Switching Cell Research Articles

IMPLEMENTATION OF VECTOR MODULATION APPLIED TO THE THREE-PHASE DC-AC CONVERTER VSI USING A FOUR-STATE SWITCHING CELL

This article presents the implementation of spatial vector modulation applied to the three-phase VSI converter with four-state switching cell. The methodology used is shown in detail, indicating the vectors used, the applied switching sequence and the calculations of the vector activation times. It also contains the results of the converter operation in simulation, showing the main waveforms. The following presents the results obtained by experimentation with the assembled prototype.

High‐Resolution Optical Convolutional Neural Networks Using Phase‐Change Material‐Based Microring Hybrid Waveguides

In the More‐than‐Moore era, the explosive growth of data and information has driven the exploration of alternative non‐von Neumann computational paradigms. Photonic neuromorphic computing has emerged as a promising approach, offering high speed, wide bandwidth, and massive parallelism. Herein, a high‐resolution optical convolutional neural network (OCNN) is introduced using phase‐change material Ge2Sb2Te5 (GST)‐based microring hybrid waveguides. This on‐chip optical computing platform integrates GST into photonic devices, enabling versatile programming and in‐memory computing capabilities. Central to this platform is a photonic convolutional computational kernel, constructed from photonic switching cells embedded with GST on a microring resonator. This programmable photonic switch leverages the refractive index modulation during the GST phase transition to achieve up to 64 discrete levels of transmission contrast, suitable for representing matrix elements in neural network algorithms with 6‐bit resolution. Using these matrix elements, an OCNN capable of performing parallelized image edge detection and digital recognition tasks with high accuracy is demonstrated. The architecture is scalable for large‐scale photonic neural networks, offering ultrahigh computational throughput, a compact design, complementary metal‐oxide‐semiconductor‐compatible fabrication, and broad bandwidth.

Effect of surface alignment on electric-field-induced phase transitions in blue phases

This study investigates the critical electric field thresholds required for phase transitions in the blue phases of liquid crystals (BPs) confined within vertical field switching cells. BPs are attractive for electro-optical applications due to their polarization-independent response and fast switching times; however; challenges remain regarding their limited temperature stability and previously reported high operational voltages. We employ a combined approach of polarized optical microscopy and electrical impedance analysis to identify the electric field thresholds triggering BP transitions to focal conic domains in cells with and without planar polyimide alignment layers. We show that surface alignment layers stabilize the blue phases and allow for higher applied electric fields before transitioning into the focal conic state. This suggests the possibility of a wider operational voltage range in thinner cells with alignment layers. These findings significantly improve our understanding of BPs, addressing key challenges and paving the way for their integration into advanced photonic devices, based on the CMOS technology.

Design of a new modular‐isolated‐forward‐based active snubber cell for power switches

AbstractIn this paper, a new modular‐isolated‐forward‐based active snubber cell (SC) for power switches is designed. In the proposed new SC, the zero voltage transition (ZVT) technique is implemented with a forward converter although the current counterparts generally use a flyback converter. In the converter with the new SC, the main switch is turned on with ZVT (full zero voltage switching [ZVS]) and turned off with ZVS, the main diode is turned off with zero current switching (ZCS), the auxiliary switch is turned on with ZCS and turned off with ZVS, and the parasitic capacitor energies are recovered. In addition, thanks to the forward converter, it has been possible to minimize the transformer leakage inductance and greatly reduce the current values of devices in the new SC. The new cell is applied to a single‐phase, grid‐connected, T‐type three‐level inverter (T2‐3LI) as an example. A detailed steady‐state analysis of this inverter was made, and the theoretical analysis was confirmed with measurement results taken from a prototype with 100 kHz and 3.3 kW values. Compared to its hard switching (HS) equivalent, in the converter with soft switching (SS) cell, the total circuit loss was reduced from about 248 W to 86 W, thus achieving an increase in the total efficiency from 92.5% to 97.4%.

