Symptomatic Arachnoid Cysts Research Articles

Symptomatic arachnoid cyst of the left frontal convexity in an adult: A case report.

Background: Arachnoid cysts are benign intra-arachnoidal cystic lesions whose content is cerebrospinal fluid. Most locations is supratentorial in the middle cranial fossa. The location in the convexity of the frontal lobe is unusual. Case Description: A previously healthy 21-year-old man was admitted to the emergency department for post-seizure loss of consciousness. Following imaging studies, a large cystic lesion in the convexity of the left frontal lobe was found. Total excision of the cyst wall was performed after craniotomy. The histology confirms the diagnosis of arachnoid cyst. Patient was followed up for the last 4 months without any symptoms or neurological deficit. Conclusion: Arachnoid Cysts in the frontal convexity are rare. Clinical symptoms is nonspecific and depend on the volume. The definite treatment if it's symptomatic is surgery.

Effect of continuous drainage of cranial arachnoid cysts into the ventricular system by stereotactic placed catheters

Background: Surgical treatment of intracranial arachnoid cysts (iACs) is challenging. Microsurgical resection, endoscopic fenestration and cysto-peritoneal shunting are the most frequently used methods, each implying their own drawbacks. Stereotactic-guided cysto-ventricular drainage has been described as an alternative method. Here we describe our experience with this technique and how we conducted volumetric measurements to evaluate the effect of permanent drainage. Methods: Standardized stereotactic planning was performed. The planned trajectory included both the iAC and the ventricle system. The catheter was shortened to the defined length and was further fenestrated along its planned course through the iAC to allow drainage into the ventricular system. Clinical and radiological control was performed on outpatient basis after a mean follow-up of 2 (1–3) months. The overall mean follow-up was 32 months (6–59). The measurement of the cyst volume was conducted by the ABC/2-method. Results: Six patients with symptomatic arachnoid cysts (4 f, 2 m) were treated between 2010 and 2016. The overall postoperative reduction in cyst volume at the first follow-up was 36.04% (at the long-term follow-up: 38.57%). Decrease of the midline-shift was achieved in all cases and averaged 57.83% (long term: 81.88%). Clinical improvement of related symptoms could be achieved in all patients (4 patients were symptom free, two patients had alleviated symptoms). There was no case of over-drainage. The catheter had to be removed after 6 months in one case due to infection. Conclusions: We demonstrate successful symptom control and volume reduction in a small series of iACs by continuous drainage into the CSF-system through stereotactic placed catheters. This method may facilitate a self-regulated egress of entrapped cyst fluid in symptomatic patients without risk of over-drainage. A literature survey of the success rate and the complications of this approach is provided. It is concluded that this minimally- invasive method may be an alternative to established fenestration techniques especially for patients with arachnoid cysts that aren’t directly adjacent to a cisternal or ventricular CSF space.

Хірургічне лікування арахноїдальних кіст середньої черепної ямки в дітей

Intracranial arachnoid cysts (ACs) are benign lesions that are usually incidental findings but can cause neurological symptoms due to the mass effect if they grow. The choice of the optimal surgical treatment for middle cranial fossa (MCF) ACs is still controversial. Such options include neuroendoscopic cystic cisternostomy, microsurgical cystic cisternostomy, cystoperitoneal shunting. Purpose - to conduct a comparative analysis of surgical techniques for the treatment of ACs in MCF; to analyze the results of surgical treatment of ACs in MCF. Materials and methods. Clinical and instrumental results and anamnesis data of all paediatric patients with ACs in MCF who underwent surgical treatment at the SI «Romodanov Institute of Neurosurgery of the NAMS of Ukraine» in 2016-2021 (19 cases) were analysed. 19 patients were selected, 10 of whom were operated on endoscopically, 3 - microsurgically, 6 - underwent cystoperitoneal bypass. Results. Improvement of the condition or disappearance of symptoms was observed in 9 (90%) out of 10 patients who underwent endoscopic surgery, in 2 (63%) out of 3 patients who were treated with microsurgery, in 6 (100%) out of 6 patients who underwent surgical treatment by gastric bypass. The frequency of repeated surgical interventions in the case of primary surgery by endoscopic method was on average 0.5 operations per 1 case, microsurgical method - on average 0.3 operations per 1 case, bypass surgery - on average 2 operations per 1 case. The length of stay in the hospital after surgery was: for patients undergoing bypass surgery - from 14 to 47 days (average - 24 days); for patients undergoing microsurgery - from 7 to 25 days (average - 13 days); for patients undergoing endoscopic surgery - from 7 to 10 days (average - 8 days). Conclusions. All surgical techniques are effective in the treatment of symptomatic ACs in MCF. Endoscopic treatment of symptomatic ACs in MCF allows to achieve a stable regression of clinical manifestations of the disease with a minimal likelihood of reoperation. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author.

