In the face of growing challenges in modern agriculture, such as climate change, sustainable resource management, and food security, drones are emerging as essential tools for transforming precision agriculture. This systematic review, based on an in-depth analysis of recent scientific literature (2020–2024), provides a comprehensive synthesis of current drone applications in the agricultural sector, primarily focusing on studies from this period while including a few notable exceptions of particular interest. Our study examines in detail the technological advancements in drone systems, including innovative aerial platforms, cutting-edge multispectral and hyperspectral sensors, and advanced navigation and communication systems. We analyze diagnostic applications, such as crop monitoring and multispectral mapping, as well as interventional applications like precision spraying and drone-assisted seeding. The integration of artificial intelligence and IoTs in analyzing drone-collected data is highlighted, demonstrating significant improvements in early disease detection, yield estimation, and irrigation management. Specific case studies illustrate the effectiveness of drones in various crops, from viticulture to cereal cultivation. Despite these advancements, we identify several obstacles to widespread drone adoption, including regulatory, technological, and socio-economic challenges. This study particularly emphasizes the need to harmonize regulations on beyond visual line of sight (BVLOS) flights and improve economic accessibility for small-scale farmers. This review also identifies key opportunities for future research, including the use of drone swarms, improved energy autonomy, and the development of more sophisticated decision-support systems integrating drone data. In conclusion, we underscore the transformative potential of drones as a key technology for more sustainable, productive, and resilient agriculture in the face of global challenges in the 21st century, while highlighting the need for an integrated approach combining technological innovation, adapted policies, and farmer training.
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