A Novel Non-Isolated Bidirectional DC-DC Converter with Improved Current Ripples for Low-Voltage On-Board Charging

This paper presents a novel single-phase non-isolated bidirectional buck converter topology. The proposed converter uses a basic switching cell structure with a coupled inductor and an interleaving switching scheme. This article addresses a crucial challenge in bidirectional DC-DC conversion by prioritizing reducing output current ripples and minimizing filter inductor size. The employed method includes using MOSFETs with fast recovery diodes to mitigate reverse recovery and body diode losses. Furthermore, the optimization of the switching frequency of the output inductor to be twice the actual switching frequency contributes to reducing the component size of the converter. The coupled inductor also helps to reduce stress on components by distributing currents among its legs. The experimental result demonstrates the proposed converter has a very low ripple current as compared to the conventional converter. The low current ripples and smaller filter inductor size enabled by high-frequency operation have improved the efficiency and size of the converter. A common ground between input and output terminals ensures robust performance without common mode current concerns. Overall, the proposed converter represents a significant improvement in DC-DC converters, promising enhanced efficiency, reliability, and compactness in bidirectional DC-DC conversion systems. In order to verify the performance of the proposed converter, a 460 W buck converter prototype was built and tested.

A Cascaded H-Bridge Multilevel Inverter with DC Cells Input Fault Tolerance Capability Based on PSC-PWM Control

Multilevel inverters have proven their efficiency in generating better AC voltage outputs. This functional quality is mainly due to the use of multi-source DC inputs. Despite the fact that this type of topology is generally reliable, switching faults caused by the complete loss of a switching component or DC input cell may still occur. Such incident may inflict heavy impacts to the conversion chain resulting in a permanent damage to the switching cells or the connected load. This article presents a dynamic switching control strategy capable of tolerating DC cells open-circuit input faults in basic symmetric Cascaded H-bridge multilevel inverter architectures. The proposed topology uses a control scheme to overcome the switching cells’ fault by adapting the configured level of conversion and bypassing the flawed unit with no additional switching components. Furthermore, the proposed control strategy is capable of reversing back the inverter configuration to its original functional state after the disappearance of the faut. This research article answers the need for a theorical study of a fault tolerant Cascaded H-Bridge multilevel inverter where the short circuit’s fault types are bypassed by Pulse width modulation alteration only.

Generalized Pulse Width Modulation Switch Model for Converters Based on the Multistate Switching Cell in Discontinuous Conduction Mode.

This work introduces a generalized version of the pulse width modulation (PWM) switch model applied in the small-signal modeling of converters based on the multistate switching cell (MSSC) operating in discontinuous conduction mode (DCM). It consists of extending the concept formerly introduced by Vorperian for the representation of multiphase converters in DCM, yielding a circuit-based approach that does not rely on matrix manipulations unlike state-space averaging (SSA). The derived dc and ac models are valid for any number of switching states and any operating region defined in terms of the duty cycle, thus allowing for determining the voltage gain and distinct transfer functions. A thorough discussion of results is presented to demonstrate the applicability of the derived models to represent distinct configurations of the MSSC.

Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury.

Excessive amounts of reactive oxygen species (ROS) lead to macromolecular damage and high levels of cell death with consequent pathological sequelae. We hypothesized that switching cell death to a tissue regenerative state could potentially improve the short-term and long-term detrimental effects of ROS-associated acute tissue injury, although the mechanisms regulating oxidative stress-induced cell fate decisions and their manipulation for improving repair are poorly understood. Here, we show that cells exposed to high oxidative stress enter a poly (ADP-ribose) polymerase 1 (PARP1)-mediated regulated cell death, and that blocking PARP1 activation promotes conversion of cell death into senescence (CODIS). We demonstrate that this conversion depends on reducing mitochondrial Ca2+ overload as a consequence of retaining the hexokinase II on mitochondria. In a mouse model of kidney ischemia-reperfusion damage, PARP inhibition reduces necrosis and increases transient senescence at the injury site, alongside improved recovery from damage. Together, these data provide evidence that converting cell death into transient senescence can therapeutically benefit tissue regeneration.

Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1

Reactive oxygen species (ROS) are highly reactive and their accumulation causes oxidative damage to cells. Cells maintain survival upon mild oxidative stress with anti-oxidative systems, such as the kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) system. On the other hand, upon severe oxidative stress, cells undergo regulated cell death, including apoptosis, for eliminating damaged cells. To execute efficient cell death, cells need to turn off the anti-oxidant systems, while triggering cell death. However, it remains unknown how cells orchestrate these two conflicting systems under excessive oxidative stress.Herein, we show that when cells are exposed to excessive oxidative damage, an E3 ubiquitin ligase Roquin-2 (also known as RC3H2) plays a key role in switching cell fate from survival to death by terminating activation of transforming growth factor-β-activated kinase 1 (TAK1), a positive regulator for Nrf2 activation. Roquin-2 interacted with TAK1 via four cysteine residues in TAK1 (C96, C302, C486, and C500) that are susceptible to oxidative stress and participate in oligomer formation via disulfide bonds, promoting K48-linked polyubiquitination and degradation of TAK1. Nrf2 was inactivated upon lethal oxidative stress in wild-type mouse embryonic fibroblast (MEF) cells, whereas it sustained activation and conferred resistance to Roquin-2 deficient cells, which was reversed by pharmacological or genetic inhibition of TAK1. These data demonstrate that in response to excessive ROS exposure, Roquin-2 promotes ubiquitination and degradation of TAK1 to suppress Nrf2 activation, and thereby contributes to an efficient cell death, providing insight into the pathogenesis of oxidative stress-related diseases, including cancer.

Thermal analysis of an integrated motor drive with a switching cell array power converter

In modern electric propulsion systems the electric motor is tightly integrated with the power converter and control unit. These so called Integrated Motor Drives can allow for vast improvements in efficiency and volume reduction, due to the elimination of redundant electric components, and the shared case and cooling system between the motor and the power converter. The cooling systems used in these applications must be carefully designed as the motor and power electronics components may feature greatly different temperature limits. This work discusses the development of a thermal model for an integrated motor drive composed by a six phase permanent magnet motor with hairpin windings and a switching-cell-array-based multilevel power converter. The system is modelled by means of a lumped parameter thermal network which includes an accurate model of the motor stator and rotor, as well as the arrangement of the power switches on the converter boards. The conductive resistances are simply obtained from geometric data and material properties. Instead, the convective resistances are evaluated by means of empirical models available in the literature and a CFD model for the cooling jacket. The developed model is employed to assess the feasibility of the presented arrangement of motor and power electronics components from the thermal point of view.

Mitigating reverse recovery power losses in MOSFET switching cell using extra Schottky diodes—Application to voltage source inverter

This article introduces a comparative study of the losses in Voltage Source Inverter (VSI) based on Metal-Oxide- Semiconductor Field-Effect Transistors (MOSFETs) depending on whether or not the latter are associated with antiparallel diodes. These diodes are optional because MOSFETs have an intrinsic diode capable of conducting reverse currents when their channel is in OFF state. However, it induces additional reverse recovery losses and damaging voltage overshoots. This undesired circumstance occurs during the mandatory switching cell dead-time and is accurately modelled and assessed in this study. Conversely, Schottky diodes feature almost zero reverse recovery losses. Hence, combining each MOSFET with an antiparallel Schottky diode may reduce the converter overall losses. To assess this strategy, an analytical model of the charge stored within the body diode is developed and then compared to experiments using the Double Pulse Test (DPT). It reveals accurate and well suited because it requires only two constant macro parameters which permits to forecast the reverse recovery losses over a wide range of operating conditions, namely switched current, current slope and dead time duration. The selected model is applied in the case where a Schottky diode is placed antiparallel to the MOSFET. It then appears clearly that the interest of such a combination depends on the static characteristics of both the MOSFET and the Schottky diode. This output is a noteworthy point for power electronics designers. Finally, the developed model is applied in the standard use case of the Voltage Source Inverter (VSI). The results reveal the advantage of the suggested model in this use case because the current evolves significantly over time. The outcome of this VSI analysis shows that a significant recovery losses decrease is achieved with good sizing fit between the MOSFET transistor and the additional Schottky diode.

Unified Small-Signal Model for DC–DC Converters Based on the Four-State Switching Cell in Discontinuous Conduction Mode

Unified Small-Signal Model for DC–DC Converters Based on the Four-State Switching Cell in Discontinuous Conduction Mode

Bispecific antibodies tethering innate receptors induce human tolerant-dendritic cells and regulatory T cells.