Clinicoradiologic Risk Stratification and Outcome Assessment in Symptomatic Intracranial Arachnoid Cyst Managed Over Fifteen Years

Arachnoid cysts (ACs) are developmental anomalies formed by splitting the arachnoid membrane's layers. ACs contribute around 2% of all intracranial space-occupying lesions. ACs are more prevalent in children. Because of varied clinical presentation, there has been a constant need for clinicoradiologic risk stratification with a possible role in outcome prediction. The present study describes the management strategies and outcomes in symptomatic intracranial ACs. All biopsy-proven symptomatic patients who underwent surgical management over last 15 years were included in this study (January 2008-December 2022), while those with non-conclusive biopsies were excluded. Patients presenting with acute deterioration were managed in the emergency department with or without cerebrospinal fluid diversion and decompression of the AC. The microsurgical or endoscopic approach was the preferred surgical modality. Postoperative clinicoradiologic improvement was evaluated at 3 months follow-up visit. A total of 108 patients were analyzed in this retrospective observational study. The median age of the patients was 27.5 years (range, 1 to 76 years). Headache was the most typical clinical presentation. Supratentorial ACs (n= 59, 54.6%) were higher than the infratentorial ACs (n= 49, 45.4%). Forty-seven patients belonged to the pediatric age group (<18 years), and seizure was their presenting complaint. In this observational study, there was no statistical difference in operative duration between microsurgical technique versus endoscopic decompression (P= 0.23). ACs are uncommon brain lesions having a broad spectrum of symptoms. The location and clinical presentation of ACs decide the preferred surgical approach. Individuals in high-risk groups must be treated on priority to achieve long-term relief of symptoms.

Incidence and Surgical Outcomes of Intracranial Arachnoid Cysts: A Systematic Review Comparing Endoscopic Fenestration, Open Craniotomy and Cystoperitoneal Shunt Approaches

ABSTRACT Background: Arachnoid cysts (ACs) are non-neoplastic collections of cerebrospinal fluid, often posing challenges in diagnosis and management due to their rarity and varied clinical presentations. This systematic review aims to investigate the frequency of ACs, analyse optimal intervention approaches and evaluate neurological complications postoperatively. Materials and Methods: A systematic search of Science Direct, PubMed and Cochrane databases was conducted using controlled vocabulary terms and keywords. Inclusion criteria encompassed studies focusing on adults with symptomatic ACs requiring surgical intervention. Data extraction involved factors influencing subdural haemorrhage, surgical techniques, drainage types and imaging approaches. Adherence to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines ensured methodological rigor and transparency. Results: The review identified multiple surgical approaches, including microsurgical fenestration, endoscopic fenestration and cystoperitoneal shunt, tailored to different cyst locations. Studies showed cystoperitoneal bypass as effective for supratentorial cysts, endoscopic fenestration for midline cysts and cystoperitoneal shunt for infratentorial cysts. Notably, endoscopic fenestration exhibited a 90% success rate, while cystoventricular drainage emerged as an alternative option. However, limitations in comparative studies and variations in follow-up durations hindered comprehensive analyses. Conclusion: Cystocysternostomy, preferably minimally invasive, showed promising outcomes in managing ACs. Wide endoscopic fenestration was recommended without causing damage to adjacent structures. Surgical adaptation for uncontrolled bleeding during procedures was suggested. Intracranial shunts were preferred due to lower infection risks. Postoperative care involving anticonvulsants and conservative antibiotic therapy exhibited low complication rates. Despite limitations in available evidence, this review highlights potential effective interventions for managing ACs, emphasising the need for further comprehensive studies.

