Introduction: This research aims to explore and design a comic book cover design that can attract the attention of adolescents, considering input from a Focus Group Discussion (FGD). Visual style and aesthetics of the comic are considered crucial to engage the primary target audience, which is adolescents. Materials & Methods: This study used a qualitative approach to explore the development of an Islamic-themed comic suitable for the pesantren (Islamic boarding school) community. The research employed a Focus Group Discussion (FGD) approach to gather input and preferences from adolescents regarding the cover design, characters, storyline, and visual aesthetics of the comic. The FGD discussion results were then used as a basis to design a comic that aligns with the target audience. Results: The development of an Islamic-themed comic for the pesantren community requires attention to several critical aspects. First, the comic must prioritize the conveyance of moral messages and Islamic teachings through its visual aesthetics, featuring scenes that reflect the ethics, morality, and religious practices upheld by the pesantren. The use of widely recognized Islamic symbols, such as Arabic calligraphy and Islamic emblems, can reinforce the Islamic identity of the comic. The selection of warm and neutral colors is also essential to create an atmosphere of peace and tranquility, which is characteristic of the religious context. A simpler, cleaner, and more realistic artistic style is generally preferred by the pesantren community. Attention to representational ethics, such as the selection of modest clothing and character appearances that reflect propriety and dignity, must also be considered. Finally, the visual aesthetics of the comic should reflect the local cultural context of the pesantren, to enrich the visual experience of the readers and strengthen the identity of the pesantren. The FGD results emphasize that the comic book cover design should be simple yet appealing, using vibrant colors that can captivate adolescents. The Japanese or Korean anime visual style is considered most suitable to the current tastes of adolescents. However, Islamic values must be maintained, such as in the character’s appearance and attitude, which should reflect an Islamic personality. Furthermore, the main character of the comic should embody a diligent and positive female role model to inspire adolescent readers. The storyline is designed to provide a comprehensive and educational narrative about personal hygiene in the life of a pesantren. Conclusion: The findings of this research emphasize the importance of a simple yet appealing comic book cover design, utilizing Japanese or Korean anime styles to capture the attention of adolescents while still maintaining Islamic values. The visual aesthetics of the comic must reflect the moral message of Islam through the use of Islamic symbols, appropriate color choices, and a simple yet realistic art style.