Symptoms Of Chronic Disease Research Articles

A Body-Temperature-Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation.

Implantable peripheral nerve electrodes are crucial for monitoring health and alleviating symptoms of chronic diseases. Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue-like electrodes suffer from unmanageable operating forces, leading to high risks of nerve injury and fragile electrode-tissue interfaces. Here, a peripheral nerve electrode is developed that simultaneously fulfills the criteria of body temperature softening and tissue-like modulus (less than 0.8MPa at 37°C) after implantation. The central core is altered from the tri-arm crosslinker to the star-branched monomer to kill two birds (close the translation temperature to 37°C and decrease the modulus after implantation) with one stone. Furthermore, the decreased interfacial impedance (325.1±46.9Ω at 1kHz) and increased charge storage capacity (111.2±5.8mCcm-2) are achieved by an in situ electrografted conductive polymer on the strain-insensitive conductive network of Au nanotubes. The electrodes are readily wrapped around nerves and applied for long-term stimulation in vivo with minimal inflammation. Neuromodulation experiments demonstrate their potential clinical utility, including vagus nerve stimulation in rats to suppress seizures and alleviation of cardiac remodeling in a canine model of myocardial infarction.

Association between moderate-to-vigorous physical activity and chronic disease risk in adults and elderly: insights from the UK Biobank study

BackgroundThis study aimed to determine the associations between different intensities of moderate to vigorous physical activity (MVPA) and the incidence of chronic diseases, and to assess the risk levels associated with these activities over time.MethodsA prospective cohort study (UK Biobank Activity Project) with data collected between June 2013 and December 2015 included 59,896 adults (mean age = 59.68; male = 38.03%) free from chronic diseases. Participants were categorized into tertiles based on their weekly MVPA: lowest (<224 min for males, <143 min for females), medium (224–444 min for males, 143–308 min for females), and highest (≥444 min for males, ≥308 min for females), stratified by gender. The mean onset of chronic disease symptoms occurred at 3.57 years, with participants followed up during this period. Wearable accelerometry data were used to quantify MVPA levels.FindingsLowest tertile of MVPA were significantly correlated with increased risks of chronic disease (24%–110% increased risk) based on odds ratios (ORs), with dose-response relationship observed. In males with the lowest tertile of MVPA, significant associations were identified with type 2 diabetes mellitus (T2DM) (OR = 1.90; CI: 1.44–2.51), neurodegenerative disease (OR = 1.80; CI: 1.19–2.71), metabolic syndrome (OR = 1.34; CI: 1.18–1.53), hypertension (OR = 1.27; CI: 1.12–1.44), and atherosclerotic cardiovascular disease (ASCVD) (OR = 1.24; CI: 1.03–1.49). In females, the lowest tertile of MVPA levels were associated with increased risks of neurodegenerative disease (OR = 2.10; CI: 1.36–3.24), T2DM (OR = 1.88; CI: 1.37–2.58), cerebrovascular disease (OR = 1.61; CI: 1.12–2.29), ASCVD (OR = 1.58; CI: 1.23–2.03), metabolic syndrome (OR = 1.49; CI: 1.32–1.69), and hypertension (OR = 1.44; CI: 1.29–1.61). Longitudinally, the lowest tertile of MVPA in males showed elevated risks for neurodegenerative disease (HR = 2.13; CI: 1.24–3.66), T2DM (HR = 1.83; CI: 1.30–2.57), hypertension (HR = 1.33; CI: 1.15–1.53), metabolic syndrome (HR = 1.32; CI: 1.14–1.54), and ASCVD (HR = 1.29; CI: 1.03–1.61). In females, the lowest tertile of MVPA was associated with similar risks for ASCVD (HR = 1.59; CI: 1.16–2.20), T2DM (HR = 1.57; CI: 1.08–2.29), hypertension (HR = 1.53; CI: 1.34–1.74), and metabolic syndrome (HR = 1.50; CI: 1.29–1.73).ConclusionUsing wearable accelerometry data, this study demonstrated the quantifiable risks of chronic diseases and their development, highlighting the importance of MVPA.

