This study employed the resource-based view theory to investigate the relationships between technological innovation, knowledge management, and sustainable competitive advantage in the hospitality sector, focusing explicitly on hotels in the Yaounde and Douala regions of Cameroon. Cluster sampling was employed to identify 370 respondents from of 35 hotels. Structural equation modelling (SEM) was utilized to analyze the data. The study found that technological innovation had a positive and significant influence on sustainable competitive advantage and knowledge management. It was observed that knowledge management had a positive and significant influence on sustainable competitive advantage. The investigation discovered that knowledge management partially mediates the relationship between technological innovation and sustainable competitive advantage. Cameroonian hotels can improve their competitive advantage by innovating technology and promoting efficient knowledge management techniques. Adopting cutting-edge technologies and fostering a culture of knowledge exchange can result in increased operational efficiency, enhanced service delivery, and differentiation from rivals, ultimately bolstering long-term competitiveness in the hospitality sector.