Syndrome In Adult Population Research Articles

Dravet syndrome in adult population

Dravet syndrome in adult population

Prevalence of Metabolic Syndrome in Adult Population in Afghanistan

Prevalence of Metabolic Syndrome in Adult Population in Afghanistan

#2653 Long term renal outcome of patients with idiopathic membranous nephropathy – Croatian single center cohort

Abstract Background and Aims Membranous nephropathy (MN) is the most prevalent cause of nephrotic syndrome in adult population. Our aim was to assess long term renal outcome of primary membranous nephropathy patients. Method In this retrospective study adult patients with biopsy proven membranous nephropathy from 2000 till 2015 with follow up of at least 5 years from UHC Zagreb were included. Extensive clinical workup was done to exclude patients with secondary MN. Except otherwise stated, data are shown as N (%) or median with interquartile range (IQR) and accompanied p levels. Results Between 2000 and 2015, 48 patients were diagnosed to have idiopathic/primary membranous nephropathy, out of which 33 (68%) MN patients had follow up of at least 5 years and where further analyzed. They were predominantly male 20 (60.6%) of average age of 52 years (min – max 19 - 76). High risk MN patient 25 (75%) were treated with immunosuppressive therapy, dominantly with cyclophosphamide and corticosteroids. During the median follow up of 10 (7 – 14) years, 19 (57%) accomplished complete remission and 11 (33%) partial remission. One (3%) patient did not achieve remission and 2 (6.1%) were in relapse of nephrotic syndrome at last follow up. Proteinuria significantly decreased (6.2 (3.3 – 10.9) vs. 0.2 (0.14 – 0,90); p < 0.001) and there was no significant change in creatinine level (87 (42.8 – 101.5) vs. 93 (68.5 – 140.5; p = 0.332)). In follow up there were 5 (15%) carcinomas detected; one of each origin (colon, pancreas, lung, prostate, lymph nodes) approximately 7,8 years after the diagnose of MN. Limitation of this study could be selection bias but there was no difference in renal function at presentation of all MN patients and those who had at least 5 years follow up. Conclusion Renal long-term outcome of patients with idiopathic MN in our cohort was excellent. Nevertheless, there is high prevalence of cancer and therefore regular screening for cancer disease should take place in this population of patients. Also, drugs with cancerogenic potential should be avoided, as well as bear in mind cumulative dose of drugs applied.

Association of Non-Alcoholic Fatty Liver Disease (NAFLD) with Metabolic Syndrome in Adult Population: A Narrative Review

Non-Alcoholic Fatty Liver Disease (NAFLD) is swiftly evolving into a prevailing liver condition on a global scale and within the United States, it stands as the primary contributor to chronic liver disease. Previously viewed as a Western disorder, obesity and NAFLD are gaining increased recognition within the Asian community. Notably, NAFLD has been observed to have strong associations with Type 2 Diabetes Mellitus (T2DM), Chronic Vascular Disease (CVD), and Chronic Kidney Disease (CKD).

IJCM_410A: Prevalence of metabolic syndrome in rural area of District Kangra of Himachal Pradesh

Background: Metabolic risk factors and abnormalities such as obesity and hypertension are rapidly rising in Indian population following widespread change in lifestyle and dietary habits. A study was conducted to estimate the current situation of metabolic syndrome in rural area of Kangra district of Himachal Pradesh. Objective: To find out the prevalence of metabolic syndrome in adult population in identified rural area of Kangra district of Himachal Pradesh. Methodology: A community based cross-sectional study was conducted among 177 individuals. The relevant anthropometric measurements and laboratory investigations were performed. NCEP ATP III (National Cholesterol Education Program Adult Treatment Panel III) guidelines were used to diagnose the metabolic syndrome. Results: The prevalence of metabolic syndrome in our study was found to be 42.4% (34.99%-50.01%) and was higher among female population (71.8%). The proportion of metabolic syndrome was higher among older age group (66.7%) and only 2.7% in those who were less than 30 years of age. Conclusion: The present study documented 42.4% prevalence of metabolic syndrome in rural population, with more prevalence among females. The data was skewed, with more proportion of females in the study. Consequent upon this, development of health policies and protocols for the screening of metabolic syndrome would aid in early diagnosis and timely management of non-communicable disease.

