Recently, many scientists have studied a wide range of strategies for solving characteristic types of symmetric differential equations, including symmetric fractional differential equations (FDEs). In our manuscript, we obtained sufficient conditions to prove the existence and uniqueness of solutions (EUS) for FDEs in the sense ψ-Caputo fractional derivative (ψ-CFD) in the second-order 1<α<2. We know that ψ-CFD is a generalization of previously familiar fractional derivatives: Riemann-Liouville and Caputo. By applying the Banach fixed-point theorem (BFPT) and the Schauder fixed-point theorem (SFPT), we obtained the desired results, and to embody the theoretical results obtained, we provided two examples that illustrate the theoretical proofs.