Syndrome In Japanese Population Research Articles

TCT-426 One-Year Clinical Outcome of Prasugrel Monotherapy After PCI for Chronic Coronary Syndrome in Japanese Population

TCT-426 One-Year Clinical Outcome of Prasugrel Monotherapy After PCI for Chronic Coronary Syndrome in Japanese Population

Association between disturbance of self-organization and irritable bowel syndrome in Japanese population using the international trauma questionnaire

Disturbance of self-organization (DSO) is defined by affective dysregulation, negative self-concept, and disturbances in relationships. Along with post-traumatic stress disorder (PTSD), DSO is a part of complex post-traumatic stress disorder (CPTSD), which often results from childhood trauma and has life-long consequences. We investigated the association between CPTSD, PTSD, DSO, childhood adversity, and irritable bowel syndrome (IBS). Individuals with IBS exhibited markedly higher prevalences of DSO, CPTSD, and PTSD symptoms and higher trauma scores compared with healthy individuals. The odds of having IBS were 3.718 and 1.924 times greater for those with DSO symptoms (p < .001) and CPTSD symptoms (p = .005), respectively. IBS severity was highest in the DSO group, followed by the CPTSD, PTSD, and non-DSO/CPTSD/PTSD groups. DSO symptoms mediate the impact of childhood adversity on IBS symptoms, explaining half of this effect, whereas PTSD symptoms do not. These findings suggest a significant role of DSO in the development of IBS.

Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating disease with no molecular diagnostics and no treatment options. To identify potential markers of this illness, we profiled 48 patients and 52 controls for standard laboratory tests, plasma metabolomics, blood immuno-phenotyping and transcriptomics, and fecal microbiome analysis. Here, we identified a set of 26 potential molecular markers that distinguished ME/CFS patients from healthy controls. Monocyte number, microbiome abundance, and lipoprotein profiles appeared to be the most informative markers. When we correlated these molecular changes to sleep and cognitive measurements of fatigue, we found that lipoprotein and microbiome profiles most closely correlated with sleep disruption while a different set of markers correlated with a cognitive parameter. Sleep, lipoprotein, and microbiome changes occur early during the course of illness suggesting that these markers can be examined in a larger cohort for potential biomarker application. Our study points to a cluster of sleep-related molecular changes as a prominent feature of ME/CFS in our Japanese cohort.

Nationwide survey of Baller‑Gerold syndrome in Japanese population.

Baller-Gerold syndrome (BGS) is a rare autosomal genetic disorder characterized by radial aplasia/hypoplasia and craniosynostosis. The causative gene for BGS encodes RECQL4, which belongs to the RecQ helicase family. To understand BGS patients in Japan, a nationwide survey was conducted, which identified 2 families and 3patients affected by the syndrome. All the three patients showed radial defects and craniosynostosis. In one patient who showed a dislocated joint of the hip and flexion contracture of both the elbow joints and wrists at birth, a homozygous large deletion in the RECQL4 gene was identified. This is the first reported case of BGS in Japan caused by RECQL4 gene mutation.

Clinical features of obstetrical antiphospholipid syndrome in Japanese population – A multicenter study

Clinical features of obstetrical antiphospholipid syndrome in Japanese population – A multicenter study

544: The relation between birthweight and metabolic syndrome in Japanese population

544: The relation between birthweight and metabolic syndrome in Japanese population

Helicobacter PyloriInfection Is Significantly Associated With Metabolic Syndrome in the Japanese Population

Metabolic syndrome comprises a cluster of metabolic abnormalities leading to insulin resistance and atherosclerosis, and Helicobacter pylori is thought to be a contributing factor. We examined the association between H. pylori infection and metabolic syndrome in a large Japanese population. Consecutive asymptomatic subjects that underwent a complete medical survey in our institute between April 2006 and March 2007 were recruited, and a total of 5,488 men and 1,906 women were cross-sectionally studied. The association of H. pylori serostatus with traditional atherosclerosis risk factors was investigated by multiple linear regression analysis. Independent and significant factors affecting metabolic syndrome were determined by multiple logistic regression analysis. H. pylori seropositivity significantly increased with age in both men and women. H. pylori seropositivity was significantly higher in cases with metabolic syndrome compared with those without metabolic syndrome (P < 0.001). There was a significant and independent association between H. pylori seropositivity and metabolic syndrome (OR 1.39, 95% CI 1.18-1.62, P < 0.001) by multiple logistic regression analysis. H. pylori seropositivity was significantly associated with higher systolic blood pressure (beta coefficient = 1.03, P= 0.014), lower high-density lipoprotein (HDL)-cholesterol level (beta coefficient =-2.00, P < 0.001), and higher LDL-cholesterol level (beta coefficient = 2.21, P= 0.005) by multiple linear regression analysis. In a large Japanese population, H. pylori infection was significantly associated with metabolic syndrome.

35.23: Incremental prognostic value of ejection fraction by ECG-gated myocardial perfusion single-photon emission computed tomography for the prediction of future acute coronary syndrome in Japanese population

35.23: Incremental prognostic value of ejection fraction by ECG-gated myocardial perfusion single-photon emission computed tomography for the prediction of future acute coronary syndrome in Japanese population