POS-138 COMPARATIVE STUDY BETWEEN SINGLE DOSE RITUXIMAB THERAPY VERSUS MULTIPLE DOSE REGIMEN IN IDIOPATHIC MEMBRANOUS NEPHROPATHY AND ITS CORRELATION WITH PERIPHERAL BLOOD CD19 COUNT

Idiopathic membranous nephropathy is a common cause of nephrotic syndrome in adult population and can lead to CKD if not treated properly. Conventional therapeutic options like Cyclophosphamide & CNI associated with significant toxicity & relapse rate. Though Rituximab is relatively safe multiple dose protocol leads to high cost burden. In this trial single dose Rituximab therapy has been compared with multiple dose regimen for this which will significantly cut down cost and drug related adverse effects.

Association between circulating microRNAs and the metabolic syndrome in adult populations: A systematic review

BackgroundCirculating microRNAs (miRNAs) are one of the most abundant classes of gene regulatory molecules, and had been associated to the metabolic syndrome, higher BMI, dyslipidemia and diabetes mellitus. In this sense, miRNAs could help to understand the mechanism behind the development of metabolic syndrome. ObjectiveTo determine the relationship between circulating microRNAs and the metabolic syndrome in adult population. MethodsWe performed a systematic review according to the recommendations of the Cochrane Collaboration and following the PRISMA Statement. The results were grouped for miRNAs levels in MetS and metabolic variables included in MetS and their statistic association with miRNAs levels. ResultsWe finally included sixteen studies with a total of 7195 individuals. We found 47 miRNAs reported to be related to metabolic syndrome (p < 0,05) and 98 associated with the metabolic alterations included in its diagnostic (p < 0,05). Forty-nine miRNAs levels were described as relate to insulin resistance, 29 with high triglycerides, 35 with hypertension, 28 with obesity, and 16 miRNAs with cholesterol HDL(p < 0,05). Changes in levels of miR-505-5p, miR-148a-3p, miR-19b-3p, miR-320b, miR-342-3p, miR-197-3p, miR-192-5p, miR-122-5p, miR-103, miR-130a, miR-155-5p and miR-375, were reported as significant in more than one study. The results only included a descriptive synthesis, clinical heterogeneity did not allow a meta-analysis. ConclusionThe findings on the current systematic review suggests a possible relationship between miRNAs with metabolic syndrome and metabolic traits. This association could help to understand the mechanism behind the develop of the metabolic syndrome. However, more studies are necessary for further validation.

7Demographics of postural orthostatic tachycardia syndrome in adult population

Abstract Background Postural Orthostatic Tachycardia Syndrome (POTS) is a dysautonomia of unclear etiology. POTS is defined as a form of orthostatic intolerance characterized by an increase in heart rate ≥ 30 bpm or to a heart rate ≥120 bpm upon standing. The clinical manifestations include dizziness, palpitations fatigue, anxiety, nausea and fainting. There is a paucity of data available on adult population. This study aims to identify and evaluate demographic features of adult patients with POTS in a large tertiary specialty clinic. Methods 447 patients diagnosed with POTS between 8/21/2018 and 8/20/2019 were randomly selected from our electronic records, and clinical data obtained during initial outpatient evaluation was reviewed retrospectively for race, gender and age. Results Out of 447 patients, 407 (91%) are female and 40 (9%) are male. Amongst them, 417 (93%) patients are White Caucasian of which 381 (91%) are female and 36 (9%) are male; 12 (3%) are Black/African-American of which 11 (92%) are female and 1 (8%) is male; 10 (2%) are Hispanic of which 100% are females; 4 (1%) are Asian of which 2 (50%) are females and 2 (50%) are males and 4 from other races of which 3 (75%) were female and 1 (25%) was male. Patients had a mean age of 32.9 with a standard deviation of 11.96. Conclusions POTS predominates in females, middle age population, and may be heavily prevalent in White Caucasians. Key messages Further clinical studies on more geographically spread populations are encouraged to support our findings on racial prevalen

SAT-001 RITUXIMAB IN THE TREATMENT OF REFRACTORY IDIOPATHIC MEMBRANOUS NEPHROPATHY IN PAKISTANI POPULATION: A CASE SERIES

This is the time of paradigm shift in the treatment armamentarium of primary membranous nephropathy which is a common cause of nephrotic syndrome in adult population and has been labelled as a cause of idiopathic primary glomerulopathy in about 90% of patients. It is responsible for about 0.7% cases of end stage kidney disease. However, unfortunately, the optimal treatment for idiopathic membranous nephropathy is still controversial. Rituximab, a chimeric monoclonal anti-CD20 antibody has been found a potential treatment option for idiopathic membranous nephropathy.