There is an urgent need for alternative therapies targeting human dendritic cells (DCs) that could reverse inflammatory syndromes in many autoimmune and inflammatory diseases and organ transplantations. Here, we describe a bispecific antibody (bsAb) strategy tethering two pathogen-recognition receptors at the surface of human DCs. This cross-linking switches DCs into a tolerant profile able to induce regulatory T-cell differentiation. The bsAbs, not parental Abs, induced interleukin 10 and transforming growth factor β1 secretion in monocyte-derived DCs and human peripheral blood mononuclear cells. In addition, they induced interleukin 10 secretion by synovial fluid cells in rheumatoid arthritis and gout patients. This concept of bsAb-induced tethering of surface pathogen-recognition receptors switching cell properties opens a new therapeutic avenue for controlling inflammation and restoring immune tolerance.

A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification

The Drosophila tracheal system is a favorable model for investigating the program of tubular morphogenesis. This system is established in the embryo by post-mitotic cells, but also undergoes remodeling by adult stem cells. Here, we provide a comprehensive cell atlas of Drosophila trachea using the single-cell RNA-sequencing (scRNA-seq) technique. The atlas documents transcriptional profiles of tracheoblasts within the Drosophila airway, delineating 9 major subtypes. Further evidence gained from in silico as well as genetic investigations highlight a set of transcription factors characterized by their capacity to switch cell fate. Notably, the transcription factors Pebbled, Blistered, Knirps, Spalt and Cut are influenced by Notch signaling and determine tracheal cell identity. Moreover, Notch signaling orchestrates transcriptional activities essential for tracheoblast differentiation and responds to protein glycosylation that is induced by high sugar diet. Therefore, our study yields a single-cell transcriptomic atlas of tracheal development and regeneration, and suggests a glycosylation-responsive Notch signaling in cell fate determination.

Thickness‐Dependent Bandgap and Atomic Structure in Elemental Tellurium Films

Elemental tellurium electrical switch, relying on a transient crystal–liquid–crystal phase transition, has recently been proposed as a promising selector candidate for the next‐generation 3D high‐density memory, bridging performance gap in today's computer. Further miniaturization of the switch cell to increase memory density strongly depends on the scalability of the tellurium film, which, however, has not been experimentally studied. Herein, the tellurium films are prepared with the thickness downscaled from 400 to 2 nm and a significant increase is found in the bandgap from 0.29 to 0.91 eV, as predicted by ab initio molecular dynamics. Interestingly, the as‐deposited tellurium films with a thickness above 3 nm are in the crystalline trigonal phase, whereas 2 nm thick film suddenly becomes amorphous, observed by both Raman and transmission electron microscopies. In this finding, since the leakage current of the elemental tellurium switch is determined by both the Schottky barrier between tellurium/electrode interface and the bandgap of the tellurium film, a reduction in leakage current is predicted with further miniaturization.

Transforming lung cancer types.

Lung cancer cells can escape targeted therapy by switching oncogenic drivers and cell identity.

Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells

Betaxolol is commonly used to manage glaucoma in clinical practice. However, its long-term use may damage the cornea. Thus, the cytotoxicity and mechanisms of betaxolol in human corneal stromal cells (HCSCs) warrant further study. In this study, we used in vitro HCSCs and in vivo rabbit corneal models to investigate betaxolol cytotoxic effects and mechanism of action. At near-clinical concentrations (0.28% and 0.14%), betaxolol inhibited caspase-8 activity, activated receptor-interacting protein kinase (RIPK)1, RIPK3, and mixed-spectrum kinase-like domain (MLKL), and phosphorylated MLKL to induce necroptosis in HCSCs. Similarly, moderate concentrations of betaxolol (0.07%–0.0175%) activated caspase-8 to trigger the exogenous apoptotic pathway. Through the intrinsic apoptotic pathway, betaxolol upregulated the expression of Bcl-2 family apoptotic proteins Bax and Bad and downregulated that of anti-apoptotic proteins Bcl-2 and Bcl-xL. This subsequently disrupted the mitochondrial membrane potential and cytoplasmic transfer of cytochrome c and apoptosis-inducing factor, activated caspase-9, and induced apoptosis in HCSCs. Furthermore, continuous treatment with low betaxolol concentrations (0.00875%) for three generations of HCSCs prevented apoptosis by promoting the expression of Bcl-xL and suppressing that of Bax. However, its toxic effects initiated cellular senescence by increasing reactive oxygen species, leading to the disruption of energy metabolism and DNA damage. Finally, clinical concentrations of betaxolol had a pro-apoptotic effect on rabbit corneal stromal cells in vivo. These results suggest that betaxolol induces cytotoxicity in a concentration-dependent manner in HCSCs, and that caspase-8 and Bcl-2 family proteins may be critical switches in the conversion of different HCSC death mechanisms.