The Relationship Between Pain Acceptance and Acceptance of Illness in Individuals with Rheumatoid Arthritis.

Managing treatment and symptoms of chronic diseases without accepting the illness is challenging. This study aimed to determine the relationship between pain acceptance and the acceptance of illness in individuals with rheumatoid arthritis (RA). In this descriptive study of 123 people diagnosed with rheumatoid arthritis (RA), data were collected through a questionnaire. The questionnaire included a Patient Information Form, Visual Analog Scale (VAS), Health Assessment Questionnaire (HAQ), Disease Activity Score 28 (DAS28), Chronic Pain Acceptance Questionnaire (CPAQ), and Acceptance of Illness Scale (AIS). The mean chronic pain acceptance score of individuals with RA was 55.32 ± 12.96, and the mean acceptance of illness score was 25.00 ± 8.02. A statistically significant relationship existed between levels of pain measured by VAS and CPAQ (r=-0.184, P=.042). A statistically significant correlation existed between AIS and CPAQ total score (r=0.284, P=.001). As the levels of pain acceptance increased in RA patients, the levels of pain decreased, and the levels of acceptance of the illness increased. Patients must first acknowledge and accept their illness to follow their treatment plan effectively. Considering that the pain acceptance of individuals diagnosed with RA affects the level of acceptance of illness, it is essential to evaluate patients' pain and disease acceptance processes and support patients to increase treatment success.

Effect of Parathyroidectomy After Renal Transplantation on Grafted Kidney Function Within One Year: A Meta-Analysis

Objective: Secondary hyperparathyroidism (sHPT) is a common symptom of chronic kidney disease (CKD), and at the time of transplantation, more than two-thirds of patients with end-stage renal disease have secondary hyperparathyroidism. After kidney transplantation, parathyroid function is normalized in some kidney transplant recipients, but up to 50% of kidney transplant recipients develop tertiary hyperparathyroidism (tHPT) one year after kidney transplantation. The effect of parathyroidectomy on the grafts is currently unclear, so we conducted a meta-analysis of these studies to assess the changes in graft function one year after parathyroidectomy after kidney transplantation to investigate the resection in renal transplant recipients. Methods: A thorough exploration was conducted across Embase, PubMed, Web of Science, and the Cochrane Library databases to gather pertinent literature spanning from January 1, 2000, to December 31, 2023. The search criteria encompassed terms such as "kidney transplantation," "parathyroidectomy," and "hyperparathyroidism." Results: Twelve studies were scrutinized to assess alterations in graft functionality at 1, 3, 6, and 12 months post-parathyroidectomy. The meta-analysis unveiled a notable decline in overall glomerular filtration rate and a concurrent elevation in serum creatinine one year post-parathyroidectomy, signifying an impairment in graft function compared to the preoperative phase. Significant heterogeneity was observed among the studies. Conclusion: Following parathyroidectomy in renal transplant recipients one year post-surgery, calcium and parathyroid hormone levels normalized. Nonetheless, there was evident impairment in graft function and an elevated risk of graft loss. Hence, the safety of parathyroidectomy in patients with secondary hyperparathyroidism post-renal transplantation necessitates meticulous consideration.

Chronic Lower Respiratory Diseases detection based on Deep Recursive Convolutional Neural Network

Recently, symptoms of Chronic Obstructive Pulmonary Disease (COPD) have been identified concerning long-term continuous treatment. Furthermore, predicting the life probability of patients with COPD is crucial for formative ensuing treatment and conduct plans. Additionally, it plays a vital role in providing complementary solutions using technologies such as Deep Learning (DL) to address experiments in the medical field. Early and timely analysis of clinical images can improve prognostic accuracy. These include COPD, pneumonia, asthma, tuberculosis and fibrosis. Conventional methods of diagnosing COPD often rely on physical exams and tests such as spirometers, chest and genetic analysis. However, respiratory diseases pose an enormous comprehensive health burden for many patients. Thus these methods are not always accurate or obtainable. However, succeeding in their accuracy involves a nonspecific diagnosis rate, time-consuming manual procedures, and extensive clinical imaging knowledge of the radiologist. To solve this problem, we use a Deep Recursive Convolutional Neural Network (DRCNN) method to detect chronic lower respiratory disease. Initially, we collected the images from the Kaggle repository, and evaluate the result based on the following stage. The first stage is pre-processing using a Gaussian filter to reduce noise and detect the edges. The second stage is segmentation used on Image Threshold Based Segmentation (ITBS), used for counting the binary image and separating the regions. In the third stage, we use the chi-square test to select the best features and evaluate the image values for each feature and threshold. Finally, classification using DRCNN detects CLRD classifying better than the previous method. In synthesis, CLRD can be detected by many staging measures, such as sensitivity, specificity, accuracy, precision, and Recall