Free Fatty Acids: Circulating Contributors of Metabolic Syndrome.

Metabolic syndrome induces an increased cardiovascular morbidity and mortality. Most importantly, the prevalence of metabolic syndrome in adult population is expanding. Both clinical and preclinical studies indicate that increased Free Fatty Acids (FFAs) are involved in the pathogenesis of insulin resistance and subsequent development of metabolic syndrome. The relevance of FFAs in protecting and restoring tissue function is quite vast. The search to correlate the functional deterioration of the tissues within the cardiovascular system and increased plasma concentrations of FFAs has been reported. The importance of reduction in the consumption of dietary fatty acids along with the identification of dysregulated genes responsible for persistent increased FFAs uptake and mitochondrial β-oxidation has been increasingly recognized. This review discusses the current empirical understanding of the different types of fatty acids and their metabolism and functions both in physiological and pathophysiological conditions. We also discuss in detail about the molecular and pathophysiological basis of increased FFAs, which augments Cardiovascular Disease (CVD).

A study on prevalence of metabolic syndrome in adult population of Ranchi

A study on prevalence of metabolic syndrome in adult population of Ranchi

VERTEBRAL PAIN SYNDROMES IN CHILDREN: ALGORITHMS OF THERAPY DEPENDING ON AGE

Актуальность. Публикации по проблеме дорсалгий у детей немногочисленны. Неадекватная коррекция болей в спине у детей и подростков способствует прогрессированию заболевания, внося свой вклад в высокую распространенность этого синдрома среди взрослого населения.

Prevalence of metabolic syndrome in adult population in Shiraz, southern Iran

AimMetabolic syndrome (MSx) is associated with increased risk of cardiovascular diseases and type 2 diabetes mellitus. This study evaluated the prevalence of MSx in adult population in Shiraz, southern Iran. MethodsIn a cross-sectional study conducted between October 2012 and April 2013, using a simple random sampling method, 377 adults aged more than 20 years who were invited for periodic health examinations to Petroleum Industry Health Organization Polyclinic, a general health care center, Shiraz, southern Iran, were studied. The revised National Cholesterol Education Program–Adult Treatment Panel III was used for the diagnosis of MSx. ResultsThe participants included 190 women and 187 men with a mean±SD age of 43.8±11.0 (range: 20–86) years. Of 377 participants, 101 (26.8%, 95% CI: 22.3–31.3%) had MSx. The prevalence in men (16.6%) was significantly (p<0.001) lower than that in women (36.8%). The prevalence increased by almost 15% with each decade of life (p<0.001). ConclusionThe prevalence of MSx in our population, particularly in women, is high. Strategies should be planned to prevent the increasing prevalence of MSx in our country.

Relationship between vitamin D deficiency and metabolic syndrome in adult population of the Community of Madrid

Abstract Backgrounds and objective Previous studies have suggested an association between MS and vitamin D deficiency, but data are not conclusive. This study was intended to find out if metabolic syndrome, according to the 2009 IDF/AHA/NHLBI, is associated to the presence of vitamin D deficiency. Material and methods A cross-sectional study was conducted on a sample of 326 subjects aged 18 years or older, recruited from a health center in Alcala de Henares. Participants underwent an interview and a standardized clinical examination. In a second visit, blood tests were performed in 255 subjects to quantify serum levels of 25-hydroxyvitamin D (25 OH-VitD) and different laboratory parameters associated to MS. The association between vitamin D deficiency and metabolic syndrome (and each of its components) was examined. Results In the study population, MS prevalence was 36.1% and prevalence of vitamin D deficiency (25 OH-Vit D P = 0.006), with an estimated prevalence ratio of 1.62 (95% CI : 1.13–2.31). Adjustment for age, sex, and body mass index did not change such association. Conclusions There is a significant association between vitamin D deficiency and MS. Both conditions are highly prevalent in our population.