Intracranial arachnoid cysts: What is the appropriate surgical technique? A retrospective comparative study with 61 pediatric patients

ObjectiveSymptomatic intracranial arachnoid cysts (ACs) should be treated either through microsurgical (MS) or endoscopic surgical (ES) fenestration. Implantation of cysto-peritoneal shunt (CPS) system is another treatment option with decreasing indication. In our study, we compared the complication and revision rates between the three operative techniques in pediatric patients. MethodsWe included patients below 18 years with symptomatic intracranial ACs operated between 2004 and 2021. Initial symptoms, location, complication rate, clinical and radiological improvement, postoperative events and revision rate were compared retrospectively. ResultsSixty-one patients; 33 (54.1%) MS operated (mean age 7.6 years), 18 (29.5%) ES operated (mean age 6.2 years) and 10 (16.4%) with CPS (mean age 3.0 years) were collected. The most common initial symptom was headache in 45.9%. 20 (32.8%) postoperative events were documented. The highest revision rate (60%) was seen in the CPS group compared to 33.3% in MS group and 16.7% in ES group. 31 patients harbored perisylvian ACs, 89% remained event-free after ES, 71% after MS and 20% after CPS. Clinical improvement immediately after surgery was observed in 58 patients (96.9% in MS, 88.9% in ES and 100% in CPS). A radiological volume reduction could be proven postoperative in 51 patients (78.8% MS, 88.9% ES and 90% CPS). ConclusionEndoscopic fenestration of AC is a safe and efficient technique which is being widely used nowadays with the highest event free survival compared to microsurgical fenestration especially in perisylvian arachnoid cysts. CPS shows on long terms the highest revision rate but carries the least surgical risks.

Enlarging symptomatic arachnoid cyst in an elderly patient: illustrative case.

Arachnoid cysts are congenital or acquired structures found within the brain and are rarely symptomatic for adults. The literature documenting enlarging arachnoid cysts in adults is also discussed. An elderly woman presented with acutely worsening headaches, photophobia, cognitive function, and a seizure-like episode. The patient had a known arachnoid cyst with a decade of radiographic stability, which was now idiopathically enlarging. The patient had a previous history of traumatic brain injuries but no reported trauma around the time of presentation. Due to the severity of midline shift and symptomatology, the decision was made to treat the patient surgically with fenestration and shunting. She recovered well postoperatively. During the workup for a symptomatic elderly patient, enlargement of a previously asymptomatic arachnoid cyst should remain on the differential until specifically ruled out, even in the absence of recent trauma. While rare, enlarging arachnoid cysts result in neurological findings and impact the quality of life for patients.

Characteristic and management of pediatric arachnoid cysts: A case series

Background/Aim: Arachnoid cysts (ACs) are the collection of fluid, which is similar in composition to cerebrospinal fluid, within the congenitally duplicated arachnoid membrane. ACs are clinically silent lesions, but sometimes they can manifest themselves with headache, convulsion, focal neurological deficits, cognitive decline, torticollis, and macrocephaly. Although the appropriate surgical approach is less clear, there is a consensus on the need for surgical treatment in symptomatic ACs. This study aims to reveal the advantages and disadvantages of cystoperitoneal shunt and microsurgical fenestration techniques.&#x0D; Methods: One hundred ninety-one consecutive patients from 1 month to 15 years old with AC were evaluated for suitability. Sixteen patients who underwent surgery were included in the study. Medical records of the patients with AC managed at our institutions were retrospectively collected and analyzed. Sixteen of 191 patients underwent surgical treatment via craniotomy for microsurgical cyst fenestration (CF) and cysto-peritoneal shunting (CS). CF was performed with partial cyst wall excision in all patients.&#x0D; Results: Seizure was the most common presentation in the patients, followed by headache and trauma, respectively. In our series the most common indications of the surgery were increased intracranial pressure (IICP). CF was performed in nine patients, and CS was performed in seven as the primary treatment. CS-related complications, such as infection (n = 2), dysfunction (n = 2) and intraabdominal abscess (n = 1) were the most commonly observed complications. No infections were observed after CF, but subdural hematoma was observed in one child.&#x0D; Conclusions: Although the most common symptoms in cases with arachnoid cysts are headache, rare symptoms, such as torticollis, may exist. Due to this, clinicians should reveal the cyst-complaint relationship first. Given the increased complications of CS, in addition to shunt independency and being free from shunt-related complications, the microsurgical CF with wide excision of the membranes seems to be the more preferable surgical option.