An Agent-Based "Virtual Clinical Trial" for the Analysis and Evaluation of COPD Patients Cohorts Behavior

Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory condition characterized by inflammation and narrowing of the airways, leading to symptoms such as shortness of breath, coughing, and chest tightness. Treatment typically involves lifestyle adjustments, medication, and pulmonary rehabilitation to improve lung function and quality of life. This study presents a model examining COPD patient behavior within cohort-based strategies, focusing on how environmental factors impact vital signs across the entire cohort. We developed a comprehensive virtual clinical trial model that encompasses study protocol design, participant recruitment, virtual data collection, outcome analysis, and conclusions. This includes remote symptom monitoring, virtual healthcare consultations, treatment adherence assessments, and research data collection. Additionally, we explore the influence of external variables such as environmental conditions, comorbidities, and lifestyle factors on chronic disease symptoms and disease stability. We used an Agent-Based Model(ABM) to incorporate these factors to assess COPD progression and treatment efficacy. Individual agents represent COPD patients, each characterized by attributes such as age, smoking history, lung function, comorbidities, and treatment plans.

Examining health literacy in the Danish general population: a cross-sectional study on the associations between individual factors and healthcare-seeking behaviour.

Knowledge about health literacy challenges among the general population is valuable for initiatives targeting social inequity in health. We investigated health literacy in various population groups and the impact of healthcare-seeking behaviour by analysing the associations between (i) lifestyle, socioeconomics, self-rated health, chronic disease, and health literacy and (ii) symptom burden, contact to general practitioner (GP), and health literacy. In total, 27488 individuals participated in a population-based survey. Questionnaire data comprised information about symptoms, GP contact, lifestyle, self-rated health, chronic disease, and four aspects of health literacy: feeling understood and supported by healthcare providers, having sufficient information about health, having social support for health, and being able to actively engage with healthcare providers. Socioeconomics were obtained from registers. Descriptive statistics and multivariable linear regression models were applied. Individuals who smoked, lived alone, had different ethnicity than Danish, and low self-rated health had more health literacy challenges reflected in lower scores for all aspects of health literacy. Individuals with high symptom burden and those who had presented a high absolute number of symptoms to their GP were less likely to have sufficient information about health and be able to actively engage, whereas individuals reporting GP contact with a high relative percentage of their symptoms were more likely to feel understood and supported by healthcare providers. Health literacy challenges are related to healthcare-seeking behaviour and several individual factors. To address social inequity in health and society, interventions aimed at both the individual and community-based health literacy are essential.

The Effect of the Severity of Chronic Obstructive Pulmonary Disease on the Pituitary Gonadal Axis

This study aims to investigate the levels of anabolic hormone implicated in specific clinical symptoms of chronic obstructive pulmonary disease (COPD) in relation to disease severity. Sixty-four male patients with COPD for at least two years were included. COPD diagnosed was based on pulmonary function tests, with severity classified using the CAT score and mMRC breathlessness scale. Levels of various hormones including TSH T3 T4, FSH, LH, testesterone, prolactin, progesterone and CRP were measured. Arterial blood gases were also analyzed. Patients were categorized according to GOLD stages. LH, FSH levels decreased during exacerbation, with a significant positive correlation between LH and low arterial oxygen levels. lower testosterone levels were statistically significant in severe COPD patients with FEV1 < 50%. A decrease in LH, testosterone FSH, TSH, progesterone and prolactin was observed with low blood oxygen levels, indicating dysfunction in the hypothalamic-pituitary-gonadal axis. However,stastistical significance varied.In conclusion, hormonal changes occur in male COPD patients, particulary related to disease severity. Testesterone levels correlate significantly with COPD severity. LH decrease during pronounced hypoxemia period was notable. Further research is necessary to evaluate the safety and efficacy of testosterone supplementation in COPD patients.

