Background: Women of reproductive age are frequently affected with Polycystic Ovarian Syndrome,an endocrine disorder that causes anovulation and infertility. There is a paucity in the evidence ofcomparing the effectiveness of the Swiss ball and resistance training among PCOS subjects.Purpose: To compare the effect of Swiss ball exercise and Resistance training in symptoms femaleswith Polycystic Ovarian Syndrome.Materials and Method: A total of 30 subjects were selected from Private Institute. As outcomemeasures, the menstrual irregularity questionnaire (MIQ), BMI, and abdominal girth measurementwere used. Subjects were divided randomly into resistance training group (n = 15) received exerciseswith dumbbells and Swiss ball training group (n = 15) received exercises with Swiss ball, in additionto aerobic exercise.Results: Females with PCOS symptoms in RTG experienced statistically significant improvement inBMI from 28.3 ± 3.3 to 25.3 ± 3.3, in Abdominal girth 93.6 ± 4.6 to 88.8 ± 4.6, in MIQ 18.3 ± 3.8 to 13.5 ±3.3, with a p value of < 0.05 than in SBG which had BMI from 28.3 ± 3.7 to 27.9 ± 3.5, Abdominal girth93.6 ± 5.3 to 92.6 ± 5.3, MIQ 18.1 ± 3.5 to 16.4 ± 3.8, with a p value < 0.05.Conclusion: In comparison to a Swiss ball exercise, resistance training programme combined withaerobic activity is more effective at helping women with PCOS symptoms.