Polyaxial locking systems are widely used for strategic surgical placement, particularly in cases of osteoporotic bones, comminuted fractures, or when avoiding pre-existing prosthetics. However, studies suggest that polyaxiality negatively impacts system stiffness. We hypothesize that a new plate design, combining a narrow plate with asymmetric holes and polyaxial capabilities, could outperform narrow plates with symmetric holes. Three configurations were tested: Group 1 with six orthogonal screws, and Groups 2 and 3 with polyaxiality in the longitudinal and transverse axes, respectively. A biomechanical model assessed the bone/plate/screw interface under cyclic compression (5000 cycles) and torsion loads until failure. Screws were inserted up to 10° angle. None of the groups showed a significant loss of stiffness during compression (p > 0.05). Group 1 exhibited the highest initial stiffness, followed by Group 3 (<29%) and Group 2 (<35%). In torsional testing, Group 1 achieved the most load cycles (29.096 ± 1.342), while Groups 2 and 3 showed significantly fewer cycles to failure (6.657 ± 3.551 and 4.085 ± 1.934). These results confirm that polyaxiality, while beneficial for surgical placement, reduces biomechanical performance under torsion. Despite this, no group experienced complete decoupling of the screw-plate interface, indicating the robustness of the locking mechanism even under high stress.