Advances in AI-based combination therapies versus standard treatments for heart failure in patients with advanced kidney injury

Background: Recent advancements in AI and Machine Learning (ML) can help manage kidney disease and heart failure by providing predictive analytics and personalized treatment plans, improving diagnostic accuracy, and assisting clinicians in controlling chronic disease symptoms like acute kidney injury (AKI) and Managing Heart Failure (HF). We evaluated AI and ML role in predicting AKI and managing HF patients and it involved analyzing various predictive models and technologies to improve early detection provide personalized treatment, and enhance overall patient outcomes in complex renal and cardiac conditions. Methodology: We conducted our search on databases Scopus, PubMed, and Web of Science. Empirical evidence and state of the art of cutting-edge literature and real-time field research was analyzed. Results: AI advancements in HF management for advanced kidney disease AKI include unsupervised machine learning for risk stratification, reinforcement learning for predictive modeling and dynamic management, and LLMs and chatbots for diagnostic support and patient education. New developments in AI and medical technology are predictive analytics for AKI, automated ultrasound interpretation, AI-enhanced dialysis monitoring, HF risk prediction, remote monitoring, and telehealth integration, and making personal treatment strategies according to patient needs. Innovations like wearable dialysis devices, bioengineered kidney tissues, ECMO, LVADs, TAVR, SGLT2 inhibitors, CRT, and nephroprotective drugs have also improved patient outcomes as these have enabled personalized care and early intervention strategies. Conclusion: It is possible to conclude that AI has revolutionized AKI and HF management. Novel technologies offer precise and adaptive care that strictly addresses individual patient needs.

The profile beyond leg pain: In basis of central sensitization, kinesiophobia, and body awareness in patients with chronic venous disease.

Objective: Leg pain has long been underestimated despite being one of the most important symptoms of chronic venous disease (CVD). Studies investigating leg pain and psychosocial profile in CVD are limited. The study aimed to investigate leg pain, central sensitization, kinesiophobia, and body awareness in patients with CVD. Methods: The ninety-eight patients (80 female, 18 male) diagnosed with CVD were included in the study. The severity of leg pain was evaluated with the Visual Analog Scale (VAS). The patients were assessed with the Central Sensitization Inventory (CSI-A and B) for central sensitization-related symptoms and -positivity, the Body Awareness Questionnaire (BAQ) for body awareness, and the Tampa Kinesiophobia Scale (TKS) for kinesiophobia. The cut-off score was admitted as 41 for TKS. Results: The leg pain (mean (SD) = 4.3 ± 2) and body awareness (mean (SD) = 82.4 ± 22) were moderate levels in patients with CVD. Nearly half of the patients (n = 46, 46.9%) had both central sensitization positivity and elevated kinesiophobia (n = 46, 47%). The CSI was correlated with the VAS (r = 0.32, p = .001), TKS (r = 0.40, p < .001), and BAQ (r = 0.20, p = .048). Significant correlations were determined between Body Mass Index and TKS (r = 0.48, p < .001) and BAQ (r = -0.31, p = .002). Also, the patients with a TKS score ≥41-points had higher CSI-A scores (p = .002) than those with a TKS score< 41. Conclusions: Leg pain, central sensitization, and kinesiophobia are commonly seen in patients with CVD, and central sensitization seems to have a negative effect on leg pain, kinesiophobia, and body awareness. The profile beyond pain should be evaluated in detail, and various rehabilitation strategies need to be developed to manage central sensitization, interoception, kinesiophobia, and weight control in patients with CVD.