193 Arachnoid Cysts as Genetically-encoded Harbingers of Neurodevelopmental Pathology

INTRODUCTION: Arachnoid cysts (ACs) are the most common congenital intracranial lesions. While familial cases implicate genetic factors, their ultimate cause remains unknown. Herein, we describe a multi-omics approach to disease state characterization including traditional whole exome sequencing, integrative genomics with analytics of large bulk-RNA and single cell RNA sequencing (scRNAseq) data, and a novel phenomics technique using natural language processing and Human Phenotypic Ontological (HPO) language clustering. METHODS: Whole exome sequencing was performed on 1560 individuals (520 parent-offspring "trios"). Genes with likely pathogenic mutations were defined as those with &gt;1 de novo variant (DNV) reaching threshold for exome-wide significance (p&lt;2.5 x 10-6) and having high pLI score (&gt;0.9). This high-confidence pathogenic gene set and a secondary probable pathogenic gene set (&gt;1 DNV, regardless of exome-wide significance or pLI score) were analyzed in bulk-RNA and scRNAseq datasets to assess spatiotemporal and cell-type relationships of gene expression. Phenomic analysis was conducted by subjecting patient medical records to a natural-language-processing (NLP) algorithm. Phenotypes were catalogued with the Human Phenotype Ontology (HPO) language tree and mapped with uniform manifold approximation and projection (UMAP) clustering. RESULTS: 7 genes reached our pathogenic threshold, ADNP, ARIDB1, KDM5C, PURA, FOXP1, MAP2K1, and SCN2A. Strikingly, all but SCN2A play critical roles in epigenetic regulation of gene expression in the developing brain. Bulk-RNA datasets reveal that these genes converge in networks essential for chromatin remodeling and mRNA processing. scRNAseq datasets revealed an association with excitatory and inter-neurons known to play a role in developmental delay. HPO clustering revealed four major phenotypic clusters defined by neurodevelopmental delay (NDD), seizures, both or asymptomatic. In a subgroup of traditionally phenotyped patients, there was statistically significant enrichment of neuraxial phenotypes - including NDD - among those harboring DNVs. CONCLUSION: This novel association between ACs and multiple epigenetic regulators of gene expression provides the first insight into intracranial AC pathobiology. HPO clustering reveals clinically relevant subsets of ACs and implies that traditionally symptomatic or asymptomatic ACs may be harbingers of genetically-driven aberrant neurodevelopment.

Microsurgical Management of Symptomatic Intracranial Arachnoid Cyst: Experience of 15 Cases

Background: Arachnoid cysts are fluid-filled sacs that occur on the arachnoid membrane that covers the brain. In most of the cases these cysts are asymptomatic and do not require any treatment. Only symptomatic arachnoid cysts require treatment. Objectives: The objective of this study was to see the results of microsurgical treatment of intracranial arachnoid cyst. Methods: This retrospective cross sectional study was carried out in the Department of Neurosurgery, National Institute of Neurosciences &amp; Hospital, Dhaka, Bangladesh. Total 15 cases were included in this study for a period of 3 years. Data were collected including their operation procedures and follow up by questionnaires and finally observed the results. Results: Among the 15 patients about one third were presented in the second decades of life with male predominant. Significant clinical improvement was observed among most of the patients. The radiological decrease of the size of the cysts was also found. The results of microsurgical excision were better than other procedures. Conclusions:Surgical treatments are needed only in symptomatic cases. Clinical and radiological outcome of the surgical treatment is satisfactory. Bang. J Neurosurgery 2021; 11(1): 13-17

Limits to Neurosurgical Care for an Undocumented Immigrant in the United States

Documentation status is a well-recognized social determinant of health in the immigrant population of the United Sates. Lack of financial means and fear of legal repercussions can delay medical attention, limit treatment options, and decrease patient follow-up. This is reinforced by current government policies that limit financial assistance in emergency situations and deny coverage of preventative or follow-up care. Here we report a case of an otherwise healthy 24-year-old undocumented immigrant who presented to a rural United States emergency room with new-onset seizure, blurry vision, and headache. The patient was admitted to the neurosurgical service where he was diagnosed and treated for a symptomatic arachnoid cyst. Here we review current healthcare legislation that restricts access to preventative and follow-up healthcare in the United States. This case highlights the ways in which the undocumented immigrant patient population remains negatively impacted by these policies, often leading to late presentation and limited neurosurgical treatment options.

