This paper investigates the different sequences that can be used in direct sequence divisionmultiple access (DS- CDMA) systems. The auto-correlation, cross correlation, the mean square correlationmeasurements ( RAC, RcC ) and merit factor (MF) are used for evaluating the performance of differentspreading sequences. The results obtained small set of Kasami sequences is the most effective of binarysequences families in terms of correlation measure, but this set suffers from the limited number ofsequences. Overall among orthogonal category, Orthogonal Gold sequences and Golay complementarysequences are a better candidate in synchronous CDMA applications.