The relationship between chronic disease and depressive symptoms in Chinese adolescents: emotion regulation as a moderator

The relationship between chronic disease and depressive symptoms in Chinese adolescents: emotion regulation as a moderator

Age-related differences in the number of chronic diseases in association with trajectories of depressive symptoms: a population-based cohort study

BackgroundThe number of chronic diseases has been associated with changes in depressive symptoms over time among middle-aged and older adults. This study aimed to explore the association between the number of chronic diseases and trajectories of depressive symptoms and the role of age in this association.MethodsA total of 12,974 middle-aged and older Chinese adults (≥ 45 years) participated in the China Health and Retirement Longitudinal Study (CHARLS) in waves 2011, 2013, 2015, 2018, and 2020. The number of chronic diseases was determined by self-reported hospital diagnosis of hypertension, dyslipidemia, diabetes, cancer, chronic lung diseases, liver disease, heart diseases, stroke, kidney diseases, digestive diseases, emotional, nervous, or psychiatric problems, memory-related disease, arthritis or rheumatism, asthma, and then obtaining the total number of chronic diseases. Depressive symptoms were measured by the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10). Group-based trajectory modeling (GBTM) was adopted to capture the trajectories of depressive symptoms over time. Multinomial logistic regressions were conducted to examine the association between the number of chronic diseases and trajectories of depressive symptoms and the role of age in this association.ResultsFour distinct trajectories of depressive symptoms were observed in 34.68% individuals in mild, 40.76% in moderate, 19.41% in increasing, and 5.15% in severe group. Compared to participants without chronic diseases, those with one, two, three or more chronic diseases had a 1.81, 3, and 7.49-fold higher risk of developing severe depressive symptom trajectory, respectively. Moreover, the association between the number of chronic diseases and severe depressive symptoms trajectory differed by age (45–59 and ≥ 60 years) (P for interaction < 0.05).ConclusionParticipants with middle age may play a promoting role in the association between the number of chronic disease and severe depressive symptoms. The severe depressive symptoms intervention may be more beneficial for middle-aged adults.

WFUMB Review Paper. Incidental Findings in Otherwise Healthy Subjects, How to Manage: Liver.

An incidental focal liver lesion (IFLL) is defined as a hepatic lesion identified in a patient imaged for an unrelated reason. They are frequently encountered in daily practice, sometimes leading to unnecessary, invasive and potentially harmful follow-up investigations. The clinical presentation and the imaging aspects play an important role in deciding if, and what further evaluation, is needed. In low-risk patients (i.e., without a history of malignant or chronic liver disease or related symptoms), especially in those younger than 40 years old, more than 95% of IFLLs are likely benign. Shear Wave liver Elastography (SWE) of the surrounding liver parenchyma should be considered to exclude liver cirrhosis and for further risk stratification. If an IFLL in a low-risk patient has a typical appearance on B-mode ultrasound of a benign lesion (e.g., simple cyst, calcification, focal fatty change, typical hemangioma), no further imaging is needed. Contrast-Enhanced Ultrasound (CEUS) should be considered as the first-line contrast imaging modality to differentiate benign from malignant IFLLs, since it has a similar accuracy to contrast-enhanced (CE)-MRI. On CEUS, hypoenhancement of a lesion in the late vascular phase is characteristic for malignancy. CE-CT should be avoided for characterizing probable benign FLL and reserved for staging once a lesion is proven malignant. In high-risk patients (i.e., with chronic liver disease or an oncological history), each IFLL should initially be considered as potentially malignant, and every effort should be made to confirm or exclude malignancy. US-guided biopsy should be considered in those with unresectable malignant lesions, particularly if the diagnosis remains unclear, or when a specific tissue diagnosis is needed.