Relationship between Alcohol Consumption and Components of the Metabolic Syndrome in Adult Population from Maracaibo City, Venezuela

Introduction. Although the relationships between alcohol and disorders such as cancer and liver disease have been thoroughly researched, its effects on cardiometabolic health remain controversial. Therefore, the objective of this study was to assess the association between alcohol consumption, the Metabolic Syndrome (MS), and its components in our locality. Materials and Methods. Descriptive, cross-sectional study with randomized, multistaged sampling, which included 2,230 subjects of both genders. Two previously determined population-specific alcohol consumption pattern classifications were utilized in each gender: daily intake quartiles and conglomerates yielded by cluster analysis. MS was defined according to the 2009 consensus criteria. Association was evaluated through various multiple logistic regression models. Results. In univariate analysis (daily intake quartiles), only hypertriacylglyceridemia was associated with alcohol consumption in both genders. In multivariate analysis, daily alcohol intake ≤3.8 g/day was associated with lower risk of hypertriacylglyceridemia in females (OR = 0.29, CI 95%: 0.09–0.86; p = 0.03). Among men, subjects consuming 28.41–47.33 g/day had significantly increased risk of MS, hyperglycemia, high blood pressure, hypertriacylglyceridemia, and elevated waist circumference. Conclusions. The relationship between drinking, MS, and its components is complex and not directly proportional. Categorization by daily alcohol intake quartiles appears to be the most efficient method for quantitative assessment of alcohol consumption in our region.

Prevalence of Obesity and Metabolic Syndrome in Adult Population of Selected Regions of the Czech Republic. Relation to Eating Habits and Smoking

Prevalence of the metabolic syndrome is around 25% in Europe but its occurrence grows in both genders with increasing age and weight. Lifestyle factors may contribute to the risk of developing metabolic syndrome. The objective of this study was to determine the relationship between metabolic syndrome and eating habits as well as length of sleep and smoking. Participants (519 women and 286 men aged 18-65 years) were chosen by random selection and questioned about their eating habits, sleep length and smoking. This information was combined with anthropometric and clinical parameters of metabolic syndrome. The female group was divided into two subgroups depending on climacteric stage (before and after menopause). Metabolic syndrome prevalence does not differ between regions in neither female (29.9%) nor male (32.5%) group. Body mass index ≥25 was detected in 50.4% of all women and 65.7% of men; 23.5% of all women and 21.7% men had body mass index ≥30. In conclusion, metabolic syndrome prevalence was proved to depend on eating habits and family heredity. Positive correlation between the above mentioned factors demonstrated itself in the total sample but not in individual regions. Metabolic syndrome prevalence in Czech adults is comparable with neighbouring countries. No significant interregional differences in metabolic syndrome prevalence within the Czech Republic were detected. In conclusion, relationship between eating habits and metabolic syndrome was confirmed.

Metabolic syndrome in normal-weight Iranian adults

Background: The risk of metabolic risk factors increases in Middle-Eastern adults within the normal limits of BMI. There is a report that 30.1% of the Iranian population had metabolic syndrome but no reports on the prevalence of this syndrome among individuals within the various BMI categories are available. The present study estimates the prevalence of metabolic syndrome in adult population with normal levels of BMI (18.5-24.9 kg/m 2 ). Methods: In this population-based cross-sectional study, a representative sample of 3444 subjects (1737 males and 1707 females) aged≥20 years with normal body mass index (BMI= 18.5-24.9 kg/m 2 for both genders) were included. Demographic data were collected; anthropometric indices and blood pressure were measured according to standard protocol. Biochemical analysis was conducted on fasting blood samples. The metabolic syndrome was defined according to the ATP Ш guidelines as the presence of three or more of the metabolic factors. Means and proportions, and multivariate odds ratios that quantify the association between metabolic syndrome and normal BMI quartiles, controlling for age, physical activity, smoking and education were presented. Results: The overall prevalence of the metabolic syndrome in normal weight men and women were 9.9% (CI 95%: 8.49-11.30) and 11.0% (CI 95%: 9.5-12.4, P=0.2), respectively. Men had slightly lower BMI than women (22.4±1.8 vs. 22.5±1.7 kg/m 2 , P<0.001), while their WC was higher (79.8±6.6 vs.79.3±7.7 cm, P<0.001). The prevalence of high WC and low HDL was higher in women, while high blood pressure, high triglyceride levels and having at least two metabolic risk factors were more prevalent in men. Individuals at the highest category of normal BMI had significantly higher odds for being at risk for metabolic syndrome compared to those at first category (OR; 5.21 for men and 2.15 for women). There was a significant increasing trend in odds for having all the metabolic syndrome components except for high FBS and high WC in men. Women revealed a similar increasing trend except for high FBS across normal BMI quartiles. Conclusion: Normal weights Iranians have excess cardiovascular risk. Therefore interventions for prevention of diabetes and cardiovascular disease could be considered in normal weight population. On the other hand, the cut-points of BMI, suggested by WHO, may be inappropriate for the Iranian adult population.