waist circumference and BP. This review can provide valuable information for research and implementation of measures to prevent metabolic syndrome in middle-aged women.

Relationship between social support and empty nest syndrome in middle-aged women; Iran

Relationship between social support and empty nest syndrome in middle-aged women; Iran

골프 운동이 중년여성들의 외적스트레스요인과 대사증후군인자에 미치는 영향

골프 운동이 중년여성들의 외적스트레스요인과 대사증후군인자에 미치는 영향

Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women\u2014a population-based study

IntroductionRecent studies suggest an increased prevalence of chronic pain conditions and restless legs syndrome (RLS) in patients with chronic pulmonary disease (CPD). We analyzed the prevalence and risk factors for pain and RLS in a population-based sample of females with comorbid CPD.MethodQuestionnaire-based data from 2745 women aged 18–64 years were analyzed regarding comorbid CPD status (severe bronchitis, emphysema, asthma). Pain status was assessed according to symptoms reflecting severity (Visual Analogue Scale, VAS rating 0–10) and duration and spreading (limited spread or widespread) of pain. A diagnosis of RLS was defined by four validated diagnostic criteria. Anthropometrics and co-morbidities were assessed as covariates in univariate and multivariate analyses.ResultsWidespread pain was overrepresented in women with CPD (44.6 vs. 24.6%, p < 0.001). The odds ratio for widespread pain in women with CPD was 1.6 (95% confidence interval (CI) 1.2–2.2, p < 0.001) in the fully adjusted model. Severe pain (VAS rating ≥ 7) was more prevalent in females with known CPD (28.8 vs. 15.4%, p < 0.001, odd ratio 1.4 (95% CI 1.0–1.9, p = 0.029)). The prevalence of RLS was 37.4 and 23.8% in subjects with or without CPD, respectively (p < 0.001). In multivariate analysis, CPD was associated with a 30% risk increase for RLS (odds ratio 1.3 (95% CI 1.0–1.7, p = 0.04)).ConclusionThis population-based study identified CPD as an independent risk factor for severe and widespread pain as well as for RLS. Further research addressing pathophysiological mechanisms linking CPD and chronic pain conditions/RLS is warranted.

Associations of vitamin D with metabolic syndrome components in Indian urban middle-aged women

Background: The prevalence of metabolic syndrome is increasing in developing countries and the prevalence is reported to be higher in Indian urban women and vitamin D deficiency is documented as a common health problem. However, little is known regarding whether vitamin D deficiency plays an important role in the heightened prevalence of metabolic syndrome. Aims and Objectives: This study was planned to assess the levels of vitamin D and their association with components of metabolic syndrome in middle-aged women. Materials and Methods: A total of 300 women volunteers who were in the age group of 35-64 years were included in the study. We used the criteria of metabolic syndrome defined by A joint interim statement of the International Diabetes Federation task force. Plasma levels of 25-hydroxyvitamin D [25(OH)D] was assessed by chemiluminescence method. Pearson’s correlation was used for associations. Results: Vitamin D levels are significantly lower in women with metabolic syndrome. Waist circumference (WC), systolic blood pressure (BP), and triglyceride concentrations were inversely associated with vitamin D concentrations. 84% are with deficient levels of vitamin D. Conclusion: Vitamin D deficiency was found to be common in Indian women. Elevated WC, BP, and triglycerides were found to inversely associate with low serum levels of 25(OH)D. Improving vitamin D status would be useful in improving the health in middle-aged urban women.

Factors Associated with Metabolic Syndrome in Middle-aged Women with and without HIV

Metabolic Syndrome is associated with an increased risk of cardiovascular disease, increases after menopause and it is probably more frequent in HIV women. Objective: To assess MetS and associated factors in HIV seropositive and seronegative middle-aged women. Methods: Cross-sectional study with 537 women (273 HIV seropositive and 264 HIV seronegative), between 40 and 60 years’ old receiving follow-up care in two medical centers in Brazil. MetS was diagnosed based on IDF criteria. Sociodemographic, clinical, and behavioral factors were evaluated. Results: The prevalence of MetS in the HIV group was 46.9% and 42.2% in the seronegative group (P=0.340). Multiple regression analysis showed MetS association with body mass index (BMI)>25 kg/m² (PR=2.34; 95% CI: 1.70- 3.21; P<0.001), aging (PR: 0.05, 95% CI: 1.02-1.07; P<0.001), and the use of highly active retroviral therapy (HAART) (PR: 1.48; 95% CI: 1.13-1.94; P=0.005). Conclusions: There was no association between MetS and HIV status overall. Although HAART was associated with MetS, it seems that HIV-positive women in good immunological status, after early institution of HAART and its effective use, have traditional factors associated with MetS like being overweight and having older age.