Cystoventricular Drainage of Intracranial Arachnoid Cysts in Adults

Intracranial arachnoid cysts (ACs) are generally benign fluid-filled cysts with a prevalence of 0.5%-2.7%. They can be treated through craniotomy with cyst removal, endoscopic fenestration, or cystoperitoneal or ventriculoperitoneal shunting. However, the outcome of these treatments has not been completely satisfactory. Cystoventricular shunting was described as an alternative method for the treatment of intracranial ACs in children in 2003. In the present report, we have described the outcomes of cystoventricular shunting in adults with symptomatic intracranial ACs. A total of 24 patients with symptomatic ACs underwent cystoventricular drainage from 2012 to 2019. The most common symptom preoperatively was headache, followed by dysphasia, motor weakness, memory loss, seizures, and balance disturbances. After radiological evaluation, a ventricular catheter was placed in the AC and another in one of the lateral ventricles and connected extracranially after subgaleal tunneling using a straight metal connector. At 3-6 months of postoperative follow-up, 21% of patients were asymptomatic and 42% showed improvement in clinical symptoms. No patient had experienced impairment or progression of symptoms postoperatively. Three patients had required revision of the catheters and one patient had developed a postoperative superficial skin infection without signs of deeper infection. Cystoventricular drainage seems to be an effective, reliable, and safe procedure to treat intracranial ACs when fenestration to the basal cisterns is not possible.

Surgical outcome of primary intradural spinal arachnoid cysts: a series of 10 cases

BackgroundPrimary intradural spinal arachnoid cysts are rare pathologies of uncertain etiology and variable presentation from no symptoms to myelopathy or radiculopathy according to cord or root compression. MRI with diffusion and contrast differentiates them from many pathologies. There is a lot of debate regarding when to treat and how to treat such rare pathologies.ObjectiveWe present a series of 10 primary intradural arachnoid cysts and evaluate outcome after surgery.MethodsThis retrospective study includes patients having primary intradural spinal arachnoid cysts operated in two tertiary care centers from October 2012 till October 2019. Symptomatic cysts were subjected to microsurgical resection or outer wall excision and inner wall marsupialization under neurophysiological monitoring. The Japanese Orthopedic Association Score was used for clinical evaluation while MRI with contrast and diffusion was used for radiological evaluation before and after surgery.ResultsThis series included 10 patients, 4 males and 6 females, with mean age of 40 years. Pain was the most common presentation. The most common location was dorsal thoracic region. Total excision was achieved in 2 cases and marsupialization in 8 cases.All symptoms improved either completely or partially after surgery. No neurological deterioration or recurrence was reported during the follow-up period in this series.ConclusionTreatment of symptomatic primary intradural spinal arachnoid cysts should be microsurgical resection, when the cyst is adherent to the cord, microscopic fenestration can be safe and effective.

Results of Surgical Treatment in Patients with Intracranial Arachnoid Cyst During Last 5 Years in a Referral Center in a Developing Country: Shiraz, Iran

To report the outcome of surgical intervention in patients diagnosed with arachnoid cyst (AC) during the last 5 years in Namazi Hospital, a tertiary center in Southern Iran. Hospitalization records of patients who had undergone surgical treatment of symptomatic intracranial AC in our center were surveyed retrospectively. Radiologic imaging was extracted from the picture archiving and communication system and analyzed. Postoperative evaluation of patients was conducted in neurosurgery clinic during their routine follow-up. Twenty-nine patients (11 female, 18 male) with an age range of 13 days to 35 years were enrolled in this study. Most (62%) of all ACs were in the temporal area, 12% in the suprasellar region, 6% in the quadrigeminal region, 6% in the cerebellopontine angle, and 3% in the anterior frontal area. Twenty-six endoscopic intervention, 2 microsurgical resection, and 1 cystoperitoneal shunt were performed. All of the patients showed complete resolution or improvement in symptoms. Eighty-nine percent of patients also showed reduction in the cyst size. Ten patients had transient postoperative complications, which were resolved at the time of follow-up. Diagnosis and appropriate surgical treatment of AC can alleviate the symptoms in patients who fulfill the criteria for surgery. Neuroendoscopy can provide a satisfactory result in symptomatic patients, whilst having less invasiveness and long-term complications. Reoperation should also be considered in situations where medical therapy fails to manage the complications.