The Expression of Circ-Astn1 Inhibits High Glucose Induced Endothelial Progenitor Cell Dysfunction by Activating Autophagy

ABSTRACT Background Diabetes mellitus (DM) and complications such as chronic kidney disease and cardiovascular symptoms pose a substantial public health burden. Increasing studies have shown that circular RNAs (circRNAs) regulate many gene expressions that are essential in diverse pathological and biological procedures. However, the roles of particular circRNAs in DM are unclear. Methods In the current investigation, endothelial progenitor cells (EPCs) were used to search for abnormal expression of circRNAs by using high-throughput sequencing under high glucose (HG) conditions. The regulatory mechanisms and targets were then studied through bioinformatics analysis, luciferase reporter analysis, angiogenic differentiation experiments, flow cytometry detection of apoptosis and RT-qPCR analysis. Results The circ-Astn1 expression in EPCs decreased after HG treatment. Overexpression or circ-Astn1 suppressed HG induced endothelial cell damage. MicroRNA (miR)-138-5p and SIRT5 were found to be the downstream targets of circ-Astn1 through luciferase reporter analysis. SIRT5 downregulation or miR-138-5p overexpression reversed circ-Astn1’s protective effect against HG induced endothelial cell dysfunction, including apoptosis and abnormal vascular differentiation. Furthermore, circ-Astn1 overexpression promoted autophagy activation by increasing SIRT5 expression under HG conditions. Our findings suggest that circ-Astn1 mediated promotion of SIRT5 facilitates autophagy by sponging miR-138-5p. Conlusion Together, our findings show that the overexpression of circ-Astn1 suppresses HG induced endothelial cell damage by targeting miR-138-5p/SIRT5 axis.

Elastic Venous Compression Devices for Pregnant and Post-Partum Women: Effects on Chronic Venous Disease Signs and Symptoms and Compliance

Pregnant women are at risk to develop Chronic Venous Disease (CVD) signs and symptoms. Compression therapy is one of the most effective conservative treatments for alleviating symptoms of CVD, particularly in pregnant women.

Consensus Statement on the Management of Nonthrombotic Iliac Vein Lesions From the VIVA Foundation, the American Venous Forum, and the American Vein and Lymphatic Society.

A nonthrombotic iliac vein lesion is defined as the extrinsic compression of the iliac vein. Symptoms of lower extremity chronic venous insufficiency or pelvic venous disease can develop secondary to nonthrombotic iliac vein lesion. Anatomic compression has been observed in both symptomatic and asymptomatic patients. Causative factors that lead to symptomatic manifestations remain unclear. To provide guidance for providers treating patients with nonthrombotic iliac vein lesion, the VIVA Foundation convened a multidisciplinary group of leaders in venous disease management with representatives from the American Venous Forum and the American Vein and Lymphatic Society. Consensus statements regarding nonthrombotic iliac vein lesions were drafted by the participants to address patient selection, imaging for diagnosis, technical considerations for stent placement, postprocedure management, and future research/educational needs.

Experiences of primary care nurses with using a handheld ultrasound device (Vscan) and a remote dielectric sensing (ReDS) device in the assessment of patients with heart failure

Abstract Background Early detection of increased lung fluids is vital to further prevent deterioration and treat worsening of heart failure (HF). However, nurses often face challenges in assessing the status of HF patients, especially in primary care, where specialized competence in cardiology may be lacking and many patients have co-morbidities. The handheld ultrasound device (Vscan) and remote dielectric sensing device (ReDS) have the potential to provide valuable support in these challenges. Purpose To describe the additional value of the information obtained with Vscan and ReDS in primary care, and to identify challenges encountered by nurses in relation to the measurements among HF patients. Methods One nurse in a Swedish primary healthcare centre used both devices on 17 separate occasions during January-June in 2023, involving a total of six patients (mean age 84.5 years, female 67%, NYHA II/III 33%/67%, lung disease 67%). The nurse made notes about the perceived value in the HF assessment and informativeness of the devices and any challenges encountered during the measurements using a self-administered questionnaire. Qualitative data was narratively reviewed and described. Results Information obtained from Vscan images such as pleural effusion and B-lines, and ReDS values contributed to the assessment of the HF status in patients, determining whether their condition worsened, remained stable or improved. These devices helped in verifying and confirming physical examination findings, including lung auscultation and subjective symptoms reported by the patient, such as shortness of breath and leg oedema. Additionally, the information (e.g., high ReDS value and the presence of B-lines) supported decisions on medication optimization, primarily through adjustments of diuretic dosages and initiation of new HF medications. It also helped to distinguish symptoms of asthma or chronic obstructive pulmonary diseases from worsening HF (e.g., presence of shortness of breath without B-lines and low ReDS value of 31). The nurse expressed uncertainty due to limited experience with using the devices, particularly when results from the two devises were not congruent. Trust in ReDS-data evolved over time and initial problems in managing the vest were resolved. Challenges associated with ReDS included difficulties in fitting the vest on patients with abnormal spine features and obesity, and issues arising from patient movements during measurements. Problems with Vscan included the generation and interpretation of ultrasound images, particularly in obese patients. Conclusion Our data suggests that both Vscan and ReDS have the potential to provide valuable information to primary care nurses in the daily management of HF patients, particularly for assessing HF status and optimizing medication. Further studies are needed to assess the effectiveness of these devices in improving patient outcomes in heart failure management in primary care.Handheld portable ultrasound (Vscan)ReDS device