Analyzing the phase and amplitude noise of RZ, NRZ and RF DACs

This article considers a multi-mode RF DACs phase and amplitude noise for non-return-to-zero (NRZ), return-to-zero (RZ), and mix/RF reconstruction waveforms under the assumption that two switch pairs (or two channels) in each current switch cells are alternately active in every clock cycle, Analysis shows that each channel of multimode DAC is completely characterized with RZ mode, and all other modes can be derived from this mode, in particular NRZ mode is not a complete analog of conventional DAC performance when reconstruction pulse duration and period are equal. When determining phase and amplitude noise of multi-mode RF DAC, one should keep in mind the phase shift between two switch pairs output pulses spectral components in NRZ and RF modes. This phase shift depends upon DAC mode (NRZ or RF) and output oscillation frequency. As consequence an analysis indicates that the 3 dB improvement of 1/F phase noise can be achieved in 1st Nyquist zone when using NRZ mode, the same in 2nd Nyquist zone with RF mode if amplitude noise of DAC switch pairs is negligible. The independence of 1/F noise from clock frequency has simple physical interpretation. As correlation period of 1/F noise is significantly greater than output oscillation period, the delay of this oscillation caused by phase fluctuations in DAC is the same for any mode, and analysis of noise spectral density for conventional DAC can be extended to multi-mode RF DACs.

Microbiota affects mitochondria and immune cell infiltrations via alternative polyadenylation during postnatal heart development.

There is a growing body of evidence supporting the significant impact of microbiota on heart development. Alternative polyadenylation (APA) is a crucial mechanism for gene expression regulation and has been implicated in postnatal heart development. Nonetheless, whether microbiota can influence postnatal heart development through the regulation of APA remains unclear. Therefore, we conducted APA sequencing on heart tissues collected from specific pathogen-free (SPF) mice and germ-free (GF) mice at three different developmental stages: within the first 24h after birth (P1), 7-day-old SPF mice, and 7-day-old GF mice. This approach allowed us to obtain a comprehensive genome-wide profile of APA sites in the heart tissue samples. In this study, we made a significant observation that GF mice exhibited noticeably longer 3' untranslated region (3' UTR) lengths. Furthermore, we confirmed significant alterations in the 3' UTR lengths of mitochondria-related genes, namely Rala, Timm13, and Uqcc3. Interestingly, the GF condition resulted in a marked decrease in mitochondrial cristae density and a reduction in the level of Tomm20 in postnatal hearts. Moreover, we discovered a connection between Rala and Src, which further implicated their association with other differentially expressed genes (DEGs). Notably, most of the DEGs were significantly downregulated in GF mice, with the exceptions being Thbs1 and Egr1. Importantly, the GF condition demonstrated a correlation with a lower infiltration of immune cells, whereby the levels of resting NK cells, Th17 cells, immature dendritic cells, and plasma cells in GF mice were comparable to those observed in P1 mice. Furthermore, we established significant correlations between these immune cells and Rala as well as the related DEGs. Our findings clearly indicated that microbiota plays a vital role in postnatal heart development by affecting APA switching, mitochondria and immune cell infiltrations.

Multifunctional two-dimensional perovskite based solar cells for photodetectors and resistive switching.

The escalating interest in low-dimensional perovskites stems from their tunable optoelectronic traits and robust stability. The pursuit of multifaceted optoelectronic devices holds substantial importance for energy-efficient and space-constrained systems. This investigation showcases the realization of multifunctional two-dimensional perovskite solar cells, incorporating transient light detection and resistive switching functions within a single device, achievable by facile external bias adjustments. Serving as a photodetector, the device exhibits commendable self-powered photodetection attributes, including an exceptionally low dark current density of 1 nA mm-2, a remarkable specific detectivity of 7.67 × 1012 Jones, a swift response time of 0.60 μs, and an expansive linear dynamic range of 72 dB. As a memristor, it showcases enduring performance across 4 × 102 cycles, a substantial on/off ratio of 106, and a rapid operation time of less than 1 μs. This endeavor unveils a pioneering avenue for advancing high-performance, air-stable multifunctional two-dimensional perovskite electronics.