Paediatric arachnoid cysts: Surgical outcomes from a Singapore children’s hospital

Arachnoid cysts (AC) are reported to have a prevalence of up to 2.6% in children. Most AC remain indolent, but others may expand or rupture to cause life-threatening symptoms of raised intracranial pressure. Currently, there are 2 controversial topics with regards to the management of ACs: the indications for surgery and the choice of surgical procedure. We therein report our institution’s neurosurgical experience for symptomatic AC over a 22-year period and corroborate our results with published literature. This is a single institution, retrospective study conducted at KK Women’s and Children’s Hospital from 01 January 1998 to 31 December 2019. A total of 38 patients with ACs that required surgery were recruited. The 3 most common anatomical locations were in the middle cranial fossa (40.5%), posterior fossa (24.3%) and interhemispheric (13.5%). Typical clinical presentations included symptoms of raised intracranial pressure (34.2%), obstructive hydrocephalus (28.9%) and AC rupture (21.1%). Surgical approaches included 17 craniotomy-based procedures, 7 endoscopic fenestrations, 11 cystoperitoneal shunts, 2 burrhole drainage operations and 1 excision of spinal AC. Thirteen patients (34.2%) underwent either another operation due to the lack of resolution of their AC-related symptoms or secondary to complications directly related to their initial surgery. Average length of followup from time of first operation was 84.1 months. Overall, our results demonstrate similarities in epidemiology, clinical presentation and surgical experience, in comparison to larger cohort studies. We advocate collaborative efforts to better understanding of the pathophysiology of paediatric ACs, particularly for deciding between the various surgical treatment modalities.

Positive outcome after endoscopic treatment of a symptomatic convexity arachnoid cyst in an elderly

Cerebral convexity arachnoid cysts (ACs) only represent around 10–14% of the cysts. Symptomatic ACs in the elderly are rare. We present a 66-year-old woman with headache and a focal epileptic seizure. Imaging revealed a left parietal AC. Conservative management chosen but the patient’s neurological condition worsened, and an endoscopic fenestration was then performed. Postoperatively, her symptoms completely resolved and MRI image showed significant shrinkage of the AC.

Management and outcome of symptomatic intracranial arachnoid cysts

Management and outcome of symptomatic intracranial arachnoid cysts

MANAGEMENT OF INTRACRANIAL ARACHNOID AND PORENCEPHALICCYSTS (CONSERVATIVE VERSUS SURGICAL)

Background: Arachnoid cysts (ACs) are benign developmental cysts that occur along the craniospinal axis. Arachnoid cysts comprise 1% of all intracranial space-occupying lesions. Objective: To evaluate the cases of intracranial arachnoid cysts clinically and radiologically and the possibility of surgery. Patients and Methods: The study was done prospectively on 22 patients presented with intracranial arachnoidcysts (15 of them were medically managed, and 7 of them were surgically managed) in the Neurosurgery Department, Al-Azhar and Alexandria Universities on patients suffering from extra-axial intracranial arachnoid cysts. The study was performed through the period from March 2019 to February 2020, and the follow up period was 6 months. All cases, either surgical or conservative cases, had been evaluated regarding (clinical improvement of symptoms, radiological reduction in size of the cyst, rate of complications, wound healing and need for subsequent lines of management. Results: Patients with satisfactory clinical outcome was observed in most of the total managed cases (72.7%). There was a statistical significant difference in clinical outcome between the medical management group and the surgical management group as almost medically managed patients (86.7%) improved clinically. Improved radiological outcome was observed in 42.9% of surgically managed patients. Postoperative complications were observed in the majority of surgically managed patients. Most common complication was hydrocephalus in 42.9% of patients. Conclusion: Management of intracranial arachnoid cysts remained controversial, and most of the patients managed conservatively, but we believe that proper clinical and radiological evaluation of symptomatic arachnoid cysts leads to better outcome.

Congenital Diaphragmatic Hernia - A Late Presentation

Congenital Diaphragmatic Hernia - A Late Presentation

Symptomatic Arachnoid Cysts are Associated With Mutations in Chromatin Remodeling Genes

Symptomatic Arachnoid Cysts are Associated With Mutations in Chromatin Remodeling Genes