Study on the impact of comprehensive geriatric assessment on anxiety and depression in chronic obstructive pulmonary disease patients.

Psychological factors such as anxiety and depression will not only aggravate the symptoms of chronic obstructive pulmonary disease (COPD) patients and reduce the quality of life of patients, but also affect the treatment effect and long-term prognosis. Therefore, it is of great significance to explore the clinical application of senile comprehensive assessment in the treatment of COPD and its influence on psychological factors such as anxiety and depression. To explore the clinical application of comprehensive geriatric assessment in COPD care and its impact on anxiety and depression in elderly patents. In this retrospective study, 60 patients with COPD who were hospitalized in our hospital from 2019 to 2020 were randomly divided into two groups with 30 patients in each group. The control group was given routine nursing, and the observation group was given comprehensive assessment. Clinical symptoms, quality of life [COPD assessment test (CAT) score], anxiety and depression Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) were compared between the two groups. CAT scores in the observation group decreased from an average of 24.5 points at admission to an average of 18.3 points at discharge, and in the control group from an average of 24.7 points at admission to an average of 18.3 points at discharge. The average score was 22.1 (P < 0.05). In the observation group, HAMA scores decreased from 14.2 points at admission to 8.6 points at discharge, and HAMD scores decreased from 13.8 points at admission to 7.4 points at discharge. The mean HAMD scores in the control group decreased from an average of 14.5 at admission to an average of 12.3 at discharge, and from an average of 14.1 at admission to an average of 11.8 at discharge. The application of comprehensive geriatric assessment in COPD care has a significant effect on improving patients' clinical symptoms and quality of life, and can effectively reduce patients' anxiety and depression.

M54 - Chronic Disease Symptoms Self-Managed With Cannabis During the COVID-19 Pandemic: Results From the COVID-19 Cannabis Health Study

M54 - Chronic Disease Symptoms Self-Managed With Cannabis During the COVID-19 Pandemic: Results From the COVID-19 Cannabis Health Study

An intelligent Health Monitoring System for Patients with Chronic Obstructive Pulmonary Disease based on Internet of Things

Abstract: Chronic obstructive pulmonary disease is an important cause of global mortality. These patients are in dire need of treatments to maintain lung function and reduce consecutive visits and hospital stays. IoT acts as a specialized assistant in healthcare, providing a wide range of potential applications such as remote monitoring. Therefore, this study has been compiled with the aim of designing a care system based on the Internet of Things for patients with chronic obstructive pulmonary disease. In this project, we designed a system for monitoring chronic obstructive pulmonary disease patients using an Arduino board and embedding three air quality sensors, heart rate and pulse oximetry, temperature sensor and Bluetooth module, and then implemented it on a patient with obstructive pulmonary disease. . The information obtained from the sensors is sent via Bluetooth to the mobile application that has the ability to share and store information and informs the doctor and the person about the changes. By using the pulse oximetry sensor, the patient increases the monitoring and part of his pulmonary rehabilitation, and by using the temperature and air quality sensor, he identifies the undesirable and harmful air and by informing the doctor and the person, he prevents the exacerbation of the symptoms of chronic obstructive pulmonary disease. This system increases the rehabilitation and self-care of patients, and by providing suitable environmental conditions, prevents unnecessary medical interventions and consecutive visits, and increases the quality of life of patients and reduces costs.