Relationships Among Physical Activity Levels, Life Habits, And Metabolic Syndrome In Middle-aged Women In Korea

Relationships Among Physical Activity Levels, Life Habits, And Metabolic Syndrome In Middle-aged Women In Korea

타이치 운동이 중년여성의 대사증후군 위험인자 및 건강관련 삶의 질에 미치는 영향

Purpose: The purpose of this study was to test the effects of the Tai Chi exercise on metabolic syndrome and health-related quality of life in middle-aged women. Methods: A quasi-experimental design was used. Subjects were sixty middle-aged women with metabolic syndrome. All of the subjects were met the criteria of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). The subjects were divided into the experiment group (n=33) trained the Tai Chi for 12 weeks and the control group (n=27). Metabolic syndrome risk factors including blood pressure, waist circumference, glucose, triglyceride (TG), and high density lipoprotein cholesterol (HDL-C) were measured before and after the 12-week period. Euro Quality of Life Questionnaire 5-Dimensional Classification (EQ-5D) was used to evaluate the health-related quality of life. Results: The experiment group showed significant decreases in diastolic blood pressure, waist circumference, glucose, and TG; and increase in HDL-C compared to the control group. For the health-related quality of life evaluation, the experiment group showed significant improvement more than the control group. Conclusion: The Tai Chi exercise may be effective intervention in preventing cardiovascular disease caused by metabolic syndrome in middle-aged women.

The Effects of Exercise Types to Metabolic Syndrome in Middle-aged Women with Abdominal Obesity

The Effects of Exercise Types to Metabolic Syndrome in Middle-aged Women with Abdominal Obesity

Reduced sitting time and metabolic syndrome in middle-aged women

Little is known about the health benefits that may be obtained by breaking prolonged periods in a seated position, especially during postprandial periods. We hypothesized that reduced sitting time magnifies the positive effects of a lifestyle based reduction of body fat, as well as reducing metabolic risk factors for overweight and obese women. Middle-aged women (n=45, aged 46.8 ± 6.5 yrs) participated in a 12-week lifestyle intervention, consisting of combined exercise and behavior modification. Based on their average time spent engaged in sedentary behaviors (i.e., sitting and lying) during postprandial periods, participants were retrospectively classified as the least sedentary group (LSG) moderately sedentary group (MSG) and highly sedentary group (HSG). Two-way RMANOVA showed significant group-by-time interactions for body composition. Following the intervention, improvements in body weight, body mass index, percentage body fat, and waist circumference were greatest in the LSG, followed by those in the MSG and HSG. Similar group-by-time interactions were associated with several metabolic risk factors. Improvements in HDL-C, fasting blood glucose and insulin levels, HOMA-IR, and the prevalence of metabolic syndrome were observed to be greatest in the LSG, followed by those of the MSG and HSG. Our findings suggest that breaking prolonged sitting time should be encouraged in order to augment the health benefits of exercise training for the treatment of obesity-related metabolic risk factors in middle-aged women.

Life Course Origins of the Metabolic Syndrome in Middle-Aged Women and Men: The Role of Socioeconomic Status and Metabolic Risk Factors in Adolescence and Early Adulthood

To assess whether body mass index (BMI), blood pressure, and socioeconomic status in adolescence and early adulthood are independently related to the metabolic syndrome in adult women and men. We based our work on a Swedish prospective cohort study that recruited participants at 16 years of age (N = 1083 at age 16; 403 women and 429 men at age 43, 78% of those still alive [N = 1071]). Blood pressure (BP) and BMI were assessed when participants were 16 and 21 years of age. At age 43, the metabolic syndrome was defined according to the International Diabetes Federation guidelines. Socioeconomic status (SES) was operationalized by the participant (age 21 and 43) or parent's (age 16) occupational status. Information on smoking, snuff, alcohol, and inactivity was collected at age 43. In women, SES at age 16 was independently related to the risk of metabolic syndrome. In women and men, BMI at age 16 was related to metabolic syndrome but was attenuated by BMI at age 21, which was significant in the final model; in women systolic BP displayed similar patterns. Our data seem to suggest two independent life course pathways for metabolic syndrome: one metabolic pathway for both women and men operating through BMI (for women also systolic BP) in adolescence and early adulthood, and for women, an apparently independent pathway through adolescent socioeconomic disadvantage.

Changes in Hormone Therapy Prescriptions Among Middle-Aged Women in Taiwan: Implications for Health Needs at Menopause

Background From the 1990s until 2002, hormone therapy (HT) was a popular treatment for menopausal syndrome in middle-aged women. Since the Women’s Health Initiatives (WHI) studies in 2002 warned that the risk of HT might exceed its benefits, there has been a reduction in its use worldwide, including in Taiwan. Many studies reported this decline, but few discussed whether HT may or may not fulfill menopausal women’s health needs. This study examines the changes in HT prescriptions and other measures by menopausal women in Taiwan and the implications of these changes in relation to their needs. Methods This study analyzes annual and monthly rates of HT prescription and outpatient care utilization among Taiwanese women in the 45- to 64-year-old age group. It is based on medical claims data of the Taiwan National Health Insurance Programs from 2000 to 2004. Results The data showed that HT was the prevailing treatment for menopausal syndrome before the WHI publications. The rate of HT prescription increased annually, peaking in 2001 at 21.6%, but declined from 2002 to 9.7% in 2004. At the same time, the number of Taiwanese women seeking traditional Chinese medicine for the menopausal syndrome increased. Conclusion HT prescriptions in Taiwan declined significantly after the WHI reports, demonstrating the elasticity of the need for HT. But utilization data in Taiwan showed that attendance at outpatient clinics at menopause remained constant and the use of traditional Chinese medicine increased. Further studies should investigate health needs from menopausal women’s perspectives to develop appropriate measures to meet their needs.

Comparison between C-reactive protein and adipocyte fatty acid-binding protein as a component of metabolic syndrome in middle-aged women

Objectives We compared the diagnostic accuracy of CRP and adipocyte fatty acid-binding protein (A-FABP) for the metabolic syndrome (MS). Design and methods We examined 310 middle-aged Caucasian women. Results CRP and AFABP values were significantly associated with the MS probability in the logistic regression model. Operating characteristic curves comparison showed similar areas under the curve. Conclusions Measurement of A-FABP is equivalent to CRP in the diagnostic utility of the MS.

Association of the Level of Serum Uric Acid and Metabolic Syndrome in Middle-aged Women

Association of the Level of Serum Uric Acid and Metabolic Syndrome in Middle-aged Women

Lifetime History of Major Depression Predicts the Development of the Metabolic Syndrome in Middle-Aged Women

To prospectively examine the association of major depression with incidence of the metabolic syndrome in women. Data were drawn from one of seven sites of the Study of Women's Health Across the Nation (SWAN), a prospective cohort study of the menopausal transition. Participants were 429 (34.5% African-American) women. Major depression and comorbid diagnoses were assessed via the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Axis I Disorders at baseline and seven annual follow-up evaluations. The metabolic syndrome was measured at baseline and each follow-up evaluation (except the second) based on National Cholesterol Education Program (NCEP) criteria. Longitudinal generalized estimating equations (GEE) models indicated that, in women who were free of the metabolic syndrome at baseline, a lifetime major depression history or current major depressive episode at baseline was significantly associated with the onset and presence of the metabolic syndrome during the follow-up (odds ratio = 1.82; 95% Confidence Interval (CI) = 1.06-3.14). Survival analyses showed that, in women who were free of the metabolic syndrome at baseline, a lifetime major depression history or current major depressive episode at baseline predicted increased risk of developing the metabolic syndrome during the follow-up (hazard ratio = 1.66; 95% CI = 0.99-3.75). Lifetime history of alcohol abuse or dependence predicted incident metabolic syndrome and attenuated the association between depression and the metabolic syndrome in both models. This study documents that major depression is a significant predictor of the onset of the metabolic syndrome. Intervention studies targeting depression may prevent the development of the metabolic